EMERGENCY OVERVIEW
Danger of cumulative effects.Cancer suspect agent.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
May cause pain, weakness and numbness with possible muscle
paralysis. May cause central nervous system effects. May cause liver
damage leading to jaundice. Ingestion of large amounts may cause an
increase in blood pressure. May cause tremors, weakness, muscular
spasms and ataxia (failure of muscular coordination).
Inhalation:
May cause effects similar to those described for ingestion. May
cause irritation of the mucous membranes.
Chronic:
Chronic exposure may cause liver damage.
**** SECTION 4 - FIRST AID MEASURES ****
Eyes:
Immediately flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15
minutes while removing contaminated clothing and shoes. Wash clothing
before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical
aid immediately. Do NOT induce vomiting. If conscious and alert,
rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If breathing
is difficult, give oxygen. Get medical aid. Do not use mouth-to-mouth
resuscitation if victim ingested or inhaled the substance; induce
artificial respiration with the aid of a pocket mask equipped with a
one-way valve or other proper respiratory medical device.
Notes to Physician:
**** SECTION 5 - FIRE FIGHTING MEASURES ****
General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. During a fire, irritating and highly toxic gases
may be generated by thermal decomposition or combustion.
Extinguishing Media:
In case of fire, use water, dry chemical, chemical foam, or
alcohol-resistant foam.
**** SECTION 6 - ACCIDENTAL RELEASE MEASURES ****
General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Sweep up, then place into a suitable container for disposal. Avoid
generating dusty conditions. Provide ventilation.
**** SECTION 7 - HANDLING and STORAGE ****
Handling:
Wash thoroughly after handling. Remove contaminated clothing and
wash before reuse. Minimize dust generation and accumulation. Do not
get in eyes, on skin, or on clothing. Do not ingest or inhale. Use
only in a chemical fume hood.
Storage:
Keep containers tightly closed. Store in a cool, dry area away from
incompatible substances.
**** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION ****
Engineering Controls:
Facilities storing or utilizing this material should be equipped
with an eyewash facility and a safety shower. Use adequate general or
local exhaust ventilation to keep airborne concentrations below the
permissible exposure limits.
Exposure Limits
CAS# 443-48-1:
Personal Protective Equipment
Eyes:
Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European
Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
A respiratory protection program that meets OSHA's 29
CFR 1910.134 and ANSI Z88.2 requirements or European
Standard EN 149 must be followed whenever workplace
conditions warrant respirator use.
**** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES ****
Physical State: Crystalline powder
Color: very slightly yellow
Odor: odorless
pH: 5.8 (sat. aq. soln.)
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 160.00 - 162.00 deg C
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: Not available.
Solubility in water: 1g/100ml (20 c)
Specific Gravity/Density: Not available.
Molecular Formula: C6H9N3O3
Molecular Weight: 176.16
**** SECTION 10 - STABILITY AND REACTIVITY ****
Chemical Stability:
Stable under normal temperatures and pressures. May discolor on
exposure to light.
Conditions to Avoid:
Incompatible materials, light, dust generation, excess heat, strong
oxidants.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and
gases, carbon dioxide, nitrogen.
Hazardous Polymerization: Will not occur.
**** SECTION 11 - TOXICOLOGICAL INFORMATION ****
RTECS#:
CAS# 443-48-1: NI5600000
LD50/LC50:
CAS# 443-48-1: Oral, mouse: LD50 = 3800 mg/kg; Oral, rat: LD50 = 3
gm/kg.
Carcinogenicity:
Metronidazole -
California: carcinogen, initial date 1/1/88
NTP: Suspect carcinogen
IARC: Group 2B carcinogen
Other:
See actual entry in RTECS for complete information.
**** SECTION 12 - ECOLOGICAL INFORMATION ****
**** SECTION 13 - DISPOSAL CONSIDERATIONS ****
Dispose of in a manner consistent with federal, state, and local regulations.
**** SECTION 14 - TRANSPORT INFORMATION ****
IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.
**** SECTION 15 - REGULATORY INFORMATION ****
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 33 Danger of cumulative effects.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
WGK (Water Danger/Protection)
CAS# 443-48-1: No information available.
Canada
CAS# 443-48-1 is listed on Canada's DSL List.
CAS# 443-48-1 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 443-48-1 is not listed on the TSCA inventory.
It is for research and development use only.
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
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the possibility of such damages.
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