SIGMA-ALDRICH
MATERIAL SAFETY DATA SHEET
Date Printed: 05/08/2007
Date Updated: 01/31/2006
Version 1.3
Section 1 - Product and Company Information
Product Name DIGITOXIN CRYSTALLINE
Product Number D5878
Brand SIGMA
Company Sigma-Aldrich
Address 3050 Spruce Street
SAINT LOUIS MO 63103 US
Technical Phone: 800-325-5832
Fax: 800-325-5052
Emergency Phone: 314-776-6555
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313
DIGITOXIN 71-63-6 Yes
Formula C41H64O13
Synonyms Acedoxin * Asthenthilo * Cardidigin * Cardigin *
Carditalin * Carditoxin * Cristapurat *
Crystalline digitalin * Crystodigin * Digimerck *
Digisidin * Digitophyllin *
Digitoxigenin-tridigitoxosid (German) *
Digitoxigenin tridigitoxoside * Digitoxinum *
Digitoxoside * Digitrin * Ditaven * Glucodigin *
Lanatoxin * Mono-digitoxid (German) *
Monodigitoxoside * Mono-glycocard * Myodigin *
Purpurid * Tardigal * Tri-digitoxoside (German) *
Unidigin
RTECS Number: IH2275000
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Highly Toxic (USA) Very Toxic (EU).
Very toxic by inhalation, in contact with skin and if swallowed.
Target organ(s): Heart. G.I. System.
HMIS RATING
HEALTH: 3*
FLAMMABILITY: 0
REACTIVITY: 0
NFPA RATING
HEALTH: 3
FLAMMABILITY: 0
REACTIVITY: 0
*additional chronic hazards present.
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
INHALATION EXPOSURE
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
Section 5 - Fire Fighting Measures
FLASH POINT
N/A
AUTOIGNITION TEMP
N/A
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Section 6 - Accidental Release Measures
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust.
Section 7 - Handling and Storage
HANDLING
User Exposure: Do not breathe dust. Avoid contact with eyes,
skin, and clothing. Avoid prolonged or repeated exposure.
STORAGE
Suitable: Keep tightly closed. Store in a cool dry place.
Section 8 - Exposure Controls / PPE
ENGINEERING CONTROLS
Safety shower and eye bath. Use only in a chemical fume hood.
PERSONAL PROTECTIVE EQUIPMENT
Other: Wear appropriate government approved respirator,
chemical-resistant gloves, safety goggles, other protective
clothing.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling. Wash contaminated clothing before
reuse.
Section 9 - Physical/Chemical Properties
Appearance Color: White
Form: Powder
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Property Value At Temperature or Pressure
Molecular Weight 764.95 AMU
pH N/A
BP/BP Range N/A
MP/MP Range 240 藲C
Freezing Point N/A
Vapor Pressure N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
SG/Density N/A
Bulk Density N/A
Odor Threshold N/A
Volatile% N/A
VOC Content N/A
Water Content N/A
Solvent Content N/A
Evaporation Rate N/A
Viscosity N/A
Surface Tension N/A
Partition Coefficient N/A
Decomposition Temp. N/A
Flash Point N/A
Explosion Limits N/A
Flammability N/A
Autoignition Temp N/A
Refractive Index N/A
Optical Rotation Degree of Rotation: 20 g/l Solvent: CHCl3
+20 - +17 (+/-1)
Miscellaneous Data N/A
Solubility N/A
N/A = not available
Section 10 - Stability and Reactivity
STABILITY
Materials to Avoid: Strong oxidizing agents, Strong acids.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
Section 11 - Toxicological Information
ROUTE OF EXPOSURE
Multiple Routes: May be fatal if inhaled, swallowed, or absorbed
through skin. May cause irritation.
TARGET ORGAN(S) OR SYSTEM(S)
Nerves. G.I. System. Heart.
SIGNS AND SYMPTOMS OF EXPOSURE
Stomach pains, vomiting, diarrhea. Exposure can cause:
TOXICITY DATA
Oral
Man
0.286 mg/kg
LDLO
Remarks: Blood:Thrombocytopenia. Peripheral Nerve and
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Sensation:Paresthesis. Cardiac:Pulse rate increased without fall
it BP.
Oral
Rat
23.75 mg/kg
LD50
Subcutaneous
Rat
16430 UG/KG
LD50
Intravenous
Rat
3900 UG/KG
LD50
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Oral
Mouse
4.95 mg/kg
LD50
Intraperitoneal
Mouse
3900 UG/KG
LD50
Subcutaneous
Mouse
22180 UG/KG
LD50
Remarks: Cardiac:Other changes. Brain and Coverings:Recordings
from specific areas of CNS. Behavioral:Convulsions or effect on
seizure threshold.
Intravenous
Mouse
4100 UG/KG
LD50
Intracerebral
Mouse
49 UG/KG
LD50
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Oral
Cat
0.18 mg/kg
LD50
Intraperitoneal
Cat
170 UG/KG
LD50
Oral
Guinea pig
3.7 mg/kg
LD50
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Intraperitoneal
Guinea pig
1800 UG/KG
LD50
Intraduodenal
Guinea pig
3 MG/KG
LD50
Remarks: Cardiac:Arrythmias (including changes it conduction).
Cardiac:Cardiomyopathy including infarction.
Intraperitoneal
Pigeon
320 UG/KG
LD50
Oral
Frog
3.05 mg/kg
LD50
Subcutaneous
Frog
1050 UG/KG
LD50
Intravenous
Frog
730 UG/KG
LD50
IRRITATION DATA
Eyes
Dog
1%
1D
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Woman
Dose: 200 UG/KG
Route of Application: Oral
Exposure Time: (27-30W PREG)
Result: Effects on Newborn: Viability index (e.g., # alive at
day 4 per # born alive). Effects on Newborn: Other neonatal
measures or effects.
Section 12 - Ecological Information
No data available.
Section 13 - Disposal Considerations
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Observe all federal, state, and local environmental regulations.
Section 14 - Transport Information
DOT
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Proper Shipping Name: Toxic solids, organic, n.o.s.
UN#: 2811
Class: 6.1
Packing Group: Packing Group I
Hazard Label: Toxic substances.
IATA
Proper Shipping Name: Toxic solid, organic, n.o.s.
IATA UN Number: 2811
Hazard Class: 6.1
Packing Group: I
Section 15 - Regulatory Information
EU DIRECTIVES CLASSIFICATION
Symbol of Danger: T
Indication of Danger: Toxic.
R: 23/25-33
Risk Statements: Toxic by inhalation and if swallowed. Danger of
cumulative effects.
S: 45
Safety Statements: In case of accident or if you feel unwell,
seek medical advice immediately (show the label where possible).
US CLASSIFICATION AND LABEL TEXT
Indication of Danger: Highly Toxic (USA) Very Toxic (EU).
Risk Statements: Very toxic by inhalation, in contact with skin
and if swallowed.
Safety Statements: Do not breathe dust. Wear suitable protective
clothing, gloves, and eye/face protection. In case of accident
or if you feel unwell, seek medical advice immediately (show the
label where possible).
US Statements: Target organ(s): Heart. G.I. System.
UNITED STATES REGULATORY INFORMATION
SARA LISTED: Yes
NOTES: This product is subject to SARA section 313 reporting
requirements.
TSCA INVENTORY ITEM: Yes
CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: No
NDSL: Yes
Section 16 - Other Information
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
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Copyright 2007 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
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