MATERIAL SAFETY DATA SHEET
PRODUCT NAME: NITRIC OXIDE (> 2.3%) IN NITROGEN
1. Chemical Product and Company Identification
BOC Gases, BOC Gases
Division of Division of
The BOC Group, Inc. BOC Canada Limited
575 Mountain Avenue 5975 Falbourne Street, Unit 2
Murray Hill, NJ 07974 Mississauga, Ontario L5R 3W6
TELEPHONE NUMBER: (908) 464-8100 TELEPHONE NUMBER: (905) 501-1700
24-HOUR EMERGENCY TELEPHONE NUMBER: 24-HOUR EMERGENCY TELEPHONE NUMBER:
CHEMTREC (800) 424-9300 (905) 501-0802
EMERGENCY RESPONSE PLAN NO: 20101
PRODUCT NAME: NITRIC OXIDE (> 2.3%) IN NITROGEN
CHEMICAL NAME: Nitric oxide (> 2.3%) in nitrogen
COMMON NAMES/SYNONYMS: Nitric oxide (> 2.3%) in nitrogen
TDG (Canada) CLASSIFICATION: 2.3
WHMIS CLASSIFICATION: A, D2A, C, E
PREPARED BY: Loss Control (908)464-8100/(905)501-1700
PREPARATION DATE: 6/1/95
REVIEW DATES: 6/17/96
2. Composition, Information on Ingredients
PEL-OSHA1 TLV-ACGIH2
INGREDIENT % VOLUME LD50 or LC50
Route/Species
NITRIC OXIDE > 2.3 25 ppm 25 ppm LC50: 1068
mg/m3/4H
FORMULA: NO
CAS: 10102-43-9 inhalatiuon/rat
RTECS #: 53019
NITROGEN < 97.70 Not Available Not Available Not Available
FORMULA: N2
CAS: 7727-37-9
RTECS #: 53011
1
As stated in 29 CFR 1910, Subpart Z (revised July 1, 1993)
2
As stated in the ACGIH 1994-95 Threshold Limit Values for Chemical Substances and Physical Agents
3. Hazards Identification
EMERGENCY OVERVIEW
Odorless, colorless, poison gas. Oxidizer. Corrosive. This product contains nitric oxide which, when
inhaled, can cause death from pulmonary edema at relatively low concentrations. If respiratory, skin
or eye irritation occurs when working with this product, inhalation exposure may have already
occurred. Prompt medical attention is mandatory in all cases of overexposure.. .
MSDS: G-207
Revised: 6/17/96 Page 1 of 7
PRODUCT NAME: NITRIC OXIDE (> 2.3% PPM) IN NITROGEN
ROUTE OF ENTRY:
Skin Contact Skin Absorption Eye Contact Inhalation Ingestion
Yes No Yes Yes No
HEALTH EFFECTS:
Exposure Limits Irritant Sensitization
Yes Yes No
Teratogen Reproductive Hazard Mutagen
No No No
Synergistic Effects
None known
Carcinogenicity: -- NTP: No IARC: No OSHA: No
EYE EFFECTS:
Overexposure may cause irritation or corrosive burns.
SKIN EFFECTS:
May cause skin irritation or corrosive burns.
INGESTION EFFECTS:
Unlikely; product is a gas.
INHALATION EFFECTS:
Nitric oxide vapors are a strong irritant to the pulmonary tract. Nitric oxide is highly toxic and hazardous
because of its ability to cause delayed chemical pneumonitis and pulmonary edema. The absence of marked
acute irritation of nitric oxide limits its warning properties.
SIGNS AND SYMPTOMS:
Initial symptoms of nitric oxide inhalation may be moderate and include irritation to the throat, tightness of the
chest, headache, nausea and gradual loss of strength. Severe symptoms may be delayed (possibly for several
hours) and include cyanosis, increased difficulty in breathing, irregular respiration, lassitude and possible
eventual death due to pulmonary edema in untreated cases.
CHRONIC EFFECTS:
Repeated exposure to nitric oxide may cause a permanent decrease in pulmonary function (Silo Filler鈥檚 Disease)
or chronic irritation of the respiratory tract with cough, headache, loss of appetite, dyspepsia, tooth corrosion
and gradual loss of strength.
TARGET ORGANS:
Overexposure may affect the respiratory tract.
NFPA HAZARD CODES HMIS HAZARD CODES RATINGS SYSTEM
Health: 3 Health: 3 0 = No Hazard
Flammability: 0 Flammability: 0 1 = Slight Hazard
Reactivity: 0 Reactivity: 0 2 = Moderate Hazard
OXIDIZER 3 = Serious Hazard
4 = Severe Hazard
MSDS: G-207
Revised: 6/17/96 Page 2 of 7
PRODUCT NAME: NITRIC OXIDE (> 2.3% PPM) IN NITROGEN
4. First Aid Measures
EYE:
Immediately flush skin with large quantities of tepid water or sterile saline solution. Seek medical attention as
soon as possible.
SKIN:
Flush affected area with tepid water. Seek medical attention.
INGESTION:
Unlikely; product is a gas.
INHALATION:
PROMPT MEDICAL ATTENTION IS MANDATORY IN ALL CASES OF OVEREXPOSURE. RESCUE
PERSONNAL SHOULD BE EQUIPPED WITH SELF-CONTAINED BREATHING APPARATUS.
Conscious persons should be CARRIED (not assisted) to an uncontaminated area and inhale fresh air with
supplemental oxygen. Quick removal from the contamination area is most important. Keep the patient warm,
quiet and under competent medical observation until the danger of delayed pulmonary edema has passed (at least
72 hours). Any physical exertion during this period should be discouraged as it may increase the severity of the
pulmonary edema or chemical pneumonitis. Bed rest is indicated.
Unconscious persons should be moved to an uncontaminated area, and if breathing has stopped, administer
artificial resuscitation and supplemental oxygen. Once respiration has been restored, they should be treated as
above.
5. Fire Fighting Measures
Conditions of Flammability: Not flammable
Flash point: Method: Autoignition
None Not Applicable Temperature: None
LEL(%): None UEL(%): None
Hazardous combustion products: None
Sensitivity to mechanical shock: None
Sensitivity to static discharge: None
FIRE AND EXPLOSION HAZARDS:
This mixture is nonflammable.
EXTINGUISHING MEDIA:
Nonflammable. Nitric oxide is a enhances combustion of organic matter and other combustible materials.
FIRE FIGHTING INSTRUCTIONS:
Firefighters should wear a NIOSH/MSHA approved self-contained breathing apparatus (SCBA) operated in
positive pressure mode and full turnout gear. Additional chemical protective clothing may be necessary to
prevent exposure.
MSDS: G-207
Revised: 6/17/96 Page 3 of 7
PRODUCT NAME: NITRIC OXIDE (> 2.3% PPM) IN NITROGEN
6. Accidental Release Measures
Evacuate all personnel from affected area. Ventilate enclosed spaces. Deny entry to persons not wearing
appropriate protective equipment. If leak is in user鈥檚 equipment, be certain to purge piping with inert gas prior to
attempting repairs. If leak is in container or container valve, contact the appropriate emergency telephone
number listed in Section 1 or call your closest BOC location. Do not re-enter hazard area until oxygen content is
re-established and nitric oxide has dispersed.
7. Handling and Storage
Electrical classification:
Nonhazardous.
Use only in well-ventilated areas. Valve protection caps must remain in place unless container is secured with
valve protection outlet piped to use point. Do not drag, slide or roll cylinders. Use a suitable hand truck for
cylinder movement. Use a pressure-reducing regulator when connecting cylinder to lower pressure (< 3000
psig) piping or systems. Do not heat cylinder by any means to increase the discharge rate of product from the
cylinder. Use a check valve or trap in the discharge line to prevent hazardous back flow into the cylinder.
Protect cylinders from physical damage. Store in cool, dry, well-ventilated area of non-combustible construction
away from heavily trafficked areas and emergency exits. Do not allow the temperature where cylinders are
stored to exceed 130潞 F (54潞 C). Cylinders should be stored upright and firmly secured to prevent falling or
being knocked over. Use a 鈥渇irst-in first-out鈥? inventory system to prevent full cylinders being stored for
excessive periods of time.
Stationary customer site vessels should operate in accordance with the manufacturer's and BOC鈥檚 instruction. Do
not attempt to repair, adjust or in any other way modify the operation of these vessels. If there is a malfunction
or other type of operations problem with the vessel, contact the closest BOC location immediately.
For additional recommendations, consult Compressed Gas Association Pamphlets G-4, P-12, P-4.
Never carry a compressed gas cylinder or a container of a gas in cryogenic liquid form in an enclosed space such
as a car trunk, van or station wagon. A leak can result in a fire, explosion, asphyxiation or a toxic exposure.
8. Exposure Controls, Personal Protection
EXPOSURE LIMITS1:
PEL-OSHA2 TLV-ACGIH3
INGREDIENT % VOLUME LD50 or LC50
Route/Species
NITRIC OXIDE > 2.30 25 ppm 25 ppm LC50: 1068
mg/m3/4H
FORMULA: NO
CAS: 10102-43-9 inhalatiuon/rat
RTECS #: 53019
NITROGEN < 97.70 Not Available Not Available Not Available
FORMULA: N2
CAS: 7727-37-9
RTECS #: 53011
1
Refer to individual state of provincial regulations, as applicable, for limits which may be more stringent than
those listed here.
2
As stated in 29 CFR 1910, Subpart Z (revised July 1, 1993)
3
As stated in the ACGIH 1994-1995 Threshold Limit Values for Chemical Substances and Physical Agents.
MSDS: G-207
Revised: 6/17/96 Page 4 of 7
PRODUCT NAME: NITRIC OXIDE (> 2.3% PPM) IN NITROGEN
ENGINEERING CONTROLS:
Local exhaust ventilation to prevent accumulation of high concentrations which can reduce the level of oxygen
in the air to less than 18 molar percent, and to prevent nitric oxide accumulation above the exposure limit.
EYE/FACE PROTECTION:
Safety goggles or glasses and face shield.
SKIN PROTECTION:
Protective gloves of any material (rubber or teflon).
RESPIRATORY PROTECTION:
Where oxygen content is sufficient, none required. Where high or unknown concentrations are anticipated, an
airline respirator with full facepiece equipped with an escape bottle or a self-contained breathing apparatus will
full facepiece should be worn.
OTHER PROTECTION:
Safety shoes, eyewash and emergency oxygen.
PERSONNEL SAMPLING PROCEDURES:
Air sampling for nitrogen oxides: Molecular sieve/oxidizer sorbent glass sealed tube with glass wool separators
(OSHA ID 182).
9. Physical and Chemical Properties
PARAMETER VALUE UNITS
Physical state (gas, liquid, solid) : Gas
Vapor pressure : Not Available
Vapor density (Air = 1) : Not Available
Evaporation point : Not Available
o
Boiling point : Not Available F
o
Freezing point : Not Available F
pH : Not Available
Specific gravity : Not Available
Oil/water partition coefficient : Not Available
Solubility (H20) : Very slight
Odor threshold : Not Applicable
Odor and appearance : Colorless, odorless gas.
10. Stability and Reactivity
STABILITY:
Stable.
INCOMPATIBLE MATERIALS:
Oxidizing agents, halides, hydrocarbons and oxygen. Reacts vigorously with fluorine, fluorine oxides and
chlorine in the presence of moisture.
HAZARDOUS DECOMPOSITION PRODUCTS:
Nitric oxide oxidizes in air to form nitrogen dioxide, which is extremely reactive and a strong oxidizer. Nitric
oxide reacts with moisture and oxygen to form nitrous and nitric acids.
HAZARDOUS POLYMERIZATION:
Will not occur.
MSDS: G-207
Revised: 6/17/96 Page 5 of 7
PRODUCT NAME: NITRIC OXIDE (> 2.3% PPM) IN NITROGEN
11. Toxicological Information
INHALATION:
Mice which inhaled a total of 320 ppm nitric oxide exhibited convulsions or effects on seizure threshold as well
as cyanosis.
SUBCHRONIC:
Rat inhalation of nitric oxide (50 mg/m3/6H/7W-I) produced changes in liver and lung weights as well as overall
weight loss or decreased weight gain.
CHRONIC:
Chronic or repeated exposures may cause permanent decrements in pulmonary function (Silo Filler鈥檚 Disease).
MUTAGENIC EFFECTS:
Mutagenic data have been reported for nitric oxide.
12. Ecological Information
A series of atmospheric chemical reaction sin which nitric oxide is involved lead to the formation of
photochemical smog.
13. Disposal Considerations
Do not attempt to dispose of residual waste or unused quantities. Return in the shipping container PROPERLY
LABELED, WITH ANY VALVE OUTLET PLUGS OR CAPS SECURED AND VALVE PROTECTION CAP
IN PLACE to BOC Gases or authorized distributor for proper disposal.
14. Transport Information
PARAMETER United States DOT Canada TDG
Compressed gases, toxic n.o.s. Compressed gases, toxic n.o.s.
PROPER SHIPPING NAME:
(Nitric oxide in Nitrogen) (Nitric oxide in Nitrogen)
2.3 2.3
HAZARD CLASS:
UN 1955 UN 1955
IDENTIFICATION NUMBER:
POISON GAS POISON GAS
SHIPPING LABEL:
Additional Marking Requirement: 鈥淚nhalation hazard鈥?
Additional Shipping Paper Description Requirement: 鈥淧oison-Inhalation Hazrd, Zone A, B, C, or D鈥?
depending on concentration of nitric oxide as follows:
Zone A, (Nitric oxide > 57.5%)
Zone B, (57.5% > Nitric oxide > 11.5%)
Zone C, (11.5% > Nitric oxide > 3.83%)
Zone D, (3.83% > Nitric oxide > 2.30%)
MSDS: G-207
Revised: 6/17/96 Page 6 of 7
PRODUCT NAME: NITRIC OXIDE (> 2.3% PPM) IN NITROGEN
15. Regulatory Information
SARA TITLE III NOTIFICATIONS AND INFORMATION
SARA TITLE III - HAZARD CLASSES:
Acute Health Hazard
Sudden Release of Pressure Hazard
Nitric oxide is listed as an extremely hazardous substance (EHS) subject to state and local reporting under
Section 304 of SARA Title III (EPCRA) with a reportable quantity (RQ) of 100 pounds.
The presence of nitric oxide in quantities in excess of the threshold planning quantity (TPQ) of 100 pounds
requires certain emergency planning activities to be conducted.
SARA TITLE III - SECTION 313 SUPPLIER NOTIFICATION:
This product contains the following toxic chemicals subject to the reporting requirements of section 313 of the
Emergency Planning and Community Right-To-Know Act (EPCRA) of 1986 and of 40 CFR 372:
CAS NUMBER INGREDIENT NAME PERCENT BY VOLUME
10102-43-9 Nitric oxide > 2.30
This information must be included on all MSDSs that are copied and distributed for this material.
16. Other Information
Compressed gas cylinders shall not be refilled without the express written permission of the owner. Shipment of
a compressed gas cylinder which has not been filled by the owner or with his/her (written) consent is a
violation of transportation regulations.
DISCLAIMER OF EXPRESSED AND IMPLIED WARRANTIES:
Although reasonable care has been taken in the preparation of this document, we extend no warranties and make
no representations as to the accuracy or completeness of the information contained herein, and assume no
responsibility regarding the suitability of this information for the user鈥檚 intended purposes or for the
consequences of its use. Each individual should make a determination as to the suitability of the information for
their particular purpose(s).
MSDS: G-207
Revised: 6/17/96 Page 7 of 7
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