PRODUCT #: 47900 NAME: FUMARIC ACID
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Wednesday, March 12, 1903 11:18AM
Sigma Chemical Co. Aldrich Chemical Co., Inc. Fluka Chemical Corp.
P.O. Box 14508 1001 West St. Paul 1001 West St. Paul
St. Louis, MO 63178 Milwaukee, WI 53233 Milwaukee, WI 53233
Phone: 314-771-5765 Phone: 414-273-3850 Phone: 414-273-3850
SECTION 1. - - - - - - - - - CHEMICAL IDENTIFICATION- - - - - - - - - -
CATALOG #: 47900
NAME: FUMARIC ACID
SECTION 2. - - - - - COMPOSITION/INFORMATION ON INGREDIENTS - - - - - -
CAS #: 110-17-8
MF: C4H4O4
EC NO: 203-743-0
SYNONYMS
ALLOMALEIC ACID * BOLETIC ACID * TRANS-BUTENEDIOIC ACID * BUTENEDIOIC
ACID, (E)- * 1,2-ETHENEDICARBOXYLIC ACID, TRANS- * TRANS-1,2-
ETHYLENEDICARBOXYLIC ACID * 1,2-ETHYLENEDICARBOXYLIC ACID, (E) *
KYSELINA FUMAROVA (CZECH) * LICHENIC ACID * NSC-2752 * U-1149 * USAF
EK-P-583 *
SECTION 3. - - - - - - - - - - HAZARDS IDENTIFICATION - - - - - - - - -
LABEL PRECAUTIONARY STATEMENTS
IRRITANT
IRRITATING TO EYES, RESPIRATORY SYSTEM AND SKIN.
RISK OF SERIOUS DAMAGE TO EYES.
TARGET ORGAN(S):
KIDNEYS
IN CASE OF CONTACT WITH EYES, RINSE IMMEDIATELY WITH PLENTY OF
WATER AND SEEK MEDICAL ADVICE.
WEAR SUITABLE PROTECTIVE CLOTHING.
SECTION 4. - - - - - - - - - - FIRST-AID MEASURES- - - - - - - - - - -
IN CASE OF CONTACT, IMMEDIATELY FLUSH EYES OR SKIN WITH COPIOUS
AMOUNTS OF WATER FOR AT LEAST 15 MINUTES WHILE REMOVING CONTAMINATED
CLOTHING AND SHOES.
ASSURE ADEQUATE FLUSHING OF THE EYES BY SEPARATING THE EYELIDS
WITH FINGERS.
IF INHALED, REMOVE TO FRESH AIR. IF NOT BREATHING GIVE ARTIFICIAL
RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN.
IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS.
CALL A PHYSICIAN.
WASH CONTAMINATED CLOTHING BEFORE REUSE.
SECTION 5. - - - - - - - - - FIRE FIGHTING MEASURES - - - - - - - - - -
EXTINGUISHING MEDIA
WATER SPRAY.
CARBON DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE FOAM.
SPECIAL FIREFIGHTING PROCEDURES
WEAR SELF-CONTAINED BREATHING APPARATUS AND PROTECTIVE CLOTHING TO
PREVENT CONTACT WITH SKIN AND EYES.
UNUSUAL FIRE AND EXPLOSIONS HAZARDS
THIS MATERIAL, LIKE MOST MATERIALS IN POWDER FORM, IS CAPABLE OF
CREATING A DUST EXPLOSION.
SECTION 6. - - - - - - - - ACCIDENTAL RELEASE MEASURES- - - - - - - - -
EVACUATE AREA.
WEAR SELF-CONTAINED BREATHING APPARATUS, RUBBER BOOTS AND HEAVY
RUBBER GLOVES.
SWEEP UP, PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL.
Page 1
PRODUCT #: 47900 NAME: FUMARIC ACID
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Wednesday, March 12, 1903 11:18AM
AVOID RAISING DUST.
VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE.
SECTION 7. - - - - - - - - - - HANDLING AND STORAGE- - - - - - - - - - -
REFER TO SECTION 8.
SECTION 8. - - - - - - EXPOSURE CONTROLS/PERSONAL PROTECTION- - - - - -
WEAR APPROPRIATE NIOSH/MSHA-APPROVED RESPIRATOR, CHEMICAL-RESISTANT
GLOVES, SAFETY GOGGLES, OTHER PROTECTIVE CLOTHING.
SAFETY SHOWER AND EYE BATH.
MECHANICAL EXHAUST REQUIRED.
DO NOT BREATHE DUST.
DO NOT GET IN EYES, ON SKIN, ON CLOTHING.
AVOID PROLONGED OR REPEATED EXPOSURE.
WASH THOROUGHLY AFTER HANDLING.
SEVERE EYE IRRITANT.
KEEP CONTAINER CLOSED.
STORE IN A COOL DRY PLACE.
SECTION 9. - - - - - - - PHYSICAL AND CHEMICAL PROPERTIES - - - - - - -
APPEARANCE AND ODOR
SOLID.
PHYSICAL PROPERTIES
AUTOIGNITION TEMPERATURE: 1364 F 739C
VAPOR PRESSURE: 1.7MM 165 C
SECTION 10. - - - - - - - - -STABILITY AND REACTIVITY - - - - - - - - -
STABILITY
STABLE.
INCOMPATIBILITIES
BASES
OXIDIZING AGENTS
REDUCING AGENTS
AMINES
HAZARDOUS COMBUSTION OR DECOMPOSITION PRODUCTS
TOXIC FUMES OF:
CARBON MONOXIDE, CARBON DIOXIDE
HAZARDOUS POLYMERIZATION
WILL NOT OCCUR.
SECTION 11. - - - - - - - - - TOXICOLOGICAL INFORMATION - - - - - - - -
ACUTE EFFECTS
MAY BE HARMFUL BY INHALATION, INGESTION, OR SKIN ABSORPTION.
CAUSES SEVERE EYE IRRITATION.
CAUSES SKIN IRRITATION.
MATERIAL IS IRRITATING TO MUCOUS MEMBRANES AND UPPER
RESPIRATORY TRACT.
EXPOSURE CAN CAUSE:
GASTROINTESTINAL DISTURBANCES
TARGET ORGAN(S):
KIDNEYS
THE TOXICOLOGICAL PROPERTIES HAVE NOT BEEN THOROUGHLY
INVESTIGATED.
RTECS #: LS9625000
FUMARIC ACID
IRRITATION DATA
SKN-RBT 500 MG/24H MLD 85JCAE -,313,1986
EYE-RBT 100 MG/24H MOD 85JCAE -,313,1986
TOXICITY DATA
ORL-RAT LD50:9300 MG/KG TXAPA9 42,417,1977
UNR-RAT LD50:6800 MG/KG TOVEFN (2),25,1994
IPR-MUS LD50:100 MG/KG NTIS** AD277-689
Page 2
PRODUCT #: 47900 NAME: FUMARIC ACID
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Wednesday, March 12, 1903 11:18AM
UNR-MUS LD50:5 GM/KG TOVEFN (2),25,1994
TARGET ORGAN DATA
GASTROINTESTINAL (OTHER CHANGES)
LIVER (OTHER CHANGES)
BLOOD (HEMORRHAGE)
ADDITIONAL INFORMATION
ORL-RAT LD50:10,700 MG/KG
SKN-RBT LD50:>7940 MG/KG
ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES
(RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR
COMPLETE INFORMATION.
SECTION 12. - - - - - - - - - ECOLOGICAL INFORMATION - - - - - - - - - -
DATA NOT YET AVAILABLE.
SECTION 13. - - - - - - - - - DISPOSAL CONSIDERATIONS - - - - - - - - -
DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE SOLVENT AND BURN IN A
CHEMICAL INCINERATOR EQUIPPED WITH AN AFTERBURNER AND SCRUBBER.
OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS.
SECTION 14. - - - - - - - - - - TRANSPORT INFORMATION - - - - - - - - -
CONTACT FLUKA CHEMICAL COMPANY FOR TRANSPORTATION INFORMATION.
SECTION 15. - - - - - - - - - REGULATORY INFORMATION - - - - - - - - - -
EUROPEAN INFORMATION
EC INDEX NO: 607-146-00-X
IRRITANT
R 36
IRRITATING TO EYES.
S 26
IN CASE OF CONTACT WITH EYES, RINSE IMMEDIATELY WITH PLENTY OF
WATER AND SEEK MEDICAL ADVICE.
REVIEWS, STANDARDS, AND REGULATIONS
OEL=MAK
NOHS 1974: HZD 33940; NIS 27; TNF 2317; NOS 44; TNE 30637
NOES 1983: HZD 33940; NIS 40; TNF 5692; NOS 58; TNE 136448; TFE 48919
EPA TSCA SECTION 8(B) CHEMICAL INVENTORY
EPA TSCA SECTION 8(D) UNPUBLISHED HEALTH/SAFETY STUDIES
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, APRIL 1997
SECTION 16. - - - - - - - - - - OTHER INFORMATION- - - - - - - - - - - -
THE ABOVE INFORMATION IS BELIEVED TO BE CORRECT BUT DOES NOT PURPORT TO
BE ALL INCLUSIVE AND SHALL BE USED ONLY AS A GUIDE. SIGMA, ALDRICH,
FLUKA SHALL NOT BE HELD LIABLE FOR ANY DAMAGE RESULTING FROM HANDLING
OR FROM CONTACT WITH THE ABOVE PRODUCT. SEE REVERSE SIDE OF INVOICE OR
PACKING SLIP FOR ADDITIONAL TERMS AND CONDITIONS OF SALE.
COPYRIGHT 1997 SIGMA CHEMICAL CO., ALDRICH CHEMICAL CO., INC.,
FLUKA CHEMIE AG
LICENSE GRANTED TO MAKE UNLIMITED PAPER COPIES FOR INTERNAL USE ONLY
Page 3
|