ACETONE CYANOHYDRIN 0611
March 1998
CAS No: 75-86-5 2-Hydroxy-2-methyl propionitrile
2-Methyl-lactonitrile
RTECS No: OD9275000
2-Cyanopropan-2-ol
UN No: 1541
p-Hydroxyisobutyronitrile
EC No: 608-004-00-X
(CH3)2C(OH)CN / C4H7NO
Molecular mass: 85.1
TYPES OF
ACUTE HAZARDS/SYMPTOMS PREVENTION FIRST AID/FIRE FIGHTING
HAZARD/
EXPOSURE
FIRE Combustible. Gives off irritating or NO open flames. Powder, AFFF, foam, carbon dioxide.
toxic fumes (or gases) in a fire.
EXPLOSION Above 74/C explosive vapour/air Above 74/C use a closed system, In case of fire: cool drums, etc., by
mixtures may be formed. ventilation. spraying with water but avoid contact
of the substance with water. Combat
fire from a sheltered position.
EXPOSURE AVOID ALL CONTACT! IN ALL CASES CONSULT A
DOCTOR!
Inhalation Convulsions. Cough. Dizziness. Closed system and ventilation. Fresh air, rest. Half-upright position.
Headache. Laboured breathing. Artificial respiration may be needed.
Nausea. Shortness of breath. Refer for medical attention.
Unconsciousness. Vomiting.
Irregular heartbeat, tightness in the
chest.
Skin MAY BE ABSORBED! Redness. Protective gloves. Protective clothing. Rinse and then wash skin with water
Pain. (See Inhalation). and soap. Refer for medical
attention.
Eyes Redness. Pain. Face shield, or eye protection in First rinse with plenty of water for
combination with breathing several minutes (remove contact
protection. lenses if easily possible), then take to
a doctor.
Ingestion Abdominal cramps. Burning Do not eat, drink, or smoke during Rinse mouth. Refer for medical
sensation. Convulsions. work. attention.
Unconsciousness. (See Notes, (see
Inhalation).
SPILLAGE DISPOSAL PACKAGING & LABELLING
Sweep spilled substance into containers. Carefully T+ Symbol Airtight. Do not transport with food
collect remainder, then remove to safe place. Do NOT N Symbol and feedstuffs. Marine pollutant.
let this chemical enter the environment. Personal R: 26/27/28-50/53
protection: complete protective clothing including S: (1/2-)7/9-27-45-60-61
self-contained breathing apparatus. UN Hazard Class: 6.1
UN Pack Group: I
EMERGENCY RESPONSE SAFE STORAGE
Transport Emergency Card: TEC (R)-61S1541 Provision to contain effluent from fire extinguishing. Separated from strong
NFPA Code: H4; F1; R2 bases, acids, water, food and feedstuffs. Well closed. Keep in a
well-ventilated room.
Prepared in the context of cooperation between the International
IPCS Programme on Chemical Safety and the European Commission 漏
IPCS 2005
International
Programme on
SEE IMPORTANT INFORMATION ON THE BACK.
Chemical Safety
0611 ACETONE CYANOHYDRIN
IMPORTANT DATA
Physical State; Appearance Routes of exposure
COLOURLESS LIQUID, WITH CHARACTERISTIC ODOUR. The substance can be absorbed into the body by inhalation,
through the skin and by ingestion.
Physical dangers
Inhalation risk
The vapour is heavier than air.
A harmful contamination of the air can be reached rather quickly
Chemical dangers on evaporation of this substance at 20/C.
The substance decomposes rapidly on heating or on contact with
Effects of short-term exposure
bases or water producing highly toxic and flammable hydrogen
cyanide (see ICSC 0492), and acetone (see ICSC 0087). Reacts The substance is irritating to the eyes, the skin and the respiratory
violently with acids and oxidants causing fire and explosion tract. The substance may cause effects on the cardiovascular
hazard. system and central nervous system, resulting in asphyxia,
cardiac disorders, convulsions, cyanosis and respiratory failure.
Occupational exposure limits Exposure may result in death. Medical observation is indicated.
TLV: (as CN) 5 mg/m 3 (Ceiling value); (skin); (ACGIH 2004). See Notes.
Effects of long-term or repeated exposure
The substance may have effects on the central nervous system
and thyroid, resulting in impaired functions.
PHYSICAL PROPERTIES
Boiling point: 95/C Vapour pressure, kPa at 20/C: 3.0
Melting point: -19/C Relative vapour density (air = 1): 2.93
Relative density (water = 1): 0.93 Flash point: 74/C c.c.
Solubility in water: freely soluble, but decomposes in water Explosive limits, vol% in air: 2.2-12
ENVIRONMENTAL DATA
The substance is very toxic to aquatic organisms. Avoid release to the environment in circumstances different to normal use.
NOTES
The occupational exposure limit value should not be exceeded during any part of the working exposure.
Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.
Hazard and toxicity of this substance is due to its major metabolite - hydrogen cyanide (see ICSC 0492).
Card has been partly updated in October 2004 and 2005. See sections Occupational Exposure Limits, EU classification, Emergency
Response.
ADDITIONAL INFORMATION
Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible
LEGAL NOTICE for the use which might be made of this information
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