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CAS

105-60-2

File Name: palomar_edu---epsilon-caprolactam_99%.asp
 
                 PRODUCT #: C2204        NAME: EPSILON-CAPROLACTAM, 99%

                     MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98

                        Printed Thursday, March 20, 1903 12:55PM



Sigma Chemical Co.         Aldrich Chemical Co., Inc.     Fluka Chemical Corp.

P.O. Box 14508             1001 West St. Paul             1001 West St. Paul

St. Louis, MO 63178        Milwaukee, WI 53233            Milwaukee, WI 53233

Phone: 314-771-5765        Phone: 414-273-3850            Phone: 414-273-3850









SECTION 1. - - - - - - - - - CHEMICAL IDENTIFICATION- - - - - - - - - -

    CATALOG #:            C2204

    NAME:                 EPSILON-CAPROLACTAM, 99%

SECTION 2. - - - - - COMPOSITION/INFORMATION ON INGREDIENTS - - - - - -

    CAS #:    105-60-2

    MF: C6H11NO

    EC NO: 203-313-2

  SYNONYMS

    A1030 * 6-AMINOCAPROIC ACID LACTAM * AMINOCAPROIC LACTAM * 6-

    AMINOHEXANOIC ACID CYCLIC LACTAM * 1-AZA-2-CYCLOHEPTANONE * 2-

    AZACYCLOHEPTANONE * 2H-AZEPIN-7-ONE, HEXAHYDRO- * CAPROLACTAM *

    EPSILON-CAPROLACTAM * OMEGA-CAPROLACTAM * EPSILON-CAPROLACTAM (ACGIH)

    * 6-CAPROLACTAM * CAPROLACTAM MONOMER * CAPROLATTAME (FRENCH) *

    CAPRON PK4 * CYCLOHEXANONE ISO-OXIME * EPSILON-CAPROLACTAM * EPSYLON

    KAPROLAKTAM (POLISH) * EXTROM 6N * HEXAHYDRO-2-AZEPINONE * HEXAHYDRO-

    2H-AZEPIN-2-ONE (9CI) * HEXAMETHYLENIMINE, 2-OXO- * 6-HEXANELACTAM *

    HEXANOIC ACID, 6-AMINO-, CYCLIC LACTAM * HEXANOIC ACID, 6-AMINO-,

    LACTAM * HEXANOLACTAM * HEXANONE ISOXIME * HEXANONISOXIM (GERMAN) * 1,

    6-HEXOLACTAM * E-KAPROLAKTAM (CZECH) * KAPROMINE * 2-

    KETOHEXAMETHYLENEIMINE * 2-KETOHEXAMETHYLENIMINE * NCI-C50646 * 2-

    OXOHEXAMETHYLENEIMINE * 2-OXOHEXAMETHYLENIMINE * 2-PERHYDROAZEPINONE *

     STILON *

SECTION 3. - - - - - - - - - - HAZARDS IDENTIFICATION - - - - - - - - -

  LABEL PRECAUTIONARY STATEMENTS

    HIGHLY TOXIC (USA)

    TOXIC (EU)

    TOXIC BY INHALATION.

    HARMFUL IN CONTACT WITH SKIN AND IF SWALLOWED.

    IRRITATING TO EYES, RESPIRATORY SYSTEM AND SKIN.

    MAY CAUSE SENSITIZATION BY SKIN CONTACT.

    TARGET ORGAN(S):

    NERVES

    IN CASE OF ACCIDENT OR IF YOU FEEL UNWELL, SEEK MEDICAL ADVICE

    IMMEDIATELY (SHOW THE LABEL WHERE POSSIBLE).

    IN CASE OF CONTACT WITH EYES, RINSE IMMEDIATELY WITH PLENTY OF

    WATER AND SEEK MEDICAL ADVICE.

    WEAR SUITABLE PROTECTIVE CLOTHING.

    DO NOT BREATHE DUST.

SECTION 4. - - - - - - - - - - FIRST-AID MEASURES- - - - - - - - - - -

    IN CASE OF CONTACT, IMMEDIATELY FLUSH EYES OR SKIN WITH COPIOUS

    AMOUNTS OF WATER FOR AT LEAST 15 MINUTES WHILE REMOVING CONTAMINATED

    CLOTHING AND SHOES.

    ASSURE ADEQUATE FLUSHING OF THE EYES BY SEPARATING THE EYELIDS

    WITH FINGERS.

    IF INHALED, REMOVE TO FRESH AIR. IF NOT BREATHING GIVE ARTIFICIAL

    RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN.

    IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS.

    CALL A PHYSICIAN.

    REMOVE AND WASH CONTAMINATED CLOTHING PROMPTLY.



                                          Page 1

                 PRODUCT #: C2204        NAME: EPSILON-CAPROLACTAM, 99%

                     MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98

                        Printed Thursday, March 20, 1903 12:55PM



SECTION 5. - - - - - - - - - FIRE FIGHTING MEASURES - - - - - - - - - -

  EXTINGUISHING MEDIA

    WATER SPRAY.

    CARBON DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE FOAM.

  SPECIAL FIREFIGHTING PROCEDURES

    WEAR SELF-CONTAINED BREATHING APPARATUS AND PROTECTIVE CLOTHING TO

    PREVENT CONTACT WITH SKIN AND EYES.

  UNUSUAL FIRE AND EXPLOSIONS HAZARDS

    EMITS TOXIC FUMES UNDER FIRE CONDITIONS.

SECTION 6. - - - - - - - - ACCIDENTAL RELEASE MEASURES- - - - - - - - -

    EVACUATE AREA.

    WEAR SELF-CONTAINED BREATHING APPARATUS, RUBBER BOOTS AND HEAVY

    RUBBER GLOVES.

    SWEEP UP, PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL.

    AVOID RAISING DUST.

    VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE.

SECTION 7. - - - - - - - - - - HANDLING AND STORAGE- - - - - - - - - - -

    REFER TO SECTION 8.

SECTION 8. - - - - - - EXPOSURE CONTROLS/PERSONAL PROTECTION- - - - - -

    CHEMICAL SAFETY GOGGLES.

    COMPATIBLE CHEMICAL-RESISTANT GLOVES.

    NIOSH/MSHA-APPROVED RESPIRATOR.

    SAFETY SHOWER AND EYE BATH.

    USE ONLY IN A CHEMICAL FUME HOOD.

    DO NOT BREATHE DUST.

    DO NOT GET IN EYES, ON SKIN, ON CLOTHING.

    WASH THOROUGHLY AFTER HANDLING.

    HIGHLY TOXIC.

    IRRITANT.

    NEUROLOGICAL HAZARD.

    SENSITIZER.

    KEEP TIGHTLY CLOSED.

    HYGROSCOPIC

    STORE IN A COOL DRY PLACE.

SECTION 9. - - - - - - - PHYSICAL AND CHEMICAL PROPERTIES - - - - - - -

  APPEARANCE AND ODOR

    WHITE CRYSTALLINE SOLID

  PHYSICAL PROPERTIES

    BOILING POINT:         136 C TO 138 C/10MM.

    MELTING POINT:       68 C TO 71 C

    EXPLOSION LIMITS IN AIR:

      UPPER                                     8%

      LOWER                                     1.4%

    AUTOIGNITION TEMPERATURE:          707 F         374C

    VAPOR PRESSURE:       <0.01MM 20 C

SECTION 10. - - - - - - - - -STABILITY AND REACTIVITY - - - - - - - - -

  INCOMPATIBILITIES

    STRONG OXIDIZING AGENTS

    STRONG BASES

  HAZARDOUS COMBUSTION OR DECOMPOSITION PRODUCTS

    TOXIC FUMES OF:

    CARBON MONOXIDE, CARBON DIOXIDE

    NITROGEN OXIDES

SECTION 11. - - - - - - - - - TOXICOLOGICAL INFORMATION - - - - - - - -

  ACUTE EFFECTS

    MAY BE FATAL IF INHALED.

    HARMFUL IF SWALLOWED OR ABSORBED THROUGH SKIN.



                                          Page 2

                 PRODUCT #: C2204        NAME: EPSILON-CAPROLACTAM, 99%

                     MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98

                        Printed Thursday, March 20, 1903 12:55PM



    CAUSES EYE AND SKIN IRRITATION.

    MATERIAL IS IRRITATING TO MUCOUS MEMBRANES AND UPPER

    RESPIRATORY TRACT.

    MAY CAUSE ALLERGIC SKIN REACTION.

    EXPOSURE CAN CAUSE:

    NAUSEA, HEADACHE AND VOMITING

    DERMATITIS

    CONVULSIONS

  ADDITIONAL INFORMATION

    EPSILON-CAPROLACTAM HAS BEEN REPORTED TO CAUSE SEIZURES, NAUSEA,

    VOMITING, DERMATITIS AND LOW-GRADE FEVER IN ONE EXPOSED HUMAN.

    EXPERIMENTS IN LABORATORY ANIMALS SHOWED NEUROPHARMACOLOGICAL

    PROPERTIES AND PRODUCED CONVULSIONS, TREMORS, MYDRIASIS,

    OPISTHOTONUS AND SALIVATION. STUDIES IN THE CAT AND RABBIT SHOWED

    CARDIOVASCULAR AND RESPIRATORY EFFECTS PRODUCING AN INITIAL INCREASE

    IN BLOOD PRESSURE FOLLOWED BY A DECREASE IN BLOOD PRESSURE AND AN

    INCREASED RESPIRATORY RATE. WORKMEN EXPOSED TO 12 PPM COMPLAINED OF A

    BITTER TASTE, NERVOUSNESS, EPISTAXIS, UPPER RESPIRATORY CATARRAH,

    FLATULENCE, HEARTBURN AND A HEAVY FEELING IN THE STOMACH.

  RTECS #: CM3675000

    2H-AZEPIN-2-ONE, HEXAHYDRO-

  IRRITATION DATA

    SKN-RBT 500 MG/24H MLD                        85JCAE -,883,1986

    EYE-RBT 20 MG/24H MOD                         85JCAE -,883,1986

  TOXICITY DATA

    ORL-RAT LD50:1210 MG/KG                       NTPTR*

     NTP-TR-214,1982

    IHL-RAT LC50:300 MG/M3/2H                     85GMAT -,32,1982

    UNR-RAT LD50:580 MG/KG                        GISAAA 55(10),33,1990

    ORL-MUS LD50:930 MG/KG                        GTPZAB 10(10),54,1966

    IHL-MUS LC50:450 MG/M3                        GTPZAB 10(10),54,1966

    IPR-MUS LD50:650 MG/KG                        JPMSAE 60,1058,1971

    SCU-MUS LD50:750 MG/KG                        IMEMDT 39,247,1986

    IVN-MUS LD50:480 MG/KG                        IMEMDT 39,247,1986

    UNR-MUS LD50:930 MG/KG                        GISAAA 55(10),33,1990

    SKN-RBT LD50:1410 UL/KG                       AIHAAP 30,470,1969

    UNR-RBT LD50:1 GM/KG                          GISAAA 55(10),33,1990

  TARGET ORGAN DATA

    SENSE ORGANS AND SPECIAL SENSES (CHROMODACRYORRHEA)

    BEHAVIORAL (CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD)

    BEHAVIORAL (MUSCLE CONTRACTION OR SPASTICITY)

    BEHAVIORAL (ANTIPSYCHOTIC)

    BEHAVIORAL (ANALGESIA)

    LUNGS, THORAX OR RESPIRATION (COUGH)

    LUNGS, THORAX OR RESPIRATION (DYSPNAE)

    GASTROINTESTINAL (CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS)

    KIDNEY, URETER, BLADDER (URINE VOLUME INCREASED)

    NUTRITIONAL AND GROSS METABOLIC (BODY TEMPERATURE DECREASE)

  ADDITIONAL INFORMATION

    ACGIH TLV-TWA: 1MG/M3 (DUST); 5 PPM OR 20MG/M3 (VAPOR). STEL: 3MG/M3

    (DUST), 10 PPM OR 40MG/M3 (VAPOR).

    ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES

    (RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR

    COMPLETE INFORMATION.

SECTION 12. - - - - - - - - - ECOLOGICAL INFORMATION - - - - - - - - - -

    DATA NOT YET AVAILABLE.

SECTION 13. - - - - - - - - - DISPOSAL CONSIDERATIONS - - - - - - - - -



                                          Page 3

                 PRODUCT #: C2204        NAME: EPSILON-CAPROLACTAM, 99%

                     MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98

                        Printed Thursday, March 20, 1903 12:55PM



    DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE SOLVENT AND BURN IN A

    CHEMICAL INCINERATOR EQUIPPED WITH AN AFTERBURNER AND SCRUBBER.

    OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS.

SECTION 14. - - - - - - - - - - TRANSPORT INFORMATION - - - - - - - - -

    CONTACT ALDRICH CHEMICAL COMPANY FOR TRANSPORTATION INFORMATION.

SECTION 15. - - - - - - - - - REGULATORY INFORMATION - - - - - - - - - -

  EUROPEAN INFORMATION

    EC INDEX NO:     613-069-00-2

    TOXIC

    R 20/22

    HARMFUL BY INHALATION AND IF SWALLOWED.

    R 36/37/38

    IRRITATING TO EYES, RESPIRATORY SYSTEM AND SKIN.

  REVIEWS, STANDARDS, AND REGULATIONS

    OEL=MAK

    ACGIH TLV-NOT CLASSIFIABLE AS A HUMAN CARCINOGEN DTLVS* TLV/BEI,1996

    ACGIH TLV-TWA 23 MG/M3 (5 PPM) (VAPOR)        DTLVS* TLV/BEI,1996

    ACGIH TLV-STEL 46 MG/M3 (10 PPM) (VAPOR)      DTLVS* TLV/BEI,1996

    ACGIH TLV-STEL 3 MG/M3 (DUST)                 DTLVS* TLV/BEI,1996

    ACGIH TLV-TWA 1 MG/M3 (DUST)                  DTLVS* TLV/BEI,1996

    IARC CANCER REVIEW:ANIMAL NO EVIDENCE         IMEMDT 39,247,1986

    IARC CANCER REVIEW:HUMAN NO ADEQUATE DATA     IMEMDT 39,247,1986

    IARC CANCER REVIEW:GROUP 4                    IMSUDL 7,56,1987

    OEL-AUSTRALIA:TWA 1 MG/M3;STEL 3 MG/M3 (DUST) JAN 1993

    OEL-AUSTRALIA:TWA 5 PPM (20 MG/M3);STEL 10 PPM (VAPOR) JAN 1993

    OEL-AUSTRIA:TWA 25 MG/M3 (DUST) JAN 1993

    OEL-BELGIUM:TWA 1 MG/M3;STEL 3 MG/M3 (DUST) JAN 1993

    OEL-BELGIUM:TWA 4.3 PPM (20 MG/M3);STEL 8.6 PPM (40 MG/M3) JAN 1993

    OEL-DENMARK:TWA 1 MG/M3 JAN 1993

    OEL-DENMARK:TWA 5 PPM (25 MG/M3) (DUST) JAN 1993

    OEL-DENMARK:TWA 5 PPM (25 MG/M3) (VAPOR) JAN 1993

    OEL-FINLAND:TWA 1 MG/M3;STEL 3 MG/M3 (DUST) JAN 1993

    OEL-FINLAND:TWA 5 PPM (20 MG/M3);STEL 10 PPM (46 MG/M3) (VAPOR) JAN

     1993

    OEL-FRANCE:TWA 1 MG/M3 (DUST) JAN 1993

    OEL-FRANCE:TWA 5 PPM (20 MG/M3) (VAPOR) JAN 1993

    OEL-GERMANY:TWA 25 MG/M3 (DUST) JAN 1993

    OEL-GERMANY:TWA 25 MG/M3 JAN93(VAPOR)

    OEL-HUNGARY:TWA 1 MG/M3;STEL 2 MG/M3 (DUST) JAN 1993

    OEL-THE NETHERLANDS:TWA 1 MG/M3 (VAPOR) JAN 1993

    OEL-THE NETHERLANDS:TWA 5 PPM (20 MG/M3) (DUST) JAN 1993

    OEL-POLAND:TWA 10 MG/M3 (DUST) JAN 1993

    OEL-RUSSIA:STEL 10 MG/M3 (DUST) JAN 1993

    OEL-SWITZERLAND:TWA 4 PPM (20 MG/M3) (VAPOR) JAN 1993

    OEL-UNITED KINGDOM:TWA 1 MG/M3;STEL 3 MG/M3 (DUST) JAN 1993

    OEL-UNITED KINGDOM:TWA 5 PPM (20 MG/M3);STEL 10 PPM (VAPOR) JAN 1993

    OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA CHECK ACGIH TLV

    OEL IN NEW ZEALAND, SINGAPORE, VIETNAM CHECK ACGIH TLV

    NIOSH REL TO CAPROLACTAM, DUST-AIR:10H TWA 1 MG/M3;STEL 3 MG/M3

     NIOSH* DHHS #92-100,1992

    NIOSH REL TO CAPROLACTAM, VAPOR-AIR:10H TWA 0.22 PPM;STEL 0.66 PPM

     NIOSH* DHHS #92-100,1992

    NOHS 1974: HZD 83732; NIS 14; TNF 955; NOS 14; TNE 6208

    NOES 1983: HZD 83732; NIS 12; TNF 812; NOS 19; TNE 25091; TFE 8291

    EPA GENETOX PROGRAM 1988, NEGATIVE: CARCINOGENICITY-MOUSE/RAT

    EPA GENETOX PROGRAM 1988, NEGATIVE: CHO GENE MUTATION

    EPA TSCA SECTION 8(B) CHEMICAL INVENTORY



                                          Page 4

                 PRODUCT #: C2204        NAME: EPSILON-CAPROLACTAM, 99%

                     MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98

                        Printed Thursday, March 20, 1903 12:55PM



    EPA TSCA SECTION 8(D) UNPUBLISHED HEALTH/SAFETY STUDIES

    ON EPA IRIS DATABASE

    EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, APRIL 1997

    NTP CARCINOGENESIS BIOASSAY (FEED);NO EVIDENCE:MOUSE,RAT

     NTPTR* NTP-TR-214,82

SECTION 16. - - - - - - - - - - OTHER INFORMATION- - - - - - - - - - - -

    THE ABOVE INFORMATION IS BELIEVED TO BE CORRECT BUT DOES NOT PURPORT TO

    BE ALL INCLUSIVE AND SHALL BE USED ONLY AS A GUIDE. SIGMA, ALDRICH,

    FLUKA SHALL NOT BE HELD LIABLE FOR ANY DAMAGE RESULTING FROM HANDLING

    OR FROM CONTACT WITH THE ABOVE PRODUCT. SEE REVERSE SIDE OF INVOICE OR

    PACKING SLIP FOR ADDITIONAL TERMS AND CONDITIONS OF SALE.

    COPYRIGHT 1997 SIGMA CHEMICAL CO., ALDRICH CHEMICAL CO., INC.,

    FLUKA CHEMIE AG

    LICENSE GRANTED TO MAKE UNLIMITED PAPER COPIES FOR INTERNAL USE ONLY









                                          Page 5
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