**** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS ****
+----------------+--------------------------------------+----------+-----------+
| CAS# | Chemical Name | % | EINECS# |
|----------------|--------------------------------------|----------|-----------|
|----------------|--------------------------------------|----------|-----------|
| 75-05-8 |Acetonitrile | 99.8 | 200-835-2 |
|----------------|--------------------------------------|----------|-----------|
| 540-69-2 |Ammonium formate | 0.2 | 208-753-9 |
+----------------+--------------------------------------+----------+-----------+
Text for R-phrases: see Section 16
Hazard Symbols: XN F
Risk Phrases: 11 20/21/22 36
**** SECTION 3 - HAZARDS IDENTIFICATION ****
EMERGENCY OVERVIEW
Highly flammable. Harmful by inhalation, in contact with skin and if
swallowed. Irritating to eyes.
Potential Health Effects
Eye:
Causes eye irritation. Lachrymator (substance which increases the
flow of tears). May produce superficial reversible injury.
Skin:
Causes mild skin irritation. If absorbed, causes symptoms similar to
those of inhalation. May be harmful if absorbed through the skin. May
be metabolized to cyanide which in turn acts by inhibiting cytochrome
oxidase impairing cellular respiration.
Ingestion:
May cause tissue anoxia, characterized by weakness, headache,
dizziness, confusion, cyanosis (bluish skin due to deficient
oxygenation of the blood), weak and irregular heart beat, collapse,
unconsciousness, convulsions, coma and death. Metabolism may release
cyanide, which may result in headache, dizziness, weakness,
collapse, unconsciousness and possible death.
Inhalation:
May cause respiratory tract irritation. May cause lung damage. May
be harmful if inhaled.
Chronic:
May be metabolized to cyanide which in turn acts by inhibiting
cytochrome oxidase impairing cellular respiration. Exposure to small
amounts of cyanide compounds over long periods of time is reported
to cause loss of appetite, headache, weakness, nausea, dizziness, and
symptoms of irritation of the upper respiratory tract and eyes.
Animal studies indicate that the product may affect the liver and
kidneys.
**** SECTION 4 - FIRST AID MEASURES ****
Eyes:
In case of contact, immediately flush eyes with plenty of water for
at least 15 minutes. Get medical aid.
Skin:
In case of contact, immediately flush skin with plenty of water for
at least 15 minutes while removing contaminated clothing and shoes.
Get medical aid immediately. Wash clothing before reuse.
Ingestion:
If swallowed, do not induce vomiting unless directed to do so by
medical personnel. Never give anything by mouth to an unconscious
person. Get medical aid.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial
respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Exposure should be treated as a cyanide poisoning. Effects may be
delayed. For methemoglobinemia, administer oxygen alone or with
Methylene Blue depending on the methemoglobin concentration in the
blood. May be partially metabolized to cyanide in the body.
Antidote:
Always have a cyanide antidote kit on hand when working with cyanide
compounds. Get medical advice to use. Methylene blue, alone or in
combination with oxygen is indicated as a treatment in nitrite
induced methemoglobinemia.
**** SECTION 5 - FIRE FIGHTING MEASURES ****
General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. Use water spray to keep fire-exposed containers
cool. Flammable liquid and vapor. Approach fire from upwind to avoid
hazardous vapors and toxic decomposition products. Vapors are
heavier than air and may travel to a source of ignition and flash
back. Vapors can spread along the ground and collect in low or
confined areas.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or appropriate foam.
**** SECTION 6 - ACCIDENTAL RELEASE MEASURES ****
General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth),
then place in suitable container. Remove all sources of ignition.
Provide ventilation. Evacuate unnecessary personnel. Approach spill
from upwind.
**** SECTION 7 - HANDLING and STORAGE ****
Handling:
Wash thoroughly after handling. Remove contaminated clothing and
wash before reuse. Ground and bond containers when transferring
material. Avoid contact with eyes, skin, and clothing. Empty
containers retain product residue, (liquid and/or vapor), and can be
dangerous. Keep container tightly closed. Keep away from heat, sparks
and flame. Do not pressurize, cut, weld, braze, solder, drill, grind,
or expose empty containers to heat, sparks or open flames. Use only
with adequate ventilation. Avoid breathing vapor or mist.
Storage:
Keep away from sources of ignition. Store in a tightly closed
container. Keep from contact with oxidizing materials. Store in a
cool, dry, well-ventilated area away from incompatible substances.
Flammables-area. Store protected from moisture.
**** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION ****
Engineering Controls:
Use explosion-proof ventilation equipment. Facilities storing or
utilizing this material should be equipped with an eyewash facility
and a safety shower. Use adequate general or local exhaust
ventilation to keep airborne concentrations below the permissible
exposure limits.
Exposure Limits
CAS# 75-05-8:
United Kingdom, WEL - TWA: 40 ppm TWA; 68 mg/m3 TWA
United Kingdom, WEL - STEL: 60 ppm STEL; 102 mg/m3 STEL
United States OSHA: 40 ppm TWA; 70 mg/m3 TWA
Belgium - TWA: 40 ppm VLE; 68 mg/m3 VLE
Belgium - STEL: 60 ppm VLE; 102 mg/m3 VLE
France - VME: 40 ppm VME; 70 mg/m3 VME
Germany: 20 ppm TWA; 34 mg/m3 TWA
Germany: Skin absorber
Malaysia: 40 ppm TWA; 67 mg/m3 TWA
Netherlands: 40 ppm MAC; 70 mg/m3 MAC
Russia: 10 mg/m3 TWA
Spain: 40 ppm VLA-ED; 68 mg/m3 VLA-ED
Spain: 60 ppm VLA-EC; 102 mg/m3 VLA-EC
CAS# 540-69-2:
Personal Protective Equipment
Eyes:
Wear chemical splash goggles.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
A respiratory protection program that meets OSHA's 29
CFR 1910.134 and ANSI Z88.2 requirements or European
Standard EN 149 must be followed whenever workplace
conditions warrant respirator use.
**** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES ****
Physical State: Liquid
Color: clear, colorless
Odor: sweetish odor - ethereal odor
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Autoignition Temperature: 524 deg C ( 975.20 deg F)
Flash Point: 6 deg C ( 42.80 deg F)
Explosion Limits, lower: 3.0 vol %
Explosion Limits, upper: 16.00 vol %
Decomposition Temperature: Not available.
Solubility in water: Not available.
Specific Gravity/Density: Not available.
Molecular Formula: Solution
Molecular Weight: 0
**** SECTION 10 - STABILITY AND REACTIVITY ****
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Ignition sources, excess heat, exposure to moist air or water.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong reducing agents, strong acids.
Hazardous Decomposition Products:
Hydrogen cyanide, nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Will not occur.
**** SECTION 11 - TOXICOLOGICAL INFORMATION ****
RTECS#:
CAS# 75-05-8: AL7700000
CAS# 540-69-2: BQ6650000
LD50/LC50:
CAS# 75-05-8: Draize test, rabbit, eye: 100 uL/24H Moderate;
Inhalation, mouse: LC50 = 2693 ppm/1H; Inhalation, rabbit: LC50 =
2828 ppm/4H; Inhalation, rat: LC50 = 7551 ppm/8H; Oral, mouse: LD50 =
269 mg/kg; Oral, rabbit: LD50 = 50 mg/kg; Oral, rat: LD50 = 2460
mg/kg; Skin, rabbit: LD50 = >2 gm/kg.
CAS# 540-69-2: Oral, mouse: LD50 = 2250 mg/kg.
Carcinogenicity:
Acetonitrile -
Not listed by ACGIH, IARC, or NTP.
Ammonium formate -
Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
**** SECTION 12 - ECOLOGICAL INFORMATION ****
Ecotoxicity:
Fish: Fathead Minnow: 1150 ppm; 24 Hr; TLm (hard water)Fish: Fathead
Minnow: 1000 mg/L; 96 Hr; TLm (soft water)Fish: Bluegill/Sunfish:
1850 mg/L; 96 Hr; TLm (soft water)Fish: Fathead Minnow: 1640 mg/L;
96 Hr; LC50 (flow-bioassay)Fish: Fathead Minnow: 1640 mg/L; 96 Hr;
EC50 (flow-bioassay)
Other
Readily biodegradable.
**** SECTION 13 - DISPOSAL CONSIDERATIONS ****
Products which are considered hazardous for supply are classified as Special
Waste and the disposal of such chemicals is covered by regulations which may
vary according to location. Contact a specialist disposal company or the local
waste regulator for advice. Empty containers must be decontaminated before
returning for recycling.
**** SECTION 14 - TRANSPORT INFORMATION ****
IATA
Shipping Name: ACETONITRILE SOLUTION
Hazard Class: 3
UN Number: 1648
Packing Group: II
IMO
Shipping Name: ACETONITRILE SOLUTION
Hazard Class: 3
UN Number: 1648
Packing Group: II
RID/ADR
Shipping Name: ACETONITRILE SOLUTION
Hazard Class: 3
UN Number: 1648
Packing group: II
USA RQ: CAS# 75-05-8: 5000 lb final RQ; 2270 kg final RQ
**** SECTION 15 - REGULATORY INFORMATION ****
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN F
Risk Phrases:
R 11 Highly flammable.
R 20/21/22 Harmful by inhalation, in contact with
skin and if swallowed.
R 36 Irritating to eyes.
Safety Phrases:
S 16 Keep away from sources of ignition - No
smoking.
S 36/37 Wear suitable protective clothing and
gloves.
WGK (Water Danger/Protection)
CAS# 75-05-8: 2
CAS# 540-69-2: No information available.
Canada
CAS# 75-05-8 is listed on Canada's DSL List.
CAS# 540-69-2 is listed on Canada's DSL List.
CAS# 75-05-8 is listed on Canada's Ingredient Disclosure List.
CAS# 540-69-2 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 75-05-8 is listed on the TSCA inventory.
CAS# 540-69-2 is listed on the TSCA inventory.
**** SECTION 16 - ADDITIONAL INFORMATION ****
Text for R-phrases from Section 2
MSDS Creation Date: 12/21/2004 Revision #3 Date: 3/31/2005
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no way shall the company be
liable for any claims, losses, or damages of any third party or for lost
profits or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if the company has been advised of
the possibility of such damages.
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