PRODUCT #: 10490 NAME: P-ANISIDINE
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Monday, March 10, 1903 11:05AM
Sigma Chemical Co. Aldrich Chemical Co., Inc. Fluka Chemical Corp.
P.O. Box 14508 1001 West St. Paul 1001 West St. Paul
St. Louis, MO 63178 Milwaukee, WI 53233 Milwaukee, WI 53233
Phone: 314-771-5765 Phone: 414-273-3850 Phone: 414-273-3850
SECTION 1. - - - - - - - - - CHEMICAL IDENTIFICATION- - - - - - - - - -
CATALOG #: 10490
NAME: P-ANISIDINE
SECTION 2. - - - - - COMPOSITION/INFORMATION ON INGREDIENTS - - - - - -
CAS #: 104-94-9
MF: C7H9NO
EC NO: 203-254-2
SYNONYMS
P-AMINOANISOLE * 4-AMINOANISOLE * 1-AMINO-4-METHOXYBENZENE * ANILINE,
P-METHOXY- * 4-ANISIDINE * P-ANISIDINE (ACGIH:OSHA) * ANISOLE, P-
AMINO- * P-ANISYLAMINE * BENZENAMINE, 4-METHOXY- (9CI) * 4-METHOXY-1-
AMINOBENZENE * P-METHOXYANILINE * 4-METHOXYANILINE * 4-
METHOXYBENZENAMINE * 4-METHOXYBENZENEAMINE * P-METHOXYPHENYLAMINE *
SECTION 3. - - - - - - - - - - HAZARDS IDENTIFICATION - - - - - - - - -
LABEL PRECAUTIONARY STATEMENTS
HARMFUL
HARMFUL BY INHALATION, IN CONTACT WITH SKIN AND IF SWALLOWED.
IRRITATING TO EYES, RESPIRATORY SYSTEM AND SKIN.
MAY CAUSE SENSITIZATION BY INHALATION AND SKIN CONTACT.
TARGET ORGAN(S):
BLOOD
IN CASE OF CONTACT WITH EYES, RINSE IMMEDIATELY WITH PLENTY OF
WATER AND SEEK MEDICAL ADVICE.
WEAR SUITABLE PROTECTIVE CLOTHING.
SECTION 4. - - - - - - - - - - FIRST-AID MEASURES- - - - - - - - - - -
IN CASE OF CONTACT, IMMEDIATELY FLUSH EYES OR SKIN WITH COPIOUS
AMOUNTS OF WATER FOR AT LEAST 15 MINUTES WHILE REMOVING CONTAMINATED
CLOTHING AND SHOES.
IF INHALED, REMOVE TO FRESH AIR. IF NOT BREATHING GIVE ARTIFICIAL
RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN.
IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS.
CALL A PHYSICIAN.
WASH CONTAMINATED CLOTHING BEFORE REUSE.
SECTION 5. - - - - - - - - - FIRE FIGHTING MEASURES - - - - - - - - - -
EXTINGUISHING MEDIA
WATER SPRAY.
CARBON DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE FOAM.
SPECIAL FIREFIGHTING PROCEDURES
WEAR SELF-CONTAINED BREATHING APPARATUS AND PROTECTIVE CLOTHING TO
PREVENT CONTACT WITH SKIN AND EYES.
UNUSUAL FIRE AND EXPLOSIONS HAZARDS
EMITS TOXIC FUMES UNDER FIRE CONDITIONS.
SECTION 6. - - - - - - - - ACCIDENTAL RELEASE MEASURES- - - - - - - - -
EVACUATE AREA.
WEAR SELF-CONTAINED BREATHING APPARATUS, RUBBER BOOTS AND HEAVY
RUBBER GLOVES.
ABSORB ON SAND OR VERMICULITE AND PLACE IN CLOSED CONTAINERS FOR
DISPOSAL.
VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE.
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PRODUCT #: 10490 NAME: P-ANISIDINE
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Monday, March 10, 1903 11:05AM
SECTION 7. - - - - - - - - - - HANDLING AND STORAGE- - - - - - - - - - -
REFER TO SECTION 8.
SECTION 8. - - - - - - EXPOSURE CONTROLS/PERSONAL PROTECTION- - - - - -
WEAR APPROPRIATE NIOSH/MSHA-APPROVED RESPIRATOR, CHEMICAL-RESISTANT
GLOVES, SAFETY GOGGLES, OTHER PROTECTIVE CLOTHING.
SAFETY SHOWER AND EYE BATH.
USE ONLY IN A CHEMICAL FUME HOOD.
DO NOT BREATHE VAPOR.
AVOID CONTACT WITH EYES, SKIN AND CLOTHING.
READILY ABSORBED THROUGH SKIN.
WASH THOROUGHLY AFTER HANDLING.
IRRITANT.
SENSITIZER.
KEEP TIGHTLY CLOSED.
STORE IN A COOL DRY PLACE.
SECTION 9. - - - - - - - PHYSICAL AND CHEMICAL PROPERTIES - - - - - - -
APPEARANCE AND ODOR
BROWN CRYSTALLINE CHIPS
PHYSICAL PROPERTIES
MELTING POINT: 56 TO 59C
FLASHPOINT 251.60F
122C
AUTOIGNITION TEMPERATURE: 959 F 514C
SECTION 10. - - - - - - - - -STABILITY AND REACTIVITY - - - - - - - - -
INCOMPATIBILITIES
ACIDS
ACID CHLORIDES
ACID ANHYDRIDES
CHLOROFORMATES
STRONG OXIDIZING AGENTS
HAZARDOUS COMBUSTION OR DECOMPOSITION PRODUCTS
TOXIC FUMES OF:
CARBON MONOXIDE, CARBON DIOXIDE
NITROGEN OXIDES
SECTION 11. - - - - - - - - - TOXICOLOGICAL INFORMATION - - - - - - - -
ACUTE EFFECTS
HARMFUL IF SWALLOWED, INHALED, OR ABSORBED THROUGH SKIN.
VAPOR OR MIST IS IRRITATING TO THE EYES, MUCOUS MEMBRANES AND UPPER
RESPIRATORY TRACT.
CAUSES SKIN IRRITATION.
ABSORPTION INTO THE BODY LEADS TO THE FORMATION OF METHEMOGLOBIN
WHICH IN SUFFICIENT CONCENTRATION CAUSES CYANOSIS. ONSET MAY BE
DELAYED 2 TO 4 HOURS OR LONGER.
CHRONIC EFFECTS
MAY CAUSE ALLERGIC RESPIRATORY AND SKIN REACTIONS.
TARGET ORGAN(S):
BLOOD
RTECS #: BZ5450000
P-ANISIDINE
TOXICITY DATA
ORL-RAT LD50:1320 MG/KG TLSMA6 128,14,1979
SKN-RAT LD50:3200 MG/KG AGGHAR 15,447,1957
IPR-RAT LD50:1400 MG/KG AGGHAR 15,447,1957
ORL-MUS LD50:1410 MG/KG ATDAEI 1,184,1992
IPR-MUS LD50:806 MG/KG JMCMAR 17,900,1974
ORL-RBT LD50:2900 MG/KG IMEMDT 27,63,1982
TARGET ORGAN DATA
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PRODUCT #: 10490 NAME: P-ANISIDINE
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Monday, March 10, 1903 11:05AM
SENSE ORGANS AND SPECIAL SENSES (OTHER EYE EFFECTS)
BEHAVIORAL (ALTERED SLEEP TIME)
BEHAVIORAL (ATAXIA)
ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES
(RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR
COMPLETE INFORMATION.
SECTION 12. - - - - - - - - - ECOLOGICAL INFORMATION - - - - - - - - - -
DATA NOT YET AVAILABLE.
SECTION 13. - - - - - - - - - DISPOSAL CONSIDERATIONS - - - - - - - - -
DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE SOLVENT AND BURN IN A
CHEMICAL INCINERATOR EQUIPPED WITH AN AFTERBURNER AND SCRUBBER.
OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS.
SECTION 14. - - - - - - - - - - TRANSPORT INFORMATION - - - - - - - - -
CONTACT FLUKA CHEMICAL COMPANY FOR TRANSPORTATION INFORMATION.
SECTION 15. - - - - - - - - - REGULATORY INFORMATION - - - - - - - - - -
EUROPEAN INFORMATION
EC INDEX NO: 612-112-00-4
HARMFUL
R 26/27/28
VERY TOXIC BY INHALATION, IN CONTACT WITH SKIN AND IF SWALLOWED.
R 33
DANGER OF CUMULATIVE EFFECTS.
R 50
VERY TOXIC TO AQUATIC ORGANISMS.
S 28
AFTER CONTACT WITH SKIN, WASH IMMEDIATELY WITH PLENTY OF WATER.
S 36/37
WEAR SUITABLE PROTECTIVE CLOTHING AND GLOVES.
S 45
IN CASE OF ACCIDENT OR IF YOU FEEL UNWELL, SEEK MEDICAL ADVICE
IMMEDIATELY (SHOW THE LABEL WHERE POSSIBLE).
S 61
AVOID RELEASE TO THE ENVIRONMENT. REFER TO SPECIAL INSTRUCTIONS/
SAFETY DATA SHEETS.
REVIEWS, STANDARDS, AND REGULATIONS
OEL=MAK
ACGIH TLV-NOT CLASSIFIABLE AS A HUMAN CARCINOGEN DTLVS* TLV/BEI,1996
ACGIH TLV-TWA 0.5 MG/M3 (0.1 PPM) (SKIN) DTLVS* TLV/BEI,1996
IARC CANCER REVIEW:HUMAN NO ADEQUATE DATA IMEMDT 27,63,1982
IARC CANCER REVIEW:GROUP 3 IMSUDL 7,56,1987
MSHA STANDARD-AIR:TWA 0.1 PPM (0.5 MG/M3) (SKIN)
DTLWS* 3,10,1973
OSHA PEL (GEN INDU):8H TWA 0.5 MG/M3 (SKIN)
CFRGBR 29,1910.1000,1994
OSHA PEL (CONSTRUC):8H TWA 0.5 MG/M3 (SKIN)
CFRGBR 29,1926.55,1994
OSHA PEL (SHIPYARD):8H TWA 0.5 MG/M3 (SKIN)
CFRGBR 29,1915.1000,1993
OSHA PEL (FED CONT):8H TWA 0.5 MG/M3 (SKIN)
CFRGBR 41,50-204.50,1994
OEL-AUSTRALIA:TWA 0.1 PPM (0.5 MG/M3);SKIN JAN 1993
OEL-AUSTRIA:TWA 0.1 PPM (0.5 MG/M3);SKIN JAN 1993
OEL-BELGIUM:TWA 0.1 PPM (0.5 MG/M3);SKIN JAN 1993
OEL-DENMARK:TWA 0.1 PPM (0.5 MG/M3);SKIN JAN 1993
OEL-FINLAND:TWA 0.5 MG/M3;STEL 1.5 MG/M3;SKIN;CARCINOGEN JAN 1993
OEL-FRANCE:TWA 0.1 PPM (0.5 MG/M3);SKIN;CARCINOGEN JAN 1993
OEL-GERMANY:TWA 0.1 PPM (0.5 MG/M3);SKIN JAN 1993
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PRODUCT #: 10490 NAME: P-ANISIDINE
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Monday, March 10, 1903 11:05AM
OEL-INDIA:TWA 0.1 PPM (0.5 MG/M3);SKIN JAN 1993
OEL-THE NETHERLANDS:TWA 0.1 PPM (0.5 MG/M3);SKIN JAN 1993
OEL-THE PHILIPPINES:TWA 0.5 MG/M3;SKIN JAN 1993
OEL-RUSSIA:STEL 1 MG/M3;SKIN JAN 1993
OEL-SWITZERLAND:TWA 0.1 PPM (0.5 MG/M3);STEL 0.2 PPM;SKIN JAN 1993
OEL-UNITED KINGDOM:TWA 0.1 PPM (0.5 MG/M3);SKIN JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA CHECK ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM CHECK ACGIH TLV
NIOSH REL TO P-ANISIDINE-AIR:10H TWA 0.5 MG/M3 (SK)
NIOSH* DHHS #92-100,1992
EPA TSCA SECTION 8(B) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, APRIL 1997
NIOSH ANALYTICAL METHOD, 1994: ANISIDINE, 2514
NTP CARCINOGENESIS STUDIES; LABORATORY ASSIGNED, APRIL 1997
U.S. INFORMATION
THIS PRODUCT IS SUBJECT TO SARA SECTION 313 REPORTING REQUIREMENTS.
SECTION 16. - - - - - - - - - - OTHER INFORMATION- - - - - - - - - - - -
THE ABOVE INFORMATION IS BELIEVED TO BE CORRECT BUT DOES NOT PURPORT TO
BE ALL INCLUSIVE AND SHALL BE USED ONLY AS A GUIDE. SIGMA, ALDRICH,
FLUKA SHALL NOT BE HELD LIABLE FOR ANY DAMAGE RESULTING FROM HANDLING
OR FROM CONTACT WITH THE ABOVE PRODUCT. SEE REVERSE SIDE OF INVOICE OR
PACKING SLIP FOR ADDITIONAL TERMS AND CONDITIONS OF SALE.
COPYRIGHT 1997 SIGMA CHEMICAL CO., ALDRICH CHEMICAL CO., INC.,
FLUKA CHEMIE AG
LICENSE GRANTED TO MAKE UNLIMITED PAPER COPIES FOR INTERNAL USE ONLY
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