Material Safety Data Sheet
HMIS
NFPA Personal Protective Equipment
Health Hazard
4
1 Fire Hazard
1
4 0
Reactivity
0 See Section 15.
Section 1. Chemical Product and Company Identification Page Number: 1
Catalog
Physostigmine salicylate PH190
Common Name/
Number(s).
Trade Name
57-64-7
CAS#
Manufacturer TJ2450000
RTECS
SPECTRUM CHEMICAL MFG. CORP.
14422 S. SAN PEDRO STREET TSCA 8(b) inventory:
TSCA
Physostigmine salicylate
GARDENA, CA 90248
Not available.
Commercial Name(s) Not available.
CI#
(3aS-cis)-1,2,3,3a,8,8a-Hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-ol
Synonym
IN CASE OF EMERGENCY
methylcarbamate salicylate
CHEMTREC (24hr) 800-424-9300
Not available.
Chemical Name
Not available. CALL (310) 516-8000
Chemical Family
C15H21N3O2.C7H6O3
Chemical Formula
SPECTRUM CHEMICAL MFG. CORP.
Supplier
14422 S. SAN PEDRO STREET
GARDENA, CA 90248
Section 2.Composition and Information on Ingredients
Exposure Limits
3
STEL (mg/m3) CEIL (mg/m3)
Name CAS # TWA (mg/m ) % by Weight
1) Physostigmine salicylate 57-64-7 100
Physostigmine salicylate:
Toxicological Data
ORAL (LD50): Acute: 2.5 mg/kg [Mouse].
on Ingredients
Section 3. Hazards Identification
Potential Acute Health Effects Extremely hazardous in case of ingestion. Very hazardous in case of eye contact (irritant), of inhalation. Slightly
hazardous in case of skin contact (irritant). Severe over-exposure can result in death. Inflammation of the eye is
characterized by redness, watering, and itching.
Extremely hazardous in case of ingestion.
Potential Chronic Health
Very hazardous in case of eye contact (irritant), of inhalation.
Effects
Slightly hazardous in case of skin contact (irritant).
CARCINOGENIC EFFECTS: Not available.
MUTAGENIC EFFECTS: Not available.
TERATOGENIC EFFECTS: Not available.
DEVELOPMENTAL TOXICITY: Not available.
The substance is toxic to the nervous system.
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Physostigmine salicylate
Repeated or prolonged exposure to the substance can produce target organs damage. Repeated exposure to an
highly toxic material may produce general deterioration of health by an accumulation in one or many human
organs.
Section 4. First Aid Measures
Eye Contact Check for and remove any contact lenses. Immediately flush eyes with running water for at least 15 minutes,
keeping eyelids open. Cold water may be used. Do not use an eye ointment. Seek medical attention.
Skin Contact After contact with skin, wash immediately with plenty of water. Gently and thoroughly wash the contaminated skin
with running water and non-abrasive soap. Be particularly careful to clean folds, crevices, creases and groin.
Cold water may be used. Cover the irritated skin with an emollient. If irritation persists, seek medical attention.
Wash contaminated clothing before reusing.
Serious Skin Contact Not available.
Inhalation Allow the victim to rest in a well ventilated area. Seek immediate medical attention.
Serious Inhalation Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or
waistband. If breathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth
resuscitation. Seek medical attention.
Ingestion Do not induce vomiting. Examine the lips and mouth to ascertain whether the tissues are damaged, a possible
indication that the toxic material was ingested; the absence of such signs, however, is not conclusive. Loosen
tight clothing such as a collar, tie, belt or waistband. If the victim is not breathing, perform mouth-to-mouth
resuscitation. Seek immediate medical attention.
Serious Ingestion Not available.
Section 5. Fire and Explosion Data
May be combustible at high temperature.
Flammability of the Product
Not available.
Auto-Ignition Temperature
Not available.
Flash Points
Not available.
Flammable Limits
These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...).
Products of Combustion
Not available.
Fire Hazards in Presence of
Various Substances
Explosion Hazards in Presence Risks of explosion of the product in presence of mechanical impact: Not available.
Risks of explosion of the product in presence of static discharge: Not available.
of Various Substances
SMALL FIRE: Use DRY chemical powder.
Fire Fighting Media
LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
and Instructions
Not available.
Special Remarks on
Fire Hazards
Special Remarks on Explosion Not available.
Hazards
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Physostigmine salicylate
Section 6. Accidental Release Measures
Small Spill Use appropriate tools to put the spilled solid in a convenient waste disposal container.
Large Spill Use a shovel to put the material into a convenient waste disposal container.
Section 7. Handling and Storage
Keep locked up Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk,
Precautions
evaporate the residue under a fume hood. Ground all equipment containing material. Do not ingest. Do not
breathe dust. Avoid contact with eyes In case of insufficient ventilation, wear suitable respiratory equipment If
ingested, seek medical advice immediately and show the container or the label.
Keep container dry. Keep in a cool place. Ground all equipment containing material. Keep container tightly
Storage
closed. Keep in a cool, well-ventilated place. Highly toxic or infectious materials should be stored in a separate
locked safety storage cabinet or room.
Section 8. Exposure Controls/Personal Protection
Engineering Controls Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below
recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to
airborne contaminants below the exposure limit.
Personal Protection Splash goggles. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent.
Gloves.
Personal Protection in Case of Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used
a Large Spill to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist
BEFORE handling this product.
Exposure Limits Not available.
Section 9. Physical and Chemical Properties
Physical state and appearance Solid. (Powdered solid.) Odorless.
Odor
Not available.
Taste
413.47 g/mole
Molecular Weight
White.
Color
5 [Acidic.]
pH (1% soln/water)
Decomposes.
Boiling Point
185掳C (365掳F)
Melting Point
Not available.
Critical Temperature
Not available.
Specific Gravity
Not applicable.
Vapor Pressure
Not available.
Vapor Density
Not available.
Volatility
Not available.
Odor Threshold
Not available.
Water/Oil Dist. Coeff.
Not available.
Ionicity (in Water)
See solubility in water, methanol, acetone.
Dispersion Properties
Soluble in methanol, acetone.
Solubility
Partially soluble in cold water.
Very slightly soluble in diethyl ether.
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Physostigmine salicylate
Section 10. Stability and Reactivity Data
The product is stable.
Stability
Not available.
Instability Temperature
Not available.
Conditions of Instability
Not available.
Incompatibility with various
substances
Non-corrosive in presence of glass.
Corrosivity
Not available.
Special Remarks on
Reactivity
Not available.
Special Remarks on
Corrosivity
No.
Polymerization
Section 11. Toxicological Information
Routes of Entry Eye contact. Inhalation. Ingestion.
Toxicity to Animals Acute oral toxicity (LD50): 2.5 mg/kg [Mouse].
Chronic Effects on Humans The substance is toxic to the nervous system.
Other Toxic Effects on Extremely hazardous in case of ingestion.
Humans Very hazardous in case of inhalation.
Slightly hazardous in case of skin contact (irritant).
Special Remarks on Not available.
Toxicity to Animals
Special Remarks on Not available.
Chronic Effects on Humans
Special Remarks on other Not available.
Toxic Effects on Humans
Section 12. Ecological Information
Not available.
Ecotoxicity
Not available.
BOD5 and COD
Possibly hazardous short term degradation products are not likely. However, long term degradation products may
Products of Biodegradation
arise.
The products of degradation are less toxic.
Toxicity of the Products
of Biodegradation
Not available.
Special Remarks on the
Products of Biodegradation
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Physostigmine salicylate
Section 13. Disposal Considerations
Waste Disposal
Section 14. Transport Information
DOT Classification CLASS 6.1: Poisonous material.
: Toxic solid, organic, n.o.s. (Physostigmine salicylate) : UN2811 PG: I
Identification
Not available.
Special Provisions for
Transport
DOT (Pictograms)
Section 15. Other Regulatory Information and Pictograms
Pennsylvania RTK: Physostigmine salicylate
Federal and State
Massachusetts RTK: Physostigmine salicylate
Regulations
TSCA 8(b) inventory: Physostigmine salicylate
SARA 302/304/311/312 extremely hazardous substances: Physostigmine salicylate
CERCLA: Hazardous substances.: Physostigmine salicylate
California prop. 65: This product contains the following ingredients for which the State of California has found
California
to cause cancer which would require a warning under the statute: No products were found.
Proposition 65
Warnings California prop. 65: This product contains the following ingredients for which the State of California has found
to cause birth defects which would require a warning under the statute: No products were found.
Other Regulations OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200).
CLASS D-1A: Material causing immediate and serious toxic effects (VERY TOXIC).
Other Classifications WHMIS (Canada)
CLASS D-2B: Material causing other toxic effects (TOXIC).
DSCL (EEC) R41- Risk of serious damage to eyes.
Health Hazard
HMIS (U.S.A.) 4 National Fire Protection Flammability
1
Association (U.S.A.)
Fire Hazard
1
0
4
Health Reactivity
Reactivity
0
Specific hazard
Personal Protection
E
WHMIS (Canada)
(Pictograms)
DSCL (Europe)
(Pictograms)
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Physostigmine salicylate
TDG (Canada)
(Pictograms)
ADR (Europe)
(Pictograms)
Protective Equipment Gloves.
Lab coat.
Dust respirator. Be sure to use an
approved/certified respirator or
equivalent. Wear appropriate respirator
when ventilation is inadequate.
Splash goggles.
Section 16. Other Information
P3820
MSDS Code
Not available.
References
Other Special Not available.
Considerations
Validated by Sonia Owen on 8/11/2006. Verified by Sonia Owen.
Printed 9/13/2006.
CALL (310) 516-8000
Notice to Reader
All chemicals may pose unknown hazards and should be used with caution. This Material Safety Data Sheet (MSDS) applies only to the material as packaged. If this product is
combined with other materials, deteriorates, or becomes contaminated, it may pose hazards not mentioned in this MSDS. It shall be the user's responsibility to develop proper
methods of handling and personal protection based on the actual conditions of use. While this MSDS is based on technical data judged to be reliable, Spectrum Quality Products,
Inc. assumes no responsibility for the completeness or accuracy of the information contained herein.
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