**** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS ****
+----------------+--------------------------------------+----------+-----------+
| CAS# | Chemical Name | % | EINECS# |
|----------------|--------------------------------------|----------|-----------|
|----------------|--------------------------------------|----------|-----------|
| 109-99-9 |Tetrahydrofuran | 99+ | 203-726-8
|----------------|--------------------------------------|----------|-----------|
| 128-37-0 |2,6-di-tert-butyl-p-cresol | 0.025 | 204-881-4
+----------------+--------------------------------------+----------+-----------+
Hazard Symbols: XI F
Risk Phrases: 11 19 36/37
**** SECTION 3 - HAZARDS IDENTIFICATION ****
EMERGENCY OVERVIEW
Highly flammable. May form explosive peroxides. Irritating to eyes
and respiratory system.Hygroscopic.
Potential Health Effects
Eye:
Contact with eyes may cause severe irritation, and possible eye
burns. Vapors may cause eye irritation.
Skin:
Causes skin irritation. May be absorbed through the skin. If
absorbed, causes symptoms similar to those of inhalation.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and
diarrhea. May cause central nervous system depression. May be
harmful if swallowed.
Inhalation:
Inhalation of high concentrations may cause central nervous system
effects characterized by nausea, headache, dizziness, unconsciousness
and coma. Vapors may cause dizziness or suffocation. Inhalation may
cause coughing, difficulty breathing and loss of consciousness.
Causes irritation of the mucous membrane and upper respiratory tract.
Chronic:
Prolonged or repeated eye contact may cause conjunctivitis.
Prolonged or repeated skin contact may cause defatting and
dermatitis. May cause liver and kidney damage. May cause reproductive
and fetal effects. Laboratory experiments have resulted in mutagenic
effects. May cause lung damage. Narcotic in high concentrations.
**** SECTION 4 - FIRST AID MEASURES ****
Eyes:
Immediately flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower eyelids. Get medical aid
immediately.
Skin:
Get medical aid. Immediately flush skin with plenty of soap and
water for at least 15 minutes while removing contaminated clothing
and shoes. Wash clothing before reuse.
Ingestion:
Do NOT induce vomiting. If victim is conscious and alert, give 2-4
cupfuls of milk or water. Never give anything by mouth to an
unconscious person. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure to fresh air
immediately. If breathing is difficult, give oxygen. Do NOT use
mouth-to-mouth resuscitation. If breathing has ceased apply
artificial respiration using oxygen and a suitable mechanical device
such as a bag and a mask.
Notes to Physician:
Treat symptomatically and supportively. Persons with kidney disease,
chronic respiratory disease, liver disease, or skin disease may be at
increased risk from exposure to this substance.
**** SECTION 5 - FIRE FIGHTING MEASURES ****
General Information:
Containers can build up pressure if exposed to heat and/or fire. As
in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. Vapors may form an explosive mixture with air.
Vapors can travel to a source of ignition and flash back. Use water
spray to keep fire-exposed containers cool. Extremely flammable
liquid and vapor. Forms peroxides of unknown stability. Containers
may explode in the heat of a fire. Vapors may be heavier than air.
They can spread along the ground and collect in low or confined
areas. Will be easily ignited by heat, sparks or flame.
Extinguishing Media:
Use water spray to cool fire-exposed containers. Water may be
ineffective. Do NOT use straight streams of water. Contact
professional fire-fighters immediately. Cool containers with flooding
quantities of water until well after fire is out. In case of fire,
use carbon dioxide, dry chemical powder or appropriate foam.
**** SECTION 6 - ACCIDENTAL RELEASE MEASURES ****
General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth),
then place in suitable container. Use water spray to dilute spill to
a non-flammable mixture. Avoid runoff into storm sewers and ditches
which lead to waterways. Remove all sources of ignition. Use a
spark-proof tool. Isolate area and deny entry. A vapor suppressing
foam may be used to reduce vapors.
**** SECTION 7 - HANDLING and STORAGE ****
Handling:
Wash thoroughly after handling. Use only in a well-ventilated area.
Ground and bond containers when transferring material. Avoid contact
with eyes, skin, and clothing. Empty containers retain product
residue, (liquid and/or vapor), and can be dangerous. Keep container
tightly closed. Avoid contact with heat, sparks and flame. Do not
ingest or inhale. Prevent build up of vapors to explosive
concentration. Do not pressurize, cut, weld, braze, solder, drill,
grind, or expose empty containers to heat, sparks or open flames.
Storage:
Keep away from heat, sparks, and flame. Keep away from sources of
ignition. Store in a cool place in the original container and
protect from sunlight. Keep under a nitrogen blanket. Keep from
contact with oxidizing materials. Flammables-area. Regularly check
inhibitor levels to maintain peroxide levels below 1%. Store
protected from moisture.
**** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION ****
Engineering Controls:
Use explosion-proof ventilation equipment. Facilities storing or
utilizing this material should be equipped with an eyewash facility
and a safety shower. Use adequate general or local exhaust
ventilation to keep airborne concentrations below the permissible
exposure limits.
Personal Protective Equipment
Eyes:
Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European
Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
A respiratory protection program that meets OSHA's 29
CFR 1910.134 and ANSI Z88.2 requirements or European
Standard EN 149 must be followed whenever workplace
conditions warrant a respirator's use.
**** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES ****
Physical State: liquid
Color: colorless liquid
Odor: ethereal odor - fruity odor
pH: Not available.
Vapor Pressure: 160 mm Hg @25C
Viscosity: 0.48 cP @ 20C
Boiling Point: 65.4 deg C
Freezing/Melting Point: -108.4 deg C
Autoignition Temperature: 321 deg C ( 609.80 deg F)
Flash Point: -21 deg C ( -5.80 deg F)
Explosion Limits, lower: 1.8 vol %
Explosion Limits, upper: 11.8 vol %
Decomposition Temperature: Not available.
Solubility in water: Miscible.
Specific Gravity/Density: 0.8880
Molecular Formula: C4H8O
Molecular Weight: 72.0554
**** SECTION 10 - STABILITY AND REACTIVITY ****
Chemical Stability:
Prolonged exposure to air and sunlight may form unstable peroxides.
Explosive peroxides may form on concentration. Peroxides can be
detonated by friction, impact, or heating. Peroxide formation may
occur in containers that have been opened and remain in storage.
Normally stable; however, on long term storage, materials containing
similar functional groups form peroxides of unknown stability. THF
should never be distilled to dryness. Prolonged exposure to air, even
from extended storage time, can deplete BHT inhibitor and rapidly
accelerate THF-peroxide formation.
Conditions to Avoid:
Prolonged exposure to air, even from extended storage time, can
deplete BHT inhibitor and rapidly accelerate THF-peroxide formation.,
incompatible materials, light, ignition sources, moisture, acids,
excess heat.
Incompatibilities with Other Materials:
Oxidizing agents, acids, bases, oxygen, caustics (e.g. ammonia,
ammonium hydroxide, calcium hydroxide, potassium hydroxide, sodium
hydroxide), bromine, metal halides, moisture, lithium
tetrahydroaluminate, borane, 2-aminophenol + potassium dioxide,
calcium hydride + heat, sodium aluminum hydride, sodium
tetrahydroaluminate, 2-aminophenol.
Hazardous Decomposition Products:
Carbon monoxide, irritating and toxic fumes and gases, carbon
dioxide.
Hazardous Polymerization: May occur.
**** SECTION 11 - TOXICOLOGICAL INFORMATION ****
RTECS#:
CAS# 109-99-9: LU5950000
CAS# 128-37-0: GO7875000
LD50/LC50:
CAS# 109-99-9: Inhalation, rat: LC50 = 21000 ppm/3H; Oral, rat: LD50
= 1650 mg/kg.
CAS# 128-37-0: Draize test, rabbit, eye: 100 mg/24H Moderate; Draize
test, rabbit, skin: 500 mg/48H Moderate; Oral, mouse: LD50 = 650
mg/kg; Oral, rat: LD50 = 890 mg/kg.
Carcinogenicity:
Tetrahydrofuran -
Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
2,6-di-tert-butyl-p-cresol -
Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
Other:
See actual entry in RTECS for complete information.
**** SECTION 12 - ECOLOGICAL INFORMATION ****
Ecotoxicity:
Fish: Fathead Minnow: LC50 = 2160 mg/L; 96 Hr; Flow through bioassay
(pH 7.5)Tetrahydrofuran is not expected to adsorb to suspended
matter in the water based on its measured Koc values. This compound
should volatilize from water surfaces. An estimated BCF value of 1
suggests that tetrahydrofuran will not bioconcentrate in aquatic
organisms.
**** SECTION 13 - DISPOSAL CONSIDERATIONS ****
Dispose of in a manner consistent with federal, state, and local regulations.
**** SECTION 14 - TRANSPORT INFORMATION ****
IATA
Shipping Name: TETRAHYDROFURAN
Hazard Class: 3
UN Number: 2056
Packing Group: II
IMO
Shipping Name: TETRAHYDROFURAN
Hazard Class: 3.1
UN Number: 2056
Packing Group: II
RID/ADR
Shipping Name: TETRAHYDROFURAN
Hazard Class: 3
UN Number: 2056
Packing group: II
**** SECTION 15 - REGULATORY INFORMATION ****
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XI F
Risk Phrases:
R 11 Highly flammable.
R 19 May form explosive peroxides.
R 36/37 Irritating to eyes and respiratory system.
Safety Phrases:
S 16 Keep away from sources of ignition - No
smoking.
S 29 Do not empty into drains.
S 33 Take precautionary measures against static
discharges.
WGK (Water Danger/Protection)
CAS# 109-99-9: 1
CAS# 128-37-0: 1
United Kingdom Occupational Exposure Limits
United Kingdom Maximum Exposure Limits
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 109-99-9 is not listed on Canada's Ingredient Disclosure List.
CAS# 128-37-0 is not listed on Canada's Ingredient Disclosure List.
Exposure Limits
CAS# 109-99-9: OEL-AUSTRALIA:TWA 200 ppm (590 mg/m3);STEL 250 ppm (735
mg/m3)
OEL-BELGIUM:TWA 200 ppm (590 mg/m3);STEL 250 ppm (738 mg/m3)
OEL-DENMARK:TWA 200 ppm (590 mg/m3)
OEL-FINLAND:TWA 100 ppm (290 mg/m3);STEL 150 ppm (440 mg/m3)
OEL-FRANCE:TWA 200 ppm (590 mg/m3)
OEL-GERMANY:TWA 200 ppm (590 mg/m3)
OEL-HUNGARY:TWA 200 mg/m3;STEL 400 mg/m3
OEL-JAPAN:TWA 200 ppm (590 mg/m3)
OEL-THE NETHERLANDS:TWA 200 ppm (590 mg/m3)
OEL-THE PHILIPPINES:TWA 200 ppm (590 mg/m3)
OEL-RUSSIA:TWA 200 ppm;STEL 100 mg/m3
OEL-SWEDEN:TWA 100 ppm (300 mg/m3);STEL 150 ppm (450 mg/m3)
OEL-SWITZERLAND:TWA 200 ppm (590 mg/m3);STEL 1000 ppm
OEL-TURKEY:TWA 200 ppm (590 mg/m3)
OEL-UNITED KINGDOM:TWA 200 ppm (590 mg/m3);STEL 250 ppm
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGI TLV
CAS# 128-37-0: OEL-AUSTRALIA:TWA 10 mg/m3
OEL-BELGIUM:TWA 10 mg/m3
OEL-FINLAND:TWA 10 mg/m3;STEL 20 mg/m3;Skin
OEL-FRANCE:TWA 10 mg/m3
OEL-THE NETHERLANDS:TWA 10 mg/m3
OEL-SWITZERLAND:TWA 10 mg/m3
OEL-UNITED KINGDOM:TWA 10 mg/m3
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGI TLV
US FEDERAL
TSCA
CAS# 109-99-9 is not listed on the TSCA inventory.
It is for research and development use only.
CAS# 128-37-0 is not listed on the TSCA inventory.
It is for research and development use only.
**** SECTION 16 - ADDITIONAL INFORMATION ****
MSDS Creation Date: 5/28/1999 Revision #4 Date: 8/15/2002
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no way shall the company be
liable for any claims, losses, or damages of any third party or for lost
profits or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if the company has been advised of
the possibility of such damages.
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