PRODUCT #: D5511 NAME: N,N-DIMETHYLACETAMIDE
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Wednesday, March 12, 1903 8:16AM
Sigma Chemical Co. Aldrich Chemical Co., Inc. Fluka Chemical Corp.
P.O. Box 14508 1001 West St. Paul 1001 West St. Paul
St. Louis, MO 63178 Milwaukee, WI 53233 Milwaukee, WI 53233
Phone: 314-771-5765 Phone: 414-273-3850 Phone: 414-273-3850
SECTION 1. - - - - - - - - - CHEMICAL IDENTIFICATION- - - - - - - - - -
CATALOG #: D5511
NAME: N,N-DIMETHYLACETAMIDE
SECTION 2. - - - - - COMPOSITION/INFORMATION ON INGREDIENTS - - - - - -
CAS #: 127-19-5
MF: C4H9NO
EC NO: 204-826-4
SYNONYMS
ACETDIMETHYLAMIDE * ACETIC ACID, DIMETHYLAMIDE * DIMETHYLACETAMIDE *
DIMETHYL ACETAMIDE (ACGIH:OSHA) * N,N-DIMETHYLACETAMIDE *
DIMETHYLACETONE AMIDE * DIMETHYLAMIDE ACETATE * DIMETHYLAMID KYSELINY
OCTOVE (CZECH) * DMA * DMAC * NSC 3138 * U-5954 *
SECTION 3. - - - - - - - - - - HAZARDS IDENTIFICATION - - - - - - - - -
LABEL PRECAUTIONARY STATEMENTS
HARMFUL
HARMFUL BY INHALATION, IN CONTACT WITH SKIN AND IF SWALLOWED.
IRRITATING TO EYES, RESPIRATORY SYSTEM AND SKIN.
POSSIBLE RISK OF HARM TO THE UNBORN CHILD.
COMBUSTIBLE.
READILY ABSORBED THROUGH SKIN.
TARGET ORGAN(S):
LIVER
KIDNEYS
IN CASE OF CONTACT WITH EYES, RINSE IMMEDIATELY WITH PLENTY OF
WATER AND SEEK MEDICAL ADVICE.
WEAR SUITABLE PROTECTIVE CLOTHING.
DO NOT BREATHE VAPOR.
SECTION 4. - - - - - - - - - - FIRST-AID MEASURES- - - - - - - - - - -
IN CASE OF CONTACT, IMMEDIATELY FLUSH EYES OR SKIN WITH COPIOUS
AMOUNTS OF WATER FOR AT LEAST 15 MINUTES WHILE REMOVING CONTAMINATED
CLOTHING AND SHOES.
IF INHALED, REMOVE TO FRESH AIR. IF NOT BREATHING GIVE ARTIFICIAL
RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN.
IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS.
CALL A PHYSICIAN.
WASH CONTAMINATED CLOTHING BEFORE REUSE.
SECTION 5. - - - - - - - - - FIRE FIGHTING MEASURES - - - - - - - - - -
EXTINGUISHING MEDIA
CARBON DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE FOAM.
SPECIAL FIREFIGHTING PROCEDURES
WEAR SELF-CONTAINED BREATHING APPARATUS AND PROTECTIVE CLOTHING TO
PREVENT CONTACT WITH SKIN AND EYES.
UNUSUAL FIRE AND EXPLOSIONS HAZARDS
COMBUSTIBLE.
EMITS TOXIC FUMES UNDER FIRE CONDITIONS.
SECTION 6. - - - - - - - - ACCIDENTAL RELEASE MEASURES- - - - - - - - -
EVACUATE AREA.
SHUT OFF ALL SOURCES OF IGNITION.
WEAR SELF-CONTAINED BREATHING APPARATUS, RUBBER BOOTS AND HEAVY
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PRODUCT #: D5511 NAME: N,N-DIMETHYLACETAMIDE
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Wednesday, March 12, 1903 8:16AM
RUBBER GLOVES.
ABSORB ON SAND OR VERMICULITE AND PLACE IN CLOSED CONTAINERS FOR
DISPOSAL.
VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE.
SECTION 7. - - - - - - - - - - HANDLING AND STORAGE- - - - - - - - - - -
REFER TO SECTION 8.
ADDITIONAL INFORMATION
REACTS EXOTHERMICALLY WITH HIGHLY HALOGENATED COMPOUNDS SUCH AS
CARBON TETRACHLORIDE, IN THE PRESENCE OF IRON.
SECTION 8. - - - - - - EXPOSURE CONTROLS/PERSONAL PROTECTION- - - - - -
WEAR APPROPRIATE NIOSH/MSHA-APPROVED RESPIRATOR, CHEMICAL-RESISTANT
GLOVES, SAFETY GOGGLES, OTHER PROTECTIVE CLOTHING.
USE ONLY IN A CHEMICAL FUME HOOD.
SAFETY SHOWER AND EYE BATH.
DO NOT BREATHE VAPOR.
DO NOT GET IN EYES, ON SKIN, ON CLOTHING.
AVOID PROLONGED OR REPEATED EXPOSURE.
READILY ABSORBED THROUGH SKIN.
WASH THOROUGHLY AFTER HANDLING.
IRRITANT.
POSSIBLE TERATOGEN.
KEEP TIGHTLY CLOSED.
KEEP AWAY FROM HEAT AND OPEN FLAME.
STORE IN A COOL DRY PLACE.
SECTION 9. - - - - - - - PHYSICAL AND CHEMICAL PROPERTIES - - - - - - -
APPEARANCE AND ODOR
LIQUID.
PHYSICAL PROPERTIES
BOILING POINT: 164.5 C TO 166 C
MELTING POINT: -20 C
FLASHPOINT 158F
70C
EXPLOSION LIMITS IN AIR:
UPPER 11.5% 160 C
LOWER 1.8% 100 C
AUTOIGNITION TEMPERATURE: 914 F 489C
VAPOR PRESSURE: 2MM 25 C 4MM 38 C
SPECIFIC GRAVITY: 0.937
VAPOR DENSITY: 3
SECTION 10. - - - - - - - - -STABILITY AND REACTIVITY - - - - - - - - -
INCOMPATIBILITIES
OXIDIZING AGENTS
HAZARDOUS COMBUSTION OR DECOMPOSITION PRODUCTS
THERMAL DECOMPOSITION MAY PRODUCE CARBON MONOXIDE, CARBON DIOXIDE,
AND NITROGEN OXIDES.
SECTION 11. - - - - - - - - - TOXICOLOGICAL INFORMATION - - - - - - - -
ACUTE EFFECTS
HARMFUL IF SWALLOWED, INHALED, OR ABSORBED THROUGH SKIN.
VAPOR OR MIST IS IRRITATING TO THE EYES, MUCOUS MEMBRANES AND UPPER
RESPIRATORY TRACT.
CAUSES SKIN IRRITATION.
CHRONIC EFFECTS
OVEREXPOSURE MAY CAUSE REPRODUCTIVE DISORDER(S) BASED ON TESTS WITH
LABORATORY ANIMALS.
TARGET ORGAN(S):
LIVER, KIDNEYS
CENTRAL NERVOUS SYSTEM
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PRODUCT #: D5511 NAME: N,N-DIMETHYLACETAMIDE
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Wednesday, March 12, 1903 8:16AM
TO THE BEST OF OUR KNOWLEDGE, THE CHEMICAL, PHYSICAL, AND
TOXICOLOGICAL PROPERTIES HAVE NOT BEEN THOROUGHLY INVESTIGATED.
RTECS #: AB7700000
ACETAMIDE, N,N-DIMETHYL-
IRRITATION DATA
SKN-RBT 10 MG/24H OPEN MLD AIHAAP 23,95,1962
EYE-RBT 100 MG MLD DCTODJ 9,147,1986
TOXICITY DATA
ORL-RAT LD50:4300 MG/KG GISAAA 45(6),76,1980
IHL-RAT LC50:2475 PPM/1H DCTODJ 9,147,1986
SKN-RAT LD50:>2 GM/KG EPASR* 8EHQ-1190-0981
IPR-RAT LD50:2750 MG/KG JRPFA4 4,219,1962
IVN-RAT LD50:2640 MG/KG ARZNAD 26,1581,1976
UNR-RAT LD50:3 GM/KG ARZNAD 19,1073,1969
ORL-MUS LD50:4620 MG/KG ARZNAD 26,1581,1976
IHL-MUS LC50:7200 MG/M3 CHYCDW 13,29,1979
SKN-MUS LD50:9600 MG/KG CHYCDW 13,29,1979
IPR-MUS LD50:2800 MG/KG YKIGAK 31,327,1980
IVN-MUS LD50:3020 MG/KG ARZNAD 26,1581,1976
SKN-RBT LD50:2240 MG/KG AIHAAP 23,95,1962
TARGET ORGAN DATA
LIVER (FATTY LIVER DEGENERATION)
PATERNAL EFFECTS (TESTES, EPIDIDYMIS, SPERM DUCT)
EFFECTS ON FERTILITY (POST-IMPLANTATION MORTALITY)
EFFECTS ON EMBRYO OR FETUS (FETOTOXICITY)
EFFECTS ON NEWBORN (GROWTH STATISTICS)
ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES
(RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR
COMPLETE INFORMATION.
SECTION 12. - - - - - - - - - ECOLOGICAL INFORMATION - - - - - - - - - -
DATA NOT YET AVAILABLE.
SECTION 13. - - - - - - - - - DISPOSAL CONSIDERATIONS - - - - - - - - -
THIS COMBUSTIBLE MATERIAL MAY BE BURNED IN A CHEMICAL INCINERATOR
EQUIPPED WITH AN AFTERBURNER AND SCRUBBER.
OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS.
SECTION 14. - - - - - - - - - - TRANSPORT INFORMATION - - - - - - - - -
CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION INFORMATION.
SECTION 15. - - - - - - - - - REGULATORY INFORMATION - - - - - - - - - -
EUROPEAN INFORMATION
EC INDEX NO: 616-011-00-4
HARMFUL
R 20/21
HARMFUL BY INHALATION AND IN CONTACT WITH SKIN.
R 36
IRRITATING TO EYES.
S 26
IN CASE OF CONTACT WITH EYES, RINSE IMMEDIATELY WITH PLENTY OF
WATER AND SEEK MEDICAL ADVICE.
S 28
AFTER CONTACT WITH SKIN, WASH IMMEDIATELY WITH PLENTY OF WATER.
S 36
WEAR SUITABLE PROTECTIVE CLOTHING.
REVIEWS, STANDARDS, AND REGULATIONS
OEL=MAK
ACGIH TLV-NOT CLASSIFIABLE AS A HUMAN CARCINOGEN DTLVS* TLV/BEI,1996
ACGIH TLV-TWA 36 MG/M3 (10 PPM) (SKIN) DTLVS* TLV/BEI,1996
MSHA STANDARD-AIR:TWA 10 PPM (35 MG/M3) (SKIN)
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PRODUCT #: D5511 NAME: N,N-DIMETHYLACETAMIDE
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Wednesday, March 12, 1903 8:16AM
DTLVS* 3,88,1971
OSHA PEL (GEN INDU):8H TWA 10 PPM (35 MG/M3) (SKIN)
CFRGBR 29,1910.1000,1994
OSHA PEL (CONSTRUC):8H TWA 10 PPM (35 MG/M3) (SKIN)
CFRGBR 29,1926.55,1994
OSHA PEL (SHIPYARD):8H TWA 10 PPM (35 MG/M3) (SKIN)
CFRGBR 29,1915.1000,1993
OSHA PEL (FED CONT):8H TWA 10 PPM (35 MG/M3) (SKIN)
CFRGBR 41,50-204.50,1994
OEL-AUSTRALIA:TWA 10 PPM (35 MG/M3);SKIN JAN 1993
OEL-BELGIUM:TWA 10 PPM (36 MG/M3);SKIN JAN 1993
OEL-DENMARK:TWA 10 PPM (35 MG/M3);SKIN JAN 1993
OEL-FINLAND:TWA 10 PPM (35 MG/M3);STEL 20 PPM (70 MG/M3);SKIN JAN 1993
OEL-FRANCE:TWA 10 PPM (35 MG/M3);SKIN JAN 1993
OEL-GERMANY:TWA 10 PPM (35 MG/M3);SKIN JAN 1993
OEL-THE NETHERLANDS:TWA 10 PPM (35 MG/M3);SKIN JAN 1993
OEL-THE PHILIPPINES:TWA 10 PPM (35 MG/M3);SKIN JAN 1993
OEL-SWITZERLAND:TWA 10 PPM (35 MG/M3);STEL 20 PPM ;SKIN JAN 1993
OEL-UNITED KINGDOM:TWA 10 PPM (35 MG/M3);STEL 15 PPM ;SKIN JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA CHECK ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM CHECK ACGIH TLV
NIOSH REL TO DIMETHYL ACETAMIDE-AIR:10H TWA 10 PPM (SK)
NIOSH* DHHS #92-100,1992
NOHS 1974: HZD 26095; NIS 5; TNF 66; NOS 13; TNE 7658
NOES 1983: HZD 26095; NIS 14; TNF 907; NOS 27; TNE 28943; TFE 15028
EPA TSCA SECTION 8(B) CHEMICAL INVENTORY
EPA TSCA SECTION 8(D) UNPUBLISHED HEALTH/SAFETY STUDIES
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, APRIL 1997
NIOSH ANALYTICAL METHOD, 1994: DIMETHYLACETAMIDE, 2004
SECTION 16. - - - - - - - - - - OTHER INFORMATION- - - - - - - - - - - -
THE ABOVE INFORMATION IS BELIEVED TO BE CORRECT BUT DOES NOT PURPORT TO
BE ALL INCLUSIVE AND SHALL BE USED ONLY AS A GUIDE. SIGMA, ALDRICH,
FLUKA SHALL NOT BE HELD LIABLE FOR ANY DAMAGE RESULTING FROM HANDLING
OR FROM CONTACT WITH THE ABOVE PRODUCT. SEE REVERSE SIDE OF INVOICE OR
PACKING SLIP FOR ADDITIONAL TERMS AND CONDITIONS OF SALE.
COPYRIGHT 1997 SIGMA CHEMICAL CO., ALDRICH CHEMICAL CO., INC.,
FLUKA CHEMIE AG
LICENSE GRANTED TO MAKE UNLIMITED PAPER COPIES FOR INTERNAL USE ONLY
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