**** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS ****
+----------------+--------------------------------------+----------+-----------+
| CAS# | Chemical Name | % | EINECS# |
|----------------|--------------------------------------|----------|-----------|
|----------------|--------------------------------------|----------|-----------|
| 90-04-0 |o-Anisidine | 0.1-0.7 | 201-963-1 |
|----------------|--------------------------------------|----------|-----------|
| 104-94-9 |p-Anisidine | > 95 | 203-254-2 |
+----------------+--------------------------------------+----------+-----------+
Text for R-phrases: see Section 16
Hazard Symbols: T+ N
Risk Phrases: 26/27/28 33 45 50
**** SECTION 3 - HAZARDS IDENTIFICATION ****
EMERGENCY OVERVIEW
Very toxic by inhalation, in contact with skin and if swallowed.
Danger of cumulative effects. May cause cancer. Very toxic to aquatic
organisms.
Potential Health Effects
Eye:
Causes severe eye irritation.
Skin:
Causes skin irritation. May be absorbed through the skin in harmful
amounts. May cause contact dermatitis.
Ingestion:
May cause irritation of the digestive tract. May cause kidney
damage. May cause methemoglobinemia, cyanosis (bluish discoloration
of skin due to deficient oxygenation of the blood), convulsions, and
death. Methemoglobinemia is characterized by dizziness, drowsiness,
headache, shortness of breath, cyanosis (bluish discoloration of skin
due to deficient oxygenation of the blood), rapid heart rate and
chocolate-brown colored blood.
Inhalation:
Causes respiratory tract irritation. Inhalation causes anoxia due to
the formation of methemoglobin and hematuria. Material has a very low
vapor pressure and inhalation exposures are not expected unless
material is heated or misted.
Chronic:
Prolonged exposure may cause anemia and methemoglobinemia,
characterized by dizziness, drowsiness, headache, breath shortness,
cyanosis (bluish skin due to deficient oxygenation of the blood),
rapid heart rate and chocolate-brown colored blood.
**** SECTION 4 - FIRST AID MEASURES ****
Eyes:
Immediately flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower eyelids. Get medical aid
immediately.
Skin:
Flush skin with plenty of water for at least 15 minutes while
removing contaminated clothing and shoes. Wash clothing before
reuse. Get medical aid if symptoms occur.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Get medical aid immediately. Do NOT induce vomiting. If conscious and
alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh
air immediately. If breathing is difficult, give oxygen. If
breathing has ceased apply artificial respiration using oxygen and a
suitable mechanical device such as a bag and a mask.
Notes to Physician:
**** SECTION 5 - FIRE FIGHTING MEASURES ****
General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. This material in sufficient quantity and reduced
particle size is capable of creating a dust explosion.
Extinguishing Media:
In case of fire, use water, dry chemical, chemical foam, or
alcohol-resistant foam.
**** SECTION 6 - ACCIDENTAL RELEASE MEASURES ****
General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal
container. Clean up spills immediately, observing precautions in the
Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.
**** SECTION 7 - HANDLING and STORAGE ****
Handling:
Wash thoroughly after handling. Remove contaminated clothing and
wash before reuse. Minimize dust generation and accumulation. Avoid
contact with eyes, skin, and clothing. Do not breathe dust. Use only
with adequate ventilation.
Storage:
Store in a tightly closed container. Store in a cool, dry,
well-ventilated area away from incompatible substances.
**** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION ****
Engineering Controls:
Facilities storing or utilizing this material should be equipped
with an eyewash facility and a safety shower. Use adequate general or
local exhaust ventilation to keep airborne concentrations below the
permissible exposure limits.
Exposure Limits
CAS# 90-04-0:
United States OSHA: 0.5 mg/m3 TWA (listed under Anisidine (o-, p
isomers)).
Belgium - TWA: (listed as anisidine (o-, p- isomers)): 0.1 ppm VL
0.5 mg/m3 VLE
France - VME: 0.1 ppm VME; 0.5 mg/m3 VME
Germany: 0.1 ppm TWA; 0.5 mg/m3 TWA
Germany: Skin absorber
Japan: 0.1 ppm OEL; 0.5 mg/m3 OEL
Malaysia: 0.1 ppm TWA; 0.5 mg/m3 TWA
Netherlands: (listed as anisidine (o-, p- isomers)): 0.1 ppm MAC;
mg/m3 MAC
Russia: 1 mg/m3 TWA
Spain: 0.1 ppm VLA-ED; 0.5 mg/m3 VLA-ED
CAS# 104-94-9:
United States OSHA: 0.5 mg/m3 TWA (listed under Anisidine (o-, p
isomers)).
Belgium - TWA: (listed as anisidine (o-, p- isomers)): 0.1 ppm VL
0.5 mg/m3 VLE
France - VME: 0.1 ppm VME; 0.5 mg/m3 VME
Germany: 0.1 ppm TWA; 0.51 mg/m3 TWA
Germany: Skin absorber
Japan: 0.1 ppm OEL; 0.5 mg/m3 OEL
Malaysia: 0.1 ppm TWA
Netherlands: (listed as anisidine (o-, p- isomers)): 0.1 ppm MAC;
mg/m3 MAC
Russia: 1 mg/m3 TWA
Spain: 0.1 ppm VLA-ED; 0.5 mg/m3 VLA-ED
Personal Protective Equipment
Eyes:
Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European
Standard EN166.
Skin:
Wear appropriate protective gloves and clothing to
prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
Wear a NIOSH/MSHA or European Standard EN 149
approved full-facepiece airline respirator in the
positive pressure mode with emergency escape
provisions. Follow the OSHA respirator regulations
found in 29 CFR 1910.134 or European Standard EN 149.
Use a NIOSH/MSHA or European Standard EN 149 approved
respirator if exposure limits are exceeded or if
irritation or other symptoms are experienced.
**** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES ****
Physical State: Solid
Color: beige
Odor: amine-like
pH: Not available.
Vapor Pressure: 0.006 mm Hg @ 25 deg C
Viscosity: Not available.
Boiling Point: 240-243 deg C @ 760 mm Hg
Freezing/Melting Point: 56-60 deg C
Autoignition Temperature: 450 deg C ( 842.00 deg F)
Flash Point: 122 deg C ( 251.60 deg F)
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: >300 deg C
Solubility in water: Slightly soluble.
Specific Gravity/Density: 1.070 g/cm3
Molecular Formula: C7H9NO
Molecular Weight: 123.15
**** SECTION 10 - STABILITY AND REACTIVITY ****
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Light, dust generation, excess heat.
Incompatibilities with Other Materials:
Strong oxidizing agents, acids, acid chlorides, acid anhydrides,
chloroformates.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Will not occur.
**** SECTION 11 - TOXICOLOGICAL INFORMATION ****
RTECS#:
CAS# 90-04-0: BZ5410000
CAS# 104-94-9: BZ5450000
LD50/LC50:
CAS# 90-04-0: Oral, mouse: LD50 = 1400 mg/kg; Oral, rabbit: LD50 =
870 mg/kg; Oral, rat: LD50 = 1150 mg/kg.
CAS# 104-94-9: Oral, mouse: LD50 = 1410 mg/kg; Oral, rabbit: LD50 =
2900 mg/kg; Oral, rat: LD50 = 1320 mg/kg; Skin, rat: LD50 = 3200
mg/kg.
Carcinogenicity:
o-Anisidine -
ACGIH: A3 - Confirmed animal carcinogen with unknown relevance to
California: carcinogen, initial date 7/1/87
IARC: Group 2B carcinogen
p-Anisidine -
Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
**** SECTION 12 - ECOLOGICAL INFORMATION ****
Ecotoxicity:
Water flea EC50 = 0.18 mg/L; 48 Hr.; UnspecifiedBacteria:
Phytobacterium phosphoreum: EC50 = 14.5 mg/L; 30 Minutes; Microtox
test, 15 degrees C
**** SECTION 13 - DISPOSAL CONSIDERATIONS ****
Dispose of in a manner consistent with federal, state, and local regulations.
**** SECTION 14 - TRANSPORT INFORMATION ****
IATA
Shipping Name: ANISIDINES, SOLID
Hazard Class: 6.1
UN Number: 2431
Packing Group: III
IMO
Shipping Name: ortho-ANISIDINE
Hazard Class: 6.1
UN Number: 2431
Packing Group: III
RID/ADR
Shipping Name: ANISIDINES
Hazard Class: 6.1
UN Number: 2431
Packing group: III
USA RQ: CAS# 90-04-0: 100 lb final RQ; 45.4 kg final RQ
**** SECTION 15 - REGULATORY INFORMATION ****
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T+ N
Risk Phrases:
R 45 May cause cancer.
R 26/27/28 Very toxic by inhalation, in contact with
skin and if swallowed.
R 33 Danger of cumulative effects.
R 50 Very toxic to aquatic organisms.
Safety Phrases:
S 53 Avoid exposure - obtain special instructions
before use.
S 28A After contact with skin, wash immediately with
plenty of water.
S 36/37 Wear suitable protective clothing and
gloves.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
S 61 Avoid release to the environment. Refer to
special instructions/safety data sheets.
WGK (Water Danger/Protection)
CAS# 90-04-0: 3
CAS# 104-94-9: 2
Canada
CAS# 90-04-0 is listed on Canada's DSL List.
CAS# 104-94-9 is listed on Canada's DSL List.
CAS# 90-04-0 is listed on Canada's Ingredient Disclosure List.
CAS# 104-94-9 is listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 90-04-0 is listed on the TSCA inventory.
CAS# 104-94-9 is listed on the TSCA inventory.
**** SECTION 16 - ADDITIONAL INFORMATION ****
Text for R-phrases from Section 2
MSDS Creation Date: 5/04/1999 Revision #4 Date: 12/15/2003
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no way shall the company be
liable for any claims, losses, or damages of any third party or for lost
profits or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if the company has been advised of
the possibility of such damages.
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