**** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS ****
+----------------+--------------------------------------+----------+-----------+
| CAS# | Chemical Name | % | EINECS# |
|----------------|--------------------------------------|----------|-----------|
| 1529-41-5 |3-Chlorobenzyl cyanide | 99 | 216-213-9 |
+----------------+--------------------------------------+----------+-----------+
Hazard Symbols: T
Risk Phrases: 23/24/25 36/37/38
**** SECTION 3 - HAZARDS IDENTIFICATION ****
EMERGENCY OVERVIEW
Toxic by inhalation, in contact with skin and if swallowed.
Irritating to eyes, respiratory system and skin.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation. Harmful if absorbed through the skin. May
be metabolized to cyanide which in turn acts by inhibiting cytochrome
oxidase impairing cellular respiration. Most nitrile compounds are
well absorbed through intact skin, and may cause delayed onset of
symptoms following exposure by this route.
Ingestion:
May cause irritation of the digestive tract. Poison by ingestion.
May cause cardiac disturbances. May cause central nervous system
depression. Metabolism may release cyanide, which may result in
headache, dizziness, weakness, collapse, unconsciousness and possible
death.
Inhalation:
Harmful if inhaled. May cause respiratory tract irritation. May
cause cardiac abnormalities. May be metabolized to cyanide which in
turns act by inhibiting cytochrome oxidase impairing cellular
respiration. Inhalation may result in symptoms similar to cyanide
poisoning which include tachypnea, hyperpnea (abnormally rapid or
deep breathing), and dyspnea (labored breathing) followed rapidly by
respiratory depression. Pulmonary edema may occur. Inhalation at high
concentrations may cause CNS depression and asphixiation.
Chronic:
May be metabolized to cyanide which in turn acts by inhibiting
cytochrome oxidase impairing cellular respiration. Chronic exposure
to cyanide solutions may lead to the development of a "cyanide" rash,
characterized by itching, and by macular, papular, and vesicular
eruptions, and may be accompanied by secondary infections. Exposure
to small amounts of cyanide compounds over long periods of time is
reported to cause loss of appetite, headache, weakness, nausea,
dizziness, and symptoms of irritation of the upper respiratory tract
and eyes.
**** SECTION 4 - FIRST AID MEASURES ****
Eyes:
In case of contact, immediately flush eyes with plenty of water for
at least 15 minutes. Get medical aid.
Skin:
In case of contact, immediately flush skin with plenty of water for
at least 15 minutes while removing contaminated clothing and shoes.
Get medical aid immediately. Wash clothing before reuse.
Ingestion:
If swallowed, do not induce vomiting unless directed to do so by
medical personnel. Never give anything by mouth to an unconscious
person. Get medical aid.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial
respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
May be partially metabolized to cyanide in the body.
Antidote:
Always have a cyanide antidote kit on hand when working with cyanide
compounds. Get medical advice to use.
**** SECTION 5 - FIRE FIGHTING MEASURES ****
General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. During a fire, irritating and highly toxic gases
may be generated by thermal decomposition or combustion. Vapors may
be heavier than air. They can spread along the ground and collect
in low or confined areas. Containers may explode when heated. Runoff
from fire control or dilution water may cause pollution. Approach
fire from upwind to avoid hazardous vapors and toxic decomposition
products.
Extinguishing Media:
For small fires, use dry chemical, carbon dioxide, or water spray.
For large fires, use dry chemical, carbon dioxide, alcohol-resistant
foam, or water spray. Cool containers with flooding quantities of
water until well after fire is out.
**** SECTION 6 - ACCIDENTAL RELEASE MEASURES ****
General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth),
then place in suitable container. Avoid runoff into storm sewers and
ditches which lead to waterways. Clean up spills immediately,
observing precautions in the Protective Equipment section. Provide
ventilation.
**** SECTION 7 - HANDLING and STORAGE ****
Handling:
Wash thoroughly after handling. Remove contaminated clothing and
wash before reuse. Do not get in eyes, on skin, or on clothing. Keep
container tightly closed. Avoid ingestion and inhalation. Use only
in a chemical fume hood. Avoid breathing vapor or mist.
Storage:
Store in a tightly closed container. Store in a cool, dry,
well-ventilated area away from incompatible substances.
**** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION ****
Engineering Controls:
Facilities storing or utilizing this material should be equipped
with an eyewash facility and a safety shower. Use adequate
ventilation to keep airborne concentrations low.
Exposure Limits
CAS# 1529-41-5:
United States OSHA: 5 mg/m3 TWA (listed under Cyanide anion).
Germany: (listed as cyanide anion): Skin absorber
Netherlands: (listed as cyanide anion): 5 mg/m3 MAC (as CN)
Personal Protective Equipment
Eyes:
Wear chemical splash goggles.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
Follow the OSHA respirator regulations found in 29
CFR 1910.134 or European Standard EN 149. Use a
NIOSH/MSHA or European Standard EN 149 approved
respirator if exposure limits are exceeded or if
irritation or other symptoms are experienced.
**** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES ****
Physical State: Liquid
Color: clear colorless to faint yellow
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: 276-278 deg C @ 760 mmHg
Freezing/Melting Point: 12 - 14 deg C
Autoignition Temperature: Not applicable.
Flash Point: > 110 deg C (> 230.00 deg F)
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: insoluble
Specific Gravity/Density: 1.19 g/cm3
Molecular Formula: ClC6H4CH2CN
Molecular Weight: 151.60
**** SECTION 10 - STABILITY AND REACTIVITY ****
Chemical Stability:
Stable at room temperature in closed containers under normal storage
and handling conditions.
Conditions to Avoid:
Excess heat.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong reducing agents, strong acids, strong
bases.
Hazardous Decomposition Products:
Hydrogen chloride, hydrogen cyanide, nitrogen oxides, carbon
monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported.
**** SECTION 11 - TOXICOLOGICAL INFORMATION ****
RTECS#:
CAS# 1529-41-5: AL8240000
LD50/LC50:
Not available.
Carcinogenicity:
3-Chlorobenzyl cyanide -
Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
**** SECTION 12 - ECOLOGICAL INFORMATION ****
**** SECTION 13 - DISPOSAL CONSIDERATIONS ****
Dispose of in a manner consistent with federal, state, and local regulations.
**** SECTION 14 - TRANSPORT INFORMATION ****
IATA
Shipping Name: Nitriles, Toxic, N.O.S.
Hazard Class: 6.1
UN Number: 3276
Packing Group: II
IMO
Shipping Name: Nitriles, Toxic, N.O.S.
Hazard Class: 6.1
UN Number: 3276
Packing Group: II
RID/ADR
Shipping Name: Nitriles, Toxic, N.O.S.
Hazard Class: 6.1
UN Number: 3276
Packing group: II
**** SECTION 15 - REGULATORY INFORMATION ****
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T
Risk Phrases:
R 23/24/25 Toxic by inhalation, in contact with skin
and if swallowed.
R 36/37/38 Irritating to eyes, respiratory system
and skin.
Safety Phrases:
S 28B After contact with skin, wash immediately with
plenty of water and soap.
S 36/37/39 Wear suitable protective clothing, gloves
and eye/face protection.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 1529-41-5: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 1529-41-5 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 1529-41-5 is not listed on the TSCA inventory.
It is for research and development use only.
**** SECTION 16 - ADDITIONAL INFORMATION ****
MSDS Creation Date: 9/02/1997 Revision #7 Date: 3/04/2004
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no way shall the company be
liable for any claims, losses, or damages of any third party or for lost
profits or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if the company has been advised of
the possibility of such damages.
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