**** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS ****
+----------------+--------------------------------------+----------+-----------+
| CAS# | Chemical Name | % | EINECS# |
|----------------|--------------------------------------|----------|-----------|
| 680-31-9 |Hexamethylphosphoramide | 99 | 211-653-8 |
+----------------+--------------------------------------+----------+-----------+
Hazard Symbols: T
Risk Phrases: 45 46
**** SECTION 3 - HAZARDS IDENTIFICATION ****
EMERGENCY OVERVIEW
May cause cancer. May cause heritable genetic damage.Cancer suspect
agent.
Potential Health Effects
Eye:
Causes eye irritation.
Skin:
Causes skin irritation. May be absorbed through the skin in harmful
amounts.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and
diarrhea. May be harmful if swallowed.
Inhalation:
Harmful if inhaled. Causes respiratory tract irritation.
Chronic:
Possible cancer hazard based on tests with laboratory animals.
**** SECTION 4 - FIRST AID MEASURES ****
Eyes:
In case of contact, immediately flush eyes with plenty of water for
at least 15 minutes. Get medical aid.
Skin:
In case of contact, flush skin with plenty of water. Remove
contaminated clothing and shoes. Get medical aid if irritation
develops and persists. Wash clothing before reuse.
Ingestion:
If swallowed, do not induce vomiting unless directed to do so by
medical personnel. Never give anything by mouth to an unconscious
person. Get medical aid.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial
respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
**** SECTION 5 - FIRE FIGHTING MEASURES ****
General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. During a fire, irritating and highly toxic gases
may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or appropriate foam.
**** SECTION 6 - ACCIDENTAL RELEASE MEASURES ****
General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth),
then place in suitable container. Avoid runoff into storm sewers and
ditches which lead to waterways. Clean up spills immediately,
observing precautions in the Protective Equipment section. Provide
ventilation.
**** SECTION 7 - HANDLING and STORAGE ****
Handling:
Wash thoroughly after handling. Remove contaminated clothing and
wash before reuse. Avoid contact with eyes, skin, and clothing. Keep
container tightly closed. Use only with adequate ventilation. Avoid
breathing vapor or mist.
Storage:
Store in a tightly closed container. Store in a cool, dry,
well-ventilated area away from incompatible substances.
**** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION ****
Engineering Controls:
Use process enclosure, local exhaust ventilation, or other
engineering controls to control airborne levels below recommended
exposure limits. Facilities storing or utilizing this material should
be equipped with an eyewash facility and a safety shower.
Exposure Limits
CAS# 680-31-9:
Personal Protective Equipment
Eyes:
Wear chemical splash goggles.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
Follow the OSHA respirator regulations found in 29
CFR 1910.134 or European Standard EN 149. Use a
NIOSH/MSHA or European Standard EN 149 approved
respirator if exposure limits are exceeded or if
irritation or other symptoms are experienced.
**** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES ****
Physical State: Liquid
Color: clear, colorless
Odor: amine-like
pH: Not available.
Vapor Pressure: 0.046 mm Hg @ 25 deg C
Viscosity: Not available.
Boiling Point: 233 deg C
Freezing/Melting Point: 7.2 deg C
Autoignition Temperature: 230 deg C ( 446.00 deg F)
Flash Point: 105 deg C ( 221.00 deg F)
Explosion Limits, lower: N/A
Explosion Limits, upper: N/A
Decomposition Temperature:
Solubility in water: Soluble.
Specific Gravity/Density: 1.0300 g/cm3
Molecular Formula: C6H18N3OP
Molecular Weight: 179.20
**** SECTION 10 - STABILITY AND REACTIVITY ****
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Excess heat.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong acids, sodium, potassium.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, oxides of phosphorus, irritating
and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported.
**** SECTION 11 - TOXICOLOGICAL INFORMATION ****
RTECS#:
CAS# 680-31-9: TD0875000
LD50/LC50:
CAS# 680-31-9: Dermal, guinea pig: LD50 = 1175 mg/kg; Oral, mouse:
LD50 = 2400 mg/kg; Oral, rat: LD50 = 2650 mg/kg; Skin, rabbit: LD50 =
2600 mg/kg.
Carcinogenicity:
Hexamethylphosphoramide -
ACGIH: A3 - Confirmed animal carcinogen with unknown relevance to
California: carcinogen, initial date 1/1/88
NTP: Suspect carcinogen
IARC: Group 2B carcinogen
Other:
See actual entry in RTECS for complete information.
**** SECTION 12 - ECOLOGICAL INFORMATION ****
Other
No information available.
**** SECTION 13 - DISPOSAL CONSIDERATIONS ****
Dispose of in a manner consistent with federal, state, and local regulations.
**** SECTION 14 - TRANSPORT INFORMATION ****
IATA
Shipping Name: NOT REGULATED
Hazard Class:
UN Number:
Packing Group:
IMO
Shipping Name: NOT REGULATED
Hazard Class:
UN Number:
Packing Group:
RID/ADR
Shipping Name: NOT REGULATED
Hazard Class: 6.1
UN Number:
Packing group: I
USA RQ: CAS# 680-31-9: 1 lb final RQ; 0.454 kg final RQ
**** SECTION 15 - REGULATORY INFORMATION ****
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T
Risk Phrases:
R 45 May cause cancer.
R 46 May cause heritable genetic damage.
Safety Phrases:
S 53 Avoid exposure - obtain special instructions
before use.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 680-31-9: No information available.
Canada
CAS# 680-31-9 is listed on Canada's NDSL List.
CAS# 680-31-9 is listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 680-31-9 is listed on the TSCA inventory.
**** SECTION 16 - ADDITIONAL INFORMATION ****
MSDS Creation Date: 10/02/1998 Revision #4 Date: 7/31/2002
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no way shall the company be
liable for any claims, losses, or damages of any third party or for lost
profits or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if the company has been advised of
the possibility of such damages.
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