PRODUCT #: R2625 NAME: ALL TRANS-RETINOIC ACID
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Thursday, March 13, 1903 3:51PM
Sigma Chemical Co. Aldrich Chemical Co., Inc. Fluka Chemical Corp.
P.O. Box 14508 1001 West St. Paul 1001 West St. Paul
St. Louis, MO 63178 Milwaukee, WI 53233 Milwaukee, WI 53233
Phone: 314-771-5765 Phone: 414-273-3850 Phone: 414-273-3850
SECTION 1. - - - - - - - - - CHEMICAL IDENTIFICATION- - - - - - - - - -
CATALOG #: R2625
NAME: ALL TRANS-RETINOIC ACID
SECTION 2. - - - - - COMPOSITION/INFORMATION ON INGREDIENTS - - - - - -
CAS #: 302-79-4
MF: C20H28O2
EC NO: 206-129-0
SYNONYMS
ABEREL * AIROL * AKNOTEN * CORDES VAS * DERMAIROL * 3,7-DIMETHYL-9-(2,
6,6-TRIMETHYL-1-CYCLOHEXEN-1-YL)-2,4,6,8-NONATETRAENOIC ACID *
EFFEDERM * EPI-ABEREL * EUDYNA * 2,4,6,8-NONATETRAENOIC ACID, 3,7-
DIMETHYL-9-(2,6,6-TRIMETHYL-1-CYCLOHEXEN-1-YL)- * NSC-122758 * BETA-
RA * RETIN-A * RETINOIC ACID * BETA-RETINOIC ACID * TRANS-RETINOIC
ACID * ALL-TRANS-RETINOIC ACID * TRETINOIN * BETA-ALL-TRANS-RETINOIC
ACID * VITAMIN A ACID *
SECTION 3. - - - - - - - - - - HAZARDS IDENTIFICATION - - - - - - - - -
LABEL PRECAUTIONARY STATEMENTS
TOXIC (USA)
HARMFUL (EU)
HARMFUL BY INHALATION, IN CONTACT WITH SKIN AND IF SWALLOWED.
IRRITATING TO EYES, RESPIRATORY SYSTEM AND SKIN.
POSSIBLE RISK OF HARM TO THE UNBORN CHILD.
REPRODUCTIVE HAZARD.
POSSIBLE MUTAGEN.
DO NOT BREATHE DUST.
IN CASE OF CONTACT WITH EYES, RINSE IMMEDIATELY WITH PLENTY OF
WATER AND SEEK MEDICAL ADVICE.
WEAR SUITABLE PROTECTIVE CLOTHING.
SECTION 4. - - - - - - - - - - FIRST-AID MEASURES- - - - - - - - - - -
IN CASE OF CONTACT, IMMEDIATELY FLUSH EYES WITH COPIOUS AMOUNTS OF
WATER FOR AT LEAST 15 MINUTES.
IN CASE OF CONTACT, IMMEDIATELY WASH SKIN WITH SOAP AND COPIOUS
AMOUNTS OF WATER.
IF INHALED, REMOVE TO FRESH AIR. IF NOT BREATHING GIVE ARTIFICIAL
RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN.
IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS.
CALL A PHYSICIAN.
WASH CONTAMINATED CLOTHING BEFORE REUSE.
SECTION 5. - - - - - - - - - FIRE FIGHTING MEASURES - - - - - - - - - -
EXTINGUISHING MEDIA
WATER SPRAY.
CARBON DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE FOAM.
SPECIAL FIREFIGHTING PROCEDURES
WEAR SELF-CONTAINED BREATHING APPARATUS AND PROTECTIVE CLOTHING TO
PREVENT CONTACT WITH SKIN AND EYES.
UNUSUAL FIRE AND EXPLOSIONS HAZARDS
EMITS TOXIC FUMES UNDER FIRE CONDITIONS.
SECTION 6. - - - - - - - - ACCIDENTAL RELEASE MEASURES- - - - - - - - -
WEAR RESPIRATOR, CHEMICAL SAFETY GOGGLES, RUBBER BOOTS AND HEAVY
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PRODUCT #: R2625 NAME: ALL TRANS-RETINOIC ACID
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Thursday, March 13, 1903 3:51PM
RUBBER GLOVES.
SWEEP UP, PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL.
AVOID RAISING DUST.
VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE.
SECTION 7. - - - - - - - - - - HANDLING AND STORAGE- - - - - - - - - - -
REFER TO SECTION 8.
SECTION 8. - - - - - - EXPOSURE CONTROLS/PERSONAL PROTECTION- - - - - -
CHEMICAL SAFETY GOGGLES.
NIOSH/MSHA-APPROVED RESPIRATOR.
USE ONLY IN A CHEMICAL FUME HOOD.
COMPATIBLE CHEMICAL-RESISTANT GLOVES.
SAFETY SHOWER AND EYE BATH.
AVOID BREATHING DUST.
AVOID CONTACT WITH EYES, SKIN AND CLOTHING.
AVOID PROLONGED OR REPEATED EXPOSURE.
WASH THOROUGHLY AFTER HANDLING.
IRRITANT.
POSSIBLE MUTAGEN/TERATOGEN.
REPRODUCTIVE HAZARD.
KEEP TIGHTLY CLOSED.
LIGHT SENSITIVE
REFRIGERATE.
SECTION 9. - - - - - - - PHYSICAL AND CHEMICAL PROPERTIES - - - - - - -
APPEARANCE AND ODOR
SOLID.
PHYSICAL PROPERTIES
MELTING POINT: 180 C TO 181 C
SECTION 10. - - - - - - - - -STABILITY AND REACTIVITY - - - - - - - - -
INCOMPATIBILITIES
STRONG OXIDIZING AGENTS
MAY DISCOLOR ON EXPOSURE TO LIGHT.
HAZARDOUS COMBUSTION OR DECOMPOSITION PRODUCTS
TOXIC FUMES OF:
CARBON MONOXIDE, CARBON DIOXIDE
SECTION 11. - - - - - - - - - TOXICOLOGICAL INFORMATION - - - - - - - -
ACUTE EFFECTS
HARMFUL IF SWALLOWED, INHALED, OR ABSORBED THROUGH SKIN.
CAUSES EYE AND SKIN IRRITATION.
MATERIAL IS IRRITATING TO MUCOUS MEMBRANES AND UPPER
RESPIRATORY TRACT.
CHRONIC EFFECTS
OVEREXPOSURE MAY CAUSE REPRODUCTIVE DISORDER(S) BASED ON TESTS WITH
LABORATORY ANIMALS.
LABORATORY EXPERIMENTS HAVE SHOWN MUTAGENIC EFFECTS.
TO THE BEST OF OUR KNOWLEDGE, THE CHEMICAL, PHYSICAL, AND
TOXICOLOGICAL PROPERTIES HAVE NOT BEEN THOROUGHLY INVESTIGATED.
RTECS #: VH6475000
RETINOIC ACID, ALL-TRANS-
IRRITATION DATA
SKN-HMN 525 MG/21D-I MLD AVSUAR 74,128,1975
TOXICITY DATA
ORL-RAT LD50:1960 MG/KG KSRNAM 7,3194,1973
IPR-RAT LD50:96 MG/KG KSRNAM 7,3194,1973
SCU-RAT LD50:53 MG/KG KSRNAM 7,3194,1973
IVN-RAT LD50:78 MG/KG KSRNAM 7,3194,1973
ORL-MUS LD50:780 MG/KG USXXAM #3878202
IPR-MUS LD50:216 MG/KG VOONAW 25(12),84,1979
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PRODUCT #: R2625 NAME: ALL TRANS-RETINOIC ACID
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Thursday, March 13, 1903 3:51PM
SCU-MUS LD50:253 MG/KG KSRNAM 7,3194,1973
IVN-MUS LD50:92 MG/KG USXXAM #3878202
TARGET ORGAN DATA
SPINAL CORD (OTHER DEGENERATIVE CHANGES)
SENSE ORGANS AND SPECIAL SENSES (OTHER OLFACTION EFFECTS)
BEHAVIORAL (SLEEP)
BEHAVIORAL (SOMNOLENCE)
BEHAVIORAL (HALLUCINATIONS, DISTORTED PERCEPTIONS)
BEHAVIORAL (ATAXIA)
LUNGS, THORAX OR RESPIRATION (RESPIRATORY DEPRESSION)
GASTROINTESTINAL (HYPERMOTILITY, DIARRHEA)
BLOOD (NORMOCYTIC ANEMIA)
EFFECTS ON FERTILITY (POST-IMPLANTATION MORTALITY)
EFFECTS ON EMBRYO OR FETUS (CYTOLOGICAL CHANGES)
EFFECTS ON EMBRYO OR FETUS (FETOTOXICITY)
EFFECTS ON EMBRYO OR FETUS (FETAL DEATH)
EFFECTS ON EMBRYO OR FETUS (OTHER EFFECTS TO EMBYRO OR FETUS)
SPECIFIC DEVELOPMENTAL ABNORMALITIES (CENTRAL NERVOUS SYSTEM)
SPECIFIC DEVELOPMENTAL ABNORMALITIES (EYE, EAR)
SPECIFIC DEVELOPMENTAL ABNORMALITIES (CRANIOFACIAL)
SPECIFIC DEVELOPMENTAL ABNORMALITIES (MUSCULOSKELETAL SYSTEM)
SPECIFIC DEVELOPMENTAL ABNORMALITIES (CARDIOVASCULAR SYSTEM)
SPECIFIC DEVELOPMENTAL ABNORMALITIES (GASTROINTESTINAL SYSTEM)
SPECIFIC DEVELOPMENTAL ABNORMALITIES (UROGENITAL SYSTEM)
EFFECTS ON NEWBORN (WEANING OR LACTATION INDEX)
EFFECTS ON NEWBORN (BEHAVIORAL)
NUTRITIONAL AND GROSS METABOLIC (WEIGHT LOSS OR DECREASED WEIGHT GAIN)
ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES
(RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR
COMPLETE INFORMATION.
SECTION 12. - - - - - - - - - ECOLOGICAL INFORMATION - - - - - - - - - -
DATA NOT YET AVAILABLE.
SECTION 13. - - - - - - - - - DISPOSAL CONSIDERATIONS - - - - - - - - -
DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE SOLVENT AND BURN IN A
CHEMICAL INCINERATOR EQUIPPED WITH AN AFTERBURNER AND SCRUBBER.
OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS.
SECTION 14. - - - - - - - - - - TRANSPORT INFORMATION - - - - - - - - -
CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION INFORMATION.
SECTION 15. - - - - - - - - - REGULATORY INFORMATION - - - - - - - - - -
EUROPEAN INFORMATION
HARMFUL
R 20/21/22
HARMFUL BY INHALATION, IN CONTACT WITH SKIN AND IF SWALLOWED.
R 36/37/38
IRRITATING TO EYES, RESPIRATORY SYSTEM AND SKIN.
R 63
POSSIBLE RISK OF HARM TO THE UNBORN CHILD.
S 22
DO NOT BREATHE DUST.
S 26
IN CASE OF CONTACT WITH EYES, RINSE IMMEDIATELY WITH PLENTY OF
WATER AND SEEK MEDICAL ADVICE.
S 36
WEAR SUITABLE PROTECTIVE CLOTHING.
REVIEWS, STANDARDS, AND REGULATIONS
OEL=MAK
EPA GENETOX PROGRAM 1988, POSITIVE/DOSE RESPONSE: IN VITRO SCE-HUMAN
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PRODUCT #: R2625 NAME: ALL TRANS-RETINOIC ACID
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Thursday, March 13, 1903 3:51PM
EPA TSCA SECTION 8(B) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, APRIL 1997
U.S. INFORMATION
CALIFORNIA PROPOSITION 65:
THIS PRODUCT IS OR CONTAINS CHEMICAL(S) KNOWN TO THE STATE OF
CALIFORNIA TO CAUSE DEVELOPMENTAL TOXICITY.
SECTION 16. - - - - - - - - - - OTHER INFORMATION- - - - - - - - - - - -
THE ABOVE INFORMATION IS BELIEVED TO BE CORRECT BUT DOES NOT PURPORT TO
BE ALL INCLUSIVE AND SHALL BE USED ONLY AS A GUIDE. SIGMA, ALDRICH,
FLUKA SHALL NOT BE HELD LIABLE FOR ANY DAMAGE RESULTING FROM HANDLING
OR FROM CONTACT WITH THE ABOVE PRODUCT. SEE REVERSE SIDE OF INVOICE OR
PACKING SLIP FOR ADDITIONAL TERMS AND CONDITIONS OF SALE.
COPYRIGHT 1997 SIGMA CHEMICAL CO., ALDRICH CHEMICAL CO., INC.,
FLUKA CHEMIE AG
LICENSE GRANTED TO MAKE UNLIMITED PAPER COPIES FOR INTERNAL USE ONLY
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