Material Safety Data Sheet
HMIS
NFPA Personal Protective Equipment
Health Hazard
2
3 Fire Hazard
3
2 1
Reactivity
0 See Section 15.
Section 1. Chemical Product and Company Identification Page Number: 1
Catalog
Tetrahydrofuran YY019, HP360, XX628,
Common Name/
Number(s). T1368, T1226, T1025,
Trade Name
US085, HP832
109-99-9
CAS#
Manufacturer LU5950000
RTECS
SPECTRUM LABORATORY PRODUCTS INC.
14422 S. SAN PEDRO STREET TSCA 8(b) inventory:
TSCA
Tetrahydrofuran
GARDENA, CA 90248
Not available.
Commercial Name(s) Not available.
CI#
Tetrahydrofuran stabilized with BHT; THF; Butylene Oxide;
Synonym
IN CASE OF EMERGENCY
Cyclotetramethylene oxide; 1,4-Epoxybutane
CHEMTREC (24hr) 800-424-9300
Tetrahydrofuran
Chemical Name
Not available. CALL (310) 516-8000
Chemical Family
C4H8O
Chemical Formula
SPECTRUM LABORATORY PRODUCTS INC.
Supplier
14422 S. SAN PEDRO STREET
GARDENA, CA 90248
Section 2.Composition and Information on Ingredients
Exposure Limits
3
STEL (mg/m3) CEIL (mg/m3)
Name CAS # TWA (mg/m ) % by Weight
1) Tetrahydrofuran 109-99-9 590 735 100
Tetrahydrofuran:
Toxicological Data
ORAL (LD50): Acute: 1650 mg/kg [Rat].
on Ingredients
Acute: 21000 mg/m3 3 hours [Rat].
VAPOR (LC50):
Section 3. Hazards Identification
Potential Acute Health Effects Hazardous in case of skin contact (irritant), of eye contact (irritant). Slightly hazardous in case of skin contact
(permeator), of ingestion, of inhalation.
CARCINOGENIC EFFECTS: Not available.
Potential Chronic Health
MUTAGENIC EFFECTS: Mutagenic for mammalian somatic cells. Mutagenic for bacteria and/or yeast.
Effects
TERATOGENIC EFFECTS: Not available.
DEVELOPMENTAL TOXICITY: Not available.
The substance may be toxic to blood, kidneys, lungs, liver, upper respiratory tract, skin, eyes, central nervous
system (CNS).
Repeated or prolonged exposure to the substance can produce target organs damage.
Continued on Next Page
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Tetrahydrofuran
Section 4. First Aid Measures
Eye Contact Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at
least 15 minutes. Cold water may be used. Get medical attention.
Skin Contact In case of contact, immediately flush skin with plenty of water. Cover the irritated skin with an emollient. Remove
contaminated clothing and shoes. Cold water may be used.Wash clothing before reuse. Thoroughly clean shoes
before reuse. Get medical attention.
Serious Skin Contact Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek immediate
medical attention.
Inhalation If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get
medical attention.
Serious Inhalation Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or
waistband. If breathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth
resuscitation. WARNING: It may be hazardous to the person providing aid to give mouth-to-mouth resuscitation
when the inhaled material is toxic, infectious or corrosive. Seek medical attention.
Ingestion Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an
unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight
clothing such as a collar, tie, belt or waistband.
Serious Ingestion Not available.
Section 5. Fire and Explosion Data
Flammable.
Flammability of the Product
321掳C (609.8掳F)
Auto-Ignition Temperature
CLOSED CUP: -14.5掳C (5.9掳F). OPEN CUP: -20掳C (-4掳F).
Flash Points
LOWER: 2% UPPER: 11.8%
Flammable Limits
These products are carbon oxides (CO, CO2).
Products of Combustion
Highly flammable in presence of open flames and sparks, of heat.
Fire Hazards in Presence of
Non-flammable in presence of shocks.
Various Substances
Explosion Hazards in Presence Risks of explosion of the product in presence of mechanical impact: Not available.
Explosive in presence of open flames and sparks, of heat.
of Various Substances
Flammable liquid, soluble or dispersed in water.
Fire Fighting Media
SMALL FIRE: Use DRY chemical powder.
and Instructions
LARGE FIRE: Use alcohol foam, water spray or fog.
Vapor may travel considerable distance to source of ignition and flash back. May form explosive mixtures with air.
Special Remarks on
Fire Hazards
Special Remarks on Explosion Reacts explosively with lithium-aluminum alloys, and Sodium Aluminum Hydride, Potassium hydroxide, Calcium
Hydride.
Hazards
It is normally stable, however, prolonged storage, and exposure to air and light may cause formation of unstable
explosive peroxides especially when anhydrous and unless it is inhibited against peroxide formation.
Explosive in the form of vapor when exposed to heat or flame.
Section 6. Accidental Release Measures
Small Spill Dilute with water and mop up, or absorb with an inert dry material and place in an appropriate waste disposal
container.
Large Spill Flammable liquid.
Keep away from heat. Keep away from sources of ignition. Stop leak if without risk. Absorb with DRY earth,
sand or other non-combustible material. Do not touch spilled material. Prevent entry into sewers, basements or
confined areas; dike if needed. Be careful that the product is not present at a concentration level above TLV.
Check TLV on the MSDS and with local authorities.
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Tetrahydrofuran
Section 7. Handling and Storage
Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not
Precautions
ingest. Do not breathe gas/fumes/ vapor/spray. Wear suitable protective clothing. In case of insufficient
ventilation, wear suitable respiratory equipment. If ingested, seek medical advice immediately and show the
container or the label. Avoid contact with skin and eyes. Keep away from incompatibles such as oxidizing agents.
Store in a segregated and approved area. Keep container in a cool, well-ventilated area. Keep container tightly
Storage
closed and sealed until ready for use. Avoid all possible sources of ignition (spark or flame).
Prolonged exposure to air and light may form unstable explosive peroxides unless it is inhibited against peroxide
formation
Section 8. Exposure Controls/Personal Protection
Engineering Controls Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their
respective threshold limit value. Ensure that eyewash stations and safety showers are proximal to the
work-station location.
Personal Protection Splash goggles. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent.
Gloves.
Personal Protection in Case of Splash goggles. Full suit. Vapor respirator. Boots. Gloves. A self contained breathing apparatus should be
a Large Spill used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist
BEFORE handling this product.
(mg/m3) from ACGIH (TLV) [United States] Inhalation
Exposure Limits TWA: 590 STEL: 737
TWA: 200 STEL: 250 (ppm) from ACGIH (TLV) [United States] Inhalation
(mg/m3) from NIOSH [United States] Inhalation
TWA: 590 STEL: 735
TWA: 200 STEL: 250 (ppm) from NIOSH [United States] Inhalation
TWA: 200 STEL: 250 (ppm) from OSHA (PEL) [United States] Inhalation
(mg/m3) from OSHA (PEL) [United States] Inhalation
TWA: 590 STEL: 735
TWA: 100 STEL: 200 (ppm) [United Kingdom (UK)] Inhalation
(mg/m3) [United Kingdom (UK)] Inhalation
TWA: 300 STEL: 599
Consult local authorities for acceptable exposure limits.
Section 9. Physical and Chemical Properties
Physical state and appearance Liquid. Ethereal. Fruity.
Odor
Pungent.
Taste
72.11 g/mole
Molecular Weight
Colorless.
Color
Not available.
pH (1% soln/water)
65掳C (149掳F) @ 760 mm Hg
Boiling Point
-108.3掳C (-162.9掳F)
Melting Point
267掳C (512.6掳F)
Critical Temperature
0.8892 (Water = 1)
Specific Gravity
19.3 kPa (@ 20掳C)
Vapor Pressure
2.5 (Air = 1)
Vapor Density
100% (v/v).
Volatility
20 ppm - 50 ppm
Odor Threshold
The product is more soluble in oil; log(oil/water) = 0.5
Water/Oil Dist. Coeff.
Not available.
Ionicity (in Water)
See solubility in water, diethyl ether, acetone.
Dispersion Properties
Easily soluble in diethyl ether, acetone.
Solubility
Partially soluble in cold water.
Solubility in water is 30%.
Miscible with alcohols, ketones, esters, hydrocarbons, and ethers.
Very soluble in benzene, ethanol, and chloroform.
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Tetrahydrofuran
Section 10. Stability and Reactivity Data
The product is stable.
Stability
Not available.
Instability Temperature
Heat, ignition sources (sparks, flames), light, air, and incompatible materials
Conditions of Instability
Reactive with oxidizing agents, acids, alkalis.
Incompatibility with various
substances
Non-corrosive in presence of glass.
Corrosivity
Reacts violently with Bromine.
Special Remarks on
Addition of anhydrous chlorides (hafnium tetrachloride, titanium tetrachloride, and zirconium tetrachloride) directly
Reactivity
to tetrahydrofuran will cause a violent exothermic reaction.
Also incompatible with Calcium Hydride + heat, caustics (e.g. ammonia, ammonium hydroxide, calcium hyroxide,
potassium hydroxide, sodium hydroxide), metal halides, moisture, lithium tetrahydroaluminate, borane,
2-aminophenol + potassium dioxide, sodium tetrahydroaluminate, and 2-aminophenol.
Prolonged exposure to air and light may form unstable peroxides especially when anhydrous and unless it is
inhibited against peroxide formation.
It will attack some forms of plastics, rubber, coatings.
Special Remarks on
Corrosivity
Will not occur.
Polymerization
Section 11. Toxicological Information
Routes of Entry Absorbed through skin. Dermal contact. Eye contact.
Toxicity to Animals WARNING: THE LC50 VALUES HEREUNDER ARE ESTIMATED ON THE BASIS OF A 4-HOUR EXPOSURE.
Acute oral toxicity (LD50): 1650 mg/kg [Rat].
Acute toxicity of the vapor (LC50): 24000 mg/m3 2 hours [Mouse].
Chronic Effects on Humans MUTAGENIC EFFECTS: Mutagenic for mammalian somatic cells. Mutagenic for bacteria and/or yeast.
May cause damage to the following organs: blood, kidneys, lungs, liver, upper respiratory tract, skin, eyes, central
nervous system (CNS).
Other Toxic Effects on Hazardous in case of skin contact (irritant).
Humans Slightly hazardous in case of skin contact (permeator), of ingestion, of inhalation.
Special Remarks on Not available.
Toxicity to Animals
Special Remarks on It is excreted in mother's milk.
Chronic Effects on Humans May cause cancer based on animal data. No human data found at this point.
May cause adverse reproductive effects (fetotoxicity) based on animal data. No human data found at this point.
May affect genetic material.
Special Remarks on other Acute Potential Health Effects:
Toxic Effects on Humans Skin: Causes skin irritation. May be absorbed through skin and cause symptoms similar those of inhalation and
ingestion.
Eyes: Contact with eyes may cause severe irritation with possible eye burns. Vapors may cause eye irritation.
Inhalation: May cause upper respiratory tract (nose, throat) irriation. High concentrations may affect
behavior/central nervous system (central nervous system depression/effects characterized by headache, general
anesthetic, dizziness, somnolence, muscle weakness, loss of conciousness, and coma), respiration (respiratory
stimulation, dyspnea), and gastrointestinal tract (nausea, vomiting).
Ingestion: May cause gastrointestinal irritation with nausea, vomiting, and diarrhea, abdominal pain. May also
affect the liver and behavior/central nervous system with symptoms similar to inhalation.
Chronic Potential Health Effects:
Skin: Prolonged or repeated skin contact may cause defatting and dermatitis.
Eyes: Prolonged or repeated eye contact may cause conjunctivitis.
Inhalation: Prolonged or repeated exposure to vapors may affect the liver, kidneys, muculosketal system,
endrocrine system (spleen and thymus), blood, cardiovascular system, thymus, spleen, and lungs (lung damage).
Ingestion: Prolonged or repeated exposure from ingestion may affect the blood, and metabolism.
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Tetrahydrofuran
Section 12. Ecological Information
Ecotoxicity in water (LC50): 2160 mg/l 96 hours [Fish (Fathead Minnow)].
Ecotoxicity
Not available.
BOD5 and COD
Possibly hazardous short term degradation products are not likely. However, long term degradation products may
Products of Biodegradation
arise.
The products of degradation are less toxic than the product itself.
Toxicity of the Products
of Biodegradation
Not available.
Special Remarks on the
Products of Biodegradation
Section 13. Disposal Considerations
Waste must be disposed of in accordance with federal, state and local environmental
Waste Disposal
control regulations.
Section 14. Transport Information
DOT Classification CLASS 3: Flammable liquid.
: Tetrahydrofuran UNNA: 2056 PG: II
Identification
Not available.
Special Provisions for
Transport
DOT (Pictograms)
Section 15. Other Regulatory Information and Pictograms
Connecticut hazardous material survey.: Tetrahydrofuran
Federal and State
Illinois toxic substances disclosure to employee act: Tetrahydrofuran
Regulations
Illinois chemical safety act: Tetrahydrofuran
New York release reporting list: Tetrahydrofuran
Rhode Island RTK hazardous substances: Tetrahydrofuran
Pennsylvania RTK: Tetrahydrofuran
Minnesota: Tetrahydrofuran
Massachusetts RTK: Tetrahydrofuran
Massachusetts spill list: Tetrahydrofuran
New Jersey: Tetrahydrofuran
New Jersey spill list: Tetrahydrofuran
Louisiana spill reporting: Tetrahydrofuran
California Director's List of Hazardous Substances: Tetrahydrofuran
TSCA 8(b) inventory: Tetrahydrofuran
TSCA 4(a) proposed test rules: Tetrahydrofuran
TSCA 8(a) PAIR: Tetrahydrofuran
TSCA 8(a) IUR: Tetrahydrofuran
TSCA 8(d) H and S data reporting: Tetrahydrofuran: effective data: 3/11/94; sunset date: 6/30/98
CERCLA: Hazardous substances.: Tetrahydrofuran: 1000 lbs. (453.6 kg)
California prop. 65: This product contains the following ingredients for which the State of California has found
California
to cause cancer which would require a warning under the statute: No products were found.
Proposition 65
Warnings California prop. 65: This product contains the following ingredients for which the State of California has found
to cause birth defects which would require a warning under the statute: No products were found.
Other Regulations OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200).
EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances.
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Page Number: 6
Tetrahydrofuran
CLASS B-2: Flammable liquid with a flash point lower than 37.8掳C (100掳F).
Other Classifications WHMIS (Canada)
CLASS D-2B: Material causing other toxic effects (TOXIC).
DSCL (EEC) R11- Highly flammable. S16- Keep away from sources of ignition - No
R19- May form explosive peroxides. smoking.
R36/37- Irritating to eyes and S29- Do not empty into drains.
respiratory system. S33- Take precautionary measures against
static discharges.
Health Hazard
HMIS (U.S.A.) 2 National Fire Protection Flammability
3
Association (U.S.A.)
Fire Hazard
3
1
2
Health Reactivity
Reactivity
0
Specific hazard
Personal Protection
h
WHMIS (Canada)
(Pictograms)
DSCL (Europe)
(Pictograms)
TDG (Canada)
(Pictograms)
3
ADR (Europe)
(Pictograms)
Protective Equipment Gloves.
Lab coat.
Vapor respirator. Be sure to use an
approved/certified respirator or
equivalent. Wear appropriate respirator
when ventilation is inadequate.
Splash goggles.
Continued on Next Page
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Tetrahydrofuran
Section 16. Other Information
T3260
MSDS Code
Not available.
References
Other Special Not available.
Considerations
Validated by Sonia Owen on 8/25/2006. Verified by Sonia Owen.
Printed 9/14/2006.
CALL (310) 516-8000
Notice to Reader
All chemicals may pose unknown hazards and should be used with caution. This Material Safety Data Sheet (MSDS) applies only to the material as packaged. If this product is
combined with other materials, deteriorates, or becomes contaminated, it may pose hazards not mentioned in this MSDS. It shall be the user's responsibility to develop proper
methods of handling and personal protection based on the actual conditions of use. While this MSDS is based on technical data judged to be reliable, Spectrum Quality Products,
Inc. assumes no responsibility for the completeness or accuracy of the information contained herein.
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