**** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS ****
+----------------+--------------------------------------+----------+-----------+
| CAS# | Chemical Name | % | EINECS# |
|----------------|--------------------------------------|----------|-----------|
| 98-86-2 |Acetophenone | 100 | 202-708-7
+----------------+--------------------------------------+----------+-----------+
Hazard Symbols: XN
Risk Phrases: 22 36
**** SECTION 3 - HAZARDS IDENTIFICATION ****
EMERGENCY OVERVIEW
Harmful if swallowed. Irritating to eyes.
Potential Health Effects
Eye:
May cause transient corneal injury. Causes severe eye irritation
and possible injury.
Skin:
May cause skin irritation.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and
diarrhea. May cause central nervous system depression, characterized
by excitement, followed by headache, dizziness, drowsiness, and
nausea. Advanced stages may cause collapse, unconsciousness, coma
and possible death due to respiratory failure. May be harmful if
swallowed.
Inhalation:
Inhalation of high concentrations may cause central nervous system
effects characterized by nausea, headache, dizziness, unconsciousness
and coma. Material has a low vapor pressure, so exposure to vapor is
not likely.
Chronic:
Prolonged or repeated eye contact may cause conjunctivitis.
Prolonged or repeated skin contact may cause defatting and
dermatitis. Laboratory experiments have resulted in mutagenic
effects. Narcotic in high concentrations.
**** SECTION 4 - FIRST AID MEASURES ****
Eyes:
Immediately flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower eyelids. Get medical aid
immediately.
Skin:
Immediately flush skin with plenty of soap and water for at least 15
minutes while removing contaminated clothing and shoes. Get medical
aid if irritation develops or persists.
Ingestion:
Call a poison control center. If swallowed, do not induce vomiting
unless directed to do so by medical personnel. Never give anything by
mouth to an unconscious person. Get medical aid.
Inhalation:
Remove from exposure to fresh air immediately. If not breathing,
give artificial respiration. If breathing is difficult, give oxygen.
Get medical aid.
Notes to Physician:
Exposure indicators: Acetophenone in expired air and hippuric acid
in urine. Treat symptomatically and supportively.
**** SECTION 5 - FIRE FIGHTING MEASURES ****
General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. During a fire, irritating and highly toxic gases
may be generated by thermal decomposition or combustion. Use water
spray to keep fire-exposed containers cool. Combustible Liquid.
Containers may explode when heated.
Extinguishing Media:
Use water spray to cool fire-exposed containers. Use water spray,
dry chemical, carbon dioxide, or appropriate foam.
**** SECTION 6 - ACCIDENTAL RELEASE MEASURES ****
General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth),
then place in suitable container. Clean up spills immediately,
observing precautions in the Protective Equipment section. Remove all
sources of ignition. Use a spark-proof tool. Provide ventilation.
**** SECTION 7 - HANDLING and STORAGE ****
Handling:
Wash thoroughly after handling. Remove contaminated clothing and
wash before reuse. Use with adequate ventilation. Use spark-proof
tools and explosion proof equipment. Avoid contact with skin and
eyes. Empty containers retain product residue, (liquid and/or
vapor), and can be dangerous. Avoid contact with heat, sparks and
flame. Avoid ingestion and inhalation. Do not pressurize, cut, weld,
braze, solder, drill, grind, or expose empty containers to heat,
sparks or open flames.
Storage:
Keep away from heat and flame. Keep away from sources of ignition.
Store in a tightly closed container. Store in a cool, dry,
well-ventilated area away from incompatible substances.
**** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION ****
Engineering Controls:
Facilities storing or utilizing this material should be equipped
with an eyewash facility and a safety shower. Use adequate general or
local explosion-proof ventilation to keep airborne levels to
acceptable levels.
Personal Protective Equipment
Eyes:
Wear chemical goggles.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to minimize
contact with skin.
Respirators:
A respiratory protection program that meets OSHA's 29
CFR 1910.134 and ANSI Z88.2 requirements or European
Standard EN 149 must be followed whenever workplace
conditions warrant a respirator's use.
**** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES ****
Physical State: Liquid
Color: colorless liquid - slightly oily
Odor: jasmine-like - orange blossom
pH: Not available.
Vapor Pressure: 0.33 mm Hg @ 20 deg C
Viscosity: 1.62 cP @ 25 deg C
Boiling Point: 202 deg C
Freezing/Melting Point: 19.6 deg C
Autoignition Temperature: 570 deg C ( 1,058.00 deg F)
Flash Point: 77 deg C ( 170.60 deg F)
Explosion Limits, lower: 1.1
Explosion Limits, upper: 6.7
Decomposition Temperature: Not available.
Solubility in water: Insoluble.
Specific Gravity/Density: 1.02
Molecular Formula: C8H8O
Molecular Weight: 120.15
**** SECTION 10 - STABILITY AND REACTIVITY ****
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Ignition sources, excess heat, oxidizers.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong reducing agents, strong bases,
perchloric acid, aldehydes, nitric acid + hydrogen peroxide.
Hazardous Decomposition Products:
Carbon monoxide, irritating and toxic fumes and gases, carbon
dioxide.
Hazardous Polymerization: Has not been reported.
**** SECTION 11 - TOXICOLOGICAL INFORMATION ****
RTECS#:
CAS# 98-86-2: AM5250000
LD50/LC50:
CAS# 98-86-2: Dermal, guinea pig: LD50 = >20 mL/kg; Draize test,
rabbit, eye: 750 ug Severe; Oral, mouse: LD50 = 740 mg/kg; Oral, rat:
LD50 = 815 mg/kg; Skin, rabbit: LD50 = 15900 uL/kg.
Carcinogenicity:
Acetophenone -
Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
Other:
See actual entry in RTECS for complete information.
**** SECTION 12 - ECOLOGICAL INFORMATION ****
Ecotoxicity:
Fish: Fathead Minnow: LC50 = 196 mg/L; 96 Hr; Flow-through at 24.6 C
(pH 7.83)Bacteria: Phytobacterium phosphoreum: EC50 = 15.5 mg/L;
5,15,30 min; Microtox test at 15 CIf released to soil, microbial
degradation is likely to be the major degradation pathway. It is
expected to be moderately to highly mobile in soil and may evaporate
from dry soil surfaces. Biodegradation and volatilization are
expected to be the major loss processes in water. The estimated
biodegradation half-lives in groundwater, river water and lake water
samples were 32 days, 8 days and 4.5 days, respectively.
**** SECTION 13 - DISPOSAL CONSIDERATIONS ****
Products which are considered hazardous for supply are classified as Special
Waste and the disposal of such chemicals is covered by regulations which may
vary according to location. Contact a specialist disposal company or the local
waste regulator for advice. Empty containers must be decontaminated before
returning for recycling.
**** SECTION 14 - TRANSPORT INFORMATION ****
IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.
**** SECTION 15 - REGULATORY INFORMATION ****
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 22 Harmful if swallowed.
R 36 Irritating to eyes.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
WGK (Water Danger/Protection)
CAS# 98-86-2: 1
United Kingdom Occupational Exposure Limits
United Kingdom Maximum Exposure Limits
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 98-86-2 is not listed on Canada's Ingredient Disclosure List.
Exposure Limits
CAS# 98-86-2: OEL-HUNGARY:TWA 15 mg/m3;STEL 30 mg/m3;Skin
OEL-RUSSIA:STEL 5 mg/m3;Skin
US FEDERAL
TSCA
CAS# 98-86-2 is not listed on the TSCA inventory.
It is for research and development use only.
**** SECTION 16 - ADDITIONAL INFORMATION ****
MSDS Creation Date: 5/21/1999 Revision #4 Date: 12/03/2002
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no way shall the company be
liable for any claims, losses, or damages of any third party or for lost
profits or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if the company has been advised of
the possibility of such damages.
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