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MSDS 
:
 Tetracycline Hydrochloride,"Can be Used as Secondary Standard"
CAS 
:
 64-75-5
SYNONYMS 
:
 Achromycin Hydrochloride; Panmycin Hydrochloride.
**** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS ****

+----------------+--------------------------------------+----------+-----------+
| CAS# | Chemical Name | % | EINECS# |
|----------------|--------------------------------------|----------|-----------|
| 64-75-5 |Tetracycline Hydrochloride | | 200-593-8 |
+----------------+--------------------------------------+----------+-----------+
Hazard Symbols: XN
Risk Phrases: 63

**** SECTION 3 - HAZARDS IDENTIFICATION ****

EMERGENCY OVERVIEW
Possible risk of harm to the unborn child.Light sensitive.Air
sensitive.Moisture sensitive.Mutagen.

Potential Health Effects
Eye:
Dust may cause mechanical irritation.
Skin:
May cause skin sensitization, an allergic reaction, which becomes
evident upon re-exposure to this material.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and
diarrhea. May cause liver and kidney damage.
Inhalation:
Excessive inhalation may cause minor respiratory irritation. May
cause effects similar to those described for ingestion.
Chronic:
May cause fetal effects. Adverse reproductive effects have been
reported in animals. Laboratory experiments have resulted in
mutagenic effects.

**** SECTION 4 - FIRST AID MEASURES ****

Eyes:
Flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid if irritation develops or persists. Wash clothing
before reuse. Flush skin with plenty of soap and water.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Never give anything by mouth to an unconscious person. Get medical
aid immediately.
Inhalation:
Remove from exposure and move to fresh air immediately. If not
breathing, give artificial respiration. If breathing is difficult,
give oxygen. Get medical aid.
Notes to Physician:

**** SECTION 5 - FIRE FIGHTING MEASURES ****

General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. Combustion generates toxic fumes. During a fire,
irritating and highly toxic gases may be generated by thermal
decomposition or combustion. Runoff from fire control or dilution
water may cause pollution.
Extinguishing Media:
Use agent most appropriate to extinguish fire. Do NOT get water
inside containers. In case of fire, use carbon dioxide, dry chemical
powder or appropriate foam.

**** SECTION 6 - ACCIDENTAL RELEASE MEASURES ****

General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal
container. Clean up spills immediately, observing precautions in the
Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation. Place under an inert atmosphere. Do not get
water inside containers.

**** SECTION 7 - HANDLING and STORAGE ****

Handling:
Wash thoroughly after handling. Remove contaminated clothing and
wash before reuse. Use with adequate ventilation. Minimize dust
generation and accumulation. Avoid contact with skin and eyes. Keep
container tightly closed. Avoid ingestion and inhalation. Store
protected from light. Handle under an inert atmosphere. Store
protected from air. Do not allow contact with water. Keep from
contact with moist air and steam.
Storage:
Store in a cool, dry, well-ventilated area away from incompatible
substances. Do not expose to air. Store protected from moisture.
Store protected from light. Store under an inert atmosphere.

**** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION ****

Engineering Controls:
Facilities storing or utilizing this material should be equipped
with an eyewash facility and a safety shower. Use adequate
ventilation to keep airborne concentrations low.
Exposure Limits
CAS# 64-75-5:


Personal Protective Equipment

Eyes:
Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European
Standard EN166.
Skin:
Wear appropriate protective gloves and clothing to
prevent skin exposure.
Clothing:
Wear appropriate protective clothing to minimize
contact with skin.
Respirators:
Follow the OSHA respirator regulations found in 29
CFR 1910.134 or European Standard EN 149. Use a
NIOSH/MSHA or European Standard EN 149 approved
respirator if exposure limits are exceeded or if
irritation or other symptoms are experienced.

**** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES ****

Physical State: Powder
Color: yellow
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 223 deg C dec
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: in water: 1:20 m/v
Specific Gravity/Density:
Molecular Formula: C22H24N2O8.HCl
Molecular Weight: 480.90

**** SECTION 10 - STABILITY AND REACTIVITY ****

Chemical Stability:
Stable under normal temperatures and pressures. Substance undergoes
color change upon exposure to light and air.
Conditions to Avoid:
High temperatures, incompatible materials, light, dust generation,
moisture, exposure to air, excess heat, strong oxidants.
Incompatibilities with Other Materials:
Oxidizing agents, moisture, air.
Hazardous Decomposition Products:
Hydrogen chloride, nitrogen oxides, carbon monoxide, irritating and
toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported

**** SECTION 11 - TOXICOLOGICAL INFORMATION ****

RTECS#:
CAS# 64-75-5: QI9100000
LD50/LC50:
CAS# 64-75-5: Oral, mouse: LD50 = 2759 mg/kg; Oral, rat: LD50 = 6443
mg/kg.
Carcinogenicity:
Tetracycline Hydrochloride -
Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

**** SECTION 12 - ECOLOGICAL INFORMATION ****



**** SECTION 13 - DISPOSAL CONSIDERATIONS ****

Dispose of in a manner consistent with federal, state, and local regulations.

**** SECTION 14 - TRANSPORT INFORMATION ****

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

**** SECTION 15 - REGULATORY INFORMATION ****

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 63 Possible risk of harm to the unborn child.
Safety Phrases:
S 36/37 Wear suitable protective clothing and
gloves.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 64-75-5: No information available.
Canada
CAS# 64-75-5 is listed on Canada's DSL List.
CAS# 64-75-5 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 64-75-5 is listed on the TSCA inventory.

**** SECTION 16 - ADDITIONAL INFORMATION ****

MSDS Creation Date: 9/02/1997 Revision #4 Date: 6/25/2002

The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no way shall the company be
liable for any claims, losses, or damages of any third party or for lost
profits or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if the company has been advised of
the possibility of such damages.
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