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MSDS Material Safety Data Sheet
CAS

26628-22-8

File Name: beckman_com---im1316aa.asp
                                                                                                                      Page 1 of 7




MATERIAL SAFETY DATA SHEET
Section 1 Company and Product Identi飥乧ation
Product Name Ki-67 Nuclear Antigen .. Doc. ID: IM1316-75 AA
. Issued (year/month/day) 2007/12/04

Part Number IM1316
Product Use For Research Use Only. See product literature for details.
Manufacturer Distributed by Beckman Coulter, Inc. for
IMMUNOTECH (A Beckman Coulter Company)
130, av.de Lattre de Tassigny - BP 177
13276 Marseille Cedex 09 - France T猫l. (33) 4 91 17 27 00
Distributor and Refer to attached list, Document ID: 472050, for local distributor
and emergency phone numbers.
Emergency Phone No.


Section 2 Hazards Identi飥乧ation
Emergency Overview
Colorless; Transparent; Liquid; Odorless
Non飥俛mmable aqueous solution.
Harmful if swallowed.
Contains material of animal origin.

Physical Hazards Sodium azide forms explosive compounds with heavy metals. Repeated contact
of low concentrations of azide with lead and copper commonly found in plumbing
drains may result in the build up of shock sensitive compounds.
Potential Health This product contains material of animal origin and should be considered as
potentially capable of transmitting infectious diseases.
Effects Summary
See Section 11 Toxicological Information for more detailed health information.
Potential No information available.
Environmental Effects
Product Hazard Meets Hazardous Criteria for Preparation/Mixture
Classi飥乧ations
EU: WHMIS: US OSHA:
Xn;R22 Not applicable
Not applicable




漏2007 Beckman Coulter, Inc.
Global MSDS 鈥? English
Ki-67 Nuclear Antigen Doc. ID: IM1316-75 AA Page 2 of 7



Section 3 Composition and Information on Ingredients
Hazardous Ingredients: Hazard Classi飥乧ation of Pure Ingredients
EU
Chemical Name CAS # EINECS # % by wt. WHMIS US OSHA

26628-22-8 2478521 Highly Toxic
Sodium Azide 0.1% N ;R50/53 D1A
Irritant
T+;R28-32
See Section 15 Regulatory Information for additional information on hazard classi飥乧ations.
See Section 16 for Risk Phrases and WHMIS Classi飥乧ation Description.


Section 4 First Aid Measures
Inhalation If product is inhaled, move exposed individual to fresh air. If breathing
has stopped, begin arti飥乧ial respiration. If breathing is dif飥乧ult or
has stopped, obtain medical attention.
Eye Contact If product enters eyes, wash eyes gently under running water for 15
minutes or longer, making sure that the eyelids are held open. If pain
or irritation occur, obtain medical attention.
Skin Contact In case of skin contact, 飥倁sh with copious amounts of water for at
least 15 minutes. Remove contaminated clothing and shoes. If pain
or irritation occur, obtain medical attention.
Ingestion If ingested, wash mouth out with water. If irritation or discomfort
occurs, seek medical attention.


Section 5 Fire Fighting Measures
Flammable Properties Non飥俛mmable aqueous solution.
Extinguishing Media Use extinguishing media suitable for surrounding 飥乺e.

Special Fire and Explosion None identi飥乪d.
Hazards
Hazardous Combustion No combustion products posing signi飥乧ant hazards are expected from
this product (an aqueous solution).
Products
Protective Equipment Self-contained breathing apparatus is recommended for 飥乺e飥乬hters
in all chemical 飥乺e situations.
for Fire飥乬hters


Section 6 Accidental Release Measures
Personal Precautions This product contains a material of biological origin. Use universal
precautions during clean up procedures.
Spill and Leak As a precautionary measure, treat spilled material with a 1:10 bleach/water solution.
Absorb liquid and place in container suitable for disposal. Avoid generation of
Procedures
aerosols during clean up. Comply with applicable waste disposal regulations.
Environmental Contain spill to prevent migration.
Precautions
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Section 7 Handling and Storage
Handling Precautions This product should be handled as though capable of transmitting infectious
diseases. Universal precautions should be followed when using this product.
Recommended Storage To maintain ef飥乧acy, store according to the instructions in the product labeling.
Conditions Keep away from incompatible material (see Section 10).


Section 8 Exposure Controls and Personal Protection
Exposure Limits
None established
US OSHA:
ACGIH:
Sodium Azide 0.29 mg/m3 Ceiling (as NaN3); 0.11 ppm Ceiling (vapor, as hydrazoic acid)
DFG MAK:
Sodium Azide 0.2 mg/m3 MAK (inhalable fraction); 0.4 mg/m3 Peak (inhalable fraction)
None established
NIOSH
Japan None established
No special engineering controls are required. Use with good general ventilation.
Engineering Controls
Respiratory Protection Under normal conditions, the use of this product should not
require respiratory protection.
Eye Protection Safety glasses or chemical goggles should be worn to prevent eye contact.
Impervious gloves, such as Nitrile or equivalent, should be worn
Skin Protection
to prevent skin contact.


Section 9 Physical and Chemical Properties
Liquid
Physical State
Color Colorless

Transparency Transparent

Odor Odorless
Not applicable
Odor Threshold
pH Not available

Freezing Point Not available

Boiling Point Not available

Flash Point Not applicable

Evaporation Rate Not available
Not applicable
Flammability (Solid, Gas)
Flammable Limits Not applicable
Ki-67 Nuclear Antigen Doc. ID: IM1316-75 AA Page 4 of 7



Section 9 Physical and Chemical Properties (Continued)
Vapor Pressure Not available

Vapor Density Not available

Speci飥乧 Gravity 鈮? 1 @20掳C

Solubility
Water Miscible
Not available
Organic
Not available
Coef飥乧ient of Water/Oil
Distribution
Autoignition Temp. Not applicable

Decomposition Temperature Not applicable

Percent Volatiles Not applicable


Section 10 Stability and Reactivity
Stability Stable in closed containers under normal temperatures and pressures.

Hazardous Incompatibilities Strong acids
Strong bases
Strong oxidizers
Metals and metallic compounds
Sodium azide forms explosive compounds with heavy metals. Repeated contact
of low concentrations of azide with lead and copper commonly found in plumbing
drains may result in the build up of shock sensitive compounds.
Hazardous Decomposition No decomposition products posing signi飥乧ant hazards would be expected
from this product (an aqueous solution).
Products
Conditions to Avoid Keep away from incompatible material.


Section 11 Toxicological Information
Toxicity Data
for Hazardous Ingredients
Sodium Azide Oral LD50 Rat: 27 mg/kg; Dermal LD50 Rabbit: 20 mg/kg
Primary Routes Common routes of entry include inhalation, ingestion and eye/skin contact. Speci飥乧
paths of concern for potentially infectious materials are skin puncture, contact with
of Exposure
broken skin, contact with mucous membranes and inhalation of aerosolized material.
Ki-67 Nuclear Antigen Doc. ID: IM1316-75 AA Page 5 of 7



Section 11 Toxicological Information (Continued)
Although its concentration in this product is low, sodium azide is highly toxic
Potential Effects of
by ingestion and skin absorption. Overexposure may result in irritation of skin,
Acute Exposure
eyes and mucous membranes, lowered blood pressure and irregular heartbeat.
Sodium azide is a chemical asphyxiant and may effect the cardiovascular,
respiratory and central nervous systems. Symptoms may include irritation,
severe, pounding headaches, dizziness, weakness, nausea, vomiting, low blood
pressure, rapid heartbeat, convulsions, collapse and death.
This product contains material of animal origin and should be considered as
potentially capable of transmitting infectious diseases.
Prolonged or repeated exposure to sodium azide may result in pounding headaches,
Potential Effects of Chronic
eye and nose irritation, low blood pressure, fatigue and dizziness.
Exposure
Symptoms of Overexposure Symptoms of overexposure may include: eye, skin, nose and throat
irritation; headache, weakness, dizziness, confusion, nausea and vomiting.
Severe cases may exhibit dif飥乧ulty in breathing, irregular heartbeat, reddish
colored skin, unconsciousness, convulsions, coma and death. Symptoms
may be delayed for several hours after exposure.
Carcinogenicity No ingredients in this product are listed as carcinogens by ACGIH,
IARC, NTP, OSHA or 67/548/EEC Annex I.
Other Effects Reproductive effects have been reported in animal studies.

Conditions Aggravated None identi飥乪d.
by Exposure


Section 12 Ecological Information
Ecotoxicity
Sodium Azide 96 Hr LC50 Oncorhynchus mykiss: 0.8 mg/L; 96 Hr LC50 Lepomis macrochirus:
0.7 mg/L; 96 Hr LC50 Pimephales promelas: 5.46 mg/L [飥俹w-through]
Biodegradability No information available.
Bioaccumulation No information available.
Mobility No information available.

Other Adverse Effects No information available.



Section 13 Disposal Considerations
Waste Disposal Dispose of waste product, unused product and contaminated packaging in
compliance with federal, state and local regulations. If unsure of the applicable
requirements, contact the authorities for information.
Sodium azide preservative may form explosive compounds in metal drain lines.
See NIOSH Bulletin: Explosive Azide Hazard (8/16/76).


Section 14 Transport Information
Transportation of this product is not regulated under ICAO, IMDG, US DOT, European ADR or Canadian TDG.
Ki-67 Nuclear Antigen Doc. ID: IM1316-75 AA Page 6 of 7




Section 15 Regulatory Information
US Federal and State Regulations
SARA 313 Sodium Azide is subject to reporting requirements of Section 313, Title III of SARA.

CERCLA RG鈥檚, Sodium Azide is listed.
40 CFR 302.4
No ingredients listed.
California Proposition 65
Massachusetts MSL Sodium Azide is listed.

New Jersey Dept. of Sodium Azide is listed.
Health RTK List
Pennsylvania RTK Sodium Azide is listed.
EU Labeling Classi飥乧ation
Classi飥乧ation Risk and Safety Phrases
R22 Harmful if swallowed.
S28 After contact with skin, wash immediately with plenty of water.
Harmful


Canada
This product does not meet WHMIS criteria for hazardous materials.
Not applicable
PIN:
Ingredients on Ingredient Sodium Azide
Disclosure List:
Ingredients with unknown None
toxicological properties:
Some hazardous ingredients listed in Section 15 are below OSHAs and WHMIS鈥? 1.0% w/w (0.1% for carcinogens)
or EU鈥檚 ingredient speci飥乧 concentrations required for reporting in Section 3.
Ki-67 Nuclear Antigen Doc. ID: IM1316-75 AA Page 7 of 7




Section 16 Other Information
Beckman Coulter Safety Flammability (Section V): 0 Code
Health (Section XI): 1 0=none
Rating
Reactivity with Water (Section X): 0 1=slight
Contact (Section VIII): 1 2=caution
3=severe
Not applicable
Revision Changes
Risk Phrases and R28 Very toxic if swallowed.
WHMIS Classi飥乧ation R32 Contact with acids liberates very toxic gas.
Description From R50/53 Very toxic to aquatic organisms, may cause long-term adverse
Section 3 effects in the aquatic environment.
D1A - Acute Dermal Toxicity
D1A - Acute Inhalation Toxicity
D1A - Acute Oral Toxicity
For further information, please contact your local Beckman Coulter representative.

WHILE BECKMAN COULTER, INC. BELIEVES THE INFORMATION CONTAINED HEREIN IS VALID AND ACCURATE, BECKMAN COULTER MAKES NO
WARRANTY OR REPRESENTATION AS TO ITS VALIDITY, ACCURACY, OR CURRENCY. BECKMAN COULTER SHALL NOT BE LIABLE OR OTHERWISE
RESPONSIBLE IN ANY WAY FOR USE OF EITHER THIS INFORMATION OR MATERIALS TO WHICH IT APPLIES. DISPOSAL OF HAZARDOUS
MATERIALS MAY BE SUBJECT TO LOCAL LAWS OR REGULATIONS.
Printed in U.S.A.

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