MATERIAL SAFETY DATA SHEET
NEW ENGLAND
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Inc. OTHER INFORMATION CALLS 1-978-927-5054
SAM
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New England Biolabs 1-978-921-1350
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Beverly MA 01915 JUNE, 2003
DATE
SECTION 1 - PRODUCT INFORMATION
Product Name: S-adenosylmethionine (SAM)
SECTION 2鈥揅HEMICAL INFORMATION
1. Ethanol 10% Cas. #64-17-5
2. Sulfuric Acid 1% Cas. #7664-93-9
SECTION 3鈥揅OMPOSITION/ INFORMATION ON INGREDIENT
SYNONYMS: Ethyl Alcohol, Ethyl Alcohol, 200 Proof USP, Ethyl
CHEMICAL NAME: ETHANOL
Hydrate, Ethyl Hydroxide, Methylcarbinol, Absolute Ethanol, Ethyl
Alcohol Anhydrous, Alcohol, Anhydrous
CHEMICAL FORMULA: C2H50H
MF: C2H60 EC No.: 200-578-6
CAS No.: 164-17-5
CAUTION: IRRITANT Target Organ (s)
Flammable (USA)
Irritating to eyes, respiratory system and skin (rinse
Nerves, Liver
Highly Flammable (EU)
immediately with plenty of water, seek medical attention)
and respiratory system. Hygroscopic
Harmful in contact with skin. Keep tightly closed.
Avoid contact and inhalation. Store in a cool dry place.
Wear suitable protective clothing. Keep away from sources of ignition-NO Smoking
SECTION 4 鈥揊IRST AID MEASURES
ORAL EXPOSURE: If swallowed, wash out mouth with water provided person is conscious. Call a physician.
INHALATION EXPOSURE: If inhaled, remove to fresh air. If not breathing give artificial respiration.
If breathing is difficult, give oxygen.
DERMAL EXPOSURE: In case of contact, immediately wash skin with soap and copious amounts of water.
EYE EXPOSURE: In case of contact, immediately flush eyes with copious amounts of water for at least 15 minutes.
SECTION 5鈥揊IRE FIGHTING MEASURES
Unusual Fire and Explosions Hazard (s):
Extinguishing Media: Water spray.
Flammable Liquid
Carbon Dioxide, dry chemical powder or appropriate foam.
Vapor may travel considerable distance to source of
Special Firefighting Procedures: Wear self contained breathing ignition and flash back.
apparatus and protective clothing to prevent contact with skin and eyes.
Container may explode under fire conditions.
Use water spray to cool fire-exposed containers.
SECTION 6 - ACCIDENTAL RELEASE MEASURES
EVACUATE AREA METHODS FOR CLEANING UP:
PROCEDURE(S) OF PERSONAL PRECAUTION(S): Cover with dry-lime, sand or soda ash. Place ion covered
Wear self-contained breathing apparatus, chemical safety goggles, containers using non-sparking tools and transport outdoors.
rubber boots, and heavy rubber gloves. Ventilate area and wash spill site after material pickup is complete.
Wear disposable coveralls and discard them after use. Evacuate area. Shut off all sources of ignition.
SECTION 7 - HANDLING AND STORAGE
Refer to Section 8.
SECTION 8- EXPOSURE CONTROLS /PPE
Engineering Controls: Safety shower and eye bath. Mechanical exhaust required. Avoid Breathing Vapor
Personal Protective Equipment:
Eye: Hand:
Respiratory
Compatible safety goggles. Compatible chemical-resistant gloves.
NIOSH/MSHA-approved respirator.
Keep away from heat, sparks and open flame.
General Hygiene Measures:
Wash thoroughly after handling. Keep tightly closed.
Store in a dry place.
Wash contaminated clothing before use.
SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES
Specific Gravity: 0.794
Boiling Point: 78掳C
Flash Point: 62掳 F
Swiss Poison Class: FREI
SECTION 10 - STABILITY AND REACTIVITY
Hazardous Decomposition Products:
Stability: Stable
Carbon monoxide, Carbon dioxide. Sulfur Oxides
Incompatibilities:
Hazardous Polymerization:
Strong oxidizing agents, alkali metals
Will not occur!
ammonia and peroxides
Protect from moisture.
SECTION 11- TOXICOLOGICAL INFORMATION
Route of Exposure:
CHRONICS EFFECTS: IRRITATION DATA:
Skin Contact:
Nerves, heart, liver. SKN-RBT 400 MG OPEN MLD UCDS** 7/22/1970
May cause skin irritation
SKN-RBT 20 MG/24H MOD 85JCAE-, 189, 1986
This product is or contains a compo-
Harmful if absorbed through skin EYE-RBT 500 MG SEV AJOPAA 29,1363,1946
nent that is not classifiable as to its
Eye Contact: EYE-RBT 500 MG/24H MLD 85JCAE -,189,1986
carcinogenicity based on its IARC, EYE-RBT 100 MG/4S RINSE MOD FCTOD7 20, 573,1982
Causes eye irritation ACGIH, NTP or EPA
Multiple Routes:
May be harmful by inhalation,
ingestion or skin absorption
Material is irritating to mucus
TOXICITY DATA:
TARGET ORGAN DATA:
membranes and upper
ORL-CHD LDLO:2 GM/KG ATXKA8 17,183,1958
BEHAVORIAL (CHANGE IN MOTOR ACTIVITY)
respiratory tract.
ORL-HMN LDLO: 1400 MG/KG NPIRI* 1,44,1974
BEHAVORIAL (SLEEP)
SCU-INF LDLO:19440 MG/KG AJCPAI 5,466,1935
BEHAVORIAL (ATAXIA)
Can cause CNS depression.
BEHAVORIAL (ANTIPSYCHOTIC) ORL-RAT LD50:7060 MG/KG TXAPA9 16, 718,1970
GASTROINTESTINAL (NAUSEA OR VOMITING IHL-RAT LC50:20000 PPM/10H NPIRI* 1,44, 1974
LIVER (TUMORS) IPR-RAT LC50:3600 UG/KG PHMGBN 2, 27, 1969
RTECS #: KQ6300000
IVN-RAT LD50; 1440 MG/KG TXAPA9 18, 60, 1971
BLOOD (LYMPHOMA INCLUDING HODGKIN'S DIEASE)
IAT-RAT LD50; 11 MG/KG TXAPA9 18, 60, 1971
LUNGS THORAX OR RESPIRATION (DYSPNAE)
IVN-MUS LD50; 1973 MG/KG HBTXAC 1, 128, 1955
SPECIFIC DEV. ABNORMALITIES (CRANIOFACIAL)
IRP-MAM LD50; 4300 MG/KG TXAPA9 13, 358, 1968
SCU-MUS LD50; 8285 MG/KG FA0NAU 48A, 99, 1970
SECTION 12- ECOLOGICAL INFORMATION
Data not yet available
Page 2 (ETHANOL)
SECTION 13- DISPOSAL CONSIDERATIONS
Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable.
Observe all federal state and local environmental regulations.
Contact a licensed professional waste disposal service to dispose of this material.
SECTION 14- TRANSPORT INFORMATION
DOMESTIC (LAND, D.O.T.)
Proper Shipping Name: AEROSOLS, FLAMMABLE N.O.S. (ETHANOL, ISOPROPANOL, METHANOL)
HAZARD CLASS: NONE
UN/NA: UN1950
PACKING GROUP: N/A
INFORMATION REPORTED FOR PRODUCT/SIZE: 11 OZ
INTERNATIONAL (WATER, I.M.O.)
Proper Shipping Name: AEROSOLS, FLAMMABLE N.O.S. (ETHANOL, ISOPROPANOL, METHANOL)
HAZARD CLASS: 2.1
UN/NA: UN1950
PACKING GROUP: N/A
INFORMATION REPORTED FOR PRODUCT/SIZE: 11 OZ
INTERNATIONAL (AIR, I.C.A.O.)
Proper Shipping Name: AEROSOLS, FLAMMABLE N.O.S. (ETHANOL, ISOPROPANOL, METHANOL)
HAZARD CLASS: 2.1
UN/NA: UN1950
PACKING GROUP: N/A
INFORMATION REPORTED FOR PRODUCT/SIZE: 11 OZ
SECTION 15- REGULATORY INFORMATION
European Information: Reviews Standards and Regulations:
EC INDEX NO: 603-002-00-5 0EL=MAK
IRRITANT ACGIH TLV: NOT Classifiable as a human carccinogen DTLVS* TLV/BEI, 1999
R11 ACGIH TLV-TWA 1000 PPM DTLVS* TLV/BEI, 1999
HIGHLY FLAMMABLE IARC Cancer Review:Animal inadequate evidence imemdt 44, 35, 1988
S7 EPA FIFRA1988 (B) Pesticide subject to registration or re-registration
KEEP CONTAINERS CLOSED OEL-FRANCE: VME 1000 PPM (1900 MG/M3), VLE 5000 PPM (2400 MG/M3)
S 16
KEEP AWAY FROM SOURCES OF IGNITION-NO SMOKING
SECTION 16- OTHER INFORMATION
New England Biolabs shall not be held liable
The above information is believed to be correct but
for any damage resulting from handling or
does not purport to be allinclusive and shall be used
from contact with the above product.
only as a guide.
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