Product # (s) 8483, 8483S, 8483B
MATERIAL SAFETY DATA SHEET
Section 1. Company Identification and Product Information
Product Name or Identity: Gliadin Cocktail Solution for Heat Processed Samples
517/372-9200
Manufacturer鈥檚 Name: Neogen Corporation Emergency Phone No.:
517/372-0108
620 Lesher Place Fax No.:
foodsafety@neogen.com
Lansing, MI 48912 e-mail:
Date Prepared or Revised: March 2008 Chemtrec: (800) 424-9300
Outside US and Canada: (703) 527-3887
Section 2. Composition / Information on Hazardous Ingredients
This product is a mixture of the substances listed below with the addition of nonhazardous materials.
Hazardous Components CAS-No. % Hazard
Specific Chemical Identity: Symbol
Guanidine Hydrochloride 50-01-1 19.0% T (Toxic)
2-Mercaptoethanol 60-24-2 1.75% Xn (Harmful)
Section 3. Health Hazard Identification
Health Hazards: Information pertaining to particular dangers for man and environment.
(Acute and Chronic) R 23 / 25, Toxic by inhalation and if swallowed.
R 36 / 38, Irritating to eyes and skin.
Section 4. First Aid Measures
Ingestion: If swallowed, seek medical attention immediately. Wash out mouth with water, provided
Emergency /
person is conscious. Show physician product label. Never give anything by mouth to an unconscious
First Aid
person.
Procedures:
Inhalation: If inhaled, supply fresh air or oxygen. Seek medical attention if breathing because difficult or
labored. If not breathing, apply artificial respiration.
Eye Contact: Rinse opened eye for at least 15 minutes under running water, lifting lower and upper
eyelids occasionally. Seek medical attention immediately.
Skin Contact: Remove contaminated clothing. Immediately wash with plenty of soap and water for at
least 15 minutes. Seek medical attention. Wash clothing before reuse.
Section 5. Fire and Explosion Hazard Data
Flash Point (Method Used): N/A Flammable Limits: LEL 鈥? N/A
UEL 鈥? N/A
Extinguishing Media: Use water spray, dry chemical, appropriate foam, or carbon dioxide.
Protective Equipment: Firefighters should wear protective equipment and self-contained breathing apparatus.
Unusual Fire and Explosion Hazards: During heating or in case of fire, poisonous gases are produced. Fine dust
dispersed in air in sufficient concentrations, and in the presence of an ignition source, is a potential dust explosion hazard.
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Product # (s) 8483, 8483S, 8483B
Section 6. Accidental Release Measures
Personal Precautions: Wear suitable protective clothing, gloves, and eye protection. Wear self-containing breathing
apparatus, rubber boots, and heavy rubber gloves. Place contaminated material in a chemical waste container.
Environmental Precautions: Prevent dispersion of material. Wipe up with damp sponge or mop.
Clean-up Methods: Avoid prolonged or repeated exposure. Absorb material, ventilate area, and wash spill site after
material has been cleaned up. Avoid inhalation, contact with eyes and skin. Prevent formation of dust. Contact safety officer
if questions arise.
Section 7. Handling and Storage
Handling: Protect against physical damage. Ensure good ventilation / exhaustion and do not breathe vapor. Avoid contact
with eyes, skin, and clothing. Avoid prolonged or repeated exposure. Do not use if skin is cut or scratched.
Storage: Keep container tightly closed. Keep away from heat, sparks, flame and incompatible material. Storage area
should be cool, dry, and away from incompatible materials. Containers of this material may be hazardous when empty since
they retain product residues.
Other Precautions: Keep respiratory protective device available.
Section 8. Exposure Controls / Personal Protection
Components with limit values that require monitoring:
Guanidine Hydrochloride (50-01-1)
OSHA鈥揚EL: 200 ml/m3 (ppm) Guanidine Hydrochloride, 100% TLV: N/A
Additional Information: Personal Protection listed below are general requirements for laboratory personnel. Follow the
usual precautionary measures for handling chemicals / powder. Avoid contact with eyes, skin, and clothing. In the event of
use above flash point, use in closed systems. Do not use compressed air by filling, discharging or handling the product.
Proper ventilation required. Safety shower and eye bath. Use adequate general or local exhaust ventilation to keep airborne
concentrations below the permissible exposure limits.
Personal Protective Equipment:
Keep away from food, beverages, and feed.
Wash hands before and after entering laboratory.
Immediately remove all soiled and contaminated clothing.
Avoid contact with eyes and skin.
Breathing Equipment: In case of brief exposure, use a chemical fume hood or a NIOSH/MSHA-approved respiratory.
Hand Protection: Use chemical resistant gloves.
Eye Protection: Wear safety glasses.
Body Protection: Wear lab coat or other protective work clothing.
Section 9. Physical and Chemical Properties
Appearance and Odor: Liquid
Boiling Point: Not determined
Melting Point: Not determined
Density: Not determined
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Product # (s) 8483, 8483S, 8483B
Section 10. Stability and Reactivity
Unstable
Stability:
Stable X Conditions to Avoid: Avoid heat, sources of ignition, shock, and friction. Sensitive to
moisture.
Incompatibility (Materials to Avoid): Incompatible with strong oxidizing agents and metals.
Hazardous Decomposition or Byproducts: Hydrogen chloride, Carbon dioxide, Carbon monoxide, and Nitrogen oxides.
May Occur Conditions to Avoid: Incompatible materials.
Hazardous Polymerization:
Will Not Occur X
Section 11. Toxicological Information
LD/LC50 values that are relevant:
LD50: ORL-RAT, 244 mg/kg (2-Mercaptoethanol)
Carcinogenicity Classification:
IARC (International Agency for Research on Cancer) 鈥? Not Listed
NTP (National Toxicology Program) - Not Listed
Eye: Produces irritation, characterized by a burning sensation, redness, tearing, and inflammation.
Ingestion: May cause gastrointestinal irritation with nausea and vomiting.
Inhalation: Harmful if inhaled. May cause a burning sensation, coughing, wheezing, laryngitis, shortness of breath, and
headache.
Chronic: Prolonged or repeated skin contact may cause dermatitis. Chronic inhalation and ingestion may cause effects
similar to those of acute inhalation and ingestion.
Additional toxicological information: Harmful. Irritant.
Section 12. Ecological Information
Ecotoxicity Tests:
Water Hazard Class 1: Slightly hazardous for water. The ecological effects have not been thoroughly investigated, but
currently none have been identified.
Section 13. Disposal Considerations
Waste Disposal Method: Dispose in accordance with all applicable federal (40 CFR 261.3), state, and local environmental
regulations.
RCRA P-Series: None listed
RCRA U-Series: None listed
Contact a licensed professional waste disposal service to dispose of this material if questions arise.
Container Information: Do not remove labels from containers until they have been cleaned.
Section 14. Transport Information
DOT Regulations:
Not Regulated
Land Transport ADR/RID (cross-border):
Not Regulated
Maritime Transport IMDG:
Not Regulated
Air Transport ICAO-TI and IATA-DGR:
Not Regulated
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Product # (s)_ 8483, 8483S, 8483B
Section 15. Regulatory Information
EU Regulations, Hazard Symbol(s):
Guanidine Hydrochloride: T (Toxic)
2-Mercaptoethanol: Xn (Harmful)
Risk Phrases:
R 23 / 25, Toxic by inhalation and if swallowed.
R 36 / 38, Irritating to eyes and skin.
Safety Phrases:
S7, Keep container tightly closed.
S 16, Keep away from ignitable materials.
S 24 / 25, Avoid contact with eyes and skin.
S 26, In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36, Wear suitable protective clothing.
Section 16. Other Information
This document is believed to be correct, but does not purport to be all inclusive and shall be used only as a guide. Neogen
Corporation shall not be held liable for any damage resulting from handling or from contact with the above product. These
suggestions should not be confused with state, municipal or insurance requirements, and constitute NO WARRANTY.
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Rev 02, March 2008
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