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Material Safety Data Sheet
Gentamycin Sulfate
ACC# 60939
Section 1 - Chemical Product and Company Identification
MSDS Name: Gentamycin Sulfate
Catalog Numbers: 61398-0010, BP918-1, NC9645150
Synonyms: Garamycin; Gentamicin Sulfate.
Company Identification:
Fisher Scientific
1 Reagent Lane
Fair Lawn, NJ 07410
For information, call: 201-796-7100
Emergency Number: 201-796-7100
For CHEMTREC assistance, call: 800-424-9300
For International CHEMTREC assistance, call: 703-527-3887
Section 2 - Composition, Information on Ingredients
CAS# Chemical Name Percent EINECS/ELINCS
1405-41-0 Gentamycin Sulfate >99 215-778-9
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Appearance: colorless to white solid.
Warning! Individuals with allergies or hypersensitivity to antibiotics should take caution. May cause allergic
respiratory and skin reaction. Causes eye and skin irritation. May cause respiratory tract irritation. Possible risk of
harm to the unborn child. May cause loss of hearing. May cause kidney damage. May cause reproductive and fetal
effects.
Target Organs: Kidneys, central nervous system, eyes, skin, auditory system.
Potential Health Effects
Eye: Causes eye irritation. Exposure to solid may cause pain and redness. May cause chemical conjunctivitis.
Skin: May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material.
May be harmful if absorbed through the skin.
Ingestion: May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause kidney damage. May
cause central nervous system effects. Hearing loss and deafness have been reported. May cause auditory damage
with possible loss of hearing. May cause neuromuscular paralysis. Causes photosensitivity with possible allergic skin
reactions when exposed to light.
Inhalation: Causes respiratory tract irritation. May cause an allergic response. May cause hearing impairment. May
cause central nervous system effects.
Chronic: May cause fetal effects. May cause adverse reproductive effects. Gentamycin is an aminoglycoside
antimicrobial. Aminoglycosides are associated with significant nephrotoxicity (toxic to kidney cells) and ototoxicity
(having a toxic effect on the structures of the ear, especially the nerve supply).
Section 4 - First Aid Measures
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower
eyelids. Get medical aid.
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Skin: Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and
shoes. Get medical aid if irritation develops or persists. Wash clothing before reuse.
Ingestion: Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Get medical
aid.
Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen. Get medical aid.
Notes to Physician: Treat symptomatically and supportively.
Section 5 - Fire Fighting Measures
General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH
(approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated
by thermal decomposition or combustion.
Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or appropriate foam.
Flash Point: Not applicable.
Autoignition Temperature: Not applicable.
Explosion Limits, Lower:Not available.
Upper: Not available.
NFPA Rating: (estimated) Health: 2; Flammability: 0; Instability: 0
Section 6 - Accidental Release Measures
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately,
observing precautions in the Protective Equipment section. Avoid generating dusty conditions. Provide ventilation.
Section 7 - Handling and Storage
Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with
adequate ventilation. Minimize dust generation and accumulation. Avoid contact with skin and eyes. Keep container
tightly closed. Avoid ingestion and inhalation.
Storage: Store in a cool, dry area away from incompatible substances.
Section 8 - Exposure Controls, Personal Protection
Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a
safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits
Chemical Name ACGIH NIOSH OSHA - Final PELs
Gentamycin Sulfate none listed none listed none listed
OSHA Vacated PELs: Gentamycin Sulfate: No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin: Wear appropriate protective gloves to prevent skin exposure.
Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a
NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or
other symptoms are experienced.
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Section 9 - Physical and Chemical Properties
Physical State: Solid
Appearance: colorless to white
Odor: none reported
pH: 3.5-5.5, 4% solution
Vapor Pressure: Not available.
Vapor Density: Not available.
Evaporation Rate:Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point:217.8-237.2 deg C
Decomposition Temperature:Not available.
Solubility: Soluble in water.
Specific Gravity/Density:Not available.
Molecular Formula:Not applicable.
Molecular Weight:Not available.
Section 10 - Stability and Reactivity
Chemical Stability: Stable under normal temperatures and pressures.
Conditions to Avoid: High temperatures, incompatible materials, dust generation.
Incompatibilities with Other Materials: Strong oxidizing agents.
Hazardous Decomposition Products: Carbon monoxide, oxides of nitrogen, oxides of sulfur, carbon dioxide.
Hazardous Polymerization: Has not been reported.
Section 11 - Toxicological Information
RTECS#:
CAS# 1405-41-0: LY2625000
LD50/LC50:
CAS# 1405-41-0:
Oral, mouse: LD50 = >11269 mg/kg;
Oral, rat: LD50 = >5 gm/kg;
.
Carcinogenicity:
CAS# 1405-41-0: Not listed by ACGIH, IARC, NTP, or CA Prop 65.
Epidemiology: No information available.
Teratogenicity: Effects of Newborn: Biochemical and Metabolic, subcutaneous-rat TDLo=660mg/kg; Growth
statistics, intra- peritoneal-rat TDLo=375mg/kg. Specific Developmental Abnormalities: Cardiovascular system and
Urogenital, subcutaneous-rat TDLo=660mg/kg.
Reproductive Effects: May impair fertility.
Mutagenicity: No information available.
Neurotoxicity: Aminoglycoside antibiotics have the potential to cause auditory nerve damage and neuromuscular
paralysis.
Other Studies:
Section 12 - Ecological Information
Ecotoxicity: No data available. No information available.
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Environmental: No information reported.
Physical: No information available.
Other: None.
Section 13 - Disposal Considerations
Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA
guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must
consult state and local hazardous waste regulations to ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.
Section 14 - Transport Information
US DOT Canada TDG
Please contact Fisher Scientific for shipping
Shipping Name: No information available.
information
Hazard Class:
UN Number:
Packing Group:
Section 15 - Regulatory Information
US FEDERAL
TSCA
CAS# 1405-41-0 is not listed on the TSCA inventory. It is for research and development use only.
Health & Safety Reporting List
None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
None of the chemicals in this material have an RQ.
SARA Section 302 Extremely Hazardous Substances
None of the chemicals in this product have a TPQ.
SARA Codes
CAS # 1405-41-0: immediate, delayed.
Section 313 No chemicals are reportable under Section 313.
Clean Air Act:
This material does not contain any hazardous air pollutants.
This material does not contain any Class 1 Ozone depletors.
This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
None of the chemicals in this product are listed as Hazardous Substances under the CWA.
None of the chemicals in this product are listed as Priority Pollutants under the CWA.
None of the chemicals in this product are listed as Toxic Pollutants under the CWA.
OSHA:
None of the chemicals in this product are considered highly hazardous by OSHA.
STATE
CAS# 1405-41-0 is not present on state lists from CA, PA, MN, MA, FL, or NJ.
California Prop 65
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WARNING: This product contains Gentamycin Sulfate, listed as `Aminoglycosides', a chemical known to the state of
California to cause developmental reproductive toxicity.
California No Significant Risk Level: None of the chemicals in this product are listed.
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
T
Risk Phrases:
R 36/38 Irritating to eyes and skin.
R 42/43 May cause sensitization by inhalation and skin contact.
R 60 May impair fertility.
R 61 May cause harm to the unborn child.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately with plenty of
water and seek medical advice.
S 36/37/39 Wear suitable protective clothing, gloves and eye/face pr
otection.
WGK (Water Danger/Protection)
CAS# 1405-41-0: 1
Canada - DSL/NDSL
None of the chemicals in this product are listed on the DSL or NDSL list.
Canada - WHMIS
This product has a WHMIS classification of D2B, D2A.
This product has been classified in accordance with the hazard criteria of the Controlled Products Regulations and the
MSDS contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
CAS# 1405-41-0 is not listed on the Canadian Ingredient Disclosure List.
Section 16 - Additional Information
MSDS Creation Date: 7/13/1999
Revision #6 Date: 1/11/2008
The information above is believed to be accurate and represents the best information currently available to us. However, we make no
warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting
from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no
event shall Fisher be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental,
consequential or exemplary damages, howsoever arising, even if Fisher has been advised of the possibility of such damages.
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