Product Name: Farmoz Cotoran SC Herbicide
Page: 1 of 6
This revision issued: July, 2005
Section 1 - Identification of Chemical Product and Company
Farmoz Pty Ltd, Suite 1, Level 4, Building B Telephone (02)9431 7800 (24 hours)
207 Pacific Highway, St Leonards, NSW 2068 Fax (02)9431 7700
ACN 050 328 973
Substance: Fluometuron is a fluorinated urea derived herbicide ingredient.
Trade Name: Farmoz Cotoran SC Herbicide
Product Use: Agricultural herbicide for use as described on the product label.
Creation Date: June, 2004
Revision Date: July, 2005
Section 2 - Hazards Identification
Statement of Hazardous Nature
This product is classified as: Not classified as hazardous according to the criteria of NOHSC Australia.
Not a Dangerous Good according to the Australian Dangerous Goods (ADG) Code.
Risk Phrases: Not Hazardous - No criteria found.
Safety Phrases: Not Hazardous - No criteria found.
SUSDP Classification: None allocated.
ADG Classification: None allocated. Not a Dangerous Good.
UN Number: None allocated
Emergency Overviiew
Emergency Overv ew
Physical Description & colour: White to beige coloured viscous liquid.
Odour: Mild, non-specific odour.
Major Health Hazards: Fluometuron is practically nontoxic by ingestion with a reported oral LD50 of 6416 to 8900
mg/kg in rats. Via the dermal route, it is also practically nontoxic; the dermal LD50 is greater than 2000 mg/kg in rats
and greater than 10,000 mg/kg in rabbits. Fluometuron is a mild skin irritant and causes skin sensitization in guinea
pigs. It may cause corneal opacity in test animals. It is irritating to the mucous membrane lining the skin,
gastrointestinal tract, and respiratory system. The inhalation LC50 in rats is greater than 2 mg/L, indicating moderate to
low toxicity by this route. While there have been no reports of cases of fluometuron poisoning in humans, this
herbicide is considered a mild inhibitor of cholinesterase.
Pottenttiiall Healltth Effffectts
Po en a Hea h E ec s
See section 11 for Chronic exposure studies.
Inhalation
Short term exposure: Available data indicates that this product is not harmful. In addition, this product is unlikely
to cause any discomfort or irritation.
Skin Contact:
Short term exposure: Available data indicates that this product is not harmful. It should present no hazards in
normal use. In addition, this product is believed to be mildly irritating, but is unlikely to cause anything more than mild
transient discomfort.
Eye Contact:
Short term exposure: Available data shows that this product is not harmful. In addition, this product is believed to
be mildly irritating, to eyes, but is unlikely to cause anything more than mild transient discomfort.
Ingestion:
Short term exposure: This product is unlikely to cause any health problems in the short or long term.
Carcinogen Status:
NOHSC: No significant ingredient is classified as carcinogenic by NOHSC.
NTP: No significant ingredient is classified as carcinogenic by NTP.
IARC: Fluometuron is Class 3 - unclassifiable as to carcinogenicity to humans.
MATERIAL SAFETY DATA SHEET
Issued by: Farmoz Pty Ltd Phone: (02)9431 7800
Product Name: Farmoz Cotoran SC Herbicide
Page: 2 of 6
This revision issued: July, 2005
Section 3 鈥? Composition/Information on Ingredients
TWA ((mg///m33) STEL ((mg///m33)
TWA (m g m 3)) STEL (m g m 3))
IIIngrrediiientts
n gre d e nts CAS No Conc,,,%
Conc %
CAS No
ng ed en s CAS No Conc % TWA mg m STEL mg m
Fluometuron 2164-17-2 50 not set not set
Propylene glycol 57-55-6 10 not set not set
Other non hazardous ingredients secret <10 not set not set
Water 7732-18-5 to 100 not set not set
This is a commercial product whose exact ratio of components may vary slightly. Minor quantities of other non
hazardous ingredients are also possible.
The TWA exposure value is the average airborne concentration of a particular substance when calculated over a normal 8 hour working day for a 5
day working week. The STEL (Short Term Exposure Limit) is an exposure value that should not be exceeded for more than 15 minutes and should
not be repeated for more than 4 times per day. There should be at least 60 minutes between successive exposures at the STEL. The term "peak "is
used when the TWA limit, because of the rapid action of the substance, should never be exceeded, even briefly.
Section 4 - First Aid Measures
General Information:
You should call The Poisons Information Centre if you feel that you may have been poisoned, burned or irritated by
this product. The number is 13 1126 from anywhere in Australia and is available at all times. Have this MSDS with
you when you call.
Inhalation: First aid is not generally required. If in doubt, contact a Poisons Information Centre or a doctor.
Skin Contact: Blot or brush away excess chemical. Wash gently and thoroughly with water (use non-abrasive soap
if necessary) for 10 minutes or until chemical is removed. Under running water, remove contaminated clothing, shoes
and leather goods (e.g. watchbands and belts). If irritation persists, repeat flushing and obtain medical advice.
Eye Contact: Quickly and gently blot or brush product away. Flush the contaminated eye(s) with lukewarm, gently
flowing water for 5 minutes, or until the product is removed, while holding the eyelid(s) open. Obtain medical advice if
irritation becomes painful or lasts more than a few minutes.
Ingestion: First aid is not generally required. If in doubt, contact a Poisons Information Centre or a doctor.
Section 5 鈥? Fire Fighting Measures
Fire and Explosion Hazards: There is no risk of an explosion from this product under normal circumstances if it is
involved in a fire.
Fire decomposition products from this product may be toxic if inhaled. Take appropriate protective measures.
This product is likely to decompose only after heating to dryness, followed by further strong heating.
Extinguishing Media: Preferred extinguishing media are carbon dioxide, dry chemical, foam, water fog.
Fire Fighting:
Flash point: No data
Upper Flammability Limit: No data.
Lower Flammability Limit: No data.
Autoignition temperature: No data.
Flammability Class: No data.
Section 6 鈥? Accidental Release Measures
Accidental release: Minor spills do not normally need any special cleanup measures. In the event of a major spill,
prevent spillage from entering drains or water courses. Wear full protective clothing including face mask, face shield
and gauntlets. All skin areas should be covered. See above under Personal Protection regarding Australian
Standards relating to personal protective equipment. Suitable materials for protective clothing include rubber, PVC.
Stop leak if safe to do so, and contain spill. Absorb onto sand, vermiculite or other suitable absorbent material. If spill
is too large or if absorbent material is not available, try to create a dike to stop material spreading or going into drains
or waterways. Sweep up and shovel or collect recoverable product into labelled containers for recycling or salvage,
and dispose of promptly. After spills, wash area preventing runoff from entering drains. If a significant quantity of
material enters drains, advise emergency services. Full details regarding disposal of used containers, spillage and
unused material may be found on the label. If there is any conflict between this MSDS and the label, instructions on
the label prevail. Ensure legality of disposal by consulting regulations prior to disposal. Thoroughly launder protective
clothing before storage or re-use. Advise laundry of nature of contamination when sending contaminated clothing to
laundry.
MATERIAL SAFETY DATA SHEET
Issued by: Farmoz Pty Ltd Phone: (02)9431 7800
Product Name: Farmoz Cotoran SC Herbicide
Page: 3 of 6
This revision issued: July, 2005
Section 7 鈥? Handling and Storage
Handling: Keep exposure to this product to a minimum, and minimise the quantities kept in work areas. Check
Section 8 of this MSDS for details of personal protective measures, and make sure that those measures are followed.
The measures detailed below under "Storage" should be followed during handling in order to minimise risks to
persons using the product in the workplace. Also, avoid contact or contamination of product with incompatible
materials listed in Section 10.
Storage: Make sure that containers of this product are kept tightly closed. Make sure that the product does not come
into contact with substances listed under "Materials to avoid" in Section 10. Some liquid preparations settle or
separate on standing and may require stirring before use. Check packaging - there may be further storage
instructions on the label.
Section 8 Exposure Controls and Personal Protection
The following Australian Standards will provide general advice regarding safety clothing and equipment:
Respiratory equipment: AS/NZS 1715, Protective Gloves: AS 2161, Industrial Clothing: AS2919, Industrial Eye
Protection: AS1336 and AS/NZS 1337, Occupational Protective Footwear: AS/NZS2210.
TWA (mg/m3) STEL (mg/m3)
Exposure Limits
Exposure limits have not been established by NOHSC for any of the significant ingredients in this product.
The ADI for Fluometuron is set at 0.02mg/kg/day. The corresponding NOEL is set at 2mg/kg/day. ADI means
Acceptable Daily Intake and NOEL means No-observable-effect-level. Values taken from Australian ADI List, January
2001.
Ventilation: No special ventilation requirements are normally necessary for this product. However make sure that
the work environment remains clean and that dusts are minimised.
Eye Protection: Eye protection such as protective glasses or goggles is recommended when this product is being
used.
Skin Protection: You should avoid contact even with mild skin irritants. Therefore you should wear suitable
impervious elbow-length gloves and facial protection when handling this product. See below for suitable material
types.
Protective Material Types: We suggest that protective clothing be made from the following materials: rubber,
PVC.
Respirator: Usually, no respirator is necessary when using this product. However, if you have any doubts consult
the Australian Standard mentioned above.
Section 9 - Physical and Chemical Properties:
Physical Description & colour: White to beige coloured viscous liquid.
Odour: Mild, non-specific odour.
Boiling Point: Boils at about 100掳C at 100kPa.
Freezing/Melting Point: No specific data. Liquid at normal temperatures.
Volatiles: Water component.
Vapour Pressure: 2.37 kPa at 20掳C (water vapour pressure).
Vapour Density: No data.
Specific Gravity: 1.10-1.13 at 20掳C
Water Solubility: Forms suspensions in water.
pH: No data.
Volatility: No data.
Odour Threshold: No data.
Evaporation Rate: No data.
Coeff Oil/water distribution: No data
Autoignition temp: No data.
Section 10 鈥? Stability and Reactivity
Reactivity: This product is unlikely to react or decompose under normal storage conditions. However, if you have
any doubts, contact the supplier for advice on shelf life properties.
Conditions to Avoid: This product should be kept in a cool place, preferably below 30掳C.
Incompatibilities: No particular incompatibilities.
Fire Decomposition: Carbon dioxide, and if combustion is incomplete, carbon monoxide and smoke. Nitrogen and
its compounds, and under some circumstances, oxides of nitrogen. Occasionally hydrogen cyanide gas. Hydrogen
fluoride gas and other compounds of fluorine. Water. Carbon monoxide poisoning produces headache, weakness,
MATERIAL SAFETY DATA SHEET
Issued by: Farmoz Pty Ltd Phone: (02)9431 7800
Product Name: Farmoz Cotoran SC Herbicide
Page: 4 of 6
This revision issued: July, 2005
nausea, dizziness, confusion, dimness of vision, disturbance of judgment, and unconsciousness followed by coma
and death. Hydrogen cyanide poisoning signs and symptoms are weakness, dizziness, headache, nausea, vomiting,
coma, convulsions, and death. Death results from respiratory arrest. Hydrogen cyanide gas acts very rapidly;
symptoms and death can both occur quickly.
Polymerisation: This product is unlikely to undergo polymerisation processes.
Section 11 鈥? Toxicological Information
Toxicity: Acute toxicity: Fluometuron is practically nontoxic by ingestion with a reported oral LD50 of 6416 to 8900
mg/kg in rats. Via the dermal route, it is also practically nontoxic; the dermal LD50 is greater than 2000 mg/kg in rats
and greater than 10,000 mg/kg in rabbits. Fluometuron is a mild skin irritant and causes skin sensitization in guinea
pigs. It may cause corneal opacity in test animals. It is irritating to the mucous membrane lining the skin,
gastrointestinal tract, and respiratory system. The inhalation LC50 in rats is greater than 2 mg/L, indicating moderate to
low toxicity by this route. While there have been no reports of cases of fluometuron poisoning in humans, this
herbicide is considered a mild inhibitor of cholinesterase. Cholinesterase inhibition was observed in guinea pigs
exposed by inhalation to about 0.6 mg/L for 2 hours. Examination of rats used for LD50 testing revealed increased
brain weight. Other symptoms of fluometuron poisoning in rats include muscular weakness, tearing or watery eyes,
extreme exhaustion, and collapse.
Chronic toxicity: Rats were fed 7.5, 75, or 750 mg/kg/day for 90 days. At the highest dose, decreased body weight
and congestion in the spleen, adrenals, liver, and kidneys, as well as abnormalities in red blood cells were evident.
When doses of 1.5, 15 or 150 mg/kg/day were fed to puppies for 90 days, congestion of the liver, kidneys, and spleen
occurred at the highest dose. No effects were seen at 15 mg/kg/day. Prolonged or repeated exposure to fluometuron
may cause conjunctivitis or skin sensitization.
Reproductive effects: There were no reproductive effects due to fluometuron seen in pregnant rats given doses as
high as 50 mg/kg/day during gestation, even though toxic effects in the mother were observed. Pregnant rabbits were
given doses of 50, 500, or 1000 mg/kg/day by stomach tube during days 6 through 19 of gestation. An increase in the
number of resorbed foetuses was found at all treatment doses. Reduction in maternal body weight and food
consumption occurred at doses of 500 and 1000 mg/kg/day. The evidence indicates that fluometuron will not cause
reproductive effects in humans at expected levels of exposure.
Teratogenic effects: Some secondary developmental effects were seen in the progeny of rats and rabbits receiving
100 mg/kg/day during gestation. These higher dose data indicate that teratogenic effects are not likely in humans at
expected exposure levels.
Mutagenic effects: In various tests for mutagenicity and genotoxicity, fluometuron has not shown activity. These
include the Ames mutagenicity assay, the Chinese hamster ovary cell culture assay for chromosome aberration, and
DNA repair inhibition tests in rat liver and human fibroblast cell lines. It reportedly did show some interference with
DNA synthesis in the testes of mice given a single oral dose of 2000 mg/kg. Based on these studies, fluometuron
does not appear to be mutagenic.
Carcinogenic effects: Mice that were given oral doses of 87 mg/kg/day for 2 years showed evidence of liver tumors
and leukemia, a condition characterized by uncontrolled growth in the number of white-blood cells. Another study
showed increased liver cell tumor incidence in male mice, but carcinogenic effects were not observed in female mice
or in rats of either sex. The available evidence in inconclusive, but suggests that carcinogenic effects in humans is not
likely.
Organ toxicity: Target organs of fluometuron as determined in animal studies include brain, spleen, adrenals, liver,
and kidneys, and red blood cells.
Fate in humans and animals: Fluometuron is absorbed only slowly into the body from the gastrointestinal tract. At
72 hours after rats were given oral doses of 50 mg/kg fluometuron, 15% of the dose was excreted in the urine and
49% was excreted unchanged in the faeces. At the same time, fluometuron or its metabolites were detected in the
rats' livers, kidneys, adrenal gland, pituitary gland, red blood cells, blood plasma, and spleen, with the highest
concentration found in red-blood cells.
Section 12 鈥? Ecological Information
Effects on birds: Fluometuron is practically nontoxic to birds; the reported acute oral LD50 values for fluometuron are
greater than 2150 mg/kg in bobwhite quail and 2974 mg/kg in mallard ducks. The reported 5- to 8-day dietary LC50
values for fluometuron were greater than 5620 ppm in bobwhite quail, 4500 ppm in mallard ducks, 3150 in ring-neck
pheasant, and 4620 ppm in Japanese quail.
Effects on aquatic organisms: Fluometuron is slightly toxic to fish. The reported 96-hour LC50 of technical
fluometuron is 30 mg/L in rainbow trout, 48 mg/L in bluegill sunfish, 170 mg/L in carp, and 55 mg/L in catfish. In
catfish, tissue concentrations in whole fish were 40 times that of the ambient water, indicating low capacity for
bioaccumulation. The reported 48 hour LC50 for fluometuron in Daphnia (water flea) is 54 mg/L , indicating slight
toxicity to aquatic invertebrates.
Effects on other organisms: Fluometuron is relatively nontoxic to bees.
Environmental Fate:
MATERIAL SAFETY DATA SHEET
Issued by: Farmoz Pty Ltd Phone: (02)9431 7800
Product Name: Farmoz Cotoran SC Herbicide
Page: 5 of 6
This revision issued: July, 2005
Breakdown in soil and groundwater: Fluometuron is moderately to highly persistent in the soil environment, with a
reported field half-life of 12 to 171 days. A representative field half-life under most conditions is estimated to be 85
days. Breakdown in the soil environment occurs mainly through photodegradation, when there is little rainfall after
application, and by microbial breakdown otherwise. Fluometuron is soluble in water, and poorly bound to most soils.
This suggests that it would be mobile in most soils, but in field studies in California and Georgia no residues were
detected below 12 inches. In addition, fluometuron was not found in groundwater during a national survey.
Breakdown in water: Fluometuron may be highly persistent in the water environment as well. The half-life of
fluometuron in water is 110 to 144 weeks. It is stable at pH values ranging from 1 to 13, at 20 C. However, exposure
of 10 ppm aqueous solutions of fluometuron to natural sunlight resulted in 88% decomposition in 3 days, with a half-
life of 1.2 days.
Breakdown in vegetation: Fluometuron is more readily absorbed by roots from soil application than by leaves from
foliar application. The addition of a surfactant or nonphytotoxic oil to spray solutions improves the absorption of
fluometuron by leaves. The rate at which it is absorbed, translocated, and subsequently broken down, (or
metabolized) differs with various plant species. An understanding of these differences is important in determining the
tolerance or susceptibility of plants and weeds to this chemical.
Section 13 鈥? Disposal Considerations
Disposal: Instructions concerning the disposal of this product and its containers are given on the product label.
These should be carefully followed.
Section 14 鈥? Transport Information
ADG Code: This product is not classified as a Dangerous Good. No special transport conditions are necessary
unless required by other regulations.
Section 15 鈥? Regulatory Information
AICS: All of the significant ingredients in this formulation are to be found in the public AICS Database.
Section 16 鈥? Other Information
Much of the Information in this MSDS came from Extoxnet, a Pesticide Information Project of Cooperative Extension
Offices of Cornell University, Oregon State University, the University of Idaho, and the University of California at Davis
and the Institute for Environmental Toxicology, Michigan State University.
This MSDS contains only safety-related information. For other data see product literature.
Acronyms:
ADG Code Australian Code for the Transport of Dangerous Goods by Road and Rail
AICS Australian Inventory of Chemical Substances
CAS number Chemical Abstracts Service Registry Number
Hazchem Number Emergency action code of numbers and letters that provide information to
emergency services especially firefighters
IARC International Agency for Research on Cancer
NOHSC National Occupational Health and Safety Commission
NOS Not otherwise specified
NTP National Toxicology Program (USA)
R-Phrase Risk Phrase
SUSDP Standard for the Uniform Scheduling of Drugs & Poisons
UN Number United Nations Number
Contact Points:
Call Farmoz on (02)9431 7800 Fax: (02)9431 7700 and ask for the technical manager.
Police and Fire Brigade: Dial 000
Emergency contact: 1800 024 973 (24 hours)
If ineffective: Dial Poisons Information Centre
(13 1126 from anywhere in Australia)
The information contained in this Material Safety Data Sheet is provided in good faith and is believed to be correct at the date
hereof. However, it is expected that individuals receiving the information will exercise their independent judgement in determining
its appropriateness for a particular purpose. Farmoz Pty Ltd makes no representation as to the accuracy or comprehensiveness of
the information and to the full extent allowed by law excludes all liability whatsoever, whether with respect to negligence or
otherwise, for any loss or damage arising from or connection with the supply or use of the information in this Material Safety Data
MATERIAL SAFETY DATA SHEET
Issued by: Farmoz Pty Ltd Phone: (02)9431 7800
Product Name: Farmoz Cotoran SC Herbicide
Page: 6 of 6
This revision issued: July, 2005
Sheet.
Please read all labels carefully before using product.
This MSDS copyright 漏 Kilford & Kilford Pty Ltd, July, 2005.
http://www.kilford.com.au/ Phone (02)9251 4532
MATERIAL SAFETY DATA SHEET
Issued by: Farmoz Pty Ltd Phone: (02)9431 7800
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