===================== Product Identification =====================
MSDS NAME:REFRIGERANT 404A, HFC-404A
NIIN:00N093346
Status Code:A
MSDS Number: CJXXG
=== Responsible Party ===
Company:NATIONAL REFRIGERANTS INC
Address:661 KENYON AVE
City:ROSEHAYN
State:NJ
ZIP:08302
Country:US
Info Phone Num:800-262-0012
Emergency Phone Num:609-455-4555
Resp. Party Other MSDS Num.:R-404A
Preparer's Name:RAY MADARIAGA
Chemtrec Ind/Phone:(800)424-9300
CAGE:4J994
=== Contractor Identification ===
Company:NATIONAL REFRIGERANTS INC
Address:661 KENYON AVE
Box:City:BRIDGETON
State:NJ
ZIP:08302
Country:US
Phone:800-262-0012/215-698-6620
CAGE:4J994
============= Composition/Information on Ingredients =============
Name:1,1,1,2-TETRAFLUOROETHANE (HFC-134A). REL: WEEL:1000 PPM
8-HR TWA (M).
CAS:811-97-2
RTECS #:KI8842500
= Wt:4.
Name:1,1,1-TRIFLUOROETHANE (R-143A); (HFC-143A)
CAS:420-46-2
RTECS #:KJ4110000
= Wt:52.
Other REC Limits:8 HR TWA:1000 PPM(M)
Name:PENTAFLUOROETHANE (R-125); (HFC-125)
CAS:354-33-6
RTECS #:KI6365000
= Wt:44.
===================== Hazards Identification =====================
LD50 LC50 Mixture:SEE TOXICOLOGICAL INFORMATION.
Routes of Entry: Inhalation:YES Skin:YES Ingestion:NO
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:EYE EFTS:RAPID VOLATILIZATION OF LIQ
MAY CAUSE FROSTBITE IF LIQ IS APPLIED TO EYES. SKIN EFTS:CONT W/LIQ
MAY CAUSE TISS TO FREEZE (FROSTBITE). CAN CAUSE IRRIT. OTHER TOX
EFTS:SKIN CONT & INHAL ARE EXP ECTED TO BE PRIMARY RTES OF OCCUP
EXPOS. AS W/MOST LIQUEFIED GASES, CONT W/RAPIDLY VOLATILIZING
LIQ/COLD VAPS CAN CAUSE FROSTBITE TO ANY TISS DUE TO CRYOGENIC
(EXTREME LOW TEMP) EFT OF THIS MATL. VAPS MAY BE MILDLY IRRIT TO
EYES. ACUTE STUDIES W/LAB ANIMALS INDICATE THAT COMPONENTS OF THIS
HALOCARBON MIXT ARE PRACTICALLY NON-TOX BY INHAL RTE. HOWEVER,
EXPOS TO HALOCARBON GASES AT HIGH CONCS MAY AF FECT NERV SYS &
PRDCE (EFTS OF OVEREXP)
Explanation of Carcinogenicity:N/P -- TOX INFO:HUMAN STRESS RXNS
RESULTED IN HEART SENSITS AT LEVELS ABOVE/ABOUT 750,000 PPM IN
DOGS. NO TOX EFTS & NO TUMORS WERE OBSERVED IN ORAL DOSE STUDY OF
RATS GIVEN CORN OIL SOLNS OF ING AT 3 00 MG/KG/DAY FOR 1 YR
FOLLOWED BY LIFETIME OBSERVATION. LONG-TERM INHAL (2-YRS) OF HIGH
CONCS (50,000 PPM) CAUSE INCR INCIDENCE OF BENIGN, NOT (FIRST AID
PROC)
Effects of Overexposure:HLTH HAZ:RAPID ANESTH EFT. DENSE VAP OF THIS
PROD DISPLACES AIR IN CONFINED SPACES, THEREBY REDUCING OXYG AVAIL
FOR BRTHG. UPON EXPOS TO SUCH ATM, PERS MAY EXPER SYMPS OF OXYG
DEFICIENCY, INCL HDCH, D IZZ, DROW, CYANOSIS, LACK OF MUSC CONTROL
FOLLOWED BY COLLAPSE. PRLNG EXPOS TO OXYG-DEFICIENT ATM MAY BE
FATAL. AS W/MANY OTHER HALOGENATED HYDROCARBONS, INHAL OF THIS CMPD
MAY CAUSE INCR IN SENSITIVI TY OF HEART TO ADRENALINE, WHICH COULD
RSLT IN IRREG HEARTBEATS (CARD ARRHYS). RAPID HEARTBEATS
(TACHYCARDIA) & REDUCED HEART FUNC. -- OTHER INFO:SIGNIFICATION NEW
USE RULES (SNUR) PUBLISHED BY EPA AS FOLLOWS: HFC-125 - (MED
CNDTNS)
Medical Cond Aggravated by Exposure:DUE TO POTNTL FOR THIS EFT, WORKERS
W/HEART DISEASE/COMPROMISED HEART FUNC SHOULD ONLY HAVE LTD EXPOS
TO THIS MATL. -- EFTS OF OVEREXP: 40 CFR 721.3240; HVC-143A - 40
CFR 721.3254.
======================= First Aid Measures =======================
First Aid:INGEST:N/A-PROD IS GAS AT AMBIENT CNDTNS. EYES:IMMED FLUSH
W/PLENTY OF WATER FOR AT LEAST 15 MINS. GET MED ATTN IF IRRIT
PERSISTS. SKIN:FLUSH EXPOS SKIN W/LUKEWARM WATER (NOT HOT) - OR USE
OTHER MEANS TO WARM SLOWLY. GET MED ATTN IF FROSTBITTEN BY LIQ/IF
IRRIT OCCURS. INHAL:REMOVE TO FRESH AIR. IF NOT BRTHG, GIVE ARTF
RESP. IF BRTHG IS DFCLT GIVE OXYG. GET MED ATTN. DO NOT GIVE
ADRENALINE, EPINEPH RINE/SIMILAR DRUGS FOLLOWING EXPOS TO THIS
PROD. -- EXPLAN OF CARCIN:LIFE-THREATENING TUMORS OF TESTES IN
RATS. NO EXPOS-RELATED EFTS/TUMORS WERE OBSERVED AT 10,000 PPM IN
THIS STUDY. NEG IN MOUSE DOM INANT LETHAL ASSAY. NO (EXTING MEDIA)
===================== Fire Fighting Measures =====================
Flash Point:NONFLAMMABLE
Autoignition Temp:Autoignition Temp Text:N/E
Extinguishing Media:USE WATER SPRAY/FOG, CO*2, DRY CHEM/WATER STREAM.
-- FIRST AID PROC:BIRTH DEFECTS WERE NOTED IN RATS & RABBITS EXPOS
BY INHAL DURING PREGNANCY, EVEN AT LEVELS (FIRE FIGHT PROC)
Fire Fighting Procedures:USE NIOSH APPRVD SCBA & FULL PROT EQUIP . FIRE
FIGHTING EQUIP SHOULD BE THORO DECONTAM AFTER USE. - EXTING
MEDIA:(300,000 PPM & 500,000 PPM, RESPECTIVELY) WHICH PRDCD TOX
EFTS IN MOTHERS & THEIR OFFSPRING. ING PRDCD NO GENETIC CHANGES IN
STD TEST USING ANIMALS (VIVO TEST) & ANIMAL/BACTERIAL CELLS. (SPILL
PROC)
Unusual Fire/Explosion Hazard:PROD IS NOT FLAMM AT AMBIENT TEMPS & ATM
PRESS. HOWEVER, THIS MATL WILL BECOME COMBUST WHEN MIXED W/AIR
UNDER PRESS & EXPOS TO STRONG IGNIT SOURCES. MAY DECOMPOSE DURING
CONT W/FLAMES, HEATING ELEMENT S/IN COMBUST ENGINES RELS IRRIT, TOX
& CORR GASES. CNTNR MAY EXPLODE IF HEATED DUE TO RESULTING PRESS
RISE. (SUPP DATA)
================== Accidental Release Measures ==================
Spill Release Procedures:REMOVE/EXTING IGNIT/COMBUST SOURCES. EVACUATE
ENCLSD SPACES UNTIL GAS IS DISPERSED. KEEP UPWIND. STOP LEAK IF
POSS W/OUT RISK. DISPERSE GAS W/FLOOR-LEVEL FORCED-AIR VENT. EXHST
VAPS OUTDOORS. REMOVE A LL FLAMES, HEATING ELEMENTS & GAS ENGINES.
WASH CONTAM CLOTHES BEFORE USE. DESTROY CONTAM SHOES. -- FIRE FIGHT
PROC:METABOLISM STUDIES IN RATS EXPOS BY ORAL & INHAL RTES SHOW
THAT ING IS (NEUT AGENT)
Neutralizing Agent:N/P -- SPILL PROC:NOT METABOLIZED/ACCUMULATED IN
BODY TO ANY SIGNIFICANT EXTENT & IS RAPIDLY ELIM IN(OTHER PREC)
====================== Handling and Storage ======================
Handling and Storage Precautions:DO NOT GET IN EYES, ON SKIN/CLTHG. DO
NOT BREATHE VAP, MIST/GAS. KEEP CNTNR CLSD. KEEP AWAY FROM HEAT,
SPKS & FLAMES. STORE IN TIGHTLY CLSD CNTNRS. EMPTY CNTNR MAY
CONTAIN HAZ RESIDUE. DO NOT DROP, RE USE/REFILL CTNR. DO NOT SMOKE.
DO NOT CUT, GRIND/WELD ON/NEAR CNTNR DUE TO POSS TOX FUME
GENERATION.
Other Precautions:READ LBL BEFORE USE. PROD SHOULD NOT BE MIXED W/AIR
ABOVE ATMOSPHERIC PRESS FOR LEAK TESTING/ANY OTHER PURPOSE. -- NEUT
AGENT:EXHALED AIR. HFC-143A:SINGLE EXPOS (ACUTE) STUDIES INDICATE
INHAL - PRACTI CALLY NON-TOX TO RATS (4-HR LC50 >540,000 PPM) AS
W/MANY OTHER HALOGENATED HYDROCARBONS, INHAL OF HI GH(OTHER PROT
EQUIP)
============= Exposure Controls/Personal Protection =============
Respiratory Protection:USE NIOSH APPRVD FULL FACE (TC-19C) SUPPLIED AIR
RESP/SCBA WHERE AIRBORNE EXPOS IS LIKELY. IF USED, FULL FACEPIECE
REPLACES NEED FOR CHEM GOGGS &/OR FSHLD. IF EXPOS CANNOT BE KEPT AT
MIN W/ENGINEERING CONTROLS, USE NIOSH APPRVD RESP EQUP AS NOTED.
OBSERVE RESP USE LIMITATIONS SPECIFIED BY NIOSH/MFR. FOR EMER &
OTHER CNDTNS WHERE THERE MAY BE (OTHER INFO)
Ventilation:INVESTIGATE ENGINEERING TECHNIQUES TO REDUCE EXPOS BELOW
AIRBORNE EXPOS LIMS. PROVIDE VENT IF NEC TO CONTROL EXPOS LEVELS
BELOW AIRBORNE EXPOS LIMS.(OTHER INFO)
Protective Gloves:CHEM RESIST GLOVES. CONSULT GLOVE MFR TO DETERMINE
APPROP TYPE OF MATL.
Eye Protection:ANSI APPROVED CHEMICAL WORKERS GOGGLES AND FULL LENGTH
FACESHIELD .
Other Protective Equipment:EYE WASH & DELUGE SHWR MTG ANSI DESIGN
CRITER . WEAR APPROP CHEM RESIST PROT CLTHG TO PVNT SKIN CONT. --
OTHER PREC:CONCS (300,000 PPM), FOLLOWED BY IN INJECTION OF
EPINEPHRINE TO (HYGIENE PRACT)
Work Hygienic Practices:RINSE CONTAM SKIN PROMPTLY. WASH CONTAM CLTHG &
CLEAN PROT EQUIP BEFORE REUSE. WASH SKIN THORO AFTER HNDLG. --
OTHER PROT EQUIP:SIMULATE HUMAN STRESS RXN, RESULTED IN HEART
SENSIT IN (HAZ DECOMP PROD)
Supplemental Safety and Health
PHYSICAL PROPERTIES: MOLECULAR WT: 97.56. VAP DENS: 3.36 (AIR=1). --
EXPLO HAZ: HFC-134A - HMIS RATINGS: HLTH - 1; FLAMMABILITY - 0;
REACTIVITY - 0; & R-143A: NFPA RATINGS: HLTH - 2; FIRE - 4; REACTIV
ITY - 0. -- CNDTNS(STAB): THERMAL DECOMP. DO NOT MIX W/OXYG OR AIR
ABOVE ATMOSPHERIC PRESS.
================== Physical/Chemical Properties ==================
Boiling Pt:=-47.6C, -54.F
Melt/Freeze Pt:M.P/F.P Text:N/A / N/E
Vapor Pres:169.5 PSIA @ 70F (MM HG)
Vapor Density:SUPP DATA
Spec Gravity:1.08 @ 21C (70F) (H*2O=1)
Solubility in Water:NEGLIGIBLE
Appearance and Odor:CLEAR, COLORLESS LIQUEFIED GAS WITH FAINT ETHEREAL
(ETHER-LIKE) ODOR.
Percent Volatiles by Volume:100
================= Stability and Reactivity Data =================
Stability Indicator/Materials to Avoid:YES
AVOID CONT W/STRONG ALKALI/ALKALINE EARTH METALS, FINELY POWDERED
METALS SUCH AS ALUMINUM, MAGNESIUM/ZINC & STRONG OXIDIZERS. SINCE
THEY MAY REACT WITH/ACCELERATE DECOMP OF THIS MATL.
Stability Condition to Avoid:AVOID FLAMES, SPKS, EXTREMELY HOT SURFS,
HEATING ELEMENTS, PILOT LIGHTS, STATIC ELEC, WELDING ARCS, COMBUST
ENGINES, POTNTL IGNIT SOURCES/OTHER HIGH TEMP SOURCES WHICH
INDUCE(SUPDAT)
Hazardous Decomposition Products:THERMAL DECOMP PRODS INCL HYDROGEN
FLUORIDE, CARBON MONOXIDE & CARBON DIOXIDE. -- HYGIENE PRACT:DOGS.
FOLLOWING INHAL EXPOS TO 200,000 PPM FOR 2 HR/DAY, 6 DAYS/WK FOR 4
WKS, SLIGHT (CNDTNS (POLYM))
=================== Toxicological Information ===================
Toxicological Information:DATA FROM LAB STUDIES CONDUCTED BY ELF
ATOCHEM NORTH AMERICA, INC & FROM SCIENTIFIC LITERATURE ON INGS ARE
SUMMARIZED: HFC-134A: SINGLE EXPOS (ACUTE) STUDIES INDICATE:
INHAL-PRACTICALLY NON-TOX TO RAT S (4-HR LC50 >500,000 PPM; 30-MIN,
LC50APPROX 750,000 PPM). EYE/SKIN IRRIT-SLIGHTY IRRIT TO RABBITS
(24 HR EXPOS-SKIN). NO ALLERGIC SKIN RESPONSE WAS OBSERVED IN
GUINEA PIGS FOLLOWING RPTD EXPOS. INHA L OF VERY HIGH CONCS OF THIS
MATL (GENRLY EXCEEDING 50,000 PPM) PRDCES RAPID ANESTH EFT IN MICE,
DOGS, CATS & MONKEYS. AS W/MANY OTHER HALOGENATED HYDROCARBONS,
INHAL FOLLOWED BY IV INJECTION OF EPINE PHRINE TO STIMULATE (EXPLAN
OF CARCIN)
===================== Ecological Information =====================
Ecological:HFC-134A ECOTOXICOLOGICAL INFO:LOG OF OCTANOL/WATER
PARTITION COEFFICIENT (LOG POW) IS 1.06. ING DOES NOT DISSOCIATE IN
WATER. HFC-134A CHEM FATE INFO:28-DAY BIODEGRADATION STUDY W/ING
USING ACTIVATED SLUDGE INOCULUM PRDCD 3% BIODEGRADATION. HFC-125
ECOTOXICOLOGICAL INFO:NO DATA AVAIL. CHEM FATE INFO:WHEN RELS INTO
ENVIRON, ING MAY BE EXPECTED TO PARTITION ALMOST EXCLUSIVELY INTO
ATM. BASED ON ITS LOW N-OCTANOL/WATER PARTITION COEFFICIENT (LOG
POW OF 1.48), BIOACCUM OF ING IS CONSIDERED UNLIKELY. IN 28-DAY
READY BIODEGRADABILITY CLSD BOTTLE TEST, ING APPEARED TO BE STABLE
(ABOUT 2% DEGRADED). ING DOES NOT DISSOCIATE (OTHER INFO)
==================== Disposal Considerations ====================
Waste Disposal Methods:RECYCLE/RECLAIM IF POSS. RECLAIMED MATL MAY BE
INCIN BUT TOX & CORR COMBUST PRODS MUST BE HNDLD APPROPLY. CONSULT
FED, STATE/LOC AUTHS FOR PROPER DISP PROCS. -- CNDTNS(POLYM):NOTED
IN RATS & GUINEA PI GS. RPTD "NOSE ONLY" INHAL OF LOWER
CONCS(2000-39,000 PPM) FOR 6 HRS/DAY, 5 DAYS/WK FOR 4 WKS WAS RE
PORTED TO PRDCE TESTICULAR CHANGES(TRANSPORT INFO)
=================== MSDS Transport Information ===================
Transport Information:DOMESTIC-OTHER THAN AIR (DOT): PROPER SHIPPING
NAME:LIQUEFIED GAS, N.O.S. TRIFLUOROETHANE, PENTAFLUOROETHANE &
TETRAFLUOROETHANE. UN #:3163. HAZ CLASS/DOT LBLS:2.2 (NON-FLAMM
GAS). DOT PLACARD:NON-FLA MM GAS. PROPER SHIPPING
DESCRIPTION:LIQUEFIED GAS, N.O.S.(CONTAINS TRIFLUOROETHANE,
PENTAFLUOROETHANE & TETRAFLUOROETHANE), 2.2, UN3163. -- WASTE DISP
METH:IN RATS. SUBSEQUENT STUDY SHOWED THAT TESTIC ULAR EFTS WERE
PROBABLY DUE TO EXCESS BODY HEAT & STRESS CAUSED BY "NOSE ONLY"
EXPOS TECHNIQUE. W/LONGER-TERM INHAL (13-WKS) AT LEVELS UP TO
40,000 PPM, NO EFTS WERE REPORTED IN RATS. W/LONG-TERM (52- WKS)
ORAL ADMIN OF ING(SARA TITLE III)
===================== Regulatory Information =====================
SARA Title III Information:N/P -- TRANSPORT INFO:IN CORN OIL AT 300
MG/KG/DAY, FOLLOWING BY 73-WK OBSERVATION PERIOD, ONLY EFT REPORTED
IN RATS WAS LOWER BODY WTS. NO BIRTH DEFECTS/ANY OTHER EFTS ON
OFFSPRING/MOTHERS WERE NOTED IN RATS & RABBITS EXPOS BY INHAL TO
ING DURING PREGNANCY AT LEVELS UP TO 40,000 PPM. IT PRDCD NO
GENETIC CHANGES IN STD TESTS USING ANIMALS/ANIMAL CELLS. BOTH POS &
NEG RESPONSES HAVE BEEN REPORTED I N ASSAYS USING BACTERIAL CELLS.
ING DID NOT INDUCE PEROXISOME PROLIFERATION IN RAT LEVER CELL
ASSAY. HFC-125: SINGLE EXPOS (ACUTE) STUDIES INDICATE INHAL -
PRACTICALLY NON-TOX TO RATS (4 HR LC50 >800, 000 PPM) DURING SINGLE
(FED REGULATORY)
Federal Regulatory Information:N/P -- SARA TITLE III:INHAL EXPOS TO
HIGH CONC (800,000 PPM FOR 4-HRS), RATS EXHIBIT DECR ACTIVITY &
LABORED BRTHG, NOT NO SYMPS WERE NOTED AFTER EXPOS. AS WITH MANY
OTHER HALOGENATED HYDROCARBONS. IN HAL OF HFC 125, FOLLOWED BY
INTRAVENOUS INJECTION OF EPINEPHRIN TO STIMULATE HUMAN STRESS
REACTIONS, RESULTED IN HEART SENSIT AT LEVELS ABOVE 100,000 PPM IN
DOGS. NO CARDIAC SENSIT OCCURRED AT A CONC OF 75,000 PPM. NO
ADVERSE EFFECTS WERE OBSERVED IN A SERIES OF INHAL STUDIES WITH
RATS EXPOSED TO HF C 125 FOR 4 TO 13 WEEKS AT CONC UP TO 50,000
PPM. NO BIRTH DEFECTS OR OTHER EFFECTS ON OFFSPRING WERE NOTED IN
RATS (STATE REGULATORY INFO)
State Regulatory Information:N/P -- FED REGULATORY: AND RABBITS EXPOSED
TO HFC 125 BY INHALATION FOR 6 HOURS/DAY DURING PREGNANCY AT
CONCENTRATIONS UP TO ABOUT 50,000 PPM. HFC 125 PRODUCED NO GENETIC
CHANGES IN MANY STANDARD TEST S WHICH USE ANIMALS AND ANIMAL OR
BACTERIAL CELLS.
======================= Other Information =======================
Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.
*** END OF RECORD *** |
|