Akzo Nobel Functional Chemicals LLC
MATERIAL SAFETY DATA SHEET
Dissolvine庐 E-39
SECTION 1. CHEMICAL PRODUCT AND COMPANY INFORMATION
Dissolvine庐 E-39
Product Name:
Ethylenediaminetetraacetic acid, tetrasodium salt in water
Chemical Name:
Tetrasodium EDTA
Synonym:
64-02-8
C.A.S. Registry No.:
(NaO 鈥? CO 鈥? CH2]2 鈥? N 鈥? CH2 鈥? CH2 鈥? N 鈥? (CH2 鈥? CO 鈥? NaO]2
Chemical Formula:
Chelating agent, sequestering agent
Product Use:
Manufacturer / Supplier
Akzo Nobel Functional Chemicals LLC
525 West Van Buren St., Chicago, IL 60607-3823
Tel. [Product & Technical Information]: 1-800-906-7979
Emergency Telephone Numbers
TRANSPORTATION EMERGENCIES 1-800-424-9300 [USA 鈥? Chemtrec]
1-613-996-6666 [Canada 鈥? Canutec]
MEDICAL / HANDLING EMERGENCIES: 1-914-693-6946 [Akzo Nobel - USA]
June 20, 1995
Date of First Issue: Revision No.: 15.0
Revision Date: July 1, 2004 Changes: Sections 1, 3, 6, 9, 11, 12, 15
SECTION 2. COMPOSITION / INFORMATION ON INGREDIENTS
[See section 8 for exposure limits]
INGREDIENTS % (w/w) CAS Number
Tetrasodium EDTA 37.0 鈥? 41.0 64-02-8
Water 53.5 鈥? 59.5 7732-18-5
Sodium hydroxide 0.5 鈥? 1.9 1310-73-2
Trisodium Nitrilotriacetic acid (NTA) 1.0 鈥? 2.0 5064-31-3
SECTION 3. HAZARDS INFORMATION
EMERGENCY OVERVIEW
Appearance and odor: Clear yellow liquid with a slight ammonia odor.
WARNING !
Causes eye irritation.
Corrosive to aluminum.
Contains a small amount of impurity (Trisodium NTA) which has been shown to cause kidney
damage as well as being a possible carcinogenic substance (based on animal data).
Primary Route(s) of Exposure: Skin contact, eye contact and inhalation.
POTENTIAL HEALTH EFFECTS
Inhalation 鈥? Acute Exposure: Exposure to an excessive concentration of vapor, mist or aerosol may cause
respiratory tract discomfort.
Skin Contact 鈥? Acute Exposure: Skin contact is not expected to cause irritation.
Eye Contact 鈥? Acute Exposure: Eye contact may cause moderate irritation.
Issue date: 1-Jul-04 MSDS No.: 16 鈥? 075383
Expiry date: 1-Jul-07 Page 1 / 7
Material Safety Data Sheet
Dissolvine庐 E-39
Akzo Nobel Functional Chemicals LLC
SECTION 3. HAZARDS IDENTIFICATION (CONTINUED)
Ingestion 鈥? Acute Exposure: This product has a low order of acute toxicity.
Carcinogenicity: IARC, NTP ACGIH and OSHA do not classify this material or its components as a carcinogen
or suspect carcinogen. However, nitrilotriacetic acid (NTA) and its salts were determined to be 鈥減ossibly
carcinogenic to humans鈥? (Group 2B) by IARC, a compound which 鈥渕ay reasonably be anticipated to be a
carcinogen鈥? by NTP and a 鈥渟elect carcinogen鈥? by OSHA.
SECTION 4. FIRST AID MEASURES
Inhalation: Remove victim to fresh air. If breathing becomes difficult, oxygen may be given, preferably under
physician鈥檚 advice. If breathing has stopped, give artificial respiration. Get medical attention.
Skin Contact: Remove contaminated clothing, shoes and equipment. Wash all affected areas with soap and
plenty of water. Wash contaminated clothing and shoes before reuse. Get medical attention if irritation occurs or
persists.
Eye Contact: Flush eyes with large quantities of running water for a minimum of 15 minutes. If the victim is
wearing contact lenses, remove them. Hold the eyelids apart during the flushing to ensure rinsing of the
entire surface of the eye and lids with water. DO NOT let victim rub eye(s). Do not attempt to neutralize with
chemical agents. Oils or ointments should not be used at this time. Get medical attention if eye irritation occurs.
Ingestion: Give several glasses of water. DO NOT induce vomiting. If vomiting occurs keep head below hips to
reduce risk of aspiration. Give fluids again. Never give anything by mouth to a person who is unconscious or
convulsing. Get medical attention if health effects occur.
Medical conditions aggravated: There are no data available that address medical conditions that are generally
recognized as being aggravated by exposure to this product.
Note to Physician: Attending physician should treat exposed patients symptomatically.
SECTION 5. FIRE FIGHTING MEASURES
not flammable or combustible
Conditions of Flammability:
not applicable
Flash Point (Method):
not determined
Upper Flammable Limit (% by volume):
not determined
Lower Flammable Limit (% by volume):
not determined
Auto-Ignition Temperature:
Extinguishing Media: Use water fog or spray, dry chemical, foam or carbon dioxide extinguishing agents.
Fire Fighting Procedures: As in any fire, prevent human exposure to fire, smoke, fumes or products of
combustion. Evacuate all non-essential personnel from the fire area. Fire fighters should wear full-face, self-
contained breathing apparatus and impervious protective clothing.
Fire & Explosion Hazards: This product is not defined as flammable or combustible and should not be a fire
hazard. Under fire conditions, it does not contribute any unusual hazards.
Hazardous Combustion Products: Thermal decomposition products may release toxic and/or hazardous
fumes and gases, including nitrogen oxides and carbon oxides.
NPFA Hazard Rating 鈥? Health: 2 Fire: 1 Reactivity: 0 Other: None
[ 0 鈥? Minimal 1 - Slight 2 - Moderate 3 - High 4 - Extreme * - Chronic Health Hazard (see Section 11)]
Issue date: 1-Jul-04 MSDS No.: 16 鈥? 075383
Expiry date: 1-Jul-07 Page 2 / 7
Material Safety Data Sheet
Dissolvine庐 E-39
Akzo Nobel Functional Chemicals LLC
SECTION 6. ACCIDENTAL RELEASE MEASURES
Cleanup: Safely stop source of spill. Dike area to prevent spill from spreading. Restrict non-essential
personnel from area. All personnel involved in spill cleanup should follow good industrial hygiene practices and
avoid skin and eye contact by wearing appropriate personal protective equipment. Soak up liquid with a suitable
absorbent such as clay, sawdust or kitty litter. Sweep up absorbed material and place in a chemical waste
container for disposal. Then flush area with water.
SECTION 7. HANDLING AND STORAGE
Handling: Avoid inhalation and prolonged and/or repeated skin and eye contact.
Storage: Keep containers closed and dry. This material is suitable for any general chemical storage area.
Isolate from incompatible materials such as strong oxidizing agents. Store in PVC, PE, stainless steel or
bituminized tanks. Avoid contact with aluminum, copper, copper alloys, nickel and zinc.
Maximum Storage Temperature: Store in sealed or original containers at temperatures between 0 and 35掳C.
General Comments: Containers should not be opened until ready for use. It is recommended that products be
retested if stored for more than 3 years. Under ideal storage conditions, the shelf-life is almost indefinite.
SECTION 8. EXPOSURE CONTROL / PERSONAL PROTECTION
Respiratory Protection: Use of respiratory protection is generally not required. However, if use conditions
generate vapor, mist or aerosol and adequate ventilation (e.g., outdoor or well-ventilated area) is not available,
use a NIOSH-approved organic vapor respirator with dust, mist and fume filters to reduce potential for inhalation
exposure. Where exposure potential necessitates a higher level of protection, use a NIOSH-approved, positive-
pressure/pressure-demand, air-supplied respirator. When using respirator cartridges or canisters, they must be
changed frequently (following each use or at the end of the work shift) to assure breakthrough exposure does
not occur.
Skin Protection: Skin contact with the product should be minimized through the use of suitable protective
clothing, gloves and footwear selected according to use condition exposure potential.
Eye Protection: Since eye contact causes irritation, chemical goggles and/or a face shield should be worn
when handling this product.
Ventilation: Special ventilation is usually not required under normal use conditions. However, ensure that
existing ventilation is sufficient to prevent the circulation and/or accumulation of vapor in the air.
Other Protection: All food and smoking materials should be kept in a separate area away from the storage/use
location. Eating, drinking and smoking should be prohibited in areas where there is a potential for significant
exposure to this material. Before eating, drinking and smoking, hands and face should be thoroughly washed.
Applicable Exposure Limits: Other than any exposure limits which may be displayed below, there are no other
known exposure limits applicable to this product or its components.
OSHA 鈥? PELs ACGIH 鈥? TLVs NIOSH 鈥? RELs
3
(mg / m3) (mg / m3)
(mg / m )
SUPPLIER
Chemical Name
STEL / STEL / STEL /
TWA TWA TWA
CEIL(C) CEIL(C) CEIL(C)
N/D N/D N/D N/D N/D N/D N/D
Tetrasodium EDTA
2.0 N/D N/D 2.0 (C) N/D 2.0 (C) N/D
Sodium hydroxide
N/D N/D N/D N/D N/D N/D N/D
Trisodium NTA
N/D N/D N/D N/D N/D N/D N/D
Water
Issue date: 1-Jul-04 MSDS No.: 16 鈥? 075383
Expiry date: 1-Jul-07 Page 3 / 7
Material Safety Data Sheet
Dissolvine庐 E-39
Akzo Nobel Functional Chemicals LLC
SECTION 8. EXPOSURE CONTROL / PERSONAL PROTECTION (CONTINUED)
[Ref: ACGIH Guide to Occupational Exposure Values, 2004 Edition]
Legend :
CEIL : Ceiling Exposure Limit PEL : Permissible Exposure Limit REL: Recommended Exposure Limit
STEL : Short Term Exposure Limit TLV : Threshold Limit Value TWA : Time-Weighted Average
N/D : Not Determined
SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES
clear yellow liquid with a slight ammonia odor
Physical State / Appearance / Odor:
224.6掳F (107.0掳C)
Boiling Point:
not determined
Bulk Density:
not determined
Cloud Point:
not determined
Coefficient of oil/water distribution:
not determined
Evaporation Rate (Butyl Acetate=1):
< 0掳F (-18掳C) / freezing point
Melting Point:
not determined
Odor Threshold:
鈮? 11.5 (1% solution) ; 13.5 (as is)
pH:
not determined
Pour Point:
miscible
Solubility in water:
not determined
Solubility in other solvents:
1.25 鈥? 1.33
Specific Gravity (H2O = 1):
not determined
Vapor Density (Air = 1):
same as water
Vapor Pressure:
20 mPa.s (@ 20掳C)
Viscosity:
not determined
Volatiles (% by weight):
> 392掳F (200掳C) for solid material ; >224.6掳F (107掳C) for water loss
Other 鈥? Decomposition temperature:
not flammable or combustible
Conditions of Flammability:
not applicable
Flash Point (Method):
not applicable
Upper Flammable Limit (% by volume):
not applicable
Lower Flammable Limit (% by volume):
not applicable
Auto-Ignition Temperature:
< : less than > : greater than 鈮? : approximately
SECTION 10. STABILITY AND REACTIVITY
Stability: This product is stable at ambient temperatures and atmospheric pressures. It is not self-reactive and
is not sensitive to physical impact.
Incompatibilities / Conditions to avoid: This product is incompatible with strong oxidizers. Aqueous solution
in contact with aluminum evolves hydrogen. Avoid contact with aluminum, zinc and other metals. Avoid
prolonged storage at elevated temperatures.
Polymerization: Hazardous polymerization is not expected to occur under normal temperatures and pressures.
Decomposition Products: Under fire conditions the product may support combustion and decomposes to give
off carbon oxides fumes (CO, CO2), nitrogen oxides and water vapor.
SECTION 11. TOXICOLOGICAL INFORMATION
INHALATION
Acute exposure: The acute LC50 for this product is not available. There were no clinical signs of toxicity when
rats were exposed for 8 hours to an atmosphere enriched with Tetrasodium EDTA. The LC50 for Trisodium NTA
component is greater than 5 mg/L (rats / 4-hr test).
Chronic exposure: No known effects.
Issue date: 1-Jul-04 MSDS No.: 16 鈥? 075383
Expiry date: 1-Jul-07 Page 4 / 7
Material Safety Data Sheet
Dissolvine庐 E-39
Akzo Nobel Functional Chemicals LLC
SECTION 11. TOXICOLOGICAL INFORMATION (CONTINUED)
SKIN
Acute contact: Dermal toxicity for this product is not available. A solution containing 40% Tetrasodium EDTA
was not irritating to rabbit skin when applied undiluted for 4 hours.
Chronic contact: No known effects.
EYES: A 40% solution of Tetrasodium EDTA was classified as moderately irritating to rabbit eyes. Corneal
opacity, iritis and moderate to severe conjunctivitis were reported.
INGESTION
Acute exposure: The oral LD50 is greater than 2,000 mg/kg (rat) for a 40% solution of Tetrasodium EDTA.
Chronic exposure: No other known effects for the mixture. Chronic ingestion of NTA and its trisodium salt has
been shown to cause kidney toxicity.
SENSITIZATION: Not determined.
CARCINOGENICITY: IARC, NTP ACGIH and OSHA do not classify this material as a carcinogen or suspect
carcinogen. However, nitrilotriacetic acid (NTA) and its salts were determined to be 鈥減ossibly carcinogenic to
humans鈥? (Group 2B) by IARC, a compound which 鈥渕ay reasonably be anticipated to be a carcinogen鈥? by NTP
and a 鈥渟elect carcinogen鈥? by OSHA.
MUTAGENICITY
Tetrasodium EDTA component is not mutagenic in a series of tests, including the Ames Assay, the
Chromosomal Aberration and the Mouse Lymphoma.
NTA and its sodium salts were not genotoxic in experimental systems in vivo. Neither the acid nor its salts
were genotoxic in mammalian cells in vitro and they were not mutagenic to bacteria. However, trisodium
NTA has been shown to be positive in the BALB/c3T3 transformation assay when tested up to 7.8 mM.
REPRODUCTIVE TOXICITY
Tetrasodium EDTA component is not teratogenic under conditions of the test [Pregnant female rats were
administered 1374 mg Na4EDTA /kg/day on gestation days 7 to 14 in half the dose, twice daily. Clinical signs
of maternal toxicity included diarrhea, reduced weight gain and depressed activity.]
Trisodium NTA is not teratogenic and did not induce reproductive toxicity.
CYTOTOXICITY: Tetrasodium EDTA did not damage normal rat kidney cells at doses of 0.1 to 20 碌M. Long-
term exposure to 0.1 or 5.0 碌M was not toxic and did not inhibit DNA synthesis.
OTHER TOXICOLOGICAL EFFECTS: Tetrasodium EDTA, administered to mice in drinking water at a dose of
25 mM, caused a reduction of calcium in bone, liver and muscle. Zinc was reduced in kidneys, muscle and liver.
Magnesium was reduced in bones and liver but was increased in the kidneys.
TARGET ORGANS: Eyes.
SECTION 12. ECOLOGICAL INFORMATION
Ecotoxicity: Tetrasodium EDTA is expected to have low toxicity to fish and daphnia Magna.
LC50 (96h 鈥? Lepomis machrochirus) = 157 mg/L, 1030 mg/L and 2070 mg/L for a product containing 39%
Tetrasodium EDTA in very soft water, medium hard water and very hard water respectively.
LC50 (96h 鈥? Lepomis machrochirus) = 486 mg/L for solid Tetrasodium EDTA tested in very hard water
EC50 (24h 鈥? Daphnia magna) = greater than 500 mg/L
Chemical Fate: Tetrasodium EDTA is not expected to undergo hydrolysis. The substance is not expected to
enter the atmosphere significantly due to its high water solubility.
Issue date: 1-Jul-04 MSDS No.: 16 鈥? 075383
Expiry date: 1-Jul-07 Page 5 / 7
Material Safety Data Sheet
Dissolvine庐 E-39
Akzo Nobel Functional Chemicals LLC
SECTION 12. ECOLOGICAL INFORMATION (CONTINUED)
Biodegradation 鈥? Following data relates to Tetrasodium EDTA component:
Tetrasodium EDTA (39% in water) was not biodegraded over 28 days in the Sturm CO2 evolution test.
Tetrasodium EDTA was not biodegradable in the Closed Bottle Test conducted with natural seawater.
Other Ecotoxicity information (for Tetrasodium EDTA component):
Algae (Cell multiplication inhibition test) : toxicity threshold of Tetrasodium EDTA to the green algae and the
blue-green algae was 11 mg/L and 76 mg/L respectively.
Growth inhibition EC5 (Protozoa-Chilomonas paramaecium) of Tetrasodium EDTA was 663 mg/L
Bioaccumulation: Logpow = -13.17 (derived from EPIWIN / KOWWIN models)
SECTION 13. DISPOSAL CONSIDERATIONS
Waste Disposal: The characteristic of corrosivity per RCRA would be exhibited by unused product if it becomes
a waste material. It is the responsibility of the waste generator to evaluate whether his wastes are hazardous by
characteristic or listing. Dispose in accordance with all local, state and federal regulations.
NOTE 鈥? State and local regulations may be more stringent than federal regulations.
Container Disposal: Containers should be cleaned of residual product before disposal or return. Empty
containers should be disposed of or shipped in accordance with all applicable laws and regulations.
SECTION 14. TRANSPORT INFORMATION
SHIPPING INFORMATION
Domestic Land Shipments (motor vehicle or rail car): This product is not regulated as hazardous by
DOT, per 49CFR 搂173.154 (d) exception for materials corrosive to aluminum.
Air / Water / International Shipments: This product is regulated as corrosive material, as follows:
Corrosive liquid, basic, organic, n.o.s.
(contains Ethylenediaminetetraacetic acid tetrasodium salt, Sodium hydroxide)
8, UN 3267, PG III
North American Emergency Response Guide No.: 153
Required Labels
Domestic land shipments: No transport label required
Air / Water / International shipments: Corrosive labels required
Environmentally Hazardous Substances [ 49 CFR 172.101, Appendix A ]
Sodium hydroxide: RQ = 1000 lbs (454 kg)
SECTION 15. REGULATORY INFORMATION
The components are subject to the following environmental regulatory lists:
US STATE RIGHT-TO-
Substance Name CAA CERCLA IARC PROP 65 SARA
KNOW LISTS
N/R N/R N/R N/R N/R N/R
Tetrasodium EDTA
N/R N/R N/R N/R N/R N/R
Water
CA / FL / MA / MN / NJ X
N/R N/R N/R
Sodium hydroxide X
/ PA and RI 302
X
X1
N/R N/R
Trisodium NTA X MA
Gr 2B
N/R = Non Regulated X = Listed / Regulated
1
- Related product 鈥淭risodium NTA monohydrate鈥? [CAS # 18662-53-8] is reportable under California Proposition 65.
Issue date: 1-Jul-04 MSDS No.: 16 鈥? 075383
Expiry date: 1-Jul-07 Page 6 / 7
Material Safety Data Sheet
Dissolvine庐 E-39
Akzo Nobel Functional Chemicals LLC
SECTION 15. REGULATORY INFORMATION (CONTINUED)
National Chemical Inventories Status:
Canada Japa
US EU Australia Korea Philippines
Substance Name China
n
DSL NDSL
TSCA EINECS AICS KECL PICCS
ENCS
X X X X X X X x
Tetrasodium EDTA
X X X X X X X X
Water
X X X X X X X X
Sodium hydroxide
X X X X X X X X
Trisodium NTA
X = Listed
Legend
AICS Australian Inventory of Chemical Substances
CA List California 鈥? Directors List of Hazardous Substances
CAA Clean Air Act, Section 112
CERCLA CERCLA Hazardous Substances
DSL Domestic Substances List 鈥? Canada
EINECS European Inventory of Existing Commercial Chemical Substances
ENCS Japan Existing and New Chemical Substances
FL List Florida 鈥? Substance List
IARC International Agency for Research on Cancer 鈥? Carcinogens 鈥? Groups 1, 2A or 2B
KECL Korea Existing and Evaluated Chemical Substances
MA List Massachusetts 鈥? R-T-K Substance List
MN List Minnesota 鈥? Hazardous Substance List
NDSL Non-Domestic Substances List 鈥? Canada
NJ R-T-K New Jersey 鈥? R-T-K Hazard List
PA List Pennsylvania Hazardous Substance List
PICCS Philippines Inventory of Chemicals and Chemical Substances
Prop 65 California Proposition 65
RI List Rhode Island 鈥? Hazardous Substance List
SARA SARA Title III, Section 302 / 313
TSCA Toxic Substances Control Act 鈥? USA
WHMIS (Workplace Hazardous Materials Information System - Canada):
D2A & D2B [Other toxic effects]
[Corrosive to metal]
E
This product has been classified in accordance with the hazard criteria of the Controlled Products Regulations (CPR) and the
MSDS contains all the information required by the CPR.
Other Regulatory Information:
This product contains a small amount of CAS #19019-43-3 that is subject to TSCA 12(b) Export Notification.
This product contains a chemical known to the State of California to cause cancer.
Contact Akzo Nobel for additional information regarding the use and approval of Dissolvine E-39
(Tetrasodium EDTA) as an indirect food additive.
HMIS RATING 鈥? Health: 2 Flammability: 1 Reactivity: 1 Other: none
SECTION 16. OTHER INFORMATION
Other Information: Dissolvine庐 is a registered trademark of Akzo Nobel Chemicals Inc.
Prepared by: Regulatory Toxicology Dept. [M. Morin 鈥? Tel. (613) 273-8095]
The information in this Material Safety Data Sheet should be provided to all who will use, handle, store, transport or otherwise be exposed to this product. All information concerning this
product and/or all suggestions for handling and use contained herein are offered in good faith and are believed to be reliable as of the date of publication. Akzo Nobel Functional
Chemicals LLC, however, makes no warranty as to the accuracy of and/or sufficiency of such information and/or suggestions, as to the product's merchantability or fitness for any particular
purpose, or that any suggested use will not infringe any patent. Nothing contained herein shall be construed as granting or extending any license under any patent. Buyer shall determine
for himself, by preliminary tests or otherwise, the suitability of this product for his purposes, including mixing with other products. The information contained herein supersedes all
previously issued bulletins on the subject matter covered. If the date of this document is more than three years old, please call to ensure that this sheet is current.
Issue date: 1-Jul-04 MSDS No.: 16 鈥? 075383
Expiry date: 1-Jul-07 Page 7 / 7
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