BASF Corporation
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Safety data sheet
LUPRANATE庐5030 ISOCYANATE
Revision date : 2004/06/25 Page: 1/7
Version: 2.0 (30243817/MDS_GEN_US/EN)
1. Substance/preparation and company identification
Company 24 Hour Emergency Response Information
BASF Corporation CHEMTREC: (800) 424-9300
3000 Continental Drive - North BASF HOTLINE: (800) 832-HELP
Mount Olive, NJ 07828-1234
Chemical family: aromatic isocyanates
Synonyms: POLYMETHYLENE POLYPHENYLISOCYANATE
2. Composition/information on ingredients
CAS Number Content (W/W) Chemical name
101-68-8 50.0 % Diphenylmethane-4,4'-diisocyanate (MDI)
< 50.0 % Isocyanate Prepolymer
26447-40-5 < 3.0 % MDI Mixed Isomers
3. Hazard identification
Emergency overview
CAUTION: CONTAINS DIPHENYLMETHANE DIISOCYANATE (CAS No. 101-68-8). INHALATION OF MDI
MISTS OR VAPORS MAY CAUSE RESPIRATORY IRRITATION, BREATHLESSNESS, CHEST
DISCOMFORT AND REDUCED PULMONARY FUNCTION. OVEREXPOSURE WELL ABOVE THE PEL
MAY RESULT IN BRONCHITIS, BRONCHIAL SPASMS AND PULMONARY EDEMA. LONG-TERM
EXPOSURE TO ISOCYANATES HAS BEEN HAS BEEN REPORTED TO CAUSE LUNG DAMAGE,
INCLUDING REDUCED LUNG FUNCTION WHICH MAY BE PERMANENT. ACUTE OR CHRONIC
OVEREXPOSURE TO ISOCYANATES MAY CAUSE SENSITIZATION IN SOME INDIVIDUALS,
RESULTING IN ALLERGIC RESPIRATORY REACTIONS INCLUDING WHEEZING, SHORTNESS OF
BREATH AND DIFFICULTY BREATHING.
Potential health effects
Primary routes of exposure
Routes of entry for solids and liquids include eye and skin contact, ingestion and inhalation. Routes of entry
for gases include inhalation and eye contact. Skin contact may be a route of entry for liquified gases.
Acute toxicity:
Information on: MDI
Inhalation of MDI vapors may cause irritation of the mucous membranes of the nose, throat or
trachea, breathlessness, chest discomfort, difficult breathing and reduced pulmonary function. Air-
borne overexposure well above the PEL may result additionally in eye irritation, headache, chemical
bronchitis, asthma-like findings or pulmonary edema. Isocyanates have also been reported to
cause hypersensitivity pneumonitis, which is characterized by flu-like symptoms, the onset of which
may bedelayed. Gastrointestinal symptoms include nausea, vomiting and abdominal pain.
Irritation:
Information on: Diisocyanates
Eye contact with isocyanates may result in conjunctival irritation and mild corneal opacity. Skin
contact may result in dermatitis, either irritative or allergic.
Repeated dose toxicity:
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Safety data sheet
LUPRANATE庐5030 ISOCYANATE
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Version: 2.0 (30243817/MDS_GEN_US/EN)
Information on: MDI
Results from a lifetime inhalation study in rats indicate that MDI aerosol was carcinogenic at 6
mg/m3, the highest dose tested. This is well above the recommended TLV of 5 ppb (0.05 mg/m3).
Only irritation was noted at the lower concentration of 0.2 and 1 mg/m3. No birth defects or
teratogenic effects were reported in a teratology study with rats exposed to 1, 4, and 12 mg/m3
polymeric MDI for 6 hr/day on days 6-15 of gestation. Embryotoxicity and fetotoxicity was reported
at the top dose in the presence of maternal toxicity.
Information on: Isocyanates
As a result of previous repeated overexposures or a single large dose, certain individuals will
develop isocyanate sensitization (chemical asthma) which will cause them to react to a later
exposure to isocyanate at levels well below the PEL/TLV. These symptoms, which include chest
tightness, wheezing, cough, shortness of breath, or asthmatic attack, could be immediate or
delayed up to several hours after exposure. Similar to many non-specific asthmatic responses,
there are reports that once sensitized an individual can experience these symptoms upon exposure
to dust, cold air, or other irritants. This increased lung sensitivity can persist for weeks and in
severe cases for several years. Chronic overexposure to isocyanates has also been reported to
cause lung damage, including a decrease in lung function, which may be permanent. Sensitization
may be either temporary or permanent. Prolonged contact can cause reddening, swelling, rash,
scaling, or blistering. In those who have developed a skin sensitization, these symptoms can
develop as a result of contact with very small amounts of liquid material, or even as a result of
vapor-only exposure.
Medical conditions aggravated by overexposure:
Medical supervision of all employees who handle or come into contact with isocyanates is recommended.
The isocyanate component is a respiratory sensitizer. It may cause allergic reaction leading to asthma-like
spasms of the bronchial tubes and difficulty in breathing.
Preemployment and periodic medical examinations with respiratory function tests (FEV, FVC as a minimum)
are suggested.
Persons with history of respiratory disease or hypersensitivity should not be exposed to this product.
Persons with asthmatic conditions, chronic bronchitis, other chronic respiratory diseases, recurrent eczema
or pulmonary sensitization should be excluded from working with isocyanates. Once a person is diagnosed
as having pulmonary sensitization (allergic asthma) to isocyanates, further exposure is not recommended.
An animal study indicated that MDI may induce respiratory hypersensitivity following dermal exposure.
4. First-aid measures
General advice:
Remove contaminated clothing.
If inhaled:
Remove the affected individual into fresh air and keep the person calm. Assist in breathing if necessary.
Immediate medical attention required.
If on skin:
Wash affected areas thoroughly with soap and water. Immediate medical attention required.
If in eyes:
In case of contact with the eyes, rinse immediately for at least 15 minutes with plenty of water. Immediate
medical attention required.
If swallowed:
Rinse mouth and then drink plenty of water. Do not induce vomiting. Never induce vomiting or give anything
by mouth if the victim is unconscious or having convulsions. Immediate medical attention required.
Note to physician
Antidote: Specific antidotes or neutralizers to isocyanates do not exist.
Treatment: Treatment should be supportive and based on the judgement of the physician in
response to the reaction of the patient.
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Safety data sheet
LUPRANATE庐5030 ISOCYANATE
Revision date : 2004/06/25 Page: 3/7
Version: 2.0 (30243817/MDS_GEN_US/EN)
5. Fire-fighting measures
Flash point: 200 掳C (ASTM D92)
Autoignition: No data available.
Suitable extinguishing media:
water, dry extinguishing media, carbon dioxide, foam
Hazards during fire-fighting:
nitrous gases, fumes/smoke, isocyanate, vapour
Protective equipment for fire-fighting:
Firefighters should be equipped with self-contained breathing apparatus and turn-out gear.
6. Accidental release measures
Personal precautions:
Clear area. Ensure adequate ventilation. Wear suitable personal protective clothing and equipment.
Environmental precautions:
Do not discharge into drains/surface waters/groundwater.
Cleanup:
Dike spillage.
For small amounts: Absorb isocyanate with suitable absorbent material (see 搂 40 CFR, sections 260, 264
and 265 for further information). Shovel into open container. Do not make container pressure tight. Move
container to a well-ventilated area (outside). Spill area can be decontaminated with the following
recommended decontamination solution: Mixture of 90 % water, 8 % concentrated ammonia, 2 % detergent.
Add at a 10 to 1 ratio. Allow to stand for at least 48 hours to allow escape of evolved carbon dioxide.
For large amounts: If temporary control of isocyanate vapor is required, a blanket of protein foam or other
suitable foam (available from most fire departments) may be placed over the spill. Transfer as much liquid as
possible via pump or vacuum device into closed but not sealed containers for disposal.
For residues: The following measures should be taken for final cleanup: Wash down spill area with
decontamination solution. Allow solution to stand for at least 10 minutes.
7. Handling and storage
Handling
General advice:
Mix thoroughly before use. If bulging of drum occurs, transfer to well ventilated area, puncture to relieve
pressure, open vent and let stand for 48 hours before resealing.
Protection against fire and explosion:
No explosion proofing necessary.
Storage
General advice:
Formation of CO2 and build up of pressure possible.
Storage incompatibility:
General: Segregate from bases.
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Safety data sheet
LUPRANATE庐5030 ISOCYANATE
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Version: 2.0 (30243817/MDS_GEN_US/EN)
Storage stability:
Storage temperature: 60 - 80 掳F
Protect against moisture.
8. Exposure controls and personal protection
Components with workplace control parameters
Diphenylmethane-4,4'- OSHA CLV 0.02 ppm 0.2 mg/m3 ;
diisocyanate (MDI) ACGIH TWA value 0.005 ppm ;
Advice on system design:
Provide local exhaust ventilation to maintain recommended P.E.L.
Personal protective equipment
Respiratory protection:
For situations where the airborne concentrations may exceed the level for which an air purifying respirator is
effective, or where the levels are unknown or Immediately Dangerous to Life or Health (IDLH), use NIOSH-
certified full facepiece pressure demand self-contained breathing apparatus (SCBA) or a full facepiece
pressure demand supplied-air respirator (SAR) with escape provisions. When atmospheric levels may
exceed the occupational exposure limit (PEL or TLV) NIOSH-certified air-purifying respirators equipped with
an organic vapor sorbent and particulate filter can be used as long as appropriate precautions and change
out schedules are in place.
Hand protection:
Chemical resistant protective gloves
Eye protection:
Tightly fitting safety goggles (chemical goggles). Wear face shield if splashing hazard exists.
Body protection:
Suitable materials, saran-coated material
General safety and hygiene measures:
Observe the appropriate PEL value. Eye wash fountains and safety showers must be easily accessible.
Wear protective clothing as necessary to prevent contact. Wash soiled clothing immediately. Contaminated
equipment or clothing should be cleaned after each use or disposed of.
9. Physical and chemical properties
Form: liquid
Odour: faint odour, aromatic
Colour: yellow, clear
pH value: Not applicable
Freezing point: 20 掳C ( 1 ATM)
Boiling point: 200 掳C ( 5 mmHg)
Bulk density: 9.58 lb/USg
Viscosity, dynamic: 1,130 mPa.s ( 25 掳C)
10. Stability and reactivity
Conditions to avoid:
Avoid moisture.
BASF Corporation
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Safety data sheet
LUPRANATE庐5030 ISOCYANATE
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Version: 2.0 (30243817/MDS_GEN_US/EN)
Substances to avoid:
water, alcohols, strong bases, Substances/products that react with isocyanates.
Hazardous reactions:
The product is chemically stable.
Reacts with water, with formation of carbon dioxide. Risk of bursting. Reacts with alcohols. Reacts with
acids. Reacts with alkalies. Reacts with amines. Risk of exothermic reaction. Risk of violent reaction. Risk of
polymerization. Contact with certain rubbers and plastics can cause brittleness of the substance/product with
subsequent loss in strength.
Decomposition products:
Hazardous decomposition products: carbon monoxide, hydrogen cyanide, nitrogen oxides, aromatic
isocyanates, gases/vapours
Thermal decomposition:
No data available.
Corrosion to metals:
No corrosive effect on metal.
11. Toxicological information
Acute toxicity
Oral:
LD50/rat: > 10,000 mg/kg
Practically nontoxic.
Inhalation:
LC50/rat: > 2.240 mg/l / 1 h
Moderately toxic.
12. Ecological information
Environmental toxicity
Acute and prolonged toxicity to fish:
static
zebra fish/LC50 (24 h): > 500 mg/l
Practically nontoxic.
Acute toxicity to aquatic invertebrates:
Daphnia magna/EC50 (24 h): > 500 mg/l
Practically nontoxic.
13. Disposal considerations
Waste disposal of substance:
Incinerate or dispose of in a licensed facility.
Do not discharge substance/product into sewer system.
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Safety data sheet
LUPRANATE庐5030 ISOCYANATE
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Contaminated packaging:
Steel drums must be emptied and can be sent to a licensed drum reconditioner for reuse, a scrap metal
dealer or an approved landfill. Refer to 40 CFR 搂 261.7 (residues of hazardous waste in empty containers).
Check with reconditioner to determine if decontamination is required. Decontaminate containers prior to
disposal. Recommend crushing, puncturing or other means to prevent unauthorized use of used containers.
14. Transport information
Reference Bill of Lading
15. Regulatory information
Federal Regulations
Registration status:
TSCA, US released / listed
TSCA 12B released / listed
OSHA hazard category: Other carcinogen, Sensitizer, Acute target organ effects reported, Skin
and/or eye irritant, OSHA PEL established, Highly toxic - inhalation, Chronic target organ effects reported,
ACGIH TLV established
5,000 lb
CERCLA RQ:
SARA hazard categories (EPCRA 311/312): Chronic, Acute
SARA 313:
CAS Number Chemical name
Diisocyanates
State regulations
State RTK
CAS Number Chemical name State RTK
101-68-8 Diphenylmethane-4,4'-diisocyanate (MDI) MA, NJ, PA
16. Other information
HMIS III rating
Health: 2 Flammability: 1 Physical hazard: 1
HMIS uses a numbering scale ranging from 0 to 4 to indicate the degree of hazard. A value of zero means that the
substance possesses essentially no hazard; a rating of four indicates high hazard.
Local contact information
William Robert
1-734-324-5244
LUPRANATE is a registered trademark of BASF Corporation or BASF AG
BASF Corporation
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Safety data sheet
LUPRANATE庐5030 ISOCYANATE
Revision date : 2004/06/25 Page: 7/7
Version: 2.0 (30243817/MDS_GEN_US/EN)
IMPORTANT: WHILE THE DESCRIPTIONS, DESIGNS, DATA AND INFORMATION CONTAINED HEREIN
ARE PRESENTED IN GOOD FAITH AND BELIEVED TO BE ACCURATE, IT IS PROVIDED FOR YOUR
GUIDANCE ONLY. BECAUSE MANY FACTORS MAY AFFECT PROCESSING OR APPLICATION/USE,
WE RECOMMEND THAT YOU MAKE TESTS TO DETERMINE THE SUITABILITY OF A PRODUCT FOR
YOUR PARTICULAR PURPOSE PRIOR TO USE. NO WARRANTIES OF ANY KIND, EITHER
EXPRESSED OR IMPLIED, INCLUDING WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A
PARTICULAR PURPOSE, ARE MADE REGARDING PRODUCTS DESCRIBED OR DESIGNS, DATA OR
INFORMATION SET FORTH, OR THAT THE PRODUCTS, DESIGNS, DATA OR INFORMATION MAY BE
USED WITHOUT INFRINGING THE INTELLECTUAL PROPERTY RIGHTS OF OTHERS. IN NO CASE
SHALL THE DESCRIPTIONS, INFORMATION, DATA OR DESIGNS PROVIDED BE CONSIDERED A
PART OF OUR TERMS AND CONDITIONS OF SALE. FURTHER, YOU EXPRESSLY UNDERSTAND AND
AGREE THAT THE DESCRIPTIONS, DESIGNS, DATA, AND INFORMATION FURNISHED BY BASF
HEREUNDER ARE GIVEN GRATIS AND BASF ASSUMES NO OBLIGATION OR LIABILITY FOR THE
DESCRIPTION, DESIGNS, DATA AND INFORMATION GIVEN OR RESULTS OBTAINED, ALL SUCH
BEING GIVEN AND ACCEPTED AT YOUR RISK.
BASF CORPORATION WILL NOT MAKE ITS PRODUCTS AVAILABLE TO CUSTOMERS FOR USE IN
THE MANUFACTURE OF MEDICAL DEVICES WHICH ARE INTENDED FOR PERMANENT
IMPLANTATION IN THE HUMAN BODY OR IN PERMANENT CONTACT WITH INTERNAL BODILY
TISSUES OR FLUIDS.
END OF DATA SHEET
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