1-Methyl-2-pyrrolidone, special automatic peptide synthesizer grade
CAS
:
872-50-4
SYNONYMS
:
N-Methylpyrrolidone; NMP
**** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS ****
+----------------+--------------------------------------+----------+-----------+
| CAS# | Chemical Name | % | EINECS# |
|----------------|--------------------------------------|----------|-----------|
| 872-50-4 |1-Methyl-2-pyrrolidone | | 212-828-1 |
+----------------+--------------------------------------+----------+-----------+
Hazard Symbols: XI
Risk Phrases: 36/38
**** SECTION 3 - HAZARDS IDENTIFICATION ****
EMERGENCY OVERVIEW
Irritating to eyes and skin.Hygroscopic.Light sensitive.
Potential Health Effects
Eye:
Causes eye irritation.
Skin:
Causes skin irritation.
Ingestion:
May cause irritation of the digestive tract.
Inhalation:
Inhalation of vapor may cause respiratory tract irritation. May
cause abdominal pain, nausea, vomiting, and inflammation of the gums
and mouth.
Chronic:
Not available.
**** SECTION 4 - FIRST AID MEASURES ****
Eyes:
Flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Flush skin with plenty of soap and water for at least 15 minutes
while removing contaminated clothing and shoes. Get medical aid if
irritation develops or persists.
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure to fresh air immediately.
Notes to Physician:
**** SECTION 5 - FIRE FIGHTING MEASURES ****
General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. Will burn if involved in a fire. Combustible
Liquid.
Extinguishing Media:
Use water spray to cool fire-exposed containers. Use water spray,
dry chemical, carbon dioxide, or chemical foam.
**** SECTION 6 - ACCIDENTAL RELEASE MEASURES ****
General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth),
then place in suitable container.
**** SECTION 7 - HANDLING and STORAGE ****
Handling:
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin
and eyes.
Storage:
Keep away from sources of ignition. Store in a cool, dry place.
Store in a tightly closed container. Keep under a nitrogen blanket.
**** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION ****
Engineering Controls:
Facilities storing or utilizing this material should be equipped
with an eyewash facility and a safety shower.
Personal Protective Equipment
Eyes:
Not available.
Skin:
Wear appropriate gloves to prevent skin exposure.
Clothing:
Wear a chemical apron.
Respirators:
Follow the OSHA respirator regulations found in 29CFR
1910.134 or European Standard EN 149. Always use a
NIOSH or European Standard EN 149 approved respirator
when necessary.
**** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES ****
Physical State: Clear liquid
Appearance: almost colorless
Odor: amine-like - mild odor
pH: 7.7-8 @100g/l aq.sol
Vapor Pressure: .7 mbar @ 25 deg C
Viscosity: 1.67 mPas 20 deg C
Boiling Point: 202 deg C @ 760.00mm Hg
Freezing/Melting Point: -24 deg C
Autoignition Temperature: 346 deg C ( 654.80 deg F)
Flash Point: 91 deg C ( 195.80 deg F)
Explosion Limits, lower: .10 vol %
Explosion Limits, upper: .01 vol %
Decomposition Temperature:
Solubility in water: miscible
Specific Gravity/Density: 1.03
Molecular Formula: C5H9NO
Molecular Weight: 99.13
**** SECTION 10 - STABILITY AND REACTIVITY ****
Chemical Stability:
Stable at room temperature in closed containers under normal storage
and handling conditions.
Conditions to Avoid:
Incompatible materials, light, temperatures above 100C, exposure to
moist air or water.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong acids, strong bases.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Will not occur.
**** SECTION 11 - TOXICOLOGICAL INFORMATION ****
RTECS#:
CAS# 872-50-4: UY5790000
LD50/LC50:
CAS# 872-50-4: Draize test, rabbit, eye: 100 mg Moderate; Oral,
mouse: LD50 = 5130 mg/kg; Oral, rat: LD50 = 3914 mg/kg; Skin,
rabbit: LD50 = 8 gm/kg.
Carcinogenicity:
1-Methyl-2-pyrrolidone -
Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
Other:
See actual entry in RTECS for complete information.
Dispose of in a manner consistent with federal, state, and local regulations.
**** SECTION 14 - TRANSPORT INFORMATION ****
IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
No information available.
**** SECTION 15 - REGULATORY INFORMATION ****
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XI
Risk Phrases:
R 36/38 Irritating to eyes and skin.
Safety Phrases:
S 41 In case of fire and/or explosion do not breathe
fumes.
WGK (Water Danger/Protection)
CAS# 872-50-4: 1
United Kingdom Occupational Exposure Limits
CAS# 872-50-4: OES-United Kingdom, TWA 25 ppm TWA; 103 mg/m3 TWA
CAS# 872-50-4: OES-United Kingdom, STEL 75 ppm STEL; 309 mg/m3 STEL
Canada
CAS# 872-50-4 is listed on Canada's DSL List.
CAS# 872-50-4 is not listed on Canada's Ingredient Disclosure List.
Exposure Limits
CAS# 872-50-4: OEL-DENMARK:TWA 100 ppm (400 mg/m3)
OEL-GERMANY:TWA 100 ppm (400 mg/m3)
OEL-THE NETHERLANDS:TWA 100 ppm (400 mg/m3)
OEL-RUSSIA:STEL 100 mg/m3
OEL-SWITZERLAND:TWA 200 ppm (400 mg/m3)
OEL-UNITED KINGDOM:TWA 100 ppm (400 mg/m3)
US FEDERAL
TSCA
CAS# 872-50-4 is listed on the TSCA inventory.
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no way shall the company be
liable for any claims, losses, or damages of any third party or for lost
profits or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if the company has been advised of
the possibility of such damages.
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