=====================  Product Identification  =====================

MSDS NAME:4456 ULTANE SEVOFLURANE
Status Code:A
MSDS Number: CJFYL
=== Responsible Party ===
Company:ABBOTT LABORATORIES,HOSPITAL PRODUCTS DIV
Address:200 ABBOTT PARK RD
City:ABBOTT PARK
State:IL
ZIP:60064-3537
Country:US
Info Phone Num:708-937-6100
Emergency Phone Num:1-847-937-7970
Chemtrec Ind/Phone:(800)424-9300
CAGE:60060
=== Contractor Identification ===
Company:ABBOTT LABORATORIES INC
Address:200 ABBOTT PARK RD
Box:City:NORTH CHICAGO
State:IL
ZIP:60064
Country:US
Phone:847-935-7177
CAGE:60060

=============  Composition/Information on Ingredients  =============

Name:SEVOFLURANE
CAS:28523-86-6
RTECS #:KO0737000

=====================  Hazards Identification  =====================

Routes of Entry: Inhalation:YES  Skin:UNKNOWN  Ingestion:NO
Health Hazards Acute and Chronic:THIS MATERIAL IS USED TO PRODUCE
    ANESTHESIA (SLEEP). TARGET ORGANS INCLUDE THE CENTRAL NERVOUS
    SYSTEM, RESPIRATORY SYSTEM, CARDIOVASCULAR SYSTEM & POSSIBLY THE
    FETUS.
Effects of Overexposure:SEVOFLURANE PRODUCES ANESTHESIA W/SYMPTOMS OF:
    RESPIRATORY DEPRESSION, HYPOTENSION, BRADYCARDIA, SHIVERING,
    NAUSEA, HEADACHE.
Medical Cond Aggravated by Exposure:PATIENTS SENSITIVE TO HALOGENATED
    ANESTHETICS;  CARDIOVASCULAR/RESPIRATORY DISEASES.

=======================  First Aid Measures  =======================

First Aid:EYES/SKIN/INGESTION/INHALATION: REMOVE FROM SOURCE OF
    EXPOSURE. FLUSH SKIN & EYES W/COPIOUS AMOUNTS OF WATER. PROVIDE
    SYMPTOMATIC/SUPPORTIVE CARE, MAINTAINING VENTILATION W/PURE OXYGEN
    AS NECESSARY.

=====================  Fire Fighting Measures  =====================

Extinguishing Media:WATER SPRAY, CO2/DRY CHEMICAL POWDER
Fire Fighting Procedures:WEAR SELF CONTAINED BREATHING APPARATUS.
Unusual Fire/Explosion Hazard:AVOID INHALATION OF COMBUSTION PRODUCTS.

==================  Accidental Release Measures  ==================

Spill Release Procedures:VENTILATE AREA & WASH SITE AFTER MATERIAL WIPE
    UP IS COMPLETE. COLLECT AS POISONOUS ORGANIC CHEMICAL, PLACE IN
    CONTAINER & HOLD FOR WASTE DISPOSAL.

======================	Handling and Storage  ======================

Handling and Storage Precautions:STORE AT CONTROLLED ROOM TEMPERATURE
    OF 59-86F. KEEP CONTAINERS CLOSED & AWAY FROM LIGHT.

=============  Exposure Controls/Personal Protection  =============

Respiratory Protection:IF ENGINEERING CONTROLS ARE IN PLACE,
    RESPIRATORS ARE GENERALLY NOT REQUIRED. ENTRY INTO AREAS OF UNKNOWN
    AIRBORNE CONCENTRATION OF THIS PRODUCT SHOULD ONLY BE MADE W/A SELF
    CONTAINED BREATHING APPARA TUS.
Ventilation:IN THE LABORATORY ENVIRONMENT, THIS PRODUCT SHOULD BE
    HANDLED IN A HOOD.
Protective Gloves:IMPERIVOUS
Eye Protection:UNDER NORMAL USE CONDITIONS, NO PROTECTION IS
    ANTICIPATED.
Supplemental Safety and Health

==================  Physical/Chemical Properties  ==================

Boiling Pt:=58.5C, 137.5F
Vapor Pres:245.5
Vapor Density:6.94
Spec Gravity:1.525
pH:7-7.5
Evaporation Rate & Reference:HIGHLY VOLATILE
Solubility in Water:0.01%
Appearance and Odor:CLEAR, COLORLESS LIQUID

=================  Stability and Reactivity Data  =================

Stability Indicator/Materials to Avoid:YES
ALKALINE EARTH METALS, STRONG BASES
Hazardous Decomposition Products:CO, CO2, HYDROGEN FLUORIDE

===================  Toxicological Information	===================

Toxicological Information:SPECIAL TARGET ORGAN EFFECTS: CLINICALLY,
    SEVOFLURANE PRODUCES ANESTHESIA W/A MINIMUM ALVEOLAR CONCENTRATION
    OF 20,000 PPM. A SMALL AMOUNT OF AN INSPIRED DOSE IS METABOLIZED TO
    FLUORIDE & A FLUORIDE C ONTAINING METABOLITE. LARGE CONCENTRATIONS
    OF SEVOFLURANE HAVE PRODUCED SLIGHT ELEVATIONS IN SERUM ENZYMES &
    PRODUCED MATERNAL EFFECTS, FETAL EFFECTS (DECREASED WEIGHT GAINS),
    CLEFT PALATE & DECREASED  REPRODUCTIVE PERFORMANCE IN ANIMAL
    STUDIES.

====================  Disposal Considerations  ====================

Waste Disposal Methods:DISPOSE OF IN ACCORDANCE W/LOCAL, STATE &
    FEDERAL REGULATIONS.

=======================  Other Information  =======================

 Disclaimer (provided with this information by the compiling agencies):
 This information is formulated for use by elements of the Department
 of Defense.  The United States of America in no manner whatsoever,
 expressly or implied, warrants this information to be accurate and
 disclaims all liability for its use.  Any person utilizing this
 document should seek competent professional advice to verify and
 assume responsibility for the suitability of this information to their
 particular situation.

*** END OF RECORD ***