**** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS ****
+----------------+--------------------------------------+----------+-----------+
| CAS# | Chemical Name | % | EINECS# |
|----------------|--------------------------------------|----------|-----------|
|----------------|--------------------------------------|----------|-----------|
|----------------|--------------------------------------|----------|-----------|
| 16649-49-3 |(Acetic anhydride)-d6, | 98.5 | 240-697-0 |
+----------------+--------------------------------------+----------+-----------+
Text for R-phrases: see Section 16
Hazard Symbols: C
Risk Phrases: 10 20/22 34
**** SECTION 3 - HAZARDS IDENTIFICATION ****
EMERGENCY OVERVIEW
Flammable. Harmful by inhalation and if swallowed. Causes
burns.Moisture sensitive.
Potential Health Effects
Eye:
Causes eye burns. Vapors cause eye irritation. Lachrymator
(substance which increases the flow of tears).
Skin:
Contact with liquid is corrosive and causes severe burns and
ulceration.
Ingestion:
Causes gastrointestinal tract burns.
Inhalation:
Causes chemical burns to the respiratory tract. May be harmful if
inhaled.
Chronic:
No information found.
**** SECTION 4 - FIRST AID MEASURES ****
Eyes:
Immediately flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower eyelids. Get medical aid
immediately. Do NOT allow victim to rub eyes or keep eyes closed.
Skin:
Get medical aid immediately. Immediately flush skin with plenty of
water for at least 15 minutes while removing contaminated clothing
and shoes.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4
cupfuls of milk or water. Never give anything by mouth to an
unconscious person. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh
air immediately. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen.
Notes to Physician:
**** SECTION 5 - FIRE FIGHTING MEASURES ****
General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. Vapors may form an explosive mixture with air.
Vapors can travel to a source of ignition and flash back. Use water
spray to keep fire-exposed containers cool. Flammable liquid and
vapor. Vapors may be heavier than air. They can spread along the
ground and collect in low or confined areas. Containers may explode
when heated.
Extinguishing Media:
In case of fire, use water, dry chemical, chemical foam, or
alcohol-resistant foam. Use water spray to cool fire-exposed
containers.
**** SECTION 6 - ACCIDENTAL RELEASE MEASURES ****
General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Use water spray to dilute spill to a non-flammable mixture. Avoid
runoff into storm sewers and ditches which lead to waterways. Use
water spray to disperse the gas/vapor. Remove all sources of
ignition. Spill may be carefully neutralized with lime (calcium
oxide, CaO). Cover with material such as dry soda ash or calcium
carbonate and place into a closed container for disposal. Do not get
water inside containers.
**** SECTION 7 - HANDLING and STORAGE ****
Handling:
Wash thoroughly after handling. Wash hands before eating. Remove
contaminated clothing and wash before reuse. Use only in a
well-ventilated area. Do not allow water to get into the container
because of violent reaction. Ground and bond containers when
transferring material. Do not get in eyes, on skin, or on clothing.
Empty containers retain product residue, (liquid and/or vapor), and
can be dangerous. Keep away from heat, sparks and flame. Do not
ingest or inhale. Do not pressurize, cut, weld, braze, solder,
drill, grind, or expose empty containers to heat, sparks or open
flames.
Storage:
Keep away from heat, sparks, and flame. Keep away from sources of
ignition. Do not store in direct sunlight. Store in a tightly closed
container. Keep from contact with oxidizing materials. Store in a
cool, dry, well-ventilated area away from incompatible substances.
Keep away from water. Store protected from moisture.
**** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION ****
Engineering Controls:
Facilities storing or utilizing this material should be equipped
with an eyewash facility and a safety shower. Use adequate general or
local explosion-proof ventilation to keep airborne levels to
acceptable levels.
Exposure Limits
CAS# 108-24-7:
United Kingdom, WEL - TWA: 0.5 ppm TWA; 2.5 mg/m3 TWA
United Kingdom, WEL - STEL: 2 ppm STEL; 10 mg/m3 STEL
United States OSHA: 5 ppm TWA; 20 mg/m3 TWA
Belgium - TWA: 5 ppm VLE; 21 mg/m3 VLE
France - VLE: 5 ppm VLE; 20 mg/m3 VLE
Germany: 5 ppm TWA; 21 mg/m3 TWA
Japan: 5 ppm Ceiling; 21 mg/m3 Ceiling
Malaysia: 5 ppm TWA; 21 mg/m3 TWA
Spain: 5 ppm VLA-ED; 21 mg/m3 VLA-ED
CAS# 16649-49-3:
Personal Protective Equipment
Eyes:
Wear chemical splash goggles.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
Follow the OSHA respirator regulations found in 29
CFR 1910.134 or European Standard EN 149. Use a
NIOSH/MSHA or European Standard EN 149 approved
respirator if exposure limits are exceeded or if
irritation or other symptoms are experienced.
**** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES ****
Physical State: Liquid
Color: clear, colorless
Odor: pungent, acetic odor
pH: Not available.
Vapor Pressure: 4 mm Hg @ 20 deg C
Viscosity: Not available.
Boiling Point: 139 deg C
Freezing/Melting Point: -74 deg C
Autoignition Temperature: 332 deg C ( 629.60 deg F)
Flash Point: 52 deg C ( 125.60 deg F)
Explosion Limits, lower: 2.9%
Explosion Limits, upper: 10.3%
Decomposition Temperature:
Solubility in water: Decomposes.
Specific Gravity/Density: 1.14
Molecular Formula: C4D6O3
Molecular Weight: 108.14
**** SECTION 10 - STABILITY AND REACTIVITY ****
Chemical Stability:
Stable. However, may decompose if exposed to moist air or water.
Substance is readily hydrolyzed. Reacts with water to form
corresponding acid.
Conditions to Avoid:
Light, ignition sources, contact with water.
Incompatibilities with Other Materials:
Acetic acid + water, ammonium nitrate + hexamethylenetetraminium
acetate + nitric acid, barium peroxide, boric acid,
bromohydroxybiphenyl + pyridine + water, N-tert-butylphthalamic acid
+ tetrafluoroboric acid, chromic acid, chromium trioxide,
1,3-diphenyltriazine, ethanol + sodium hydrogen sulfate, glycerol +
phosphoryl chloride, hydrochloric acid + water, hydrogen peroxide,
hypochlorous acid, metal nitrates, nitric acid, perchloric acid +
water, peroxyacetic acid, polyphosphoric acid + water, potassium
permanganate, sodium percarbonate, tetrafluoroboric acid,
4-toluenesulfonic acid + water, water,
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported.
**** SECTION 11 - TOXICOLOGICAL INFORMATION ****
RTECS#:
CAS# 108-24-7: AK1925000
CAS# 16649-49-3 unlisted.
LD50/LC50:
CAS# 108-24-7: Inhalation, rat: LC50 = 1000 ppm/4H; Oral, rat: LD50
= 1780 mg/kg; Skin, rabbit: LD50 = 4 mL/kg.
CAS# 16649-49-3.
Carcinogenicity:
Acetic anhydride -
Not listed by ACGIH, IARC, or NTP.
(Acetic anhydride)-d6, -
Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
**** SECTION 12 - ECOLOGICAL INFORMATION ****
**** SECTION 13 - DISPOSAL CONSIDERATIONS ****
Dispose of in a manner consistent with federal, state, and local regulations.
**** SECTION 14 - TRANSPORT INFORMATION ****
IATA
Shipping Name: ACETIC ANHYDRIDE
Hazard Class: 8 (3)
UN Number: 1715
Packing Group: II
IMO
Shipping Name: ACETIC ANHYDRIDE
Hazard Class: 8 (3)
UN Number: 1715
Packing Group: II
RID/ADR
Shipping Name: ACETIC ANHYDRIDE
Hazard Class: 8
UN Number: 1715
Packing group: II
USA RQ: CAS# 108-24-7: 5000 lb final RQ; 2270 kg final RQ
**** SECTION 15 - REGULATORY INFORMATION ****
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: C
Risk Phrases:
R 10 Flammable.
R 20/22 Harmful by inhalation and if swallowed.
R 34 Causes burns.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 36/37/39 Wear suitable protective clothing, gloves
and eye/face protection.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 108-24-7: 1
CAS# 16649-49-3: No information available.
Canada
CAS# 108-24-7 is listed on Canada's DSL List.
CAS# 108-24-7 is listed on Canada's Ingredient Disclosure List.
CAS# 16649-49-3 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 108-24-7 is listed on the TSCA inventory.
CAS# 16649-49-3 is not listed on the TSCA inventory.
It is for research and development use only.
**** SECTION 16 - ADDITIONAL INFORMATION ****
Text for R-phrases from Section 2
MSDS Creation Date: 10/31/1997 Revision #5 Date: 2/24/2005
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no way shall the company be
liable for any claims, losses, or damages of any third party or for lost
profits or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if the company has been advised of
the possibility of such damages.
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