**** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS ****
+----------------+--------------------------------------+----------+-----------+
| CAS# | Chemical Name | % | EINECS# |
|----------------|--------------------------------------|----------|-----------|
|----------------|--------------------------------------|----------|-----------|
| 75-05-8 |Acetonitrile | 50-86 | 200-835-2 |
|----------------|--------------------------------------|----------|-----------|
| 7732-18-5 |Water | 14-50 | 231-791-2 |
+----------------+--------------------------------------+----------+-----------+
Text for R-phrases: see Section 16
Hazard Symbols: XN F
Risk Phrases: 11 20/21/22 36
**** SECTION 3 - HAZARDS IDENTIFICATION ****
EMERGENCY OVERVIEW
Highly flammable. Harmful by inhalation, in contact with skin and if
swallowed. Irritating to eyes.Lachrymator (substance which increases
the flow of tears).
Potential Health Effects
Eye:
Causes eye irritation. Lachrymator (substance which increases the
flow of tears). May produce superficial reversible injury.
Skin:
Causes mild skin irritation. Harmful if absorbed through the skin.
May be metabolized to cyanide which in turn acts by inhibiting
cytochrome oxidase impairing cellular respiration.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and
diarrhea. May cause effects similar to those for inhalation
exposure. May cause tissue anoxia, characterized by weakness,
headache, dizziness, confusion, cyanosis (bluish skin due to
deficient oxygenation of the blood), weak and irregular heart beat,
collapse, unconsciousness, convulsions, coma and death. May cause
central nervous system depression. Metabolism may release cyanide,
which may result in headache, dizziness, weakness, collapse,
unconsciousness and possible death.
Inhalation:
Aspiration may lead to pulmonary edema. Vapors may cause dizziness
or suffocation. Causes upper respiratory tract irritation. May be
metabolized to cyanide which in turns act by inhibiting cytochrome
oxidase impairing cellular respiration. May cause tissue anoxia,
characterized by weakness, headache, dizziness, confusion, cyanosis
(bluish discoloration of skin due to deficient oxygenation of the
blood), weak and irregular heart beat, collapse, unconsciousness,
convulsions, coma and death.
Chronic:
Prolonged or repeated skin contact may cause dermatitis. Chronic
inhalation and ingestion may cause effects similar to those of acute
inhalation and ingestion. May cause liver and kidney damage. May be
metabolized to cyanide which in turn acts by inhibiting cytochrome
oxidase impairing cellular respiration. Animal studies have reported
that fetal effects/abnormalities may occur when maternal toxicity is
seen. Laboratory experiments have resulted in mutagenic effects.
Exposure to small amounts of cyanide compounds over long periods of
time is reported to cause loss of appetite, headache, weakness,
nausea, dizziness, and symptoms of irritation of the upper
respiratory tract and eyes.
**** SECTION 4 - FIRST AID MEASURES ****
Eyes:
Immediately flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower eyelids. Get medical aid
immediately. Do NOT allow victim to rub eyes or keep eyes closed.
Skin:
Get medical aid immediately. Immediately flush skin with plenty of
water for at least 15 minutes while removing contaminated clothing
and shoes. Wash clothing before reuse.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4
cupfuls of milk or water. Never give anything by mouth to an
unconscious person. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh
air immediately. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen. Do NOT use mouth-to-mouth
resuscitation.
Notes to Physician:
Exposure should be treated as a cyanide poisoning. Effects may be
delayed. For methemoglobinemia, administer oxygen alone or with
Methylene Blue depending on the methemoglobin concentration in the
blood. May be partially metabolized to cyanide in the body.
Antidote:
Always have a cyanide antidote kit on hand when working with cyanide
compounds. Get medical advice to use. Methylene blue, alone or in
combination with oxygen is indicated as a treatment in nitrite
induced methemoglobinemia.
**** SECTION 5 - FIRE FIGHTING MEASURES ****
General Information:
Containers can build up pressure if exposed to heat and/or fire. As
in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. Water runoff can cause environmental damage. Dike
and collect water used to fight fire. Vapors may form an explosive
mixture with air. During a fire, irritating and highly toxic gases
may be generated by thermal decomposition or combustion. Use water
spray to keep fire-exposed containers cool. Water may be ineffective.
Material is lighter than water and a fire may be spread by the use of
water. Flammable liquid and vapor. Approach fire from upwind to avoid
hazardous vapors and toxic decomposition products. Vapors are heavier
than air and may travel to a source of ignition and flash back.
Vapors can spread along the ground and collect in low or confined
areas.
Extinguishing Media:
For small fires, use dry chemical, carbon dioxide, water spray or
alcohol-resistant foam. Use water spray to cool fire-exposed
containers. Water may be ineffective. Do NOT use straight streams of
water. For large fires, use dry chemical, carbon dioxide,
alcohol-resistant foam, or water spray. Cool containers with
flooding quantities of water until well after fire is out.
**** SECTION 6 - ACCIDENTAL RELEASE MEASURES ****
General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Avoid runoff into storm sewers and ditches which lead to waterways.
Clean up spills immediately, observing precautions in the Protective
Equipment section. Remove all sources of ignition. Absorb spill using
an absorbent, non-combustible material such as earth, sand, or
vermiculite. Do not use combustible materials such as sawdust.
Provide ventilation. A vapor suppressing foam may be used to reduce
vapors. Water spray may reduce vapor but may not prevent ignition in
closed spaces. Approach spill from upwind.
**** SECTION 7 - HANDLING and STORAGE ****
Handling:
Remove contaminated clothing and wash before reuse. Use only in a
well-ventilated area. Ground and bond containers when transferring
material. Do not breathe dust, vapor, mist, or gas. Do not get in
eyes, on skin, or on clothing. Empty containers retain product
residue, (liquid and/or vapor), and can be dangerous. Keep container
tightly closed. Keep away from heat, sparks and flame. Do not ingest
or inhale. Do not pressurize, cut, weld, braze, solder, drill,
grind, or expose empty containers to heat, sparks or open flames.
Storage:
Keep away from heat, sparks, and flame. Keep away from sources of
ignition. Store in a tightly closed container. Keep from contact
with oxidizing materials. Store in a cool, dry, well-ventilated area
away from incompatible substances. Flammables-area.
**** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION ****
Engineering Controls:
Use explosion-proof ventilation equipment. Facilities storing or
utilizing this material should be equipped with an eyewash facility
and a safety shower. Use adequate general or local exhaust
ventilation to keep airborne concentrations below the permissible
exposure limits.
Exposure Limits
CAS# 75-05-8:
United Kingdom, WEL - TWA: 40 ppm TWA; 68 mg/m3 TWA
United Kingdom, WEL - STEL: 60 ppm STEL; 102 mg/m3 STEL
United States OSHA: 40 ppm TWA; 70 mg/m3 TWA
Belgium - TWA: 40 ppm VLE; 68 mg/m3 VLE
Belgium - STEL: 60 ppm VLE; 102 mg/m3 VLE
France - VME: 40 ppm VME; 70 mg/m3 VME
Germany: 20 ppm TWA; 34 mg/m3 TWA
Germany: Skin absorber
Malaysia: 40 ppm TWA; 67 mg/m3 TWA
Netherlands: 40 ppm MAC; 70 mg/m3 MAC
Russia: 10 mg/m3 TWA
Spain: 40 ppm VLA-ED; 68 mg/m3 VLA-ED
Spain: 60 ppm VLA-EC; 102 mg/m3 VLA-EC
CAS# 7732-18-5:
Personal Protective Equipment
Eyes:
Wear chemical splash goggles.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
A respiratory protection program that meets OSHA's 29
CFR 1910.134 and ANSI Z88.2 requirements or European
Standard EN 149 must be followed whenever workplace
conditions warrant respirator use.
**** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES ****
Physical State: Liquid
Color: colorless
Odor: acetic odor
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Autoignition Temperature: Not applicable.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: Not available.
Solubility in water: Miscible (acetonitrile)
Specific Gravity/Density: Not available.
Molecular Formula: Mixture
Molecular Weight: 0
**** SECTION 10 - STABILITY AND REACTIVITY ****
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Ignition sources, excess heat.
Incompatibilities with Other Materials:
Oxidizing agents, reducing agents, acids, bases, alkali metals,
fluorine, nitric acid, perchlorates, sulfuric acid, chlorosulfonic
acid, oleum, dinitrogen tetraoxide, sulfites, indium, moisture,
Attacks some forms of plastics, rubbers, and coatings., nitrating
agents, N-fluoro compounds (e.g. perfluorourea + acetonitrile),
lanthanide perchlorates, iron (III) perchlorate, 2-Cyano-2-propyl
nitrate, trichlorosilane, diphenyl sulfoxide.
Hazardous Decomposition Products:
Hydrogen cyanide, nitrogen oxides, carbon monoxide, irritating and
toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported.
**** SECTION 11 - TOXICOLOGICAL INFORMATION ****
RTECS#:
CAS# 75-05-8: AL7700000
CAS# 7732-18-5: ZC0110000
LD50/LC50:
CAS# 75-05-8: Draize test, rabbit, eye: 100 uL/24H Moderate;
Inhalation, mouse: LC50 = 2693 ppm/1H; Inhalation, rabbit: LC50 =
2828 ppm/4H; Inhalation, rat: LC50 = 7551 ppm/8H; Oral, mouse: LD50 =
269 mg/kg; Oral, rabbit: LD50 = 50 mg/kg; Oral, rat: LD50 = 2460
mg/kg; Skin, rabbit: LD50 = >2 gm/kg.
CAS# 7732-18-5: Oral, rat: LD50 = >90 mL/kg.
Carcinogenicity:
Acetonitrile -
Not listed by ACGIH, IARC, or NTP.
Water -
Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
**** SECTION 12 - ECOLOGICAL INFORMATION ****
Ecotoxicity:
Fish: Fathead Minnow: 1150 ppm; 24 Hr; TLm (hard water)Fish: Fathead
Minnow: 1000 mg/L; 96 Hr; TLm (soft water)Fish: Bluegill/Sunfish:
1850 mg/L; 96 Hr; TLm (soft water)Fish: Fathead Minnow: 1640 mg/L;
96 Hr; LC50 (flow-bioassay)Fish: Fathead Minnow: 1640 mg/L; 96 Hr;
EC50 (flow-bioassay)
Other
Biodegradable.
**** SECTION 13 - DISPOSAL CONSIDERATIONS ****
Products which are considered hazardous for supply are classified as Special
Waste and the disposal of such chemicals is covered by regulations which may
vary according to location. Contact a specialist disposal company or the local
waste regulator for advice. Empty containers must be decontaminated before
returning for recycling.
**** SECTION 14 - TRANSPORT INFORMATION ****
IATA
Shipping Name: ACETONITRILE
Hazard Class: 3
UN Number: 1648
Packing Group: II
IMO
Shipping Name: ACETONITRILE
Hazard Class: 3
UN Number: 1648
Packing Group: II
RID/ADR
Shipping Name: ACETONITRILE
Hazard Class: 3
UN Number: 1648
Packing group: II
USA RQ: CAS# 75-05-8: 5000 lb final RQ; 2270 kg final RQ
**** SECTION 15 - REGULATORY INFORMATION ****
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN F
Risk Phrases:
R 11 Highly flammable.
R 20/21/22 Harmful by inhalation, in contact with
skin and if swallowed.
R 36 Irritating to eyes.
Safety Phrases:
S 16 Keep away from sources of ignition - No
smoking.
S 36/37 Wear suitable protective clothing and
gloves.
WGK (Water Danger/Protection)
CAS# 75-05-8: 2
CAS# 7732-18-5: No information available.
Canada
CAS# 75-05-8 is listed on Canada's DSL List.
CAS# 7732-18-5 is listed on Canada's DSL List.
CAS# 75-05-8 is listed on Canada's Ingredient Disclosure List.
CAS# 7732-18-5 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 75-05-8 is listed on the TSCA inventory.
CAS# 7732-18-5 is listed on the TSCA inventory.
**** SECTION 16 - ADDITIONAL INFORMATION ****
Text for R-phrases from Section 2
MSDS Creation Date: 4/13/1999 Revision #5 Date: 1/23/2004
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no way shall the company be
liable for any claims, losses, or damages of any third party or for lost
profits or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if the company has been advised of
the possibility of such damages.
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