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@Beckman
CoulterTM MATERIAL SAFETY DATA SHEET
Section 1 Company and Product Identi铿乧ation
Fixative Solution
Product Name
Doc. ID IM3515-75 AA
Issued (year/month/day) 2002/09/17
Part Number IM3515
IOTest 3铮?
Series Name
Manufacturer Distributed by Beckman Coulter, Inc. for
IMMUNOTECH (A Beckman Coulter Company)
130, av.de Lattre de Tassigny鈥擝P 177
13276 Marseille Cedex 09鈥擣rance T猫l. (33) 4 91 17 27 00
陇
Distributor and Refer to attached list, Document ID: 472050, for local distributor and
Emergency Phone No. emergency phone numbers.
Section 2 Composition and Information on Ingredients
Hazardous Ingredients: Meets Hazardous Criteria:
Chemical Name CAS # % by wt. EU US OSHA WHMIS
<10
Formaldehyde 50-00-0 Carc. category Yes Yes
3;R 40
T;R 23/24/25
C;R 34; R43
See Section 15 Regulatory Information for additional information on hazard classi铿乧ations.
Section 3 Hazards Identi铿乧ation
Emergency Overview
Colorless; Transparent; Liquid; Odorless
Non铿俛mmable aqueous solution.
Harmful by inhalation, in contact with skin and if swallowed.
May cause irritation of skin, eyes, mucous
membranes and upper respiratory tract.
Suspect carcinogen.
Physical Hazards No physical hazards were determined from a review of available literature.
Potential Health May cause eye, skin and respiratory tract irritation or burns and central nervous
Effects Summary system depression with headache, dizziness, nausea and unconsciousness. Potental
cancer hazard.
See Section 11 Toxicological Information for more detailed health information.
Product Hazard EU: WHMIS: US OSHA:
Classi铿乧ations Xn;R20/21/22-36/37/38- D2B; D2A Hazardous
40-43
铮?2002 Beckman Coulter, Inc.
Global MSDS 鈥? English
Fixative Solution MSDS # IM3515-75 AA Page 2 of 5
Section 3 Hazards Identi铿乧ation (Continued)
Beckman Coulter Safety Flammability (Section V): 0 Code
Rating Health (Section XI): 2 0=none
Reactivity with Water (Section X): 0 1=slight
Contact (Section VIII): 2 2=caution
3=severe
Section 4 First Aid Measures
Inhalation If product is inhaled, move exposed individual to fresh air. If individual is not
breathing, begin arti铿乧ial respiration immediately and obtain medical attention.
Eye Contact If product enters eyes, wash eyes gently under running water for 15 minutes or
longer, making sure that the eyelids are held open. If pain or irritation occur, obtain
medical attention.
Skin Contact In case of skin contact, 铿倁sh with copious amounts of water for at least 15 minutes. If
pain or irritation occur, obtain medical attention.
Ingestion If ingested, wash mouth out with water. If irritation or discomfort occurs, seek medical
attention.
Section 5 Fire Fighting Measures
Flash Point Not applicable
Flammable Limits Not applicable
Autoignition Temp. Not applicable
Extinguishing Media Use extinguishing media suitable for surrounding 铿乺e.
Special Fire and No special hazards determined.
Explosion Hazards
Hazardous Combustion No combustion products posing signi铿乧ant hazards are expected from this product (an
Products aqueous solution).
Protective Equipment Self-contained breathing apparatus is recommended for 铿乺e铿乬hters in all chemical 铿乺e
for Fire铿乬hters situations.
Section 6 Accidental Release Measures
Personal Precautions Use good laboratory procedures; avoid eye and skin contact.
Spill and Leak Absorb spilled material with an appropriate inert, non-铿俛mmable absorbent and
Procedures dispose according to local regulations.
Environmental Contain spill to prevent migration.
Precautions
Section 7 Handling and Storage
Handling Precautions No special precautions are necessary; use good laboratory procedures.
Recommended Storage To maintain ef铿乧acy, store according to the instructions in the product labeling.
Conditions
Fixative Solution MSDS # IM3515-75 AA Page 3 of 5
Section 8 Exposure Controls and Personal Protection
Exposure Limits
US OSHA:
Formaldehyde 0.75 ppm TWA; 2 ppm STEL
ACGIH:
Formaldehyde 0.3 ppm Ceiling; 0.37 mg/m3 Ceiling
DFG MAK:
Formaldehyde 0.3 ppm MAK; 0.37 mg/m3 MAK; 0.6 ppm Peak; 0.74 mg/m3 Peak (during exposure
to mixtures it should be ensured that irritant effects do not occur); danger of skin
sensitization
Engineering Controls No special engineering controls are required. Use with good general ventilation.
Respiratory Protection Under normal conditions, the use of this product should not require respiratory
protection. If overexposure should occur and ventilation is not adequate to maintain
airborne concentrations at acceptable levels, the use of respiratory protection should
be evaluated by a quali铿乪d professional.
Eye Protection Safety glasses or chemical goggles should be worn to prevent eye contact.
Skin Protection Impervious gloves, such as latex or equivalent, should be worn to prevent skin
contact.
Section 9 Physical and Chemical Properties
Physical State Liquid
Color Colorless
Transparency Transparent
Odor Odorless
Odor Threshold Formaldehyde no geometric mean air odor threshold
pH 7.5
Boiling Point Not available
Melting Point Not available
Speci铿乧 Gravity 1.0 @20掳C
Vapor Pressure Not available
Vapor Density Not available
Evaporation Rate Not available
Solubility
Water Miscible
Organic Not available
Section 10 Stability and Reactivity
Stability Stable in closed containers under normal temperatures and pressures.
Fixative Solution MSDS # IM3515-75 AA Page 4 of 5
Section 10 Stability and Reactivity (Continued)
Hazardous Strong acids
Incompatibilities Strong bases
Strong oxidizers
Hazardous Formaldehyde
Decomposition Products
Conditions to Avoid Avoid contact with incompatible materials.
Section 11 Toxicological Information
Toxicity Data
for Hazardous Ingredients
Formaldehyde Inhalation LC50 Rat: 203 mg/m3; Inhalation LC50 Mouse: 454 mg/m3/4H;
Oral LD50 Rat: 100 mg/kg; Oral LD50 Mouse: 42 mg/kg; Dermal LD50 Rabbit:
270 uL/kg
Primary Routes The most likely routes of exposure are skin and eye contact.
of Exposure
Potential Effects of May cause irritation or burning of skin and eyes by contact. Inhalation and ingestion
Acute Exposure of large volumes may cause burning of mucous membrane, respiratory irritation.
Potential Effects of Prolonged and/or repeated exposure may result in conjunctivitis, dermatitis and
Chronic Exposure allergic reactions.
Symptoms of Symptoms may include redness and itching or burning of the skin and eyes, and
Overexposure irritation or burning sensation of the upper respiratory tract with coughing and dif铿乧ulty
in breathing.
Carcinogenicity Formaldehyde is listed with OSHA as a carcinogen; NTP as Anticipated Human
carcinogen; IARC as Group 2A with Animal Suf铿乧ient Evidence and Human Limited
Evidence; ACGIH as Group A2 Suspected Human Carcinogen and EU as Category 1
Carcinogen.
Other Effects None identi铿乪d.
Conditions Aggravated Individuals with skin, eye, or respiratory tract disorders may 铿乶d these conditions
by Exposure aggravated by exposure to this product.
Section 12 Ecological Information
Ecotoxicity Toxic to 铿乻h and other water organisms.
Biodegradability No information available.
Mobility No information available.
Section 13 Disposal Considerations
Waste Disposal Dispose of waste product, unused product and contaminated packaging in compliance
with federal, state and local regulations. If unsure of the applicable requirements,
contact the authorities for information.
Section 14 Transport Information
Transportation of this product is not regulated under ICAO, IMDG, US DOT, European ADR or Canadian TDG.
Fixative Solution MSDS # IM3515-75 AA Page 5 of 5
Section 15 Regulatory Information
US Federal and State Regulations
SARA 313 Formaldehyde is subject to reporting requirements of Section 313, Title III of SARA.
CERCLA RG鈥檚, Formaldehyde is listed.
40 CFR 302.4
California Proposition 65 Formaldehyde has been identi铿乪d by the State of California to cause cancer. The State
of California has adopted a regulation which requires a warning be given to individuals
who may be exposed to chemicals identi铿乪d by the State to cause cancer or reproductive
harm. Accordingly, Beckman Coulter advises you of the following warning:
WARNING: This product contains a chemical known to the State of California to cause
cancer.
Massachusetts MSL Formaldehyde is listed.
New Jersey Dept. of Formaldehyde is listed.
Health RTK List
Pennsylvania RTK Formaldehyde is listed.
Florida Substance List Formaldehyde is listed.
EU Labeling Classi铿乧ation
Classi铿乧ation Risk and Safety Phrases
Xn R20/21/22 Harmful by inhalation, in contact with skin and if swallowed.
R36/37/38 Irritating to eyes, respiratory system and skin.
Harmful
R40 Possible risks of irreversible effects.
R43 May cause sensitization by skin contact.
Canada
WHMIS Classi铿乧ation: D2B鈥擯oisonous and Infectious Material: Division 2鈥擮ther Toxic Effects: Toxic (Chronic
Toxic Effects)
D2A鈥擯oisonous and Infections Material: Division 2鈥擮ther Toxic Effects: Very Toxic
(Carcinogenicity)
PIN: Not applicable
Ingredients on Ingredient Formaldehyde
Disclosure List:
Ingredients with unknown None
toxicological properties:
Section 16 Other Information
For further information, please contact your local Beckman Coulter representative.
WHILE BECKMAN COULTER, INC. BELIEVES THE INFORMATION CONTAINED HEREIN IS VALID AND ACCURATE, BECKMAN COULTER MAKES NO WARRANTY OR
REPRESENTATION AS TO ITS VALIDITY, ACCURACY, OR CURRENCY. BECKMAN COULTER SHALL NOT BE LIABLE OR OTHERWISE RESPONSIBLE IN ANY WAY FOR USE
OF EITHER THIS INFORMATION OR MATERIALS TO WHICH IT APPLIES. DISPOSAL OF HAZARDOUS MATERIALS MAY BE SUBJECT TO LOCAL LAWS OR REGULATIONS.
Printed in U.S.A.
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