**** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS ****
+----------------+--------------------------------------+----------+-----------+
| CAS# | Chemical Name | % | EINECS# |
|----------------|--------------------------------------|----------|-----------|
|----------------|--------------------------------------|----------|-----------|
|----------------|--------------------------------------|----------|-----------|
| 51594-55-9 |(R)-(-)-Epichlorohydrin | 99 | 424-280-2 |
+----------------+--------------------------------------+----------+-----------+
Text for R-phrases: see Section 16
Hazard Symbols: T
Risk Phrases: 10 23/24/25 34 43 45
**** SECTION 3 - HAZARDS IDENTIFICATION ****
EMERGENCY OVERVIEW
Flammable. Toxic by inhalation, in contact with skin and if
swallowed. Causes burns. May cause sensitization by skin contact.
May cause cancer.Corrosive.Cancer suspect agent.
Potential Health Effects
Eye:
Causes severe eye irritation.
Skin:
Harmful if absorbed through the skin. May cause skin sensitization,
an allergic reaction, which becomes evident upon re-exposure to this
material. Skin contact causes itching, erythema (redness), and severe
burns, which may appear after a latent period ranging from several
minutes to days.
Ingestion:
Harmful if swallowed. May cause systemic toxicity with acidosis.
Causes gastrointestinal tract irritation.
Inhalation:
Harmful if inhaled. May cause asthmatic attacks due to allergic
sensitization of the respiratory tract. Causes severe respiratory
tract irritation.
Chronic:
Prolonged or repeated skin contact may cause sensitization
dermatitis and possible destruction and/or ulceration. May cause
liver and kidney damage. May cause cancer according to animal
studies. May cause reproductive and fetal effects.
**** SECTION 4 - FIRST AID MEASURES ****
Eyes:
Immediately flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower eyelids. Get medical aid
immediately.
Skin:
Get medical aid immediately. Immediately flush skin with plenty of
water for at least 15 minutes while removing contaminated clothing
and shoes. Discard contaminated clothing in a manner which limits
further exposure.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Never give anything by mouth to an unconscious person. Get medical
aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh
air immediately. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen.
Notes to Physician:
**** SECTION 5 - FIRE FIGHTING MEASURES ****
General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. Vapors may form an explosive mixture with air.
Vapors can travel to a source of ignition and flash back. During a
fire, irritating and highly toxic gases may be generated by thermal
decomposition or combustion. Use water spray to keep fire-exposed
containers cool. Flammable liquid and vapor. Vapors may be heavier
than air. They can spread along the ground and collect in low or
confined areas. May polymerize explosively when involved in a fire.
May be ignited by heat, sparks, and flame. Containers may explode if
exposed to fire.
Extinguishing Media:
For small fires, use dry chemical, carbon dioxide, water spray or
alcohol-resistant foam. Use water spray to cool fire-exposed
containers. Do NOT use straight streams of water. For large fires,
use dry chemical, carbon dioxide, alcohol-resistant foam, or water
spray. Cool containers with flooding quantities of water until well
after fire is out.
**** SECTION 6 - ACCIDENTAL RELEASE MEASURES ****
General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth),
then place in suitable container. Clean up spills immediately,
observing precautions in the Protective Equipment section. Remove all
sources of ignition. Provide ventilation. A vapor suppressing foam
may be used to reduce vapors. Prevent spreading of vapors through
sewers, ventilation systems and confined areas.
**** SECTION 7 - HANDLING and STORAGE ****
Handling:
Wash thoroughly after handling. Wash hands before eating. Remove
contaminated clothing and wash before reuse. Use only in a
well-ventilated area. Ground and bond containers when transferring
material. Use spark-proof tools and explosion proof equipment. Do not
get in eyes, on skin, or on clothing. Empty containers retain product
residue, (liquid and/or vapor), and can be dangerous. Do not ingest
or inhale. Do not pressurize, cut, weld, braze, solder, drill, grind,
or expose empty containers to heat, sparks or open flames.
Storage:
Keep away from heat, sparks, and flame. Keep away from sources of
ignition. Keep refrigerated. (Store below 4C/39F.) Store in a
tightly closed container. Store in a cool, dry, well-ventilated area
away from incompatible substances. Flammables-area. Outside or
detached storage is preferred.
**** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION ****
Engineering Controls:
Facilities storing or utilizing this material should be equipped
with an eyewash facility and a safety shower. Use adequate general or
local exhaust ventilation to keep airborne concentrations below the
permissible exposure limits.
Exposure Limits
CAS# 106-89-8:
United Kingdom, WEL - TWA: 0.5 ppm TWA; 1.9 mg/m3 TWA
United Kingdom, WEL - STEL: 1.5 ppm STEL; 5.8 mg/m3 STEL
United States OSHA: 5 ppm TWA; 19 mg/m3 TWA
Belgium - TWA: 2 ppm VLE; 7.7 mg/m3 VLE
France - VLE: 2 ppm VLE; 10 mg/m3 VLE
Germany: 3 ppm TWA; 12 mg/m3 TWA
Germany: Skin absorber
Malaysia: 0.5 ppm TWA; 1.9 mg/m3 TWA
Russia: 1 mg/m3 TWA
Spain: 0.5 ppm VLA-ED; 1.9 mg/m3 VLA-ED
CAS# 51594-55-9:
Personal Protective Equipment
Eyes:
Wear chemical splash goggles and face shield.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
Wear a NIOSH/MSHA or European Standard EN 149
approved full-facepiece airline respirator in the
positive pressure mode with emergency escape
provisions.
**** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES ****
Physical State: Liquid
Color: clear, colorless
Odor: Irritating chloroform-like odor.
pH: Not available.
Vapor Pressure: 13 mm Hg @ 20 deg C
Viscosity: 1.02 cP @ 25C
Boiling Point: 114 deg C
Freezing/Melting Point: -57 deg C
Autoignition Temperature: 411 deg C ( 771.80 deg F)
Flash Point: 28 deg C ( 82.40 deg F)
Explosion Limits, lower: 3.8
Explosion Limits, upper: 21.0
Decomposition Temperature: Not available.
Solubility in water: Soluble.
Specific Gravity/Density: 1.183
Molecular Formula: C3H5ClO
Molecular Weight: 92.52
**** SECTION 10 - STABILITY AND REACTIVITY ****
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
High temperatures, mechanical shock, ignition sources.
Incompatibilities with Other Materials:
Acids, bases, ammonia, amines, sodium, zinc, magnesium, aluminum, and
halides. Explosive reaction with aniline, trichloroethylene (through
the formation of dichloroacetylene), potassium tert-butoxide
(ignition), sulfuric acid, or isopropylamine.
Hazardous Decomposition Products:
Hydrogen chloride, chlorine, phosgene, carbon monoxide, carbon
dioxide.
Hazardous Polymerization: May occur.
**** SECTION 11 - TOXICOLOGICAL INFORMATION ****
RTECS#:
CAS# 106-89-8: TX4900000
CAS# 51594-55-9: RR0427000
LD50/LC50:
CAS# 106-89-8: Draize test, rabbit, eye: 100 mg Severe; Draize test,
rabbit, eye: 100 mg/24H Moderate; Inhalation, rat: LC50 = 250 ppm/8H;
Oral, mouse: LD50 = 195 mg/kg; Oral, rabbit: LD50 = 345 mg/kg; Oral,
rat: LD50 = 90 mg/kg; Skin, rabbit: LD50 = 515 mg/kg.
CAS# 51594-55-9.
Carcinogenicity:
Epichlorohydrin -
ACGIH: A3 - Confirmed animal carcinogen with unknown relevance to
California: carcinogen, initial date 10/1/87
NTP: Suspect carcinogen
IARC: Group 2A carcinogen
(R)-(-)-Epichlorohydrin -
Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
**** SECTION 12 - ECOLOGICAL INFORMATION ****
Ecotoxicity:
Fish: Bluegill/Sunfish: LC50 = 35 mg/L; 96 Hr.; UnspecifiedFish:
Goldfish: LC50 = 42 mg/L; 96 Hr.; Static, 23 degrees CFish: LC50 =
36 mg/L; 48 Hr.; Unspecified
**** SECTION 13 - DISPOSAL CONSIDERATIONS ****
Dispose of in a manner consistent with federal, state, and local regulations.
**** SECTION 14 - TRANSPORT INFORMATION ****
IATA
Shipping Name: Epichlorohydrin
Hazard Class: 6.1
UN Number: 2023
Packing Group: II
IMO
Shipping Name: Epichlorohydrin
Hazard Class: 6.1
UN Number: 2023
Packing Group: II
RID/ADR
Shipping Name: Epichlorohydrin
Hazard Class: 6.1
UN Number: 2023
Packing group:
USA RQ: CAS# 106-89-8: 100 lb final RQ; 45.4 kg final RQ
**** SECTION 15 - REGULATORY INFORMATION ****
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T
Risk Phrases:
R 45 May cause cancer.
R 10 Flammable.
R 23/24/25 Toxic by inhalation, in contact with skin
and if swallowed.
R 34 Causes burns.
R 43 May cause sensitization by skin contact.
Safety Phrases:
S 53 Avoid exposure - obtain special instructions
before use.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 106-89-8: 3
CAS# 51594-55-9: No information available.
Canada
CAS# 106-89-8 is listed on Canada's DSL List.
CAS# 106-89-8 is listed on Canada's Ingredient Disclosure List.
CAS# 51594-55-9 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 106-89-8 is listed on the TSCA inventory.
CAS# 51594-55-9 is not listed on the TSCA inventory.
It is for research and development use only.
**** SECTION 16 - ADDITIONAL INFORMATION ****
Text for R-phrases from Section 2
MSDS Creation Date: 5/30/2000 Revision #1 Date: 5/21/2002
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no way shall the company be
liable for any claims, losses, or damages of any third party or for lost
profits or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if the company has been advised of
the possibility of such damages.
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