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Material Safety Data Sheet
Section 1: Chemical Identification
Chemical name: Phenylmethylsulfonyl fluoride
Identity (As used on label and list): Phenylmethanesulfonyl fluoride;
alpha-Toluenesulfonyl fluoride; PMSF
Catalog number: P4170-5, P4170-100, P4170-250
Manufactured by:
BIOSYNTH AG Tel: +41(0)71 858 20 20
Rietlistrasse 4 Fax: +41(0)71 858 20 30
Postfach 125
9422 Staad
Switzerland
Distributed by:
Gold Biotechnology, Inc.鈩? (800) 248-7609
10748 Indian Head Industrial Blvd fax: (314) 890-0503
St. Louis, MO 63132 email: contactgbt86@goldbio.com
Section 2: Composition/Information on Ingredients
CAS No. Chemical name Percent EINECS Classification
[329-98-6] Phenylmethylsulfonyl fluoride 100 206-350-2 C; T; R: 15-34-25
Section 3: Hazardous Ingredients/Identity Information
Emergency Overview
Caution! To the best of our knowledge the toxicological properties of this material have not been
thoroughly investigated. May be fatal if swallowed, inhaled or absorbed through skin. Material is
extremely destructive to tissue of mucous membranes and upper respiratory tract.
Target Organs Behavioral, central nervous system.
Potential Health Effects
Eye Causes severe eye irritation and eye burns.
Skin Toxic in contact with skin. Causes severe skin irritation.
Ingestion May be fatal if swallowed. Causes gastrointestinal irritation with nausea, vomiting and
diarrhea.
Inhalation May cause severe irritation of the respiratory tract with sore throat, burns, coughing,
shortness of breath and delayed lung edema.
Chronic Behavioral - convulsions or effect on seizure threshold. Highly toxic cholinesterase
inhibitor. Exposure can cause neurotoxic effects.
Section 4: First Aid Measures
Eye In case of contact, immediately flush eyes with copious amounts of water for at
least 15 minutes. Assure adequate flushing by separating the eyelids with fingers.
Call a physician.
Skin In case of contact, immediately flush skin with copious amounts of water for at
least 15 minutes while removing contaminated clothing and shoes. Call a
physician. Discard contaminated clothes and shoes.
Ingestion If swallowed, wash out mouth with water provided person is conscious. Call a
physician.
Inhalation If inhaled, remove to fresh air, immediately. If not breathing give artificial
respiration. If breathing is difficult, give oxygen. Call a physician.
Notes to Physician Treat symptomatically and supportively.
Section 5: Fire Fighting Measures
General Information As in any fire, wear self-contained breathing apparatus and protective
clothing to prevent contact with skin and eyes. During a fire, irritating and
highly toxic gases may be generated by thermal decomposition or
combustion.
Extinguishing Media In case of fire use carbon dioxide, dry chemical powder or appropriate
foam. Do not use water!
Autoignition Temperature Not available
Flash Point Not available
NFPA Rating Not published. Explosion Limits, Lower: Not available. Upper: Not available
Section 6: Accidental Release Measures
General Information Evacuate area, wear self-contained breathing apparatus, rubber boots and
heavy rubber gloves.
Spills/Leaks Sweep up, place in a bag and hold for waste disposal; avoid raising dust;
ventilate area and wash spill site after material pickup is complete.
Section 7: Handling and Storage
Handling Avoid ingestion and inhalation. Do not breathe dust. Avoid contact with skin, eyes and
clothing. Avoid prolonged or repeated exposure. Wash thoroughly after handling.
Remove contaminated clothing and wash before reuse.
Storage Keep container tightly closed when not in use. Refrigerate (2-8掳C). Store dry. Protect from
light. Protect from humidity (material is hygroscopic). Contact with water liberates
extremely flammable gases.
Section 8: Control Measures
Engineering Controls Mechanical exhaust required. Safety shower and eye bath. Use only in a
chemical fume hood.
Exposure Limit OEL = MAK
Personal Protective Equipment
Eyes Wear appropriate protective eyeglasses or chemical safety goggles as described
by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European
Standard EN166.
Skin Wear compatible chemical-resistant gloves and clothing to prevent skin
exposure.
Hand Wear compatible chemical-resistant gloves to prevent skin exposure.
Clothing Wear appropriate protective clothing to prevent exposure.
Respirator Wear a NIOSH/MSHA or European Standard EN 149 approved full-face airline
respirator in the positive pressure mode with emergency escape provisions.
Section 9: Physical And Chemical Properties
Appearance White to slightly off-white crystalline powder / colorless crystals
Odor Not available
pH Not available
Boiling Point Not available
Melting Point 93 - 95掳 C
Flash Point Not available
Autoignition Temperature Not available
Vapor Pressure Not available
Vapor Density Not available
Specific Gravity/Density Not applicable
Coefficient octanol/water Not available
Solubility in water Soluble in water
Solubility other Soluble in chloroform, diethyl ether, ethanol
Other physical data Not available
Molecular Formula C7H7FO2S
Molecular Weight 174.20 g/mol
Section 10: Stability And Reactivity Data
Stability Stable
Conditions to Avoid Incompatible materials, light, moisture
Incompatibilities Strong oxidizing agents, strong bases
Hazardous Decomposition Products Toxic fumes of: carbon monoxide, carbon dioxide, sulfur oxides,
hydrogen fluoride gas
Hazardous Polymerization Will not occur
Section 11: Toxicological Information
RTECS XT 8040000
CAS No. [329-98-6]
LD50/LC50 IPR-RAT LD50: 150 mg/kg; ORL-MUS LD50: 200 mg/kg IPR-MUS LD50: 215 mg/kg
Carcinogenity Not available
Epidemiology Not available
Teratogen Not available
Reproductive Effects Not available
Neurotoxicity May cause central nervous system depression
Mutagen Not available
Other Studies Only selected Registry of toxic effects of chemical substances (RTECS) data is
presented here. See actual entry in RTECS for complete information
Section 12: Ecological Information
Ecotoxicity Not available
Environmental Fate Not available
Physical/Chemical Not available
Other Not available
Section 13: Disposal Considerations
Disposal should be handled by an approved waste disposal facility
Section 14: Transport Information
IATA
UN Number UN 2923
Proper Shipping Name Corrosive solid, toxic, n.o.s. (Phenylmethylsulfonyl fluoride)
Class 8
Packing Group II
RID/ADR
UN Number UN 2923
Proper Shipping Name Corrosive solid, toxic, n.o.s. (Phenylmethylsulfonyl fluoride)
Class 8
Packing Group II
Section 15: Regulatory Information
European / International Regulations
Hazard Symbols CT
R-Phrase No. R15/R34/R25
Risk Phrases Contact with water liberates extremely flammable gases. Causes burns. Toxic if
swallowed.
S-Phrase No. S26/S36/S37/S39/S45/22
Safety Phrases In case of contact with eyes, rinse immediately with plenty of water and seek
medical advice. Wear suitable protective clothing, gloves and eye/face
protection. In case of accident, or if you feel unwell, seek medical advice
immediately (show the label where possible).Do not breathe dust.
International Regulations
On TSCA January 2004 Inventory Tape. On DSL, Supplement to Canada Gazette, Part I, January 26,
1991. Oh ASIA-PAC
Various
Exposure Limit OEL = MAK
Section 16: Other Information
While Gold Biotechnology, Inc.鈩? believes the information contained herein to be true and accurate, it
has relied on information provided by others. Gold Biotechnology, Inc.鈩? makes no warranties, express
or implied, as to the accuracy or adequacy of the information contained herein or with respect to the
results to be obtained from the use of the product. Gold Biotechnology, Inc.鈩? disclaims all liability with
respect to the use of this product, including without limitation, liability for injury to the user or third-party
persons.
date updated: 06/21/07
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