**** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS ****
+----------------+--------------------------------------+----------+-----------+
| CAS# | Chemical Name | % | EINECS# |
|----------------|--------------------------------------|----------|-----------|
|----------------|--------------------------------------|----------|-----------|
| 75-05-8 |Acetonitrile | 30.0 | 200-835-2 |
|----------------|--------------------------------------|----------|-----------|
| 506-68-3 |Cyanogen bromide | 70.0 | 208-051-2 |
+----------------+--------------------------------------+----------+-----------+
Text for R-phrases: see Section 16
Hazard Symbols: T+ F
Risk Phrases: 11 26/27/28 34
**** SECTION 3 - HAZARDS IDENTIFICATION ****
EMERGENCY OVERVIEW
Highly flammable. Very toxic by inhalation, in contact with skin and
if swallowed. Causes burns.Flammable liquid.Air
sensitive.Corrosive.Moisture sensitive.Lachrymator (substance which
increases the flow of tears).
Potential Health Effects
Eye:
Causes eye burns. Lachrymator (substance which increases the flow
of tears). May cause chemical conjunctivitis and corneal damage.
Skin:
Causes skin burns. Toxic in contact with skin. If absorbed, may
cause symptoms similar to those for ingestion. May be metabolized to
cyanide which in turn acts by inhibiting cytochrome oxidase impairing
cellular respiration. May cause skin rash (in milder cases), and cold
and clammy skin with cyanosis or pale color.
Ingestion:
May be fatal if swallowed. May cause severe and permanent damage to
the digestive tract. Causes gastrointestinal tract burns. May cause
perforation of the digestive tract. May cause central nervous system
effects. Metabolism may release cyanide, which may result in
headache, dizziness, weakness, collapse, unconsciousness and
possible death. Ingestion may result in symptoms similar to cyanide
poisoning which is characterized by asphyxiation. May cause systemic
effects. Large doses of cyanide may result in suddden loss of
consciousness and prompt death; small doses will prolong the above
symptoms 1 to 2 hours.
Inhalation:
Inhalation of high concentrations may cause central nervous system
effects characterized by nausea, headache, dizziness, unconsciousness
and coma. May cause liver and kidney damage. Causes chemical burns to
the respiratory tract. May cause effects similar to those described
for ingestion. Inhalation may be fatal as a result of spasm,
inflammation, edema of the larynx and bronchi, chemical pneumonitis
and pulmonary edema. Aspiration may lead to pulmonary edema. Vapors
may cause dizziness or suffocation. Inhalation may produce tearing,
sneezing, rhinorrhea (the free discharge of a thin nasal mucus),
cough, dyspnea (labored breathing), bronchial asthma, and cyanosis
(bluish discoloration of skin due to deficient oxygenation of the
blood). Exposure may cause coughing, breathing difficulty, and
possible pulmonary edema. May cause systemic effects. High
concentrations may cause pulmonary edema and lung hemmorrages. May
be metabolized to cyanide which in turns act by inhibiting cytochrome
oxidase impairing cellular respiration. Inhalation may result in
symptoms similar to cyanide poisoning which include tachypnea,
hyperpnea (abnormally rapid or deep breathing), and dyspnea (labored
breathing) followed rapidly by respiratory depression. Pulmonary
edema may occur.
Chronic:
Chronic inhalation and ingestion may cause effects similar to those
of acute inhalation and ingestion. May be metabolized to cyanide
which in turn acts by inhibiting cytochrome oxidase impairing
cellular respiration. Animal studies have reported that fetal
effects/abnormalities may occur when maternal toxicity is seen.
Effects may be delayed.
**** SECTION 4 - FIRST AID MEASURES ****
Eyes:
Flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower eyelids. Get medical aid
immediately. Do NOT allow victim to rub eyes or keep eyes closed.
Extensive irrigation with water is required (at least 30 minutes).
Skin:
Get medical aid immediately. Flush skin with plenty of water for at
least 15 minutes while removing contaminated clothing and shoes.
Immediately flush skin with plenty of water for at least 15 minutes
while removing contaminated clothing and shoes. Wash clothing before
reuse. Destroy contaminated shoes. Treat patient as for inhalation.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4
cupfuls of milk or water. Never give anything by mouth to an
unconscious person. Get medical aid immediately. SPEED IS ESSENTIAL.
A DOCTOR MUST BE NOTIFIED AT ONCE. Treat patient as for inhalation.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh
air immediately. If breathing is difficult, give oxygen. Do NOT use
mouth-to-mouth resuscitation. If breathing has ceased apply
artificial respiration using oxygen and a suitable mechanical device
such as a bag and a mask. SPEED IS ESSENTIAL, OBTAIN MEDICAL AID
IMMEDIATELY.
Notes to Physician:
Exposure should be treated as a cyanide poisoning. Effects may be
delayed.
Antidote:
Always have a cyanide antidote kit on hand when working with cyanide
compounds. Get medical advice to use.
**** SECTION 5 - FIRE FIGHTING MEASURES ****
General Information:
Containers can build up pressure if exposed to heat and/or fire. As
in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. Vapors may form an explosive mixture with air.
During a fire, irritating and highly toxic gases may be generated by
thermal decomposition or combustion. Water Reactive. Material will
react with water and may release a flammable and/or toxic gas.
Flammable liquid and vapor. Reaction with water may generate much
heat which will increase the concentration of fumes in the air.
Contact with metals may evolve flammable hydrogen gas. Containers
may explode when heated. Containers may explode when heated or if
contaminated with water.
Extinguishing Media:
DO NOT USE WATER! Do NOT get water inside containers. For large
fires, use water spray, fog or alcohol-resistant foam. For small
fires, use carbon dioxide, dry chemical, dry sand, or
alcohol-resistant foam.
**** SECTION 6 - ACCIDENTAL RELEASE MEASURES ****
General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Avoid runoff into storm sewers and ditches which lead to waterways.
Clean up spills immediately, observing precautions in the Protective
Equipment section. Remove all sources of ignition. Absorb spill using
an absorbent, non-combustible material such as earth, sand, or
vermiculite. Do not use combustible materials such as sawdust.
Provide ventilation. Do not get water inside containers. A vapor
suppressing foam may be used to reduce vapors. Use water spray to
reduce vapors or divert vapor cloud drift.
**** SECTION 7 - HANDLING and STORAGE ****
Handling:
Wash thoroughly after handling. Remove contaminated clothing and
wash before reuse. Use only in a well-ventilated area. Ground and
bond containers when transferring material. Do not breathe dust,
vapor, mist, or gas. Do not get in eyes, on skin, or on clothing.
Empty containers retain product residue, (liquid and/or vapor), and
can be dangerous. Keep container tightly closed. Keep away from
heat, sparks and flame. Do not ingest or inhale. Do not allow
contact with water. Discard contaminated shoes. Do not pressurize,
cut, weld, braze, solder, drill, grind, or expose empty containers to
heat, sparks or open flames. Keep from contact with moist air and
steam.
Storage:
Keep away from heat, sparks, and flame. Keep away from sources of
ignition. Keep container closed when not in use. Store in a tightly
closed container. Keep from contact with oxidizing materials. Store
in a cool, dry, well-ventilated area away from incompatible
substances. Keep away from acids. Keep containers tightly closed.
Store protected from moisture.
**** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION ****
Engineering Controls:
Facilities storing or utilizing this material should be equipped
with an eyewash facility and a safety shower. Use adequate
ventilation to keep airborne concentrations low.
Exposure Limits
CAS# 75-05-8:
United Kingdom, WEL - TWA: 40 ppm TWA; 68 mg/m3 TWA
United Kingdom, WEL - STEL: 60 ppm STEL; 102 mg/m3 STEL
United States OSHA: 40 ppm TWA; 70 mg/m3 TWA
Belgium - TWA: 40 ppm VLE; 68 mg/m3 VLE
Belgium - STEL: 60 ppm VLE; 102 mg/m3 VLE
France - VME: 40 ppm VME; 70 mg/m3 VME
Germany: 20 ppm TWA; 34 mg/m3 TWA
Germany: Skin absorber
Malaysia: 40 ppm TWA; 67 mg/m3 TWA
Netherlands: 40 ppm MAC; 70 mg/m3 MAC
Russia: 10 mg/m3 TWA
Spain: 40 ppm VLA-ED; 68 mg/m3 VLA-ED
Spain: 60 ppm VLA-EC; 102 mg/m3 VLA-EC
CAS# 506-68-3:
Personal Protective Equipment
Eyes:
Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European
Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
Follow the OSHA respirator regulations found in 29
CFR 1910.134 or European Standard EN 149. Use a
NIOSH/MSHA or European Standard EN 149 approved
respirator if exposure limits are exceeded or if
irritation or other symptoms are experienced.
**** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES ****
Physical State: Liquid
Color: Not available.
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Autoignition Temperature: Not available.
Flash Point: 2 deg C ( 35.60 deg F)
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: BrCN
Molecular Weight: 105.93
**** SECTION 10 - STABILITY AND REACTIVITY ****
Chemical Stability:
Polymerization at low temperatures may occur. Reacts with water to
form toxic fumes. Unstable. May react with carbon dioxide in the air
to form toxic hydrogen cyanide.
Conditions to Avoid:
Incompatible materials, ignition sources, moisture, contact with
water, excess heat, prolonged exposure to air.
Incompatibilities with Other Materials:
Metals, oxidizing agents, reducing agents, acids, alcohols, amines,
ammonia.
Hazardous Decomposition Products:
Hydrogen cyanide, nitrogen oxides, carbon monoxide, carbon dioxide,
hydrogen bromide, nitrogen.
Hazardous Polymerization: May occur.
**** SECTION 11 - TOXICOLOGICAL INFORMATION ****
RTECS#:
CAS# 75-05-8: AL7700000
CAS# 506-68-3: GT2100000
LD50/LC50:
CAS# 75-05-8: Draize test, rabbit, eye: 100 uL/24H Moderate;
Inhalation, mouse: LC50 = 2693 ppm/1H; Inhalation, rabbit: LC50 =
2828 ppm/4H; Inhalation, rat: LC50 = 7551 ppm/8H; Oral, mouse: LD50 =
269 mg/kg; Oral, rabbit: LD50 = 50 mg/kg; Oral, rat: LD50 = 2460
mg/kg; Skin, rabbit: LD50 = >2 gm/kg.
CAS# 506-68-3.
Carcinogenicity:
Acetonitrile -
Not listed by ACGIH, IARC, or NTP.
Cyanogen bromide -
Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
**** SECTION 12 - ECOLOGICAL INFORMATION ****
Ecotoxicity:
Fish: Pseudomonas putida:
**** SECTION 13 - DISPOSAL CONSIDERATIONS ****
Dispose of in a manner consistent with federal, state, and local regulations.
**** SECTION 14 - TRANSPORT INFORMATION ****
IATA
No information available.
IMO
No information available.
RID/ADR
No information available.
USA RQ: CAS# 75-05-8: 5000 lb final RQ; 2270 kg final RQ
USA RQ: CAS# 506-68-3: 1000 lb final RQ; 454 kg final RQ
**** SECTION 15 - REGULATORY INFORMATION ****
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T+ F
Risk Phrases:
R 11 Highly flammable.
R 26/27/28 Very toxic by inhalation, in contact with
skin and if swallowed.
R 34 Causes burns.
Safety Phrases:
S 16 Keep away from sources of ignition - No
smoking.
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 28A After contact with skin, wash immediately with
plenty of water.
S 36/37/39 Wear suitable protective clothing, gloves
and eye/face protection.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 75-05-8: 2
CAS# 506-68-3: 3
Canada
CAS# 75-05-8 is listed on Canada's DSL List.
CAS# 506-68-3 is listed on Canada's DSL List.
CAS# 75-05-8 is listed on Canada's Ingredient Disclosure List.
CAS# 506-68-3 is listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 75-05-8 is listed on the TSCA inventory.
CAS# 506-68-3 is listed on the TSCA inventory.
**** SECTION 16 - ADDITIONAL INFORMATION ****
Text for R-phrases from Section 2
MSDS Creation Date: 9/14/1998 Revision #4 Date: 5/08/2002
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no way shall the company be
liable for any claims, losses, or damages of any third party or for lost
profits or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if the company has been advised of
the possibility of such damages.
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