PRODUCT #: T5267 NAME: TETRAHYDROFURAN
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Tuesday, March 18, 1903 2:30PM
Sigma Chemical Co. Aldrich Chemical Co., Inc. Fluka Chemical Corp.
P.O. Box 14508 1001 West St. Paul 1001 West St. Paul
St. Louis, MO 63178 Milwaukee, WI 53233 Milwaukee, WI 53233
Phone: 314-771-5765 Phone: 414-273-3850 Phone: 414-273-3850
SECTION 1. - - - - - - - - - CHEMICAL IDENTIFICATION- - - - - - - - - -
CATALOG #: T5267
NAME: TETRAHYDROFURAN
SECTION 2. - - - - - COMPOSITION/INFORMATION ON INGREDIENTS - - - - - -
CAS #: 109-99-9
MF: C4H8O
EC NO: 203-726-8
SYNONYMS
AGRISYNTH THF * BUTANE, 1,4-EPOXY- * BUTANE, ALPHA,DELTA-OXIDE *
CYCLOTETRAMETHYLENE OXIDE * DIETHYLENE OXIDE * 1,4-EPOXYBUTANE *
FURANIDINE * NCI-C60560 * OXACYCLOPENTANE * OXOLANE * RCRA WASTE
NUMBER U213 * TETRAHYDROFURAAN (DUTCH) * TETRAHYDROFURAN (ACGIH:DOT:
OSHA) * TETRAHYDROFURANNE (FRENCH) * TETRAIDROFURANO (ITALIAN) *
TETRAMETHYLENE OXIDE * UN2056 (DOT) *
SECTION 3. - - - - - - - - - - HAZARDS IDENTIFICATION - - - - - - - - -
LABEL PRECAUTIONARY STATEMENTS
FLAMMABLE (USA)
HIGHLY FLAMMABLE (EU)
HARMFUL
MAY FORM EXPLOSIVE PEROXIDES.
HARMFUL IF SWALLOWED.
IRRITATING TO EYES, RESPIRATORY SYSTEM AND SKIN.
TARGET ORGAN(S):
CENTRAL NERVOUS SYSTEM
LIVER
KEEP AWAY FROM SOURCES OF IGNITION - NO SMOKING.
TAKE PRECAUTIONARY MEASURES AGAINST STATIC DISCHARGES.
IN CASE OF CONTACT WITH EYES, RINSE IMMEDIATELY WITH PLENTY OF
WATER AND SEEK MEDICAL ADVICE.
WEAR SUITABLE PROTECTIVE CLOTHING.
SECTION 4. - - - - - - - - - - FIRST-AID MEASURES- - - - - - - - - - -
IN CASE OF CONTACT, IMMEDIATELY FLUSH EYES OR SKIN WITH COPIOUS
AMOUNTS OF WATER FOR AT LEAST 15 MINUTES WHILE REMOVING CONTAMINATED
CLOTHING AND SHOES.
IF INHALED, REMOVE TO FRESH AIR. IF NOT BREATHING GIVE ARTIFICIAL
RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN.
IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS.
CALL A PHYSICIAN.
WASH CONTAMINATED CLOTHING BEFORE REUSE.
SECTION 5. - - - - - - - - - FIRE FIGHTING MEASURES - - - - - - - - - -
EXTINGUISHING MEDIA
CARBON DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE FOAM.
WATER MAY BE EFFECTIVE FOR COOLING, BUT MAY NOT EFFECT EXTINGUISHMENT.
SPECIAL FIREFIGHTING PROCEDURES
WEAR SELF-CONTAINED BREATHING APPARATUS AND PROTECTIVE CLOTHING TO
PREVENT CONTACT WITH SKIN AND EYES.
USE WATER SPRAY TO COOL FIRE-EXPOSED CONTAINERS.
FLAMMABLE LIQUID.
UNUSUAL FIRE AND EXPLOSIONS HAZARDS
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PRODUCT #: T5267 NAME: TETRAHYDROFURAN
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Tuesday, March 18, 1903 2:30PM
VAPOR MAY TRAVEL CONSIDERABLE DISTANCE TO SOURCE OF IGNITION AND
FLASH BACK.
CONTAINER EXPLOSION MAY OCCUR UNDER FIRE CONDITIONS.
EMITS TOXIC FUMES UNDER FIRE CONDITIONS.
SECTION 6. - - - - - - - - ACCIDENTAL RELEASE MEASURES- - - - - - - - -
EVACUATE AREA.
SHUT OFF ALL SOURCES OF IGNITION.
WEAR SELF-CONTAINED BREATHING APPARATUS, RUBBER BOOTS AND HEAVY
RUBBER GLOVES.
COVER WITH DRY-LIME, SAND, OR SODA ASH. PLACE IN COVERED CONTAINERS
USING NON-SPARKING TOOLS AND TRANSPORT OUTDOORS.
VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE.
SECTION 7. - - - - - - - - - - HANDLING AND STORAGE- - - - - - - - - - -
REFER TO SECTION 8.
ADDITIONAL INFORMATION
DO NOT DISTILL TO DRYNESS.
TEST FOR PEROXIDE FORMATION PERIODICALLY AND BEFORE
DISTILLATION.
IN THE ABSENCE OF INHIBITORS, TETRAHYDROFURAN TENDS TO ABSORB AND REACT
WITH OXYGEN FROM THE AIR TO FORM EXPLOSIVE PEROXIDES WHICH MAY DETONATE
WHEN THEY BECOME CONCENTRATED BY EVAPORATION OR DISTILLATION, ARE
COMBINED WITH OTHER COMPOUNDS RESULTING IN AN EXPLOSIVE MIXTURE OR ARE
DISTURBED BY HEAT, SHOCK OR FRICTION.
SECTION 8. - - - - - - EXPOSURE CONTROLS/PERSONAL PROTECTION- - - - - -
WEAR APPROPRIATE NIOSH/MSHA-APPROVED RESPIRATOR, CHEMICAL-RESISTANT
GLOVES, SAFETY GOGGLES, OTHER PROTECTIVE CLOTHING.
MECHANICAL EXHAUST REQUIRED.
SAFETY SHOWER AND EYE BATH.
USE NONSPARKING TOOLS.
DO NOT BREATHE VAPOR.
AVOID CONTACT WITH EYES, SKIN AND CLOTHING.
AVOID PROLONGED OR REPEATED EXPOSURE.
WASH THOROUGHLY AFTER HANDLING.
HARMFUL LIQUID.
IRRITANT.
KEEP TIGHTLY CLOSED.
KEEP AWAY FROM HEAT, SPARKS, AND OPEN FLAME.
STORE IN A COOL DRY PLACE.
SECTION 9. - - - - - - - PHYSICAL AND CHEMICAL PROPERTIES - - - - - - -
APPEARANCE AND ODOR
LIQUID.
PHYSICAL PROPERTIES
BOILING POINT: 65 C TO 67 C
MELTING POINT: -108 C TO C
FLASHPOINT 1F
-17.22C
EXPLOSION LIMITS IN AIR:
UPPER 11.8%
LOWER 1.8%
AUTOIGNITION TEMPERATURE: 610 F 320C
VAPOR PRESSURE: 143MM 20 C 114MM 15 C
SPECIFIC GRAVITY: 0.889
VAPOR DENSITY: 2.5
SECTION 10. - - - - - - - - -STABILITY AND REACTIVITY - - - - - - - - -
STABILITY
STABLE.
CONDITIONS TO AVOID
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PRODUCT #: T5267 NAME: TETRAHYDROFURAN
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Tuesday, March 18, 1903 2:30PM
DEPLETION OF INHIBITOR
INCOMPATIBILITIES
ACIDS
BASES
OXIDIZING AGENTS
OXYGEN
HAZARDOUS COMBUSTION OR DECOMPOSITION PRODUCTS
TOXIC FUMES OF:
CARBON MONOXIDE, CARBON DIOXIDE
HAZARDOUS POLYMERIZATION
MAY OCCUR.
CONDITIONS TO AVOID
ACIDS
SECTION 11. - - - - - - - - - TOXICOLOGICAL INFORMATION - - - - - - - -
ACUTE EFFECTS
HARMFUL IF SWALLOWED.
MAY BE HARMFUL IF INHALED.
MAY BE HARMFUL IF ABSORBED THROUGH THE SKIN.
VAPOR OR MIST IS IRRITATING TO THE EYES, MUCOUS MEMBRANES AND UPPER
RESPIRATORY TRACT.
CAUSES SKIN IRRITATION.
PROLONGED OR REPEATED EXPOSURE TO SKIN CAUSES DEFATTING AND
DERMATITIS.
CAN CAUSE CNS DEPRESSION.
EXPOSURE CAN CAUSE:
NARCOTIC EFFECT
COUGHING, CHEST PAINS, DIFFICULTY IN BREATHING.
NAUSEA, DIZZINESS AND HEADACHE
UNCONSCIOUSNESS
CHRONIC EFFECTS
TARGET ORGAN(S):
CENTRAL NERVOUS SYSTEM
LIVER
KIDNEYS
RTECS #: LU5950000
FURAN, TETRAHYDRO-
TOXICITY DATA
ORL-RAT LD50:1650 MG/KG GAFCC*
IHL-RAT LC50:21000 PPM/3H SSEIBV 20,141,1984
IPR-RAT LD50:2900 MG/KG SAIGBL 24,373,1982
IPR-MUS LD50:1900 MG/KG SAIGBL 24,373,1982
ORL-GPG LD50:2300 MG/KG GISAAA 34(9),114,1969
TARGET ORGAN DATA
LIVER (FATTY LIVER DEGENERATION)
EFFECTS ON FERTILITY (POST-IMPLANTATION MORTALITY)
ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES
(RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR
COMPLETE INFORMATION.
SECTION 12. - - - - - - - - - ECOLOGICAL INFORMATION - - - - - - - - - -
DATA NOT YET AVAILABLE.
SECTION 13. - - - - - - - - - DISPOSAL CONSIDERATIONS - - - - - - - - -
BURN IN A CHEMICAL INCINERATOR EQUIPPED WITH AN AFTERBURNER AND
SCRUBBER BUT EXERT EXTRA CARE IN IGNITING AS THIS MATERIAL IS HIGHLY
FLAMMABLE.
OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS.
SECTION 14. - - - - - - - - - - TRANSPORT INFORMATION - - - - - - - - -
CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION INFORMATION.
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PRODUCT #: T5267 NAME: TETRAHYDROFURAN
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Tuesday, March 18, 1903 2:30PM
SECTION 15. - - - - - - - - - REGULATORY INFORMATION - - - - - - - - - -
EUROPEAN INFORMATION
EC INDEX NO: 603-025-00-0
HIGHLY FLAMMABLE
HARMFUL
R 11
HIGHLY FLAMMABLE.
R 19
MAY FORM EXPLOSIVE PEROXIDES.
R 36/37
IRRITATING TO EYES AND RESPIRATORY SYSTEM.
S 16
KEEP AWAY FROM SOURCES OF IGNITION - NO SMOKING.
S 29
DO NOT EMPTY INTO DRAINS.
S 33
TAKE PRECAUTIONARY MEASURES AGAINST STATIC DISCHARGES.
REVIEWS, STANDARDS, AND REGULATIONS
OEL=MAK
ACGIH TLV-STEL 737 MG/M3 (250 PPM) DTLVS* TLV/BEI,1996
ACGIH TLV-TWA 590 MG/M3 (200 PPM) DTLVS* TLV/BEI,1996
MSHA STANDARD-AIR:TWA 200 PPM (590 MG/M3)
DTLVS* 3,252,1971
OSHA PEL (GEN INDU):8H TWA 200 PPM (590 MG/M3)
CFRGBR 29,1910.1000,1994
OSHA PEL (CONSTRUC):8H TWA 200 PPM (590 MG/M3)
CFRGBR 29,1926.55,1994
OSHA PEL (SHIPYARD):8H TWA 200 PPM (590 MG/M3)
CFRGBR 29,1915.1000,1993
OSHA PEL (FED CONT):8H TWA 200 PPM (590 MG/M3)
CFRGBR 41,50-204.50,1994
OEL-AUSTRALIA:TWA 200 PPM (590 MG/M3);STEL 250 PPM (735 MG/M3) JAN 1993
OEL-BELGIUM:TWA 200 PPM (590 MG/M3);STEL 250 PPM (738 MG/M3) JAN 1993
OEL-DENMARK:TWA 200 PPM (590 MG/M3) JAN 1993
OEL-FINLAND:TWA 100 PPM (290 MG/M3);STEL 150 PPM (440 MG/M3) JAN 1993
OEL-FRANCE:TWA 200 PPM (590 MG/M3) JAN 1993
OEL-GERMANY:TWA 200 PPM (590 MG/M3) JAN 1993
OEL-HUNGARY:TWA 200 MG/M3;STEL 400 MG/M3 JAN 1993
OEL-JAPAN:TWA 200 PPM (590 MG/M3) JAN 1993
OEL-THE NETHERLANDS:TWA 200 PPM (590 MG/M3) JAN 1993
OEL-THE PHILIPPINES:TWA 200 PPM (590 MG/M3) JAN 1993
OEL-RUSSIA:TWA 200 PPM;STEL 100 MG/M3 JAN 1993
OEL-SWEDEN:TWA 100 PPM (300 MG/M3);STEL 150 PPM (450 MG/M3) JAN 1993
OEL-SWITZERLAND:TWA 200 PPM (590 MG/M3);STEL 1000 PPM JAN 1993
OEL-TURKEY:TWA 200 PPM (590 MG/M3) JAN 1993
OEL-UNITED KINGDOM:TWA 200 PPM (590 MG/M3);STEL 250 PPM JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA CHECK ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM CHECK ACGIH TLV
NIOSH REL TO TETRAHYDROFURAN-AIR:10H TWA 200 PPM;STEL 250 PPM
NIOSH* DHHS #92-100,1992
NOHS 1974: HZD 71695; NIS 72; TNF 4141; NOS 60; TNE 95003
NOES 1983: HZD 71695; NIS 101; TNF 17866; NOS 83; TNE 356038; TFE 47382
EPA TSCA SECTION 8(B) CHEMICAL INVENTORY
EPA TSCA SECTION 8(D) UNPUBLISHED HEALTH/SAFETY STUDIES
ON EPA IRIS DATABASE
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, APRIL 1997
NIOSH ANALYTICAL METHOD, 1994: TETRAHYDROFURAN, 1609
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PRODUCT #: T5267 NAME: TETRAHYDROFURAN
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Tuesday, March 18, 1903 2:30PM
NTP CARCINOGENESIS STUDIES; TEST COMPLETED (POST PEER REVIEW), APRIL
1997
SECTION 16. - - - - - - - - - - OTHER INFORMATION- - - - - - - - - - - -
THE ABOVE INFORMATION IS BELIEVED TO BE CORRECT BUT DOES NOT PURPORT TO
BE ALL INCLUSIVE AND SHALL BE USED ONLY AS A GUIDE. SIGMA, ALDRICH,
FLUKA SHALL NOT BE HELD LIABLE FOR ANY DAMAGE RESULTING FROM HANDLING
OR FROM CONTACT WITH THE ABOVE PRODUCT. SEE REVERSE SIDE OF INVOICE OR
PACKING SLIP FOR ADDITIONAL TERMS AND CONDITIONS OF SALE.
COPYRIGHT 1997 SIGMA CHEMICAL CO., ALDRICH CHEMICAL CO., INC.,
FLUKA CHEMIE AG
LICENSE GRANTED TO MAKE UNLIMITED PAPER COPIES FOR INTERNAL USE ONLY
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