EMS CATALOG NO: 22050
EMS PRODUCT: Toluidine Blue O
DATE: December 30, 2001
PAGE NUMBER: One of 7
MATERIAL SAFETY DATA SHEET
The information contained herein is based on data considered
accurate. However, no warranty is expressed or implied
regarding the accuracy of these data or the results to be
obtained from the use thereof.
Electron Microscopy Sciences assumes no responsibility for
personal injury or property damage to vendees, users or
third parties caused by the material. Such vendees or users
assume all risks associated with the use of the material.
ELECTRON MICROSCOPY SCIENCES
321 MORRIS ROAD
P.O. BOX 251
FORT WASHINGTON, PA 19034 24 HOUR EMERGENCY PHONE NUMBER
(215) 646-1566 CHEMTREC: (800) 424-9300
_________________________________________________________________
FOR PRODUCT AND SALES INFORMATION
_________________________________________________________________
CONTACT ELECTRON MICROSCOPY SCIENCES OFFICE ABOVE.
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PRODUCT IDENTIFICATION
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COMMON NAME: Toluidine Blue O
COMMERCIAL NAME(S): Basic Blue 17
SYNONYM: Tolonium Chloride
CHEMICAL NAME:
3-Amino-70(dimethylamino)-2-Methylphenothiazin-5-ium Chloride
CHEMICAL FAMILY: Coloring Material
CHEMICAL FORMULA: C15H16N3S.Cl
CAS#: 92-31-9
RTECS: SP5670000
TSCA: TSCA 8(b) INVENTORY: Toluidine Blue O
CI#: 52040
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COMPOSITION AND INFORMATION ON INGREDIENTS
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NAME: Toluidine Blue O
CAS#: 92-31-9
% BY WEIGHT: 100
TOXICOLOGICAL DATA ON INGREDIENTS:
(LD50): Not available.
(LC50): Not available.
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HAZARDS IDENTIFICATION
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POTENTIAL ACUTE HEALTH EFFECTS:
Hazardous in case of skin contact (irritant), of eye contact
(irritant), of inhalation. Slightly hazardous in case of
skin contact (permeator).
POTENTIAL CHRONIC HEALTH EFFECTS:
CARCINOGENIC EFFECTS: Not available.
MUTAGENIC EFFECTS: Not available.
TERATOGENIC EFFECTS: Not available.
DEVELOPMENTAL TOXICITY: Not available.
Repeated or prolonged exposure is not known to aggravate
medical condition.
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FIRST AID MEASURES
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EYE CONTACT:
Check for and remove any contact lenses. Immediately flush
eyes with running water for at least 15 minutes, keeping
eyelids open. Cold water may be used. Do not use an eye
ointment. Seek medical attention.
SKIN CONTACT:
After contact with skin, wash immediately with plenty of
water. Gently and thoroughly wash the contaminated skin
with running water and non-abrasive soap. Be particularly
careful to clean folds, crevices, creases and groin. Cold
water may be used. Cover the irritated skin with an
emollient. If irritation persists, seek medical attention.
Wash contaminated clothing before reusing.
SERIOUS SKIN CONTACT:
Wash with a disinfectant soap and cover the contaminated
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skin with an anti-bacterial cream. Seek medical attention.
INHALATION:
Allow the victim to rest in a well ventilated area. Seek
immediate medical attention.
SERIOUS INHALATION: Not available.
INGESTION:
Do not induce vomiting. Loosen tight clothing such as a
collar, tie, belt or waistband. If the victim is not
breathing, perform mouth-to-mouth resuscitation. Seek
immediate medical attention.
SERIOUS INGESTION: Not available.
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FIRE AND EXPLOSION DATA
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FLAMMABILITY OF THE PRODUCT:
May be combustible at high temperature.
AUTO-IGNITION TEMPERATURE: Not available.
FLASH POINTS: Not available.
FLAMMABLE LIMITS: Not available.
PRODUCTS OF COMBUSTION: These products are carbon oxides (CO, CO2),
nitrogen oxides (NO, NO2...), sulfur oxides (SO2, SO3...).
FIRE HAZARDS IN PRESENCE OF VARIOUS SUBSTANCES: Flammable in
presence of open flames and sparks.
EXPLOSION HAZARDS IN PRESENCE OF VARIOUS SUBSTANCES:
RISKS OF EXPLOSION OF THE PRODUCT IN PRESENCE OF MECHANICAL
IMPACT: Not available.
RISKS OF EXPLOSION OF THE PRODUCT IN PRESENCE OF STATIC
DISCHARGE: Not available.
FIRE FIGHTING MEDIA AND INSTRUCTIONS:
SMALL FIRE: Use DRY chemical powder.
LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
SPECIAL REMARKS ON FIRE HAZARDS: Not available.
SPECIAL REMARKS ON EXPLOSION HAZARDS: Not available.
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ACCIDENTAL RELEASE MEASURES
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SMALL SPILL:
Use appropriate tools to put the spilled solid in a
convenient waste disposal container. Finish cleaning by
spreading water on the contaminated surface and dispose of
according to local and regional authority requirements.
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LARGE SPILL:
Use a shovel to put the material into a convenient waste
disposal container. Finish cleaning by spreading water on
the contaminated surface and allow to evacuate through the
sanitary system.
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HANDLING AND STORAGE
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PRECAUTIONS:
Keep away from heat. Keep away from sources of ignition.
Empty containers pose a fire risk, evaporate the residue
under a fume hood. Ground all equipment containing
material. do not breathe dust. Wear suitable protective
clothing. In case of insufficient ventilation, wear
suitable respiratory equipment. If you feel unwell, seek
medical attention and show the label when possible. Avoid
contact with skin and eyes.
STORAGE:
Keep container dry. Keep in a cool place. Ground all
equipment containing material. Keep container tightly
closed. Keep in a cool, well-ventilated place. Combustible
materials should be stored away from extreme heat and away
from strong oxidizing agents.
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EXPOSURE CONTROLS/PERSONAL PROTECTION
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ENGINEERING CONTROLS:
Use process enclosures, local exhaust ventilation, or other
engineering controls to keep airborne levels below
recommended exposure limits. If user operations generate
dust, fume or mist, use ventilation to keep exposure to
airborne contaminants below the exposure limit.
PERSONAL PROTECTION:
Splash goggles. Lab coat. Dust respirator. Be sure to use
an approved/certified respirator or equivalent. Gloves.
PERSONAL PROTECTION IN CASE OF A LARGE SPILL:
Splash goggles. Full suit. Dust respirator. Boots.
Gloves. A self contained breathing apparatus should be used
to avoid inhalation of the product. Suggested protective
clothing might not be sufficient; consult a specialist
BEFORE handling this product.
EXPOSURE LIMITS: Not available.
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PHYSICAL AND CHEMICAL PROPERTIES
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PHYSICAL STATE AND APPEARANCE: Solid (Powder or flakes solid).
ODOR: Not available.
TASTE: Not available.
COLOR: Green. (Dark).
MOLECULAR WEIGHT: 305.83 g/mole
pH (1% SOLN/WATER): Not available.
BOILING POINT: Not available.
MELTING POINT: Decomposes.
CRITICAL TEMPERATURE: Not available.
SPECIFIC GRAVITY: Not available.
VAPOR PRESSURE: Not applicable.
VAPOR DENSITY: Not available.
VOLATILITY: Not available.
ODOR THRESHOLD: Not available.
WATER/OIL DIST. COEFF.: Not available.
IONICITY (IN WATER): Not available.
DISPERSION PROPERTIES: See solubility in water.
SOLUBILITY: Partially soluble in cold water, hot water.
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STABILITY AND REACTIVITY DATA
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STABILITY: The product is stable.
INSTABILITY TEMPERATURE: Not available.
CONDITIONS OF INSTABILITY: Not available.
INCOMPATIBILITY WITH VARIOUS SUBSTANCES: Not available.
CORROSIVITY: Non-corrosive in presence of glass.
SPECIAL REMARKS ON REACTIVITY: Not available.
SPECIAL REMARKS ON CORROSIVITY: Not available.
POLYMERIZATION: No.
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TOXICOLOGICAL INFORMATION
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ROUTES OF ENTRY: Eye contact. Inhalation. Ingestion.
TOXICITY TO ANIMALS:
LD50: Not available.
LC50: Not available.
CHRONIC EFFECTS ON HUMANS: Not available.
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OTHER TOXIC EFFECTS ON HUMANS:
Hazardous in case of skin contact (irritant), of ingestion,
of inhalation. Slightly hazardous in case of skin contact
(permeator).
SPECIAL REMARKS ON TOXICITY TO ANIMALS: Not available.
SPECIAL REMARKS ON CHRONIC EFFECTS ON HUMANS: Not available.
SPECIAL REMARKS ON OTHER TOXIC EFFECTS ON HUMANS: Not available.
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ECOLOGICAL INFORMATION
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ECOTOXICITY: Not available.
BOD5 AND COD: Not available.
PRODUCTS OF BIODEGRADATION:
Possibly hazardous short term degradation products are not
likely. However, long term degradation products may arise.
TOXICITY OF THE PRODUCTS OF BIODEGRADATION:
The products of degradation are more toxic.
SPECIAL REMARKS ON THE PRODUCTS OF BIODEGRADATION: Not available.
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DISPOSAL CONSIDERATIONS
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WASTE DISPOSAL: Recycle to process, if possible. Consult your
local or regional authorities.
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TRANSPORT INFORMATION
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DOT CLASSIFICATION: Not a DOT controlled material (United States).
IDENTIFICATION: Not applicable.
SPECIAL PROVISIONS FOR TRANSPORT: Not applicable.
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OTHER REGULATORY INFORMATION
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FEDERAL AND STATE REGULATIONS:
TSCA 8(b) INVENTORY: Toluidine Blue O
OTHER REGULATIONS: Not available.
OTHER CLASSIFICATIONS:
WHMIS (CANADA): Not controlled under WHMIS (Canada).
DSCLA (EEC): R36/38-Irritating to eyes and skin.
HMIS (U.S.A.):
HEALTH HAZARD: 2
FIRE HAZARD: 1
REACTIVITY: 0
PERSONAL PROTECTION: E
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NATIONAL FIRE PROTECTION ASSOCIATION (U.S.A.)
HEALTH: 2
FLAMMABILITY: 1
REACTIVITY: 0
SPECIFIC HAZARD:
PROTECTIVE EQUIPMENT:
Gloves.
Lab Coat.
Dust Respirator. Be sure to use an approved/certified
respirator or equivalent.
Splash goggles.
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