**** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS ****
+----------------+--------------------------------------+----------+-----------+
| CAS# | Chemical Name | % | EINECS# |
|----------------|--------------------------------------|----------|-----------|
| 518-28-5 |Podophyllotoxin | 95 | 208-250-4 |
+----------------+--------------------------------------+----------+-----------+
Hazard Symbols: T
Risk Phrases: 23/25
**** SECTION 3 - HAZARDS IDENTIFICATION ****
EMERGENCY OVERVIEW
Toxic by inhalation and if swallowed.Toxic.
Potential Health Effects
Eye:
Causes eye irritation. May cause chemical conjunctivitis.
Skin:
Causes skin irritation. Harmful if absorbed through the skin.
Substance is readily absorbed through the skin.
Ingestion:
Causes gastrointestinal irritation with nausea, vomiting and
diarrhea. May cause gastrointestinal tract damage.
Inhalation:
Causes irritation of the mucous membrane and upper respiratory
tract.
Chronic:
No information found.
**** SECTION 4 - FIRST AID MEASURES ****
Eyes:
Immediately flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower eyelids. Get medical aid
immediately.
Skin:
Get medical aid immediately. Immediately flush skin with plenty of
water for at least 15 minutes while removing contaminated clothing
and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical
aid immediately. Do NOT induce vomiting. If conscious and alert,
rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh
air immediately. If breathing is difficult, give oxygen. Do not use
mouth-to-mouth resuscitation if victim ingested or inhaled the
substance; induce artificial respiration with the aid of a pocket
mask equipped with a one-way valve or other proper respiratory
medical device.
Notes to Physician:
**** SECTION 5 - FIRE FIGHTING MEASURES ****
General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. During a fire, irritating and highly toxic gases
may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or appropriate foam.
**** SECTION 6 - ACCIDENTAL RELEASE MEASURES ****
General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Clean up spills immediately, observing precautions in the Protective
Equipment section. Sweep up, then place into a suitable container for
disposal. Avoid generating dusty conditions. Provide ventilation.
**** SECTION 7 - HANDLING and STORAGE ****
Handling:
Wash thoroughly after handling. Remove contaminated clothing and
wash before reuse. Use with adequate ventilation. Do not get in eyes,
on skin, or on clothing. Do not ingest or inhale. Use only in a
chemical fume hood.
Storage:
Store in a cool, dry place. Keep containers tightly closed.
**** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION ****
Engineering Controls:
Facilities storing or utilizing this material should be equipped
with an eyewash facility and a safety shower. Use adequate
ventilation to keep airborne concentrations low.
Exposure Limits
CAS# 518-28-5:
Personal Protective Equipment
Eyes:
Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European
Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
A respiratory protection program that meets OSHA's 29
CFR 1910.134 and ANSI Z88.2 requirements or European
Standard EN 149 must be followed whenever workplace
conditions warrant respirator use.
**** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES ****
Physical State: Powder
Color: off-white
Odor: none reported
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 175.00 - 177.00 deg C
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: Not available.
Solubility in water: 120 mg/L @ 23C
Specific Gravity/Density: Not available.
Molecular Formula: C22H22O8
Molecular Weight: 414.40
**** SECTION 10 - STABILITY AND REACTIVITY ****
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, strong oxidants.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong acids, strong bases.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported
**** SECTION 11 - TOXICOLOGICAL INFORMATION ****
RTECS#:
CAS# 518-28-5: LV2500000
LD50/LC50:
CAS# 518-28-5: Oral, mouse: LD50 = 100 mg/kg; Skin, rabbit: LD50 =
200 mg/kg; Skin, rat: LD50 = 500 mg/kg.
Carcinogenicity:
Podophyllotoxin -
Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
**** SECTION 12 - ECOLOGICAL INFORMATION ****
Other
No information available.
**** SECTION 13 - DISPOSAL CONSIDERATIONS ****
Dispose of in a manner consistent with federal, state, and local regulations.
**** SECTION 14 - TRANSPORT INFORMATION ****
IATA
Shipping Name: TOXIC SOLID, ORGANIC, N.O.S.*
Hazard Class: 6.1
UN Number: 2811
Packing Group: III
IMO
Shipping Name: TOXIC SOLID, ORGANIC, N.O.S.
Hazard Class: 6.1
UN Number: 2811
Packing Group: III
RID/ADR
Shipping Name: TOXIC SOLID, ORGANIC, N.O.S.
Hazard Class: 6.1
UN Number: 2811
Packing group: III
**** SECTION 15 - REGULATORY INFORMATION ****
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T
Risk Phrases:
R 23/25 Toxic by inhalation and if swallowed.
Safety Phrases:
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 518-28-5: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 518-28-5 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 518-28-5 is not listed on the TSCA inventory.
It is for research and development use only.
**** SECTION 16 - ADDITIONAL INFORMATION ****
MSDS Creation Date: 9/02/1997 Revision #4 Date: 3/18/2003
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no way shall the company be
liable for any claims, losses, or damages of any third party or for lost
profits or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if the company has been advised of
the possibility of such damages.
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
|
|
|
| ALL MSDS PAGES IN THIS GROUP
| | NAME | CAS |
|
3-Ethyl-3-methylglutaric anhydride, 97%
| 6970-57-6 |
|
2-Aminonicotinic Acid, 98%
| 5345-47-1 |
|
4,4'-Bis(Dimethylamino)Thiobenzophenone, 98% (UV-VIS)
| 1226-46-6 |
|
Benzoyl chloride-d5, 99+ atom% d
| 43019-90-5 |
|
1-Propanethiol, 98%
| 107-03-9 |
|
Diethyl Ethoxymethylenemalonate, 99+%
| 87-13-8 |
|
1,2-O-Isopropylidene-D-glucofuranose, 98%
| 18549-40-1 |
|
Podophyllotoxin, 95%(tlc)
| 518-28-5 |
|
S-Acetylthiocholine Bromide, 99%
| 25025-59-6 |
|
Ethyl p-dimethylaminobenzoate, 99+%
| 10287-53-3 |
|
1,7-Octadiyne, 99%
| 871-84-1 |
|
2,3-Dichlorobenzoic acid, 98%
| 50-45-3 |
|
1,2-O-Cyclohexylidene-Alpha-D-Xylopentodi- Aldo-1,4-Furanose, 98%
| 15356-27-1 |
|
Ethylenediaminetetraacetic acid, tetrasodium salt dihydrate
| 64-02-8 |
|
2,3,5-Trichlorophenol, 99%
| 933-78-8 |
|
(2S)-(+)-Glycidyl tosylate, 99+%
| 70987-78-9 |
|
(-)-alpha-Amino-gamma-butyrolactone hydroiodide, 98%
| 171736-85-9 |
|
alpha-Methylbenzyl cyanide, tech.
| 1823-91-2 |
|
Vinylidene chloride, 99.9%, stabilized with 200 ppm MEHQ
| 75-35-4 |
|
Dibutyl Phosphite, 96%
| 1809-19-4 |
|
Sodium phosphate monobasic dihydrate
| 7558-80-7 |
|
5-Chloro-2,4-Dimethoxyaniline, 99+%
| 97-50-7 |
|
Ascarite (II)-,CO2 Absorbent, 20-to 30 Mesh
| 81133-20-2 |
|
Tri-M-Tolyl Phosphate (Pract), 93% (GC)
| 563-04-2 |
|
2,3-Epoxypropyl 4'-methoxyphenyl ether, 99%
| 2211-94-1 |
|
O-Anisoyl Chloride, 99% (Titr.)
| 21615-34-9 |
|
1-Tridecene, 99%
| 2437-56-1 |
|
Benzoylferrocene 98%
| 1272-44-2 |
|
4-Bromophenylacetic acid, 99%
| 1878-68-8 |
|
Triphenylarsine Oxide
| 1153-05-5 |
|
Copper(i) oxide, 97%
| 1317-39-1 |
|
2-Iodopropane, 98+% stabilized over copper
| 75-30-9 |
|
Glycyrrhizic Acid, Monoammonium Salt Tri-Hydrate, 98%
| 53956-04-0 |
|
Methyl (s)-(-)-4-bromo-3-tert- butyldimethylsilyloxybutanoate
| 101703-35-9 |
|
2-Fluorobenzonitrile, 99%
| 394-47-8 |
|
3-Aminophenyl-Sulfone, 97%(TLC)
| 599-61-1 |
|
Ammonium Hexafluorophosphate, 99.5%
| 16941-11-0 |
|
2-Methyl-1-phenyl-2-propanol
| 100-86-7 |
|
Aluminum Phthalocyanine Chloride, 99% (UV-Vis)
| 14154-42-8 |
|
2-Amino-6-chloro-4-pyrimidinol hydrate, 95%
| 1194-21-4 |
|
Phenyl acetate, 97%
| 122-79-2 |
|
Oligomycin, Mixture of A, B and C
| 1404-19-9 |
|
Sodium atomic absorption standard solution, 1 mg/ml Na in 0.5N HNO3
| 7440-23-5 |
|
Bromodichloromethane, 98+%, stabilized with potassium carbonate
| 75-27-4 |
|
2,2,5-Trichloropentanal, 96%
| |
|
BOC-L-Glutamic Acid-5-Benzylester DCHA, 99.5+%
| 13574-84-0 |
|
3-Nitrophenylhydrazine hydrochloride, 98%
| 636-95-3 |
|
2,3-Dimercapto-1-propanol, 93% (GC)
| 59-52-9 |
|
4,6-Dimethyl-2-Mercaptopyrimidine, 99%
| 22325-27-5 |
|
2-Fluorobenzamide, 98%
| 445-28-3 |
|
|