MSDS No.: 3396
Variant: U.S.A.-EN
Material Safety Data Sheet Version No: 1.2
Validation Date: 12/23/2004
GLYCOL ETHER EB
SECTION 1: IDENTIFICATION
Product Name: GLYCOL ETHER EB
Product Number: 000000000000005044
Chemical Family: Glycol Ethers
CAS Number: 111-76-2
Chemical Name: 2-butoxyethanol
Synonyms: ethylene glycol monobutyl ether; glycol butyl ether
Type of Use: Chemical intermediaries. Solvent. Stabilizing agent
Manufacturer Business Contact
Equistar Chemicals, LP Customer Service
One Houston Center, Suite 700 888 777-0232
1221 McKinney St. Product Safety
P.O. Box 2583 800 700-0946
Houston Texas 77252-2583
24 Hour Emergency Contact
CHEMTREC 800 424-9300
EQUISTAR 800-245-4532
SECTION 2 : COMPOSITION/INFORMATION ON INGREDIENTS
Component Name CAS # EU Inventory Concentration Wt.%* Risk Symbol
Ethylene glycol monobutyl 111-76-2 203-905-0 99.0 <= 99.9 R20/21/22, Xn
ether R36/38
1,2-Ethanediol 107-21-1 203-473-3 <= 1.0 R22 Xn
* Concentration of gaseous products or materials is given in Mole %
Compositions given are typical values not specifications.
SECTION 3: HAZARD IDENTIFICATION
Emergency Overview
This material is HAZARDOUS by OSHA Hazard Communication definition.
Signal Word
WARNING!
Hazards
Inhalation of vapors may cause central nervous system depression. Eye irritant. Skin irritant.
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MSDS No.: 3396
Variant: U.S.A.-EN
Material Safety Data Sheet Version No: 1.2
Validation Date: 12/23/2004
GLYCOL ETHER EB
HMIS庐
NFPA庐
2
Health * 2
Flammability 2
2 0
Reactivity 0
Physical State
Liquid.
Color
Colorless.
Odor
Ether-like odor.
Odor Threshold
No value available.
Potential Health Effects
Routes of Exposure
Skin. Eye Inhalation
Signs and Symptoms of Acute Exposure
See component summary.
鈥? Ethylene glycol monobutyl ether 111-76-2
May be irritating to the eyes, skin, and respiratory system. Exposure could cause central nervous system depression and
liver and kidney damage.
鈥? 1,2-Ethanediol 107-21-1
Ingestion hazard. Ingestion may include inebriation, nausea and vomiting, metabolic acidosis, and CNS depression.
Cardiopulmonary effects including tachycardia, hypertension, severe metabolic acidosis with hyperventilation, hypoxia,
congestive heart failure and adult respiratory distress syndrome, as well as, renal failure are also possible. May also
produce a local irritation effect on the digestive system, and cause pain and bleeding. Irritation of the eyes and respiratory
system. Effects of eye irritation are reversible. High aerosol concentrations may cause respiratory irritation. Mildly irritating
to the skin but not a skin sensitizer. Not a skin absorption hazard.
Skin
May cause slight irritation if left in contact with skin.
Inhalation
May produce symptoms of central nervous system depression including headache, dizziness, nausea, euphoria, loss of
equilibrium, drowsiness, visual disturbances, fatigue, unconsciousness and respiratory arrest.
Eye
Eye contact may cause conjunctival irritation and slight transitory irritation of the cornea.
Ingestion
This material is low to moderately toxic. May cause headache, dizziness and gastrointestinal distress.
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MSDS No.: 3396
Variant: U.S.A.-EN
Material Safety Data Sheet Version No: 1.2
Validation Date: 12/23/2004
GLYCOL ETHER EB
Chronic Health Effects
See component summary.
鈥? Ethylene glycol monobutyl ether 111-76-2
May cause dermatitis by defatting the skin from prolonged or repeated contact. This substance may have effects on the
haematopoietic system, resulting in blood disorders.
鈥? 1,2-Ethanediol 107-21-1
Repeated or prolonged exposure may result in kidney damage. May produce symptoms of central nervous system
depression including headache, dizziness, nausea, euphoria, loss of equilibrium, drowsiness, visual disturbances, fatigue,
unconsciousness and respiratory arrest.
Conditions Aggravated by Exposure
Any pre-existing disorders or diseases of the nervous system, liver, respiratory system, skin, eyes, blood-forming organs,
kidneys, and gastrointestinal system
SECTION 4: FIRST AID MEASURES
General
Take proper precautions to ensure your own health and safety before attempting rescue and providing first aid. For specific
information refer to the Emergency Overview in Section 3 of this MSDS.
Skin
Immediately remove excess chemical and contaminated clothing; thoroughly wash contaminated skin with mild soap and
water. If irritation persists after washing, seek medical attention. Thoroughly clean contaminated clothing before reuse;
discard contaminated leather goods (gloves, shoes, belts, wallets, etc.).
Inhalation
Move the exposed person to fresh air at once. If breathing has stopped, perform artificial respiration. When breathing is
difficult, properly trained personnel may assist the affected person by administering oxygen. Keep the affected person
warm and at rest. Get medical attention immediately.
Eye
Thoroughly flush the eyes with large amounts of clean low-pressure water for at least 15 minutes, occasionally lifting the
upper and lower eyelids. If irritation persists, seek medical attention.
Ingestion
If victim is conscious and able to swallow, have victim drink water to dilute. Never give anything by mouth if victim is
unconscious or having convulsions. Induce vomiting only if advised by a physician or Poison Control Center. CALL A
PHYSICIAN OR POISON CONTROL CENTER IMMMEDIATELY!
SECTION 5: FIRE FIGHTING MEASURES
Flammable Properties
Classification
OSHA/NFPA Class IIIA Combustible Liquid.
Flash Point:
72 掳C (161.6 掳F) ASTM D-56 (Tag Closed Cup)
Auto-Ignition Temperature
244 掳C (471.2 掳F)
Lower Flammable Limit
1.1 vol%
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MSDS No.: 3396
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Material Safety Data Sheet Version No: 1.2
Validation Date: 12/23/2004
GLYCOL ETHER EB
Upper Flammable Limit
10.6 vol%
Extinguishing Media
Suitable: SMALL FIRE: Use dry chemicals, CO2, water spray or alcohol-resistant foam. LARGE FIRE: Use water spray,
water fog or alcohol-resistant foam.
Unsuitable: Do not use solid water stream.
Protection of Firefighters
Protective Equipment/Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Structural
firefighters protective clothing will only provide limited protection.
Fire Fighting Guidance: Vapors can travel to a source of ignition and flash back. Fight fire from maximum distance or use
unmanned hose holders or monitor nozzles. Move containers from fire area if you can do it without risk. Cool containers
with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety
devices or discoloration of tank. Always stay away from tanks engulfed in fire. For massive fire, use unmanned hose
holders or monitor nozzles; if this is impossible, withdraw from area and let fire burn.
Hazardous Combustion Products: Carbon oxides (CO, CO2)
SECTION 6: ACCIDENTAL RELEASE MEASURES
Release Response
Eliminate all sources of ignition. All equipment used when handling this product must be grounded. Do not touch or walk
through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or
confined areas. A vapor suppressing foam may be used to reduce vapors. Absorb or cover with dry earth, sand or other
non-combustible material and transfer to containers. Use clean non-sparking tools to collect absorbed material.
SECTION 7: HANDLING AND STORAGE
Handling
Containers, even those that have been emptied, will retain product residue and vapor and should be handled as if they were
full. Do not eat, drink or smoke in areas where this material is used. After handling, always wash hands thoroughly with
soap and water. Do not handle near heat, sparks, or flame. Avoid contact with incompatible agents. Use only with
adequate ventilation/personal protection. Avoid contact with eyes, skin and clothing. Do not enter storage area unless
adequately ventilated. Metal containers involved in the transfer of this material should be grounded and bonded.
Storage
Store containers in a cool, dry, ventilated, fire resistant area away from sources of ignition and incompatible materials. Keep
container tightly closed and properly labeled.
SECTION 8: EXPOSURE CONTROLS AND PERSONAL PROTECTION
Engineering Controls
Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below
recommended exposure limits. Emergency shower and eyewash facility should be in close proximity (ANSI Z358.1)
Personal Protection
Inhalation A respiratory protection program that meets OSHA's 29 CFR 1910.134 or ANSI Z88.2 requirements must be
followed whenever workplace conditions warrant respirator use.
Skin Wear chemical resistant gloves such as: Rubber Use PPE that is chemical resistant to the product and prevents skin
contact.
Eye Wear safety glasses as minimum eye protection. Conditions may warrant the use of chemical goggles and possibly a
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MSDS No.: 3396
Variant: U.S.A.-EN
Material Safety Data Sheet Version No: 1.2
Validation Date: 12/23/2004
GLYCOL ETHER EB
face shield. Consult your standard operating procedure or safety professional for advice. Use protective eye and face
devices that comply with ANSI Z87.1-1987.
Additional Remarks
Selection of appropriate personal protective equipment should be based on an evaluation of the performance
characteristics of the protective equipment relative to the task(s) to be performed, conditions present, duration of use, and
the hazards and/or potential hazards that may be encountered during use.
Occupational Exposure Limits
Component Name Source / Date Value Type Notation
Ethylene glycol monobutyl ether US (ACGIH) / 2003 20 ppm 8 HRS/TWA
US (OSHA) / 2003 50 ppm 8 HRS/TWA Skin.
1,2-Ethanediol US (ACGIH) 100 mg/m3 CEILING
Aerosol
US (OSHA) N/L
SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES
Appearance: Liquid. Colorless.
Odor: Ether-like odor.
Odor Threshold: No value available.
pH: No Data Available.
Boiling Point/Boiling Range: 169 掳C (336.2 掳F) @ 760 mm Hg
Freezing Point/Melting Point: -70 掳C (-94 掳F)
Flash Point: 72 掳C (161.6 掳F) ASTM D-56 (Tag Closed Cup)
Auto-ignition: 244 掳C (471.2 掳F)
Flammability: OSHA/NFPA Class IIIA Combustible Liquid.
Lower Flammable Limit: 1.1 vol%
Upper Flammable Limit: 10.6 vol%
Explosive Properties: No Data Available.
Oxidizing Properties: No Data Available.
Vapor Pressure: 0.6 mm Hg @ 20 掳C (68 掳F)
Evaporation Rate: 0.1 (butyl acetate = 1) (butyl acetate = 1)
Relative Density: 0.901 - 0.904 @ 20 掳C (68 掳F) (Water = 1)
Relative Vapor Density: 4.1 (Air = 1.0)
Viscosity: 6.4 mPa.s @ 20 掳C (68 掳F)
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MSDS No.: 3396
Variant: U.S.A.-EN
Material Safety Data Sheet Version No: 1.2
Validation Date: 12/23/2004
GLYCOL ETHER EB
Solubility (Water): Miscible
Partition Coefficient (Kow): Log Kow = 0.83 Estimated.
Additional Physical and Chemical Properties: No additional information available.
SECTION 10: STABILITY AND REACTIVITY
Chemical Stability
The product is stable.
Conditions to Avoid
All sources of ignition.
Substances to Avoid
Oxidizers, Acids, Alkalis Lime, ammonia, organic amines, chlorates, chlorine, sodium hydroxide.
Decomposition Products
Carbon Monoxide and Carbon dioxide.
Hazardous Polymerization
Will not occur.
Reactions with Air and Water
May form peroxides in the presence of air.
SECTION 11: TOXICOLOGICAL INFORMATION
PRODUCT INFORMATION
Product Summary
No additional toxicology information is available for this material. (See Component Toxicity Information).
COMPONENT INFORMATION
鈥? Ethylene glycol monobutyl ether 111-76-2
Acute Toxicity - Lethal Doses
LC50 (Inhl) Rat 450 PPM (FEMALE) 4 HOURS
Rat 486 MG/KG (MALE) 4 HOURS
LD50 (Oral) Rat 1746 MG/KG BWT
LD50 (Skin) Rabbit. 680 MG/KG BWT
Acute Toxicity - Effects
Inhalation Short term exposure to high concentrations of vapors (300 - 600 ppm) can cause respiratory and eye irritation,
CNS depression, and possible damage to kidney and liver.
Ingestion The major toxic effect in acute and subchronic animal studies was intravascular red cell hemolysis (destruction).
This was often associated with secondary effects such as spleen and liver enlargement and nephropathy. Studies show
that hemolysis and secondary effects are not relevent to humans.
Irritation
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MSDS No.: 3396
Variant: U.S.A.-EN
Material Safety Data Sheet Version No: 1.2
Validation Date: 12/23/2004
GLYCOL ETHER EB
Skin This substance is a mild skin irritant.
Eye This product is expected to be an eye irritant.
Target Organ Effects
Skin. Eye. Respiratory system. Central nervous system effects. Blood. May cause liver and/or kidney damage.
Repeated Dose Toxicity
Administration of ethylene glycol butyl ether (EGBE) to rats (855 mg/kg/day) and mice (1000 mg/kg/day) for periods of 5-6
weeks showed no effects on the testes. NTP reported testicular weight changes in rats and mice ingesting up to 6000 ppm
(443 and 694 mg/kg/day in rats and mice) of EGBE in a 13 week drinking water study. No chemically related microscopic
lesions were seen.
鈥? 1,2-Ethanediol 107-21-1
Acute Toxicity - Lethal Doses
LD50 (Oral) Rat 5890 - 13,400 MG/KG BWT
NOAEL Rabbit > 3549 MG/KG BWT (SKIN)
Irritation
Skin May be irritating to the skin. Not expected to be a sensitizer. No significant signs or symptoms indicative of any health
hazard are expected to occur as a result of skin absorption exposure.
Eye May cause minor eye irritation. Effects of eye irritation are reversible.
Sensitization
Not expected to be a sensitizer.
Target Organ Effects
Central nervous system effects. Blood (metabolic acidosis). Respiratory system. Cardiovascular system. Kidneys.
Repeated Dose Toxicity
If exposures are sufficiently high to cause accumulation of calcium oxalate crystals, kidney pathology may occur. In male
rats, crystal nephropathy has been seen after dietary administration of 500 mg/kg/day bwt for 16 weeks, whereas no effects
were seen in rats that ingested 200 mg/kg/day bwt for 2 years or in several animal species that inhaled 12 mg/m3 for 3
months . Human exposures at occupational relevant concentrations are unlikely to cause crystal nephropathy.
Reproductive Effects
No evidence of adverse effects on reproductive organs or fertility in rats and rabbits have occurred from ethylene glycol
exposure. Mice exposed to doses considerably higher than those associated with developmental effects or kidney effects in
rats exhibited reduced number of litters and smaller litters. No reproductive effects expected from human exposures.
Developmental Effects
Doses of ethylene glycol that result in high levels of the metabolite glycolic acid induce developmental/teratogenic effects in
rats and mice, although at doses greater than those associated with kidney effects in rats. Human exposure is not expected
to generate sufficient levels of glycolic acid; therefore, no developmental effects are expected in humans.
Genetic Toxicity
Negative for genotoxicity both in vitro and in vivo tests.
Carcinogenicity
Ethylene glycol was not carcinogenic in two year studies in rats and mice. This material is not classified as a carcinogen.
Not listed by IARC, NTP, or OSHA.
Other Information
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MSDS No.: 3396
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Material Safety Data Sheet Version No: 1.2
Validation Date: 12/23/2004
GLYCOL ETHER EB
Human acute toxicity has three recognized stages: Stage 1. (0.5 to 12 hours post ingestion) may include inebriation, nausea
and vomiting, metabolic acidosis, and CNS depression. Stage 2. (12-24 hours) cardiopulmonary effects include
tachycardia, hypertension, severe metabolic acidosis with hyperventilation, hypoxia, congestive heart failure and adult
respiratory distress syndrome. Stage 3. (24-72 hours) renal failure. Ethylene glycol may also produce a local irritation effect
on the digestive system, and cause pain and bleeding.
SECTION 12: ECOLOGICAL INFORMATION
PRODUCT INFORMATION
Ecotoxicity
This material is highly soluble in water. Laboratory toxicity tests indicate that is not significantly toxic to fish and aquatic
invertebrates, although amphibians may be more sensitive. Wildlife species may be more susceptible since mammals and
birds do not readily metabolize this material. The odor and flavor of this material may attract some wildlife and cause them
to consume spilled material.
Environmental Fate and Pathway
This material will biodegrade relatively rapidly in both soil and water, and will not persist in the environment. Due care
should be taken to avoid accidental releases to aquatic or terrestrial systems.
Persistance and Degradability
Bioaccumulation: Because of this material's high solubility and rapid biodegradability, it is unlikely that bioaccumulation will
occur in aquatic or terrestrial systems. Models estimate that this material will preferentially partition to water versus air or
soil.
COMPONENT INFORMATION
鈥? Ethylene glycol monobutyl ether 111-76-2
Ecotoxicity
This material is not expected to be harmful to waterfowl or aquatic life.
Acute toxicity to fish
LC50 / 96 HOUR bluegill. 1,490 mg/l
LC50 / 96 HOUR silverside minnow. 1,250 mg/l
Acute toxicity to aquatic invertebrates
LC50 / 48 HOUR common shrimp (mysid) 800 mg/l
Toxicity to aquatic plants
Summary: No Data Available.
Environmental Fate and Pathway
Expected to have high mobility in soils. It is not expected to adsorb onto soils or sediments. Volatilization from dry soil
surfaces is expected. Expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase is degraded in the
atmosphere by reaction with photochemically produced hydroxyl radicals.
Persistance and Degradability
Biodegradation: This material is expected to be readily biodegradable.
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Material Safety Data Sheet Version No: 1.2
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GLYCOL ETHER EB
Bioaccumulation: Estimated BCF = 2.5 This material is not expected to bioaccumulate.
鈥? 1,2-Ethanediol 107-21-1
Ecotoxicity
Terrestrial plant and avian NOEC (No Observed Effect Concentration) data are available upon request.
Acute toxicity to fish
LC50 / 96 HOUR rainbow trout. 22,810 mg/l
LC50 / 96 HOUR fathead minnow 49,000 mg/l
Summary: This material is not classified as harmful or toxic to fish.
Acute toxicity to aquatic invertebrates
EC50 / 48 HOUR Daphnia magna. 41,000 mg/l
EC50 / 48 HOUR daphnia 10,000 mg/l
Summary: This material is not classified as harmful or toxic to invertebrates.
Toxicity to aquatic plants
Toxicity Threshold / 7 DAY blue green algae. 2,000 mg/l
Summary: This material is not classified as harmful or toxic to algae or higher aquatic plants.
Toxicity to microorganisms
Toxicity Threshold / 16 HOUR bacteria. > 10,000 mg/l
Chronic toxicity to fish
LC50 / 12 DAY rainbow trout. 20,403 mg/l
Chronic toxicity to aquatic invertebrates
LC50 / 7 DAY daphnia 30,461 mg/l
Environmental Fate and Pathway
Mobile in soil. Not expected to volatilize from surface waters or soils. Not likely to adsorb to suspended solids and sediment
in water. Environmental half-life of 0.35 to 24 days in soil, air, surface and ground water. Not expected to undergo
hydrolysis. Undergoes photooxidation with hydroxyl radicals in air with a half-life of 8.3 to 83 hours.
Persistance and Degradability
Biodegradation: Reported biodegradation studies show ethylene glycol with 97% biodegradation after 20 days, and 96%
biodegradation after 28 days. Biodegradable under aerobic conditions.
Bioaccumulation: BCF = 0.21 - 0.61 (crawfish) BCF = 10.0 (fish) This material is not expected to bioaccumulate.
SECTION 13: DISPOSAL CONSIDERATIONS
Dispose of all waste and contaminated equipment in accordance with all applicable federal, state and local health and
environmental regulations. Recovery and reuse, rather than disposal, should be the ultimate goal of handling efforts. The
materials resulting from clean-up operations may be hazardous wastes and therefore, subject to specific regulations. Use
only licensed transporters and permitted facilities for waste disposal.
SECTION 14: TRANSPORT INFORMATION
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MSDS No.: 3396
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Material Safety Data Sheet Version No: 1.2
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GLYCOL ETHER EB
Special Requirements
Not regulated by U.S. Department of Transportation (USDOT) when shipped in packages of 119 gallons or less. If you
reformulate or further process this material, you should consider re-evaluation of the regulatory status of the components
listed in the composition section of this sheet, based on final composition of your product.
Proper Shipping Name Combustible liquid, n.o.s. (ETHYLENE GLYCOL MONOBUTYL ETHER)
ID No. NA1993
Hazard Class Combustible Liquid
PG III
SECTION 15: REGULATORY INFORMATION
Regulatory Status
Country Inventory
Australia AICS X
X = All components are included or are otherwise
Canada DSL X
exempt from inclusion on this inventory.
Canada NDSL
China IECS X
European Union EINECS X
European Union ELINCS
European Union NLP C = Contact Lyondell/Equistar by e-mail at
product.safety@lyondell.com or
Japan ENCS X
product.safety@equistarchem.com for additional
Korea ECL X
information.
Philippines PICCS X
United States TSCA X
If identified components of this product are listed under the TSCA 12(b) Export Notification rule, they will be listed below.
SARA 302/304
This material contains a component(s) with known CAS numbers classified as hazardous substances subject to the
reporting of CERCLA (40 CFR 302) and/or to the release reporting requirements of SARA (Section 302) based on
reportable quantities (RQs).
Component RQ
Ethylene glycol / CAS# 107-21-1 5,000 lbs
SARA 311/312
Based upon available information, this material is classified as the following health and/or physical hazards according to
Section 311 & 312:
Immediate (Acute) Health Hazard.
Delayed (Chronic) Health Hazard.
Fire Hazard.
SARA 313
This material contains the following chemicals with known CAS numbers subject to the reporting requirements of SARA Title
III, Section 313 and 40 CFR 372:
Component Reporting Threshold
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Material Safety Data Sheet Version No: 1.2
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GLYCOL ETHER EB
Ethylene Glycol Monobutyl Ether / CAS# 111-76-2 1.0%
Ethylene glycol / CAS# 107-21-1 1.0%
State Reporting
This material is not known to contain any chemicals currently listed as carcinogens or reproductive toxins under California
Proposition 65 at levels which would be subject to the proposition.
SECTION 16: OTHER INFORMATION
Latest Revision(s)
Revised Section(s): 2 Revised Section(s): 5 9 15 Date of Revision: May 4 2004
DISCLAIMER OF RESPONSIBILITY
The information on this MSDS was obtained from sources which we believe are reliable. However, the information is
provided without any warranty, expressed or implied, regarding its correctness. Some information presented and
conclusions drawn herein are from sources other than direct test data on the substance itself. The conditions or methods
of handling, storage, use and disposal of the product are beyond our control and may be beyond our knowledge. For this
and other reasons, we do not assume responsibility and expressly disclaim liability for loss, damage, or expense arising
out of or in any way connected with handling, storage, use, or disposal of this product. If the product is used as a
component in another product, this MSDS information may not be applicable.
Numerical Data Presentation
The presentation of numerical data, such as that used for physical and chemical properties and toxicological values, is
expressed using a comma (,) to separate digits into groups of three and a period (.) as the decimal marker. For example,
1,234.56 mg/kg = 1 234,56 mg/kg
Language Translations
The information presented in this document has been translated from English by a vendor Lyondell believes to be reliable.
Lyondell and its vendor have made a good-faith effort to verify the accuracy of the translation, but assume no responsibility
for any errors that may have occurred. Please refer to our web sites (www.lyondell.com and www.equistarchem.com) for
the original document written in English.
< end of document >
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