PRODUCT #: M6144 NAME: 4,4'-METHYLENE-BIS(N,N-DIMETHYLANILINE)
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Tuesday, March 18, 1903 2:36PM
Sigma Chemical Co. Aldrich Chemical Co., Inc. Fluka Chemical Corp.
P.O. Box 14508 1001 West St. Paul 1001 West St. Paul
St. Louis, MO 63178 Milwaukee, WI 53233 Milwaukee, WI 53233
Phone: 314-771-5765 Phone: 414-273-3850 Phone: 414-273-3850
SECTION 1. - - - - - - - - - CHEMICAL IDENTIFICATION- - - - - - - - - -
CATALOG #: M6144
NAME: 4,4'-METHYLENE-BIS(N,N-DIMETHYLANILINE)
SECTION 2. - - - - - COMPOSITION/INFORMATION ON INGREDIENTS - - - - - -
CAS #: 101-61-1
MF: C17H22N2
EC NO: 202-959-2
SYNONYMS
BAZE MICHLEROVA (CZECH) * BENZENAMINE, 4,4'-METHYLENEBIS(N,N-DIMETHYL-
(9CI) * P,P'-BIS(DIMETHYLAMINO)DIPHENYLMETHANE * 4,4'-
BIS(DIMETHYLAMINO)DIPHENYLMETHANE * BIS(P-DIMETHYLAMINOPHENYL)METHANE
* BIS(4-(DIMETHYLAMINO)PHENYL)METHANE * BIS(P-(N,N-DIMETHYLAMINO)
PHENYL)METHANE * BIS(4-(N,N-DIMETHYLAMINO)PHENYL)METHANE * P,P'-BIS(N,
N-DIMETHYLAMINOPHENYL)METHANE * P,P-DIMETHYLAMINODIPHENYLMETHANE *
DIPHENYLMETHANE, TETRAMETHYLDIAMINO- * METHANE BASE * METHANE, BIS(P-
(DIMETHYLAMINO)PHENYL)- * METHYLENE BASE * 4,4'-METHYLENEBIS(N,N-
DIMETHYLANILINE) * 4,4'-METHYLENEBIS(N,N-DIMETHYLBENZENAMINE) *
MICHLER'S BASE * MICHLER'S HYDRIDE * MICHLER'S METHANE * NCI-C01990 *
REDUCED MICHLER'S KETONE * TETRA-BASE *
TETRAMETHYLDIAMINODIPHENYLMETHANE * P,P-
TETRAMETHYLDIAMINODIPHENYLMETHANE * N,N,N'N'-TETRAMETHYL-P,P'-
DIAMINODIPHENYLMETHANE * N,N,N'N'-TETRAMETHYL-4,4'-
DIAMINODIPHENYLMETHANE *
SECTION 3. - - - - - - - - - - HAZARDS IDENTIFICATION - - - - - - - - -
LABEL PRECAUTIONARY STATEMENTS
TOXIC
MAY CAUSE CANCER.
MAY CAUSE HERITABLE GENETIC DAMAGE.
HARMFUL BY INHALATION, IN CONTACT WITH SKIN AND IF SWALLOWED.
IRRITATING TO EYES, RESPIRATORY SYSTEM AND SKIN.
TARGET ORGAN(S):
LIVER
THYROID
IN CASE OF ACCIDENT OR IF YOU FEEL UNWELL, SEEK MEDICAL ADVICE
IMMEDIATELY (SHOW THE LABEL WHERE POSSIBLE).
IN CASE OF CONTACT WITH EYES, RINSE IMMEDIATELY WITH PLENTY OF
WATER AND SEEK MEDICAL ADVICE.
WEAR SUITABLE PROTECTIVE CLOTHING, GLOVES AND EYE/FACE
PROTECTION.
DO NOT BREATHE DUST.
SECTION 4. - - - - - - - - - - FIRST-AID MEASURES- - - - - - - - - - -
IN CASE OF CONTACT, IMMEDIATELY FLUSH EYES OR SKIN WITH COPIOUS
AMOUNTS OF WATER FOR AT LEAST 15 MINUTES WHILE REMOVING CONTAMINATED
CLOTHING AND SHOES.
IF INHALED, REMOVE TO FRESH AIR. IF NOT BREATHING GIVE ARTIFICIAL
RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN.
IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS.
CALL A PHYSICIAN.
DISCARD CONTAMINATED CLOTHING AND SHOES.
Page 1
PRODUCT #: M6144 NAME: 4,4'-METHYLENE-BIS(N,N-DIMETHYLANILINE)
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Tuesday, March 18, 1903 2:36PM
SECTION 5. - - - - - - - - - FIRE FIGHTING MEASURES - - - - - - - - - -
EXTINGUISHING MEDIA
WATER SPRAY.
CARBON DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE FOAM.
SPECIAL FIREFIGHTING PROCEDURES
WEAR SELF-CONTAINED BREATHING APPARATUS AND PROTECTIVE CLOTHING TO
PREVENT CONTACT WITH SKIN AND EYES.
UNUSUAL FIRE AND EXPLOSIONS HAZARDS
EMITS TOXIC FUMES UNDER FIRE CONDITIONS.
SECTION 6. - - - - - - - - ACCIDENTAL RELEASE MEASURES- - - - - - - - -
EVACUATE AREA.
WEAR SELF-CONTAINED BREATHING APPARATUS, RUBBER BOOTS AND HEAVY
RUBBER GLOVES.
WEAR DISPOSABLE COVERALLS AND DISCARD THEM AFTER USE.
SWEEP UP, PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL.
VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE.
SECTION 7. - - - - - - - - - - HANDLING AND STORAGE- - - - - - - - - - -
REFER TO SECTION 8.
SECTION 8. - - - - - - EXPOSURE CONTROLS/PERSONAL PROTECTION- - - - - -
WEAR APPROPRIATE NIOSH/MSHA-APPROVED RESPIRATOR, CHEMICAL-RESISTANT
GLOVES, SAFETY GOGGLES, OTHER PROTECTIVE CLOTHING.
SAFETY SHOWER AND EYE BATH.
USE ONLY IN A CHEMICAL FUME HOOD.
DO NOT BREATHE DUST.
AVOID ALL CONTACT.
AVOID PROLONGED OR REPEATED EXPOSURE.
WASH THOROUGHLY AFTER HANDLING.
CARCINOGEN.
IRRITANT.
MUTAGEN.
KEEP TIGHTLY CLOSED.
STORE IN A COOL DRY PLACE.
SECTION 9. - - - - - - - PHYSICAL AND CHEMICAL PROPERTIES - - - - - - -
APPEARANCE AND ODOR
OFF-WHITE CRYSTALLINE POWDER
PHYSICAL PROPERTIES
MELTING POINT: 88 C TO 89 C
SECTION 10. - - - - - - - - -STABILITY AND REACTIVITY - - - - - - - - -
INCOMPATIBILITIES
STRONG OXIDIZING AGENTS
HAZARDOUS COMBUSTION OR DECOMPOSITION PRODUCTS
TOXIC FUMES OF:
CARBON MONOXIDE, CARBON DIOXIDE
NITROGEN OXIDES
SECTION 11. - - - - - - - - - TOXICOLOGICAL INFORMATION - - - - - - - -
ACUTE EFFECTS
HARMFUL IF SWALLOWED, INHALED, OR ABSORBED THROUGH SKIN.
CAUSES EYE AND SKIN IRRITATION.
MATERIAL IS IRRITATING TO MUCOUS MEMBRANES AND UPPER
RESPIRATORY TRACT.
ABSORPTION INTO THE BODY LEADS TO THE FORMATION OF METHEMOGLOBIN
WHICH IN SUFFICIENT CONCENTRATION CAUSES CYANOSIS. ONSET MAY BE
DELAYED 2 TO 4 HOURS OR LONGER.
CHRONIC EFFECTS
CARCINOGEN.
MAY ALTER GENETIC MATERIAL.
TARGET ORGAN(S):
Page 2
PRODUCT #: M6144 NAME: 4,4'-METHYLENE-BIS(N,N-DIMETHYLANILINE)
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Tuesday, March 18, 1903 2:36PM
LIVER
THYROID
RTECS #: BY5250000
ANILINE, 4,4'-METHYLENEBIS(N,N-DIMETHYL-
TOXICITY DATA
ORL-MUS LD50:3160 MG/KG NCILB*
NCI-E-C-72-3252,1973
ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES
(RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR
COMPLETE INFORMATION.
SECTION 12. - - - - - - - - - ECOLOGICAL INFORMATION - - - - - - - - - -
DATA NOT YET AVAILABLE.
SECTION 13. - - - - - - - - - DISPOSAL CONSIDERATIONS - - - - - - - - -
DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE SOLVENT AND BURN IN A
CHEMICAL INCINERATOR EQUIPPED WITH AN AFTERBURNER AND SCRUBBER.
OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS.
SECTION 14. - - - - - - - - - - TRANSPORT INFORMATION - - - - - - - - -
CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION INFORMATION.
SECTION 15. - - - - - - - - - REGULATORY INFORMATION - - - - - - - - - -
EUROPEAN INFORMATION
TOXIC
R 45
MAY CAUSE CANCER.
R 46
MAY CAUSE HERITABLE GENETIC DAMAGE.
R 20/21/22
HARMFUL BY INHALATION, IN CONTACT WITH SKIN AND IF SWALLOWED.
R 36/37/38
IRRITATING TO EYES, RESPIRATORY SYSTEM AND SKIN.
S 45
IN CASE OF ACCIDENT OR IF YOU FEEL UNWELL, SEEK MEDICAL ADVICE
IMMEDIATELY (SHOW THE LABEL WHERE POSSIBLE).
S 26
IN CASE OF CONTACT WITH EYES, RINSE IMMEDIATELY WITH PLENTY OF
WATER AND SEEK MEDICAL ADVICE.
S 36/37/39
WEAR SUITABLE PROTECTIVE CLOTHING, GLOVES AND EYE/FACE
PROTECTION.
S 22
DO NOT BREATHE DUST.
REVIEWS, STANDARDS, AND REGULATIONS
OEL=MAK
IARC CANCER REVIEW:ANIMAL LIMITED EVIDENCE IMEMDT 27,119,1982
IARC CANCER REVIEW:HUMAN NO ADEQUATE DATA IMEMDT 27,119,1982
IARC CANCER REVIEW:GROUP 3 IMSUDL 7,56,1987
OEL-GERMANY;CARCINOGEN JAN 1993
OEL-SWITZERLAND;CARCINOGEN JAN 1993
OEL-UNITED KINGDOM:TWA 0.1 PPM (0.8 MG/M3);STEL 0.5 PPM JAN 1993
NOHS 1974: HZD M3405; NIS 4; TNF 53; NOS 11; TNE 1563
NOES 1983: HZD M3405; NIS 15; TNF 631; NOS 9; TNE 4140
EPA GENETOX PROGRAM 1988, POSITIVE: CARCINOGENICITY-MOUSE/RAT;
SHE-CLONAL ASSAY
EPA GENETOX PROGRAM 1988, POSITIVE: CELL TRANSFORM.-RLV F344 RAT
EMBRYO; HOST-MEDIATED ASSAY
EPA GENETOX PROGRAM 1988, POSITIVE: E COLI POLA WITHOUT S9
EPA GENETOX PROGRAM 1988, NEGATIVE: IN VITRO UDS-HUMAN FIBROBLAST; S
CEREVISIAE-HOMOZYGOSIS
Page 3
PRODUCT #: M6144 NAME: 4,4'-METHYLENE-BIS(N,N-DIMETHYLANILINE)
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Tuesday, March 18, 1903 2:36PM
EPA TSCA SECTION 8(B) CHEMICAL INVENTORY
ON EPA IRIS DATABASE
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, APRIL 1997
NCI CARCINOGENESIS BIOASSAY (FEED);CLEAR EVIDENCE:MOUSE,RAT
NCITR* NCI-TR-186,79
NTP 7TH ANNUAL REPORT ON CARCINOGENS, 1992 : ANTICIPATED TO BE
CARCINOGEN
U.S. INFORMATION
THIS PRODUCT IS SUBJECT TO SARA SECTION 313 REPORTING REQUIREMENTS.
CALIFORNIA PROPOSITION 65:
THIS PRODUCT IS OR CONTAINS CHEMICAL(S) KNOWN TO THE STATE OF
CALIFORNIA TO CAUSE CANCER.
SECTION 16. - - - - - - - - - - OTHER INFORMATION- - - - - - - - - - - -
THE ABOVE INFORMATION IS BELIEVED TO BE CORRECT BUT DOES NOT PURPORT TO
BE ALL INCLUSIVE AND SHALL BE USED ONLY AS A GUIDE. SIGMA, ALDRICH,
FLUKA SHALL NOT BE HELD LIABLE FOR ANY DAMAGE RESULTING FROM HANDLING
OR FROM CONTACT WITH THE ABOVE PRODUCT. SEE REVERSE SIDE OF INVOICE OR
PACKING SLIP FOR ADDITIONAL TERMS AND CONDITIONS OF SALE.
COPYRIGHT 1997 SIGMA CHEMICAL CO., ALDRICH CHEMICAL CO., INC.,
FLUKA CHEMIE AG
LICENSE GRANTED TO MAKE UNLIMITED PAPER COPIES FOR INTERNAL USE ONLY
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