**** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS ****
+----------------+--------------------------------------+----------+-----------+
| CAS# | Chemical Name | % | EINECS# |
|----------------|--------------------------------------|----------|-----------|
| 95-53-4 |o-Toluidine | 99 | 202-429-0
+----------------+--------------------------------------+----------+-----------+
Hazard Symbols: T N
Risk Phrases: 23/25 36 45 50
**** SECTION 3 - HAZARDS IDENTIFICATION ****
EMERGENCY OVERVIEW
Toxic by inhalation and if swallowed. Irritating to eyes. May cause
cancer. Very toxic to aquatic organisms.Light sensitive.Air
sensitive.Cancer suspect agent.Dangerous for the environment.
Potential Health Effects
Eye:
Causes severe eye irritation. May result in corneal injury.
Skin:
Causes skin irritation. May be absorbed through the skin. Causes
symptoms similar to those of inhalation. May cause dermatitis.
Excessive drying of the skin may result from repeated or prolonged
contact.
Ingestion:
Harmful if swallowed. May cause irritation of the digestive tract.
May cause effects similar to those for inhalation exposure.
Inhalation:
Harmful if inhaled. Causes respiratory tract irritation. May cause
anoxia, characterized by weakness, headache, dizziness, confusion,
cyanosis, weak and irregular heart beat, collapse, unconsciousness,
convulsions, coma and death. Exposure produces central nervous
system depression. May cause kidney damage. May cause headache and
cyanosis of the lips, mucous membranes and fingernail beds and the
tongue. Clinical signs of intoxication with o-toluidine in humans
have included methemoglobinemia, hematuria, marked renal & bladder
irritation, & physiological & psychological disturbances.
o-Toluidine has been absorbed via the respiratory tract & skin.
Chronic:
Chronic inhalation may cause effects similar to those of acute
inhalation. May cause kidney injury. May cause cancer according to
animal studies. Absorption into the body leads to the formation of
methemoglobin which in sufficient concentrations causes cyanosis
(bluish discoloration of skin due to deficient oxygenation of the
blood). This substance has caused adverse reproductive and fetal
effects in laboratory animals. The chronic (long-term) effects in
workers exposed to o-toluidine include anemia, anorexia, weight loss,
skin lesions, central nervous system depression, cyanosis, and
methemoglobinemia.
**** SECTION 4 - FIRST AID MEASURES ****
Eyes:
In case of contact, immediately flush eyes with plenty of water for
at least 15 minutes. Get medical aid immediately.
Skin:
In case of contact, immediately flush skin with plenty of water for
at least 15 minutes while removing contaminated clothing and shoes.
Get medical aid immediately. Wash clothing before reuse.
Ingestion:
If swallowed, do not induce vomiting unless directed to do so by
medical personnel. Never give anything by mouth to an unconscious
person. Get medical aid.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial
respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
For methemoglobinemia, administer oxygen alone or with Methylene
blue depending on the methemoglobinemia concentration in the blood.
Absorption of this product into the body may cause cyanosis (bluish
discoloration of skin due to deficient oxygenation of the blood).
Moderate degrees of cyanosis need to be treated only by supportive
measures: bed rest and oxygen inhalation. Cleansing of the entire
contaminated area of the body is of utmost importance.
Antidote:
Methylene blue, alone or in combination with oxygen is indicated as
a treatment in nitrite induced methemoglobinemia.
**** SECTION 5 - FIRE FIGHTING MEASURES ****
General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. During a fire, irritating and highly toxic gases
may be generated by thermal decomposition or combustion. Use water
spray to keep fire-exposed containers cool. Combustible liquid and
vapor. Vapors are heavier than air and may travel to a source of
ignition and flash back. Vapors can spread along the ground and
collect in low or confined areas.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or appropriate foam.
**** SECTION 6 - ACCIDENTAL RELEASE MEASURES ****
General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth),
then place in suitable container. Avoid runoff into storm sewers and
ditches which lead to waterways. Clean up spills immediately,
observing precautions in the Protective Equipment section. Remove all
sources of ignition. Provide ventilation. Approach spill from upwind.
Use water spray to cool and disperse vapors and protect personnel.
**** SECTION 7 - HANDLING and STORAGE ****
Handling:
Wash thoroughly after handling. Remove contaminated clothing and
wash before reuse. Do not get in eyes, on skin, or on clothing. Keep
container tightly closed. Do not ingest or inhale. Use only in a
chemical fume hood. Avoid contact with air and sunlight. Use only
with adequate ventilation. Keep away from heat and flame.
Storage:
Keep away from heat and flame. Keep away from sources of ignition.
Do not store in direct sunlight. Store in a tightly closed container.
Store in a cool, dry, well-ventilated area away from incompatible
substances. Store protected from light and air. Material darkens on
exposure to air. Separate from oxidizing materials.
**** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION ****
Engineering Controls:
Facilities storing or utilizing this material should be equipped
with an eyewash facility and a safety shower. Use adequate general or
local exhaust ventilation to keep airborne concentrations below the
permissible exposure limits.
Personal Protective Equipment
Eyes:
Wear chemical goggles.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
A respiratory protection program that meets OSHA's 29
CFR 1910.134 and ANSI Z88.2 requirements or European
Standard EN 149 must be followed whenever workplace
conditions warrant a respirator's use.
**** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES ****
Physical State: Liquid
Color: clear slightly yellow
Odor: amine-like
pH: Not available.
Vapor Pressure: 0.26 mm Hg @ 25 deg C
Viscosity: Not available.
Boiling Point: 200 deg C
Freezing/Melting Point: -16 deg C
Autoignition Temperature: 482 deg C ( 899.60 deg F)
Flash Point: 85 deg C ( 185.00 deg F)
Explosion Limits, lower: 1.50 vol %
Explosion Limits, upper: Not available.
Decomposition Temperature: >200 deg C
Solubility in water: Slightly soluble.
Specific Gravity/Density: 1.0000 g/cm3
Molecular Formula: C7H9N
Molecular Weight: 107.15
**** SECTION 10 - STABILITY AND REACTIVITY ****
Chemical Stability:
Stable under normal temperatures and pressures. Substance undergoes
color change upon exposure to light and air.
Conditions to Avoid:
Light, exposure to air, excess heat.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong acids, strong bases, nitric acid.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and
gases, carbon dioxide.
Hazardous Polymerization: Will not occur.
**** SECTION 11 - TOXICOLOGICAL INFORMATION ****
RTECS#:
CAS# 95-53-4: XU2975000
LD50/LC50:
Not available.
Carcinogenicity:
o-Toluidine -
Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
Other:
See actual entry in RTECS for complete information.
**** SECTION 12 - ECOLOGICAL INFORMATION ****
Ecotoxicity:
Bacteria: Phytobacterium phosphoreum: EC50 = 13.2 mg/L; 30 min;
Microtox testIf released on land, o-toluidine will be lost by a
combination of biodegradation, oxidation, and chemical binding to
soil components. If released into water, it will also be primarily
lost by biodegradation, oxidation and photooxidation. There will
also be some adsorption to sediment. Bioconcentration in fish should
not be an important fate process. In the atmosphere, o-toluidine
will photodegrade (estimated half-life 2.4 hr).
**** SECTION 13 - DISPOSAL CONSIDERATIONS ****
Dispose of in a manner consistent with federal, state, and local regulations.
**** SECTION 14 - TRANSPORT INFORMATION ****
IATA
Shipping Name: TOLUIDINES
Hazard Class: 6.1
UN Number: 1708
Packing Group: II
IMO
Shipping Name: TOLUIDINES
Hazard Class: 6.1
UN Number: 1708
Packing Group: II
RID/ADR
Shipping Name: TOLUIDINES
Hazard Class: 6.1
UN Number: 1708
Packing group: II
**** SECTION 15 - REGULATORY INFORMATION ****
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T N
Risk Phrases:
R 23/25 Toxic by inhalation and if swallowed.
R 36 Irritating to eyes.
R 45 May cause cancer.
R 50 Very toxic to aquatic organisms.
Safety Phrases:
S 53 Avoid exposure - obtain special instructions
before use.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
S 61 Avoid release to the environment. Refer to
special instructions/Safety data sheets.
WGK (Water Danger/Protection)
CAS# 95-53-4: 3
United Kingdom Occupational Exposure Limits
United Kingdom Maximum Exposure Limits
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 95-53-4 is not listed on Canada's Ingredient Disclosure List.
Exposure Limits
CAS# 95-53-4: OEL-AUSTRALIA:TWA 2 ppm (9 mg/m3);Skin;Carcinogen
OEL-BELGIUM:TWA 2 ppm (8.8 mg/m3);Skin;Carcinogen
OEL-CZECHOSLOVAKIA:TWA 5 mg/m3;STEL 20 mg/m3 JAN9
OEL-DENMARK:TWA 2 ppm (9 mg/m3);Skin;Carcinogen
OEL-FINLAND:TWA 5 ppm (22 mg/m3);STEL 10 ppm (44 mg/m3);Skin;CAR
OEL-FRANCE:TWA 2 ppm (9 mg/m3);Carcinogen
OEL-FRANCE;CAR (salts)
OEL-GERMANY;Skin;Carcinogen
OEL-THE PHILIPPINES:TWA 5 ppm (22 mg/m3);Skin
OEL-POLAND:TWA 3 mg/m3
OEL-RUSSIA:TWA 0.5 mg/m3;STEL 1 mg/m3;Skin;Carcinogen
OEL-SWEDEN;Carcinogen
OEL-SWITZERLAND:TWA 2 ppm (9 mg/m3);Skin;Carcinogen
OEL-TURKEY:TWA 5 ppm (22 mg/m3);Skin
OEL-UNITED KINGDOM:TWA 2 ppm (9 mg/m3);STEL 5 ppm (22 mg/m3)
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGI TLV
US FEDERAL
TSCA
CAS# 95-53-4 is not listed on the TSCA inventory.
It is for research and development use only.
**** SECTION 16 - ADDITIONAL INFORMATION ****
MSDS Creation Date: 5/18/1999 Revision #2 Date: 11/12/2002
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no way shall the company be
liable for any claims, losses, or damages of any third party or for lost
profits or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if the company has been advised of
the possibility of such damages.
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