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MSDS Material Safety Data Sheet
CAS

52-86-8

File Name: palomar_edu---serne.asp
                         PRODUCT #: H1512        NAME: HALOPERIDOL
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Thursday, March 13, 1903 4:14PM

Sigma Chemical Co. Aldrich Chemical Co., Inc. Fluka Chemical Corp.
P.O. Box 14508 1001 West St. Paul 1001 West St. Paul
St. Louis, MO 63178 Milwaukee, WI 53233 Milwaukee, WI 53233
Phone: 314-771-5765 Phone: 414-273-3850 Phone: 414-273-3850




SECTION 1. - - - - - - - - - CHEMICAL IDENTIFICATION- - - - - - - - - -
CATALOG #: H1512
NAME: HALOPERIDOL
SECTION 2. - - - - - COMPOSITION/INFORMATION ON INGREDIENTS - - - - - -
CAS #: 52-86-8
MF: C21H23CLFNO2
EC NO: 200-155-6
SYNONYMS
ALDO * ALOPERIDIN * ALOPERIDOLO (ITALIAN) * BROTOPON * 1-BUTANONE, 4-
(4-(4-CHLOROPHENYL)-4-HYDROXY-1-PIPERIDINYL)-1-(4-FLUOROPHENYL)- *
BUTYROPHENONE, 4'-FLUORO-4-(4-(P-CHLOROPHENYL)-4-HYDROXYPIPERIDINO)- *
GAMMA-(4-(P-CHLORPHENYL)-4-HYDROXPIPERIDINO)-P-FLUORBUTYROPHENONE *
4-(4-(4-CHLOROPHENYL)-4-HYDROXY-1-PIPERIDINYL)-1-(4-FLUOROPHENYL)-1-
BUTANONE * DOZIC * EINALON S * EUKYSTOL * 1-(3-P-FLUOROBENZOYLPROPYL)-
4-P-CHLOROPHENYL-4-HYDROXYPIPERIDINE * 4'-FLUORO-4-(4-(P-CHLOROPHENYL)
-4-HYDROXYPIPERIDINYL)BUTYROPHENONE * 4'-FLUORO-4-(4-HYDROXY-4-(4'-
CHLOROPHENYL)PIPERIDINO)BUTYROPHENONE * FORTUNAN * GALOPERIDOL *
HALDOL * HALOPERIDOL * 4-(4-HYDROXY-4'-CHLORO-4-PHENYLPIPERIDINO)-4'-
FLUOROBUTYROPHENONE * KESELAN * LEALGIN COMPOSITUM * LINTON * MCN-JR-
1625 * PELUCES * PERNOX * R 1625 * SERENACE * SERENASE * SERENELFI *
SERNAS * SERNEL *
SECTION 3. - - - - - - - - - - HAZARDS IDENTIFICATION - - - - - - - - -
LABEL PRECAUTIONARY STATEMENTS
TOXIC
TOXIC IF SWALLOWED.
IRRITATING TO EYES, RESPIRATORY SYSTEM AND SKIN.
MAY CAUSE SENSITIZATION BY SKIN CONTACT.
PHOTOSENSITIZER.
TARGET ORGAN(S):
BLOOD
CENTRAL NERVOUS SYSTEM
IN CASE OF ACCIDENT OR IF YOU FEEL UNWELL, SEEK MEDICAL ADVICE
IMMEDIATELY (SHOW THE LABEL WHERE POSSIBLE).
IN CASE OF CONTACT WITH EYES, RINSE IMMEDIATELY WITH PLENTY OF
WATER AND SEEK MEDICAL ADVICE.
WEAR SUITABLE PROTECTIVE CLOTHING, GLOVES AND EYE/FACE
PROTECTION.
SECTION 4. - - - - - - - - - - FIRST-AID MEASURES- - - - - - - - - - -
IN CASE OF CONTACT, IMMEDIATELY FLUSH EYES OR SKIN WITH COPIOUS
AMOUNTS OF WATER FOR AT LEAST 15 MINUTES WHILE REMOVING CONTAMINATED
CLOTHING AND SHOES.
IF INHALED, REMOVE TO FRESH AIR. IF NOT BREATHING GIVE ARTIFICIAL
RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN.
IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS.
CALL A PHYSICIAN.
WASH CONTAMINATED CLOTHING BEFORE REUSE.
SECTION 5. - - - - - - - - - FIRE FIGHTING MEASURES - - - - - - - - - -
EXTINGUISHING MEDIA
WATER SPRAY.

Page 1
PRODUCT #: H1512 NAME: HALOPERIDOL
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Thursday, March 13, 1903 4:14PM

CARBON DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE FOAM.
SPECIAL FIREFIGHTING PROCEDURES
WEAR SELF-CONTAINED BREATHING APPARATUS AND PROTECTIVE CLOTHING TO
PREVENT CONTACT WITH SKIN AND EYES.
UNUSUAL FIRE AND EXPLOSIONS HAZARDS
EMITS TOXIC FUMES UNDER FIRE CONDITIONS.
SECTION 6. - - - - - - - - ACCIDENTAL RELEASE MEASURES- - - - - - - - -
EVACUATE AREA.
WEAR SELF-CONTAINED BREATHING APPARATUS, RUBBER BOOTS AND HEAVY
RUBBER GLOVES.
SWEEP UP, PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL.
AVOID RAISING DUST.
VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE.
SECTION 7. - - - - - - - - - - HANDLING AND STORAGE- - - - - - - - - - -
REFER TO SECTION 8.
SECTION 8. - - - - - - EXPOSURE CONTROLS/PERSONAL PROTECTION- - - - - -
WEAR APPROPRIATE NIOSH/MSHA-APPROVED RESPIRATOR, CHEMICAL-RESISTANT
GLOVES, SAFETY GOGGLES, OTHER PROTECTIVE CLOTHING.
SAFETY SHOWER AND EYE BATH.
USE ONLY IN A CHEMICAL FUME HOOD.
DO NOT BREATHE DUST.
DO NOT GET IN EYES, ON SKIN, ON CLOTHING.
AVOID PROLONGED OR REPEATED EXPOSURE.
WASH THOROUGHLY AFTER HANDLING.
KEEP TIGHTLY CLOSED.
STORE IN A COOL DRY PLACE.
SECTION 9. - - - - - - - PHYSICAL AND CHEMICAL PROPERTIES - - - - - - -
APPEARANCE AND ODOR
WHITE CRYSTALLINE POWDER
PHYSICAL PROPERTIES
MELTING POINT: 150 C TO 152 C
SECTION 10. - - - - - - - - -STABILITY AND REACTIVITY - - - - - - - - -
INCOMPATIBILITIES
STRONG OXIDIZING AGENTS
HAZARDOUS COMBUSTION OR DECOMPOSITION PRODUCTS
TOXIC FUMES OF:
CARBON MONOXIDE, CARBON DIOXIDE
NITROGEN OXIDES
HYDROGEN CHLORIDE GAS
HYDROGEN FLUORIDE
SECTION 11. - - - - - - - - - TOXICOLOGICAL INFORMATION - - - - - - - -
ACUTE EFFECTS
TOXIC IF SWALLOWED.
MAY BE HARMFUL IF INHALED.
MAY BE HARMFUL IF ABSORBED THROUGH THE SKIN.
CAUSES EYE AND SKIN IRRITATION.
MATERIAL IS IRRITATING TO MUCOUS MEMBRANES AND UPPER
RESPIRATORY TRACT.
TARGET ORGAN(S):
BLOOD
CENTRAL NERVOUS SYSTEM
CARDIOVASCULAR SYSTEM
LIVER
EYES
OVEREXPOSURE TO HALOPERIDOL CAN RESULT IN SEVERE EXTRAPYRAMIDAL
REACTIONS MANIFESTED BY MUSCULAR WEAKNESS, RIGIDITY, (WITH A GENERALIZED
OR LOCALIZED TREMOR). HYPOTENSION OR SEDATION, TARDIVE DYSKINESIA,

Page 2
PRODUCT #: H1512 NAME: HALOPERIDOL
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Thursday, March 13, 1903 4:14PM

CHOLESTATIC HEPATITIS, MILD LEUKOPENIA, LEUKOCYTOSIS,
GASTROINTESTINAL EFFECTS AND ENDOCRINE DISORDERS HAVE BEEN REPORTED.
ADDITIONAL CNS EFFECTS INCLUDE ANXIETY, RESTLESSNESS, AGITATION,
EUPHORIA, INSOMNIA, DROWSINESS, DEPRESSION, LETHARGY, VERTIGO, GRAND
MAL SEIZURES AND HALLUCINATIONS.
TO THE BEST OF OUR KNOWLEDGE, THE CHEMICAL, PHYSICAL, AND
TOXICOLOGICAL PROPERTIES HAVE NOT BEEN THOROUGHLY INVESTIGATED.
RTECS #: EU1575000
BUTYROPHENONE, 4-(4-(P-CHLOROPHENYL)-4-HYDROXYPIPERIDINO)-4'-FLUORO-
TOXICITY DATA
ORL-RAT LD50:128 MG/KG ARZNAD 24,45,1974
IPR-RAT LD50:27 MG/KG 27ZQAG -,190,1972
SCU-RAT LD50:60 MG/KG ARZNAD 24,45,1974
IVN-RAT LD50:15 MG/KG ARZNAD 24,45,1974
ORL-MUS LD50:71 MG/KG FRPSAX 31,442,1976
IPR-MUS LD50:30 MG/KG BCFAAI 111,293,1972
SCU-MUS LD50:41 MG/KG OYYAA2 1,74,1967
IVN-MUS LD50:13 MG/KG ARZNAD 11,932,1961
UNR-MUS LD50:18 MG/KG CLPTAT 3,432,1962
ORL-DOG LD50:90 MG/KG CLPTAT 8,770,1967
SCU-DOG LD50:>80 MG/KG CLPTAT 8,770,1967
IVN-DOG LD50:18 MG/KG CLPTAT 8,770,1967
SCU-MKY LD50:>1250 UG/KG ARZNAD 11,932,1961
SCU-CAT LD50:>2500 UG/KG ARZNAD 11,932,1961
IVN-RBT LD50:8 MG/KG CLPTAT 8,770,1967
ORL-MAM LD50:80 MG/KG DANKAS 320,242,1991
UNR-MAM LD50:80 MG/KG KHFZAN 24(7),27,1990
TARGET ORGAN DATA
PERIPHERAL NERVE AND SENSATION (FASCICULATION)
BEHAVIORAL (SOMNOLENCE)
BEHAVIORAL (HALLUCINATIONS, DISTORTED PERCEPTIONS)
BEHAVIORAL (TREMOR)
BEHAVIORAL (EXCITEMENT)
BEHAVIORAL (CHANGE IN MOTOR ACTIVITY)
BEHAVIORAL (MUSCLE WEAKNESS)
BEHAVIORAL (ATAXIA)
BEHAVIORAL (RIGIDITY)
BEHAVIORAL (MUSCLE CONTRACTION OR SPASTICITY)
BEHAVIORAL (IRRITABILITY)
BEHAVIORAL (AGGRESSION)
GASTROINTESTINAL (TUMORS)
LIVER (TUMORS)
BLOOD (ANGRANULOCYTOSIS)
BLOOD (LEUKEMIA)
PATERNAL EFFECTS (TESTES, EPIDIDYMIS, SPERM DUCT)
PATERNAL EFFECTS (PROSTATE, SEMINAL VESICLE, COWPER'S, ACCESSORY GLANDS
PATERNAL EFFECTS (OTHER EFFECTS ON MALE)
MATERNAL EFFECTS (OVARIES, FALLOPIAN TUBES)
MATERNAL EFFECTS (UTERUS, CERVIX, VAGINA)
MATERNAL EFFECTS (PARTURITION)
MATERNAL EFFECTS (POSTPARTUM)
EFFECTS ON FERTILITY (MATING PERFORMANCE)
EFFECTS ON FERTILITY (PRE-IMPLANTATION MORTALITY)
EFFECTS ON FERTILITY (POST-IMPLANTATION MORTALITY)
EFFECTS ON FERTILITY (LITTER SIZE)
EFFECTS ON FERTILITY (OTHER MEASURES OF FERTILITY)
EFFECTS ON EMBRYO OR FETUS (FETOTOXICITY)

Page 3
PRODUCT #: H1512 NAME: HALOPERIDOL
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Thursday, March 13, 1903 4:14PM

EFFECTS ON EMBRYO OR FETUS (FETAL DEATH)
SPECIFIC DEVELOPMENTAL ABNORMALITIES (CENTRAL NERVOUS SYSTEM)
SPECIFIC DEVELOPMENTAL ABNORMALITIES (EYE, EAR)
SPECIFIC DEVELOPMENTAL ABNORMALITIES (CRANIOFACIAL)
SPECIFIC DEVELOPMENTAL ABNORMALITIES (BODY WALL)
SPECIFIC DEVELOPMENTAL ABNORMALITIES (MUSCULOSKELETAL SYSTEM)
SPECIFIC DEVELOPMENTAL ABNORMALITIES (CARDIOVASCULAR SYSTEM)
EFFECTS ON NEWBORN (APGAR SCORE)
EFFECTS ON NEWBORN (VIABILITY INDEX)
EFFECTS ON NEWBORN (GROWTH STATISTICS)
EFFECTS ON NEWBORN (BEHAVIORAL)
EFFECTS ON NEWBORN (DELAYED EFFECTS)
NUTRITIONAL AND GROSS METABOLIC (BODY TEMPERATURE INCREASE)
TUMORIGENIC (CARCINOGENIC BY RTECS CRITERIA)
ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES
(RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR
COMPLETE INFORMATION.
SECTION 12. - - - - - - - - - ECOLOGICAL INFORMATION - - - - - - - - - -
DATA NOT YET AVAILABLE.
SECTION 13. - - - - - - - - - DISPOSAL CONSIDERATIONS - - - - - - - - -
DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE SOLVENT AND BURN IN A
CHEMICAL INCINERATOR EQUIPPED WITH AN AFTERBURNER AND SCRUBBER.
OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS.
SECTION 14. - - - - - - - - - - TRANSPORT INFORMATION - - - - - - - - -
CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION INFORMATION.
SECTION 15. - - - - - - - - - REGULATORY INFORMATION - - - - - - - - - -
EUROPEAN INFORMATION
TOXIC
R 25
TOXIC IF SWALLOWED.
R 36/37/38
IRRITATING TO EYES, RESPIRATORY SYSTEM AND SKIN.
R 43
MAY CAUSE SENSITIZATION BY SKIN CONTACT.
S 45
IN CASE OF ACCIDENT OR IF YOU FEEL UNWELL, SEEK MEDICAL ADVICE
IMMEDIATELY (SHOW THE LABEL WHERE POSSIBLE).
S 26
IN CASE OF CONTACT WITH EYES, RINSE IMMEDIATELY WITH PLENTY OF
WATER AND SEEK MEDICAL ADVICE.
S 36/37/39
WEAR SUITABLE PROTECTIVE CLOTHING, GLOVES AND EYE/FACE
PROTECTION.
REVIEWS, STANDARDS, AND REGULATIONS
OEL=MAK
NOES 1983: HZD X5240; NIS 2; TNF 331; NOS 4; TNE 15179; TFE 13312
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, APRIL 1997
SECTION 16. - - - - - - - - - - OTHER INFORMATION- - - - - - - - - - - -
THE ABOVE INFORMATION IS BELIEVED TO BE CORRECT BUT DOES NOT PURPORT TO
BE ALL INCLUSIVE AND SHALL BE USED ONLY AS A GUIDE. SIGMA, ALDRICH,
FLUKA SHALL NOT BE HELD LIABLE FOR ANY DAMAGE RESULTING FROM HANDLING
OR FROM CONTACT WITH THE ABOVE PRODUCT. SEE REVERSE SIDE OF INVOICE OR
PACKING SLIP FOR ADDITIONAL TERMS AND CONDITIONS OF SALE.
COPYRIGHT 1997 SIGMA CHEMICAL CO., ALDRICH CHEMICAL CO., INC.,
FLUKA CHEMIE AG
LICENSE GRANTED TO MAKE UNLIMITED PAPER COPIES FOR INTERNAL USE ONLY


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