Valid 11/1999 - 01/2000
Riedel-de Haen
3050 Spruce St.
St. Louis, MO 63178 USA
Tel: 314-289-6000
MATERIAL SAFETY DATA SHEET
SECTION 1. - - - - - - - - - CHEMICAL IDENTIFICATION- - - - - - - - - -
CATALOG #: 33034
NAME: L(+)-ASCORBIC ACID, MIN 99.7% ACS
SECTION 2. - - - - - COMPOSITION/INFORMATION ON INGREDIENTS - - - - - -
CAS #: 50-81-7
MF: C6H8O6
EC NO: 200-066-2
SYNONYMS
ADENEX * ALLERCORB * ANTISCORBIC VITAMIN * ANTISCORBUTIC VITAMIN *
ARCO-CEE * ASCOLTIN * ASCORBAJEN * ASCORBATE * ASCORBIC ACID * L(+)-
ASCORBIC ACID * ASCOR-B.I.D. * ASCORBUTINA * ASCORIN * ASCORTEAL *
ASCORVIT * CANTAN * CANTAXIN * CATAVIN C * CEBICURE * CEBID * CEBION *
CEBIONE * CECON * CEE-CAPS TD * CEE-VITE * CEGIOLAN * CEGLION *
CELASKON * CE LENT * CELIN * CEMAGYL * CE-MI-LIN * CEMILL * CENETONE *
CEREON * CERGONA * CESCORBAT * CETAMID * CETANE-CAPS TD * CETEMICAN *
CEVALIN * CEVATINE * CEVEX * CEVI-BID * CEVIMIN * CE-VI-SOL *
CEVITAL * CEVITAMIC ACID * CEVITAMIN * CEVITAN * CEVITEX * CEWIN *
CIAMIN * CIPCA * CITRISCORB * C-LEVEL * C-LONG * COLASCOR * CONCEMIN *
C-QUIN * C-SPAN * C-VIMIN * DORA-C-500 * DAVITAMON C * DUOSCORB * L-
THREO-HEX-2-ENONIC ACID, GAMMA-LACTONE * HICEE * HYBRIN * IDO-C * 3-
KETO-L-GULOFURANOLACTONE * L-3-KETOTHREOHEXURONIC ACID LACTONE *
KYSELINA ASKORBOVA (CZECH) * LAROSCORBINE * LEMASCORB * LIQUI-CEE * L-
LYXOASCORBIC ACID * NCI-C54808 * NSC 33832 * 3-OXO-L-
GULOFURANOLACTONE * 3-OXO-L-GULOFURANOLACTONE (ENOL FORM) * PLANAVIT
C * PROSCORBIN * REDOXON * RIBENA * ROSCORBIC * SCORBACID * SCORBU-C *
SECORBATE * TESTASCORBIC * VICELAT * VICOMIN C * VIFORCIT * VISCORIN
* VITACE * VITACEE * VITACIMIN * VITACIN * VITAMIN C * VITAMISIN *
VITASCORBOL * XITIX * L-XYLOASCORBIC ACID *
SECTION 3. - - - - - - - - - - HAZARDS IDENTIFICATION - - - - - - - - -
DATA NOT AVAILABLE
SECTION 4. - - - - - - - - - - FIRST-AID MEASURES- - - - - - - - - - -
IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS.
CALL A PHYSICIAN.
IN CASE OF SKIN CONTACT, FLUSH WITH COPIOUS AMOUNTS OF WATER
FOR AT LEAST 15 MINUTES. REMOVE CONTAMINATED CLOTHING AND
SHOES. CALL A PHYSICIAN.
IF INHALED, REMOVE TO FRESH AIR. IF BREATHING BECOMES DIFFICULT,
CALL A PHYSICIAN.
IN CASE OF CONTACT WITH EYES, FLUSH WITH COPIOUS AMOUNTS OF WATER
FOR AT LEAST 15 MINUTES. ASSURE ADEQUATE FLUSHING BY SEPARATING
THE EYELIDS WITH FINGERS. CALL A PHYSICIAN.
SECTION 5. - - - - - - - - - FIRE FIGHTING MEASURES - - - - - - - - - -
EXTINGUISHING MEDIA
WATER SPRAY.
CARBON DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE FOAM.
SPECIAL FIREFIGHTING PROCEDURES
WEAR SELF-CONTAINED BREATHING APPARATUS AND PROTECTIVE CLOTHING TO
PREVENT CONTACT WITH SKIN AND EYES.
UNUSUAL FIRE AND EXPLOSIONS HAZARDS
EMITS TOXIC FUMES UNDER FIRE CONDITIONS.
SECTION 6. - - - - - - - - ACCIDENTAL RELEASE MEASURES- - - - - - - - -
WEAR PROTECTIVE EQUIPMENT.
SWEEP UP, PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL.
AVOID RAISING DUST.
VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE.
SECTION 7. - - - - - - - - - - HANDLING AND STORAGE- - - - - - - - - - -
REFER TO SECTION 8.
SECTION 8. - - - - - - EXPOSURE CONTROLS/PERSONAL PROTECTION- - - - - -
CHEMICAL SAFETY GOGGLES.
COMPATIBLE CHEMICAL-RESISTANT GLOVES.
NIOSH/MSHA-APPROVED RESPIRATOR.
SAFETY SHOWER AND EYE BATH.
MECHANICAL EXHAUST REQUIRED.
AVOID INHALATION.
AVOID CONTACT WITH EYES, SKIN AND CLOTHING.
AVOID PROLONGED OR REPEATED EXPOSURE.
WASH THOROUGHLY AFTER HANDLING.
KEEP TIGHTLY CLOSED.
STORE IN A COOL DRY PLACE.
SECTION 9. - - - - - - - PHYSICAL AND CHEMICAL PROPERTIES - - - - - - -
APPEARANCE AND ODOR
SOLID.
PHYSICAL PROPERTIES
MELTING POINT: 193 C (DEC)
SECTION 10. - - - - - - - - -STABILITY AND REACTIVITY - - - - - - - - -
STABILITY
STABLE.
HAZARDOUS COMBUSTION OR DECOMPOSITION PRODUCTS
TOXIC FUMES OF:
CARBON MONOXIDE, CARBON DIOXIDE
HAZARDOUS POLYMERIZATION
WILL NOT OCCUR.
SECTION 11. - - - - - - - - - TOXICOLOGICAL INFORMATION - - - - - - - -
ACUTE EFFECTS
MAY BE HARMFUL BY INHALATION, INGESTION, OR SKIN ABSORPTION.
MAY CAUSE EYE IRRITATION.
MAY CAUSE SKIN IRRITATION.
MATERIAL MAY BE IRRITATING TO MUCOUS MEMBRANES AND UPPER
RESPIRATORY TRACT.
CHRONIC EFFECTS
CHRONIC INGESTION OF LARGE DOSES MAY CAUSE GASTROINTESTINAL
DISTURBANCES INCLUDING NAUSEA AND DIARRHEA, URINARY EFFECTS INVOLVING
URINE ACIDIFICATION, OXALATE AND URIC CRYSTALLIZATON IN THE
BLADDER AND KIDNEY AND DECREASED REACTION TIMES AND PSYCHOMOTOR
COORDINATION.
RTECS #: CI7650000
L-ASCORBIC ACID
TOXICITY DATA
IVN-WMN LDLO:900 MG/KG AIMDAP 145,950,1985
ORL-RAT LD50:11900 MG/KG OYYAA2 12,131,1976
SCU-RAT LD50:>10 GM/KG OYYAA2 12,131,1976
IVN-RAT LD50:>4 GM/KG OYYAA2 12,131,1976
ORL-MUS LD50:3367 MG/KG NCISP* JAN1986
IPR-MUS LD50:643 MG/KG PMRSDJ 1,682,1981
IVN-MUS LD50:518 MG/KG RPOBAR 2,269,1970
TARGET ORGAN DATA
KIDNEY, URETER, BLADDER (CHANGES IN TUBULES)
SPECIFIC DEVELOPMENTAL ABNORMALITIES (CENTRAL NERVOUS SYSTEM)
SPECIFIC DEVELOPMENTAL ABNORMALITIES (MUSCULOSKELETAL SYSTEM)
ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES
(RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR
COMPLETE INFORMATION.
SECTION 12. - - - - - - - - - ECOLOGICAL INFORMATION - - - - - - - - - -
DATA NOT YET AVAILABLE.
SECTION 13. - - - - - - - - - DISPOSAL CONSIDERATIONS - - - - - - - - -
DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE SOLVENT AND BURN IN A
CHEMICAL INCINERATOR EQUIPPED WITH AN AFTERBURNER AND SCRUBBER.
OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS.
SECTION 14. - - - - - - - - - - TRANSPORT INFORMATION - - - - - - - - -
CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION INFORMATION.
SECTION 15. - - - - - - - - - REGULATORY INFORMATION - - - - - - - - - -
REVIEWS, STANDARDS, AND REGULATIONS
OEL=MAK
NOHS 1974: HZD M0462; NIS 24; TNF 5030; NOS 33; TNE 69440
NOES 1983: HZD M0462; NIS 41; TNF 7888; NOS 56; TNE 137698; TFE 84231
EPA GENETOX PROGRAM 1988, POSITIVE: IN VITRO SCE-HUMAN LYMPHOCYTES; IN
VITRO SCE-HUMAN
EPA GENETOX PROGRAM 1988, POSITIVE: IN VITRO SCE-NONHUMAN
EPA GENETOX PROGRAM 1988, NEGATIVE: SPERM MORPHOLOGY-MOUSE
EPA GENETOX PROGRAM 1988, INCONCLUSIVE: MAMMALIAN MICRONUCLEUS;
HISTIDINE REVERSION-AMES TEST
EPA TSCA SECTION 8(B) CHEMICAL INVENTORY
NTP CARCINOGENESIS BIOASSAY (FEED);NO EVIDENCE:MOUSE,RAT
NTPTR* NTP-TR-247,1983
SECTION 16. - - - - - - - - - - OTHER INFORMATION- - - - - - - - - - - -
THE ABOVE INFORMATION IS BELIEVED TO BE CORRECT BUT DOES NOT PURPORT TO
BE ALL INCLUSIVE AND SHALL BE USED ONLY AS A GUIDE. SIGMA, ALDRICH,
FLUKA SHALL NOT BE HELD LIABLE FOR ANY DAMAGE RESULTING FROM HANDLING
OR FROM CONTACT WITH THE ABOVE PRODUCT. SEE REVERSE SIDE OF INVOICE OR
PACKING SLIP FOR ADDITIONAL TERMS AND CONDITIONS OF SALE.
COPYRIGHT 1998 SIGMA-ALDRICH CO.
LICENSE GRANTED TO MAKE UNLIMITED PAPER COPIES FOR INTERNAL USE ONLY
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