CATALOG NO: 14910
EMS PRODUCT: Epon 815 Resin
DATE: 10/16/99
PAGE NUMBER: One of 9
MATERIAL SAFETY DATA SHEET
The information contained herein is based on data considered
accurate. However, no warranty is expressed or implied
regarding the accuracy of these data or the results to be
obtained from the use thereof.
Electron Microscopy Sciences assumes no responsibility for
personal injury or property damage to vendees, users or
third parties caused by the material. Such vendees or users
assume all risks associated with the use of the material.
ELECTRON MICROSCOPY SCIENCES
321 MORRIS ROAD
P.O. BOX 251
FORT WASHINGTON, PA 19034 24 HOUR EMERGENCY PHONE NUMBER
(215) 646-1566 CHEMTREC: (800) 424-9300
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FOR PRODUCT AND SALES INFORMATION
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CONTACT ELECTRON MICROSCOPY SCIENCES OFFICE ABOVE.
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PRODUCT IDENTIFICATION
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PRODUCT NAME: Epon 815 Resin
CHEMICAL NAME: Modified Bisphenol A - Epichlorohydrin Based Epoxy
Resin
CHEMICAL FAMILY: Epoxy resins
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PRODUCT / INGREDIENT
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# COMPOSITION CAS NUMBER PERCENT
P Epon Resin 815 Mixture 100
1
1 Bisphenol A/Epichlorohydrin Resin 25068-38-6 86.5
2 N-Butyl Glycidyl Ether 2426-08-6 13.5
Component 1 is an epoxy resin produced by the condensation reaction of
Epichlorohydrin and Bisphenol-A. These raw materials are consumed in
the process. Residual levels of Epichlorohydrin are typically 2-3 ppm
in the product.
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ACUTE TOXICITY DATA
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# ACUTE ORAL LD50 ACUTE DERMAL LD50 ACUTE INHALATION LC50
P 9.0 g/kg (rat) No data available No data available
1 11.4 g/kg (rat) >20 ml/kg (rabbit) No data available
1 15.6 g/kg (mouse)
2 1.53 g/kg (mouse) 788 mg/kg (rabbit) >3500 ppm/4H (mouse)
2 2.26 g/kg (rat) 1030 ppm/8H (rat)
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HEALTH INFORMATION
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The health effects noted below are consistent with requirements under
the OSHA Hazard Communication Standard (29 CFR 1910.1200).
EYE CONTACT:
Based on similar product testing product may be severely
irritating to the eyes. May cause corneal damage.
SKIN CONTACT:
Based on human experience, component 2 is extremely irritating to
the skin and may cause skin damage. Based on human experience,
component 2 is a skin sensitizer. Based on presence of component
2 product may be toxic if absorbed.
INHALATION:
Based on human experience, component 2 may cause irritation of
the respiratory tract. Based on component 2 testing, product may
produce central nervous system (CNS) depression. Although no
specific information is known. Base on skin sensitization
experience in humans. Component 2 may also be a respiratory
tract sensitizer (see signs and symptoms). Because of its low
volatility. However, significant exposure by the inhalation
route is unlikely under most ambient conditions. But vapors,
aerosols, and mists may be formed during some applications.
Based on component 2 testing, product may be moderately toxic,
may be harmful if inhaled.
2
INGESTION:
Based on similar product testing, product may be slightly toxic.
Based on the presence of component 2, product may cause CNS
depression.
SIGNS AND SYMPTOMS:
Irritation as noted above. Skin sensitization (allergy) may be
evidenced by rashes, especially hives. Respiratory tract
sensitization (e.g., allergy, asthma) may be evidenced by
wheezing with shortness of breath and cough. Early to moderate
cns depression may be evidenced by giddiness. Headache,
dizziness, and nausea; in extreme cases, unconsciousness and
death may occur.
AGGRAVATED MEDICAL CONDITIONS:
Preexisting eye, skin, and respiratory disorders may be aggravated
by exposure to this product. Preexisting skin or respiratory
tract allergies may increase the chance of developing increased
allergy symptoms from exposure to this product.
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OCCUPATIONAL EXPOSURE LIMITS
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OSHA ACGIH
NO. PEL/TWA PEL/CEILING TLV/TWA TLV/STEL
P None Established
1 None Established
2 25 ppm 25 ppm
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EMERGENCY AND FIRST-AID PROCEDURES
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EYE CONTACT:
Immediately flush eyes with plenty of water for at least 15
minutes while holding eyelids open. Get medical attention.
SKIN CONTACT:
Immediately remove contaminated clothing or shoes, wipe excess
from skin and flush with plenty of water for at least 15 minutes.
Use soap if available or follow by washing with soap and water.
Do not reuse clothing until thoroughly cleaned.
INHALATION:
Remove victim to fresh air and provide oxygen if breathing is
difficult. Give artificial respiration if not breathing.
INGESTION:
3
Do not give liquids if victim is unconscious or very drowsy.
Otherwise, give no more than 2 glasses of water and induce
vomiting by giving 30cc (2 tablespoons) syrup of Ipecac.* If
Ipecac is unavailable, give 2 glasses of water and induce
vomiting by touching finger to back of victim's throat. Keep
victim's head below hips while vomiting. GET MEDICAL ATTENTION.
NOTE TO PHYSICIAN
* If victim is a child, give no more than 1 glass of water and 15cc (1
tablespoon) syrup of Ipecac. If symptoms such as loss of gag reflex,
convulsions or unconsciousness occur before emesis, gastric lavage
should be considered following intubation with a cuffed endotrachael
tube.
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SUPPLEMENTAL HEALTH INFORMATION
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COMPONENT 1: CHRONIC STUDIES: Recent 2-year bioassays in mice
exposed by the dermal route to Epon Resin 828, a resin similar to
component 1. The diglycidyl ether of Bisphenol a (DGEBPA), or to
other commercial resins which are composed predominantly of DGEBPA
have yielded very limited evidence of weak carcinogenicity. DGEBPA is
a component of this resin. The authors of this work concluded that
the renal tumor evidence with epon resin 828 "was of no biological
significance" and that the resin "is not a systemic carcinogen when
applied to the dorsal skin of CF1 mice." Based upon this and all
other available information, the International Agency For Research on
Cancer (IARC) concluded (1988) that DGEBPA was not classifiable as a
carcinogen (IARC GROUP 3) based on the following: Human Evidence - -
Inadequate; Animal Evidence - Inadequate.
Both Epon resin 828. A resin similar to component 1 and DGEBPA. Its
major constituent, have proved to be inactive when tested by in vivo
mutagenicity assays. They have both shown activity in vitro microbial
mutagenicity screening tests and have produced chromosomal aberrations
in cultured rat liver cells. The significance of this information to
man is unknown.
NOTE: This product contains (Trace 2-3 ppm, typical) residual
quantities of eipchlorohydrin (ECH). Cas No. 106-89-8. It is very
unlikely that normal work practices with this product could result in
measurable ECH concentrations in the workplace atmosphere.
Nevertheless, you should be aware that ECH has been reported to
produce cancer in laboratory animals and to produce mutagenic changes
in bacteria and cultured human cells. It has been classified by the
International Agency for Research on Cancer (IARC) as a probable human
carcinogen (IARC Group 2A) based on the following conclusions: Human
evidence - Inadequate; Animal Evidence - Sufficient. It has been
classified as an anticipated human carcinogen by the National
Toxicology Program (NTP).
4
NOTE: Additional Toxicological Information
Component 2: Rats exposed to N-butyl Glycidyl ether at 150 ppm for
50 7-hour exposures demonstrated significantly retarded growth. In
the same study, there was 50% mortality in rats exposed at 300 ppm,
with additional signs of toxicity in the survivors. Testicular
atrophy was observed in rats exposed at 300 ppm, but the rats were
juvenile, obscuring the significance, if any, of the result.
In a 28 day inhalation study, rats exposed at 188 ppm showed decreased
body weight and changes in blood chemistry. Severe irritation of the
upper respiratory tract was observed in rats exposed at 94 ppm and 188
ppm.
N-BGE has tested positive in a number of in vitro genetic toxicity
assays with and without metabolic activation. Mixed results were
observed in the dominant lethal and the mouse micronucleus tests.
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PHYSICAL DATA
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BOILING POINT: Not available SPECIFIC GRAVITY: 1.13
(Deg F) (H2O=1)
MELTING POINT: Not available SOLUBILITY: Negligible
(Deg F) (In water)
VAPOR PRESSURE: 1 VAPOR DENSITY: 4.5
(MM HG) (Air=1)
EVAPORATION RATE: Not available
(N-butyl acetate=1)
APPEARANCE AND ODOR: Light yellow liquid.
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FIRE AND EXPLOSION HAZARDS
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FLASH POINT AND METHOD: FLAMMABLE LIMITS /% VOLUME IN AIR
164oF (Setaflash) Lower: N/AV Upper: N/AV
EXTINGUISHING MEDIA: Use water fog, "alcohol" foam, dry chemical
or CO2.
SPECIAL FIRE FIGHTING PROCEDURES AND PRECAUTIONS:
Caution. Combustible. Do not enter confined fire space without full
bunker gear (helmet with face shield, bunker coats, gloves and rubber
boots), including a positive pressure NIOSH approved self-contained
breathing apparatus. Cool fire exposed containers with water.
5
UNUSUAL FIRE AND EXPLOSION HAZARDS:
Containers exposed to intense heat from fires should be cooled with
water to prevent vapor pressure buildup which could result in
container rupture. Container areas exposed to direct flame contact
should be cooled with large quantities of water as needed to prevent
weakening of container structure.
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REACTIVITY
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STABILITY: Stable. HAZARDOUS POLYMERIZATION: Will not occur.
CONDITIONS AND MATERIALS TO AVOID:
Avoid heat, flame and contact with strong oxidizing agents. Can
react vigorously with strong lewis or mineral acids and strong
mineral and organic bases/especially primary and secondary
aliphatic amines. Reaction with some curing agents may produce
considerable heat.
HAZARDOUS DECOMPOSITION PRODUCTS:
Carbon monoxide, aldehydes and acids may be formed during combustion.
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EMPLOYEE PROTECTION
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RESPIRATORY PROTECTION:
Avoid breathing vapors which may be produced under some conditions
such as heating or applications of uncured material in large surface
areas (e.g., flooring and painting). Avoid breathing aerosols and
mists which may be formed by various methods of application.
If exposure may or does exceed occupational exposure limits, use a
NIOSH-approved respirator to prevent overexposure. In accord with 29
CFR 1910.134 use either a full-face, atmosphere-supplying respirator
or air-purifying respirator for organic vapors.
PROTECTIVE CLOTHING:
Avoid contact with eyes. Wear chemical goggles if there is likelihood
of contact with eyes. Avoid contact with skin and clothing. Wear
chemical-resistant gloves and protective clothing.
ADDITIONAL PROTECTIVE MEASURES:
6
Use explosion-proof ventilation as required to control vapor
concentrations. Eye wash fountains and safety showers should be
available for emergency use.
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ENVIRONMENTAL PROTECTION
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SPILL OR LEAK PROCEDURES:
CAUTION. COMBUSTIBLE. ** LARGE SPILLS ** Eliminate potential sources
of ignition. Wear appropriate respirator and other protective
clothing. Shut off source of leak only if safe to do so. Dike and
contain. Remove with vacuum trucks or pump to storage/salvage vessels.
Soak up residue with an absorbent such as clay, sand, or other
suitable material; place in non-leaking containers and seal tightly
for proper disposal. Flush area with water to remove trace residue;
Dispose of flush solution as above. ** SMALL SPILLS ** Take up with
an absorbent material and place in non-leaking containers for proper
disposal.
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SPECIAL PRECAUTIONS
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Heating this resin above 300oF in the presence of air may cause slow
oxidative decomposition; above 500oF, polymerization may occur. Some
curing agents, E.G., Aliphatic polyamines can produce exothermic
reactions which in large masses can cause runaway polymerization and
charring of the reactants. Fumes and vapors from these thermal and
chemical decompositions vary widely in composition and toxicity. Do
not breathe fumes. Use a NIOSH-Approved respirator as required to
prevent over exposure. In accord with 29 CFR 1910.134, use either an
atmosphere-supply respirator or an air-purifying respirator for
organic vapors.
WARNING! COMBUSTIBLE LIQUID. Keep liquid and vapor away from heat,
sparks and flame. Surfaces that are sufficiently hot may ignite even
liquid product in the absence of sparks or flame. Extinguish pilot
lights, cigarettes and turn off other sources of ignition prior to use
and until all vapors are gone. Vapors may accumulate and travel to
ignition sources distant from the handling site; flash-fire can result.
Keep containers closed when not in use. Use with adequate ventilation.
Containers, even those that have been emptied, can contain explosive
vapors. Do not cut, drill, grind, weld or perform similar operations
on or near containers. Do not pressurize drum containers to empty
them. Static electricity may accumulate and create a fire hazard.
Ground fixed equipment. Bond and ground transfer containers and
7
equipment.
WARNING! SKIN SENSITIZER. Potential respiratory tract sensitizer. Eye
and skin irritant. Containers, even those that have been emptied, can
contain hazardous product residues. Wash with soap and water before
eating, drinking, smoking, applying cosmetics or using toilet
facilities. Launder contaminated clothing before reuse. Contaminated
leather articles, including shoes, cannot be decontaminated and should
be destroyed to prevent reuse.
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TRANSPORTATION REQUIREMENTS
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DEPARTMENT OF TRANSPORTATION CLASSIFICATION:
Combustible liquid, III
D.O.T. PROPER SHIPPING NAME: Resin Solution
OTHER REQUIREMENTS:
UN1866, Guide 26, Not regulated by D.O.T. if in a container of
119 gallon capacity or less.
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OTHER REGULATORY CONTROLS
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The components of this product are listed on the EPA/TSCA Inventory of
Chemical Substances.
Protection of stratospheric ozone (Pursuant to Section 611 of the
Clean Air Act Amendments of 1990): Per 40 CFR Part 82, This product
does not contain nor was it directly manufactured with any Class I or
Class II ozone depleting substances.
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STATE REGULATORY INFORMATION
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The following chemicals are specifically listed by individual states;
other product specific health and safety data in other sections of the
MSDS may also be applicable for state requirements.
STATE LISTED COMPONENT PERCENT STATE CODE
Butyl Glycidyl Ether 13.5 FL, IL, MA, ME, MN, PA, RI, NJ
(CAS NO: 2426-08-6)
Epichlorohydrin MA, CA65C
(CAS NO: 106-89-8 ) 2-3 ppm
8
Phenyl Glycidyl Ether CA65C
(CAS NO: 122-60-1 ) 5 ppm
Diglycidyl Ether MA
(CAS NO: 2238-07-5) <200 ppm
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FOOTNOTES
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*1= Reportable quantity of Extremely Hazardous Substance, Sec. 302
*2= Threshold Planning Quantity. Extremely Hazardous Substance,Sec.302
*3= Toxic Chemical, Sec 313
*4= Category as Required by Sec 313 (40 CFR 372.65C), must be used on
Toxic Release Inventory form
*5= Hazard Category for SARA Sec. 311/312 Reporting
Health H-1 = Immediate (Acute) health hazard
H-2 = Delayed (chronic) health hazard
Physical P-3 = Fire hazard
P-4 = Sudden release of pressure hazard
P-5 = Reactive hazard
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ENVIRONMENTAL RELEASE INFORMATION
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Keep out of surface waters, sewers, and waterways entering or leading
to surface waters. Notify authorities if any exposure to the general
public or environment occurs or is likely to occur.
PLACE IN AN APPROPRIATE DISPOSAL FACILITY IN COMPLIANCE WITH LOCAL
REGULATIONS.
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