===================== Product Identification =====================
MSDS NAME:OCTREO SCAN
NIIN:00N066947
MSDS Number: CBFBZ
=== Responsible Party ===
Company:MALLINCKRODT MEDICAL INC
Address:2703 WAGNER PLACE
City:MARYLAND HEIGHTS
State:MO
ZIP:63043
Country:US
Info Phone Num:314-770-7800
Emergency Phone Num:800-424-9300(CHEMTREC)
CAGE:FO650
=== Contractor Identification ===
Company:MALLINCKRODT DIAGNOSTICS
Address:2703 WAGNER PLACE
Box:City:MARYLAND HEIGHTS
State:MO
ZIP:63043-3421
Country:US
Phone:314-344-3800
CAGE:2A916
Company:MALLINCKRODT MEDICAL INC
Address:2703 WAGNER PLACE
City:MARYLAND HEIGHTS
State:MO
ZIP:63043-3421
Country:US
Phone:314-770-7800/314-895-2000
CAGE:FO650
============= Composition/Information on Ingredients =============
Name:LYOPHILIZED REAGENT; (PENTETREOTIDE)
CAS:138661-02-6
Fraction by Wt: 0.06%
OSHA PEL:N/K
ACGIH TLV:N/K
Name:INOSITOL
CAS:87-89-8
Fraction by Wt: 62.46%
OSHA PEL:N/K
ACGIH TLV:N/K
Name:SODIUM CITRATE; (TRISODIUM CITRATE DIHYDRATE)
CAS:6132-04-3
Fraction by Wt: 22.49%
OSHA PEL:N/K
ACGIH TLV:N/K
Name:GENTISTIC ACID
CAS:490-79-9
RTECS #:LY3850000
Fraction by Wt: 12.49%
OSHA PEL:N/K
ACGIH TLV:N/K
Name:CITRIC ACID MONOHYDRATED; (CITRIC ACID MONOHYDRATE)
CAS:5949-29-1
RTECS #:GE7810000
Fraction by Wt: 2.5%
OSHA PEL:N/K
ACGIH TLV:N/K
Name:INDIUM SALT; (INDIUM CHLORIDE IN-111)
CAS:50800-85-6
Fraction by Wt: <1%
OSHA PEL:N/K
ACGIH TLV:N/K
Name:HYDROCHLORIC ACID (SARA 302/313) (CERCLA)
CAS:7647-01-0
RTECS #:MW4025000
Fraction by Wt: <1%
OSHA PEL:5 PPM, C
ACGIH TLV:5 PPM, C
EPA Rpt Qty:5000 LBS
DOT Rpt Qty:5000 LBS
Name:FERRIC CHLORIDE (CERCLA)
CAS:7705-08-0
RTECS #:LJ9100000
Fraction by Wt: <1%
OSHA PEL:1 MG/M3 (FE)
ACGIH TLV:1 MG/M3 (FE)
EPA Rpt Qty:1000 LBS
DOT Rpt Qty:1000 LBS
Name:WATER
CAS:7732-18-5
RTECS #:ZC0110000
Fraction by Wt: >99%
OSHA PEL:N/K
ACGIH TLV:N/K
Name:LYOPHILIZED MATERIAL (CONSISTING OF INGS 1 - 5)
OSHA PEL:N/K
ACGIH TLV:N/K
Name:INDIUM CHLORIDE IN-111 STERILE SOLUTION-0.2M (CONSISTING OF
INGS 6 - 9)
OSHA PEL:N/K
ACGIH TLV:N/K
===================== Hazards Identification =====================
LD50 LC50 Mixture:NONE SPECIFIED BY MANUFACTURER.
Routes of Entry: Inhalation:NO Skin:NO Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:ACUTE:HAZ INGS FOUND IN PROD ARE SKIN
& EYE IRRITS, BUT DUE TO FORM OF MATL (LYOPHILIZED PELLET) NO
ADVERSE HLTH EFTS ARE EXPECTED TO OCCUR FROM EXPOS. FOLLOWING INFO
APPLIES TO RADIOACTIVE INDIUM (IN -111) IN KIT: INHAL:INDIUM
CHLORIDE DOES NOT EASILY BECOME AIRBORNE. NOT EXPECTED TO BE HLTH
HAZ VIA (EFTS OF OVEREXP)
Explanation of Carcinogenicity:NOT RELEVANT
Effects of Overexposure:HLTH HAZ:INHAL. INGEST:MAY CAUSE ASYMPTOMATIC
PHYSIOLOGICAL UPTAKE BY SPECIFIC TARGET ORGANS/TISSUES. SKIN
CONT:NOT EXPECTED TO PRDCE ANY ACUTE ADVERSE HLTH EFTS. EYE CONT:NO
ADVERSE EFT EXPECTED, BUT MAY CAUSE MECH IRRIT. CHRONIC:HLTH RISKS
ASSOC W/CHRONIC RADIA EXPOS (CANCER, LEUKEMIA, GENETIC &
TERATOGENIC EFTS) ARE BELIEVED TO INVOLVE LEVELS OF RADIA EXPOS
WHICH ARE MUCH HIGHER THAN THOSE PERM ITTED OCCUPATIONALLY. THIS
PROD CONTAINS SUBSTANCE KNOWN TO STATE OF CALIFORNIA TO CAUSE
CANCER.
Medical Cond Aggravated by Exposure:NO INFORMATION FOUND.
======================= First Aid Measures =======================
First Aid:MIN FIRST AID IS EXPECTED TO BE REQD AS RSLT OF EXPOS TO
LYOPHILIZED MATL. SKIN:WASH EXPOS SKIN W/SOAP & WATER. SEEK MED
ATTN IF IRRIT DEVELOPS. EYES:WASH EXPOS EYES THORO W/RUNNING WATER
FOR AT LST 1 5 MINS. SEEK MED ATTN IF IRRIT DEVELOPS. FOLLOWING
INFO APPLIES TO RADIOACTIVE INDIUM (IN-111):INHAL/INGEST:NOTIFY
RADIA SFTY PERS IMMED. AMT OF MATL INHALED/INGESTED SHOULD BE
ASSESSED & DOCUMENTED. SKIN:WASH AFFECTED AREA THORO W/SOAP &
WATER UNTIL NO MORE RADIOACTIVITY CAN BE REMOVED. ALWAYS BLOT DRY.
DO NOT ABRADE SKIN. NOTIFY RADIA SFTY PERS. EYES:WASH W/WATER FOR
AT LST 15 MINS/UNTIL NO MORE RADIOACTIVITY CAN BE REMOVED. (SUP
DAT)
===================== Fire Fighting Measures =====================
Extinguishing Media:USE ANY MEANS SUITABLE FOR EXTINGUISHING
SURROUNDING FIRE.
Fire Fighting Procedures:USE NIOSH/MSHA APPROVED SCBA & FULL PROTECTIVE
EQUIPMENT .
Unusual Fire/Explosion Hazard:NOT A FLAMMABLE MATERIAL. NOT CONSIDERED
TO BE A FIRE OR EXPLOSION HAZARD.
================== Accidental Release Measures ==================
Spill Release Procedures:IF PROD IS RECEIVED IN LEAKING CNDTN/ANY
LOSS/RELS OF RADIOACTIVE CONTENTS OCCURS, NOTIFY YOUR RADIA SFTY
DEPT & MFR AT (314)770-7800. ALL CLEANUP OPERATIONS SHOULD BE
PERFORMED TO STD OPERATING PROCS (SOP'S) ESTABLISHED FOR YOUR
FACILITY & BY NRC/OTHER APPLIC LOC, STATE/FED REGS. RQ:IN-111=100
CI; HYDROGEN CHLORIDE(ACID)=5000 LBS; FERRIC CHLORIDE=1000 LBS.
RELS TO AIR, LAND/WATER OF (SUP DAT)
Neutralizing Agent:NONE SPECIFIED BY MANUFACTURER.
====================== Handling and Storage ======================
Handling and Storage Precautions:DRUG SHOULD BE STORED AT 2C-8C BOTH
PRIOR TO & FOLLOWING RECONSTITUTION W/INDIUM CHLORIDE IN-111 &
DISCARDED AFTER 6 HRS FROM TIME OF PREPARATION.
Other Precautions:PROT FROM LIGHT. AFTER RECONSTITUTION, HNDLG TIME
SHOULD BE KEPT TO MIN & APPROP SHIELDING SHOULD BE USED. STOR &
DISP OF PROD SHOULD BE CONTROLLED IN MANNER THAT IS IN COMPLIANCE
W/APPROP REGS OF GOV T AGENCY AUTH TO LICENSE USE OF THIS
RADIONUCLIDE. NO SMOKING, EATING/DRINKING SHOULD BE ALLOWED IN ANY
AREA(OTHER INFO)
============= Exposure Controls/Personal Protection =============
Respiratory Protection:NIOSH/MSHA APPROVED RESPIRATOR APPROPRIATE FOR
EXPOSURE OF CONCERN . NOT EXPECTED TO REQUIRED PERSONAL RESPIRATOR
USAGE.
Ventilation:PROPERLY SEALED CONTAINERS ARE NOT EXPECTED TO REQUIRE ANY
SPECIAL VENTILATION.
Protective Gloves:DISPOSABLE PLASTIC, LATEX/RUBBER GLOVES.
Eye Protection:ANSI APPROVED CHEM WORKERS GOGGS .
Other Protective Equipment:EYE WASH FOUNTAIN & DELUGE SHOWER WHICH MEET
ANSI DESIGN CRITERIA . LABCOAT. HNDLG DEVICES SUCH AS SYRINGE
SHIELDS & TONGS SHOULD BE USED.
Work Hygienic Practices:NONE SPECIFIED BY MANUFACTURER.
Supplemental Safety and Health
APPEAR/ODOR:VIAL (INDIUM 111). FIRST AID PROC: NOTIFY RADIATION SAFETY
PERSONNEL. SPILL PROC: THESE HAZ SUBSTANCES WHICH EXCEED RQ MUST BE
REPORTED TO THE NATIONAL RESPONSE CENTER AT 800-424-8802.
================== Physical/Chemical Properties ==================
Boiling Pt:B.P. Text:212F,100C
Melt/Freeze Pt:M.P/F.P Text:32.0F,0.0C
Solubility in Water:SOMEWHAT SOLUBLE
Appearance and Odor:LYOPHILIZED WHITE PELLT IN 10 ML VIAL. CLEAR,
COLORLESS LIQ IN 10 ML (SUP DAT)
================= Stability and Reactivity Data =================
Stability Indicator/Materials to Avoid:YES
STRONG OXIDIZERS & REDUCING AGENTS.
Stability Condition to Avoid:PROTECT FROM LIGHT.
Hazardous Decomposition Products:WHEN HEATED TO DECOMP, LYOPHILIZED
MATL MAY EMIT CARBON DIOXIDE & CARBON MONOXIDE; SOLN MAY EMIT
RADIOACTIVE FUMES CNTNG IN-111.
==================== Disposal Considerations ====================
Waste Disposal Methods:PROD RECONSTITUTED W/INDIUM CHLORIDE IN-111 IS
RADIOACTIVE WASTE UNTIL ACTIVITY HAS DECAYED TO NONDECTABLE LEVELS.
RADIOACTIVE WASTE MUST BE HNDLD I/A/W PROCS ESTABLISHED BY YOUR
RADIA SFTY OFFICER, N RC & OTHER APPLIC REGS. IF MED WASTE IS
INVOLVED, SUCH AS BLOOD, BLOOD PRODS/SHARPS, WASTE MUST BE H NDLD
AS BIOHAZARD & DISPOSED OF (OTHER INFO)
======================= Other Information =======================
Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.
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