**** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS ****
+----------------+--------------------------------------+----------+-----------+
| CAS# | Chemical Name | % | EINECS# |
|----------------|--------------------------------------|----------|-----------|
| 4368-28-9 |Tetrodotoxin | ca 100 | 224-458-8 |
+----------------+--------------------------------------+----------+-----------+
Hazard Symbols: T+
Risk Phrases: 26/27/28
**** SECTION 3 - HAZARDS IDENTIFICATION ****
EMERGENCY OVERVIEW
Very toxic by inhalation, in contact with skin and if swallowed.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
May be fatal if swallowed. May cause irritation of the digestive
tract. May cause muscle paralysis, respiratory failure, and possible
death. Ingestion affects the muscles and causes salivation, tingling
of the mouth, convulsions, numbness, slow pulse rate, irregular heart
beat, pulmonary edema, and potassium deficiency in the blood.
Inhalation:
May cause respiratory tract irritation. May cause effects similar to
those described for ingestion. May produce numbness and tingling of
the lips, hands, and feet (paresthesia) and ataxia (failure of
muscular coordination).
Chronic:
Repeated exposure may cause central nervous system damage.
**** SECTION 4 - FIRST AID MEASURES ****
Eyes:
Flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15
minutes while removing contaminated clothing and shoes. Wash clothing
before reuse.
Ingestion:
Call a poison control center. If swallowed, do not induce vomiting
unless directed to do so by medical personnel. Never give anything by
mouth to an unconscious person. Get medical aid.
Inhalation:
Remove from exposure and move to fresh air immediately. If not
breathing, give artificial respiration. If breathing is difficult,
give oxygen. Get medical aid. Do NOT use mouth-to-mouth
resuscitation.
Notes to Physician:
**** SECTION 5 - FIRE FIGHTING MEASURES ****
General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. During a fire, irritating and highly toxic gases
may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use agent most appropriate to extinguish fire. Use water spray, dry
chemical, carbon dioxide, or appropriate foam.
**** SECTION 6 - ACCIDENTAL RELEASE MEASURES ****
General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Clean up spills immediately, observing precautions in the Protective
Equipment section. Sweep up, then place into a suitable container for
disposal. Avoid generating dusty conditions. Provide ventilation.
**** SECTION 7 - HANDLING and STORAGE ****
Handling:
Wash thoroughly after handling. Use with adequate ventilation.
Minimize dust generation and accumulation. Avoid contact with eyes,
skin, and clothing. Keep container tightly closed. Avoid ingestion
and inhalation. Use only in a chemical fume hood.
Storage:
Store in a tightly closed container. Store in a cool, dry,
well-ventilated area away from incompatible substances. Poison room
locked/refrigerator.
**** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION ****
Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Exposure Limits
CAS# 4368-28-9:
Personal Protective Equipment
Eyes:
Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European
Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
Follow the OSHA respirator regulations found in 29
CFR 1910.134 or European Standard EN 149. Use a
NIOSH/MSHA or European Standard EN 149 approved
respirator if exposure limits are exceeded or if
irritation or other symptoms are experienced.
**** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES ****
Physical State: Solid
Color: white to beige
Odor: None reported.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Decomposes
Freezing/Melting Point: 220 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: > 220 deg C
Solubility in water: slightly soluble
Specific Gravity/Density:
Molecular Formula: C11H17N3O8
Molecular Weight: 319.26
**** SECTION 10 - STABILITY AND REACTIVITY ****
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, dust generation, excess heat.
Incompatibilities with Other Materials:
Oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, oxides of nitrogen, irritating and toxic fumes and
gases, carbon dioxide.
Hazardous Polymerization: Has not been reported.
**** SECTION 11 - TOXICOLOGICAL INFORMATION ****
RTECS#:
CAS# 4368-28-9: IO1450000
LD50/LC50:
CAS# 4368-28-9: Oral, mouse: LD50 = 334 ug/kg.
Carcinogenicity:
Tetrodotoxin -
Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
**** SECTION 12 - ECOLOGICAL INFORMATION ****
**** SECTION 13 - DISPOSAL CONSIDERATIONS ****
Dispose of in a manner consistent with federal, state, and local regulations.
**** SECTION 14 - TRANSPORT INFORMATION ****
IATA
Shipping Name: TOXIC SOLID, ORGANIC, N.O.S.*
Hazard Class: 6.1
UN Number: 2811
Packing Group: I
IMO
Shipping Name: TOXIC SOLID, ORGANIC, N.O.S.
Hazard Class: 6.1
UN Number: 2811
Packing Group: I
RID/ADR
Shipping Name: TOXIC SOLID, ORGANIC, N.O.S.
Hazard Class: 6.1
UN Number: 2811
Packing group: I
**** SECTION 15 - REGULATORY INFORMATION ****
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T+
Risk Phrases:
R 26/27/28 Very toxic by inhalation, in contact with
skin and if swallowed.
Safety Phrases:
S 28A After contact with skin, wash immediately with
plenty of water.
S 36/37/39 Wear suitable protective clothing, gloves
and eye/face protection.
S 37 Wear suitable gloves.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 4368-28-9: 3
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 4368-28-9 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 4368-28-9 is not listed on the TSCA inventory.
It is for research and development use only.
**** SECTION 16 - ADDITIONAL INFORMATION ****
MSDS Creation Date: 1/07/1999 Revision #2 Date: 12/03/2002
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no way shall the company be
liable for any claims, losses, or damages of any third party or for lost
profits or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if the company has been advised of
the possibility of such damages.
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
|
|
|
| ALL MSDS PAGES IN THIS GROUP
| | NAME | CAS |
|
Cholesteryl Crotylcarbonate
| 62637-94-9 |
|
Chloroacetonitrile, 98+%
| 107-14-2 |
|
3-Quinuclidinone hydrochloride, 99% (tlc)
| 1193-65-3 |
|
2'-me-2',3',10,11-tetrahydrospiro(5h-diben
| 35926-76-2 |
|
l-Leucine methyl ester hydrochloride, 98%
| 7517-19-3 |
|
3-Methylbenzylamine, 98%
| 100-81-2 |
|
3-Amino-4-methylbenzoic acid, 99%
| 2458-12-0 |
|
Methyl 4-Nitrobutyrate, Tech. 80%
| 13013-02-0 |
|
2,3,4-Trimethoxybenzonitrile, 97%
| 43020-38-8 |
|
1-Phenyl-3-(2-Thiazolyl)-2-Thiourea, 97+%
| 14901-16-7 |
|
Hydrogen fluoride, 37 wt% solution in triethylamine
| 73602-61-6 |
|
Ammonium Sodium Phosphate Tetrahydrate 99%
| 0-00-1 |
|
5,6-Benzoquinoline, 99+%
| 85-02-9 |
|
4-Methoxy-2-nitrophenol, 99+%
| 1568-70-3 |
|
4-Hydroxybenzyl Alcohol, 97% (TLC)
| 623-05-2 |
|
1-(2-Fluorophenyl)piperazine, 97%(GC)
| 1011-15-0 |
|
Hexamethyl dewar benzene, 97%
| 7641-77-2 |
|
Triaza-12-Crown-4, 99%
| 0-01-1 |
|
alpha-Angelicalactone, 98%
| 591-12-8 |
|
3-Acetamidocoumarin
| 779-30-6 |
|
4,6-Dihydroxy-2-Methylpyrimidine, 99%
| 40497-30-1 |
|
Purpurogallin, tech.
| 569-77-7 |
|
2,3-Dimethyl-P-Nitroanisole, 98%
| 81029-03-0 |
|
4-Nitro-p-terphenyl
| 10355-53-0 |
|
2,3-Dimethylcyclohexylamine, mixture of isomers, 99+%
| 42195-92-6 |
|
Epibromohydrin, 98%
| 3132-64-7 |
|
Stearic Anhydride
| 638-08-4 |
|
Ethyl Vinyl Ether, 99% (gc)
| 109-92-2 |
|
Fluoresceinamine Isomer I, 99% (UV-Vis)
| 3326-34-9 |
|
2-Methyl-1,3-cyclohexanedione, 98+%
| 1193-55-1 |
|
(2S,3S)-2-Amino-3-Ethoxybutanoic Acid Hydrochloride, 99+%, (80% e.e.)
| 0-01-1 |
|
Thioflavin t
| 2390-54-7 |
|
Methyl dichloroacetate, 99+%
| 116-54-1 |
|
Trimethylsilyl Trifluoromethanesulfonate, 99%
| 27607-77-8 |
|
3,4-Dihydro-2H-Pyran, 99%
| 110-87-2 |
|
2-Nitrophenyl Disulfide, 95%
| 1155-00-6 |
|
Methylenedi-p-phenyl diisocyanate
| 101-68-8 |
|
1-Bromo-2,3-Dichlorobenzene, 99%
| 56961-77-4 |
|
n-Butyric Anhydride, 99%
| 106-31-0 |
|
2,2',4'-Trichloroacetophenone, 95%, containing up to 10% water,
| 4252-78-2 |
|
10-Nonadecanone, 99%
| 504-57-4 |
|
Hydrogen hexachloroiridate(IV) hexahydrate, approx. 40% Iridium
| 16941-92-7 |
|
3-(3,4,5-Trimethoxyphenyl)Propionic Acid, 98+%
| 25173-72-2 |
|
Tetrodotoxin, Citrate Free
| 4368-28-9 |
|
Acid Green 25
| 4403-90-1 |
|
Coumalic Acid, 97+%
| 500-05-0 |
|
7,8-Benzoquinoline, 97%
| 230-27-3 |
|
1,10-Diaminodecane, 97+%
| 646-25-3 |
|
Inositol, 98+% (HPLC)
| 87-89-8 |
|
Thallium (III) Nitrate Trihydrate, 99.5%
| 13453-38-8 |
|
|