The MSDS format adheres to the standards and regulatory requirements
of the United States and may not meet regulatory requirements
in other countries.
DuPont Page 1
Material Safety Data Sheet
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AGENT 1
E1001709 Revised 31-MAY-2007
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CHEMICAL PRODUCT/COMPANY IDENTIFICATION
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Material Identification
Grade : RESEARCH & DEVELOPMENT USE ONLY
Tradenames and Synonyms
A 10846; DELTAN; DEMESO; DEMASORB; DEMAVET; DEMSODROX;
DIMETYL SULFOXIDE; DIMETHYL SULPHOXIDE; DIMEXIDE;
DIPIRARTRIL-TROPICO; DMS-70; DMS-90; DMSO; DOLICUR; DOMOSO;
DROMISOL; DURASORB; GAMASOL 90; HYADUR; INFILTRINA; M 176;
METHANE, SULFINYLBIS-; METHYLSULFINYLMETHANE; NSC-763;
RIMSO-50; SOMIPRONT; SQ 9453; SULFINYLBI(METHANE); SYNTEXAN;
TOPSYM
Company Identification
MANUFACTURER/DISTRIBUTOR
DuPont/Qualicon Inc.
Experimental Station
Building 400
Rt.141 and Henry Clay Road
Wilmington, DE 19880
PHONE NUMBERS
Product Information : 1-(800)441-7515
Transport Emergency : CHEMTREC: 1-800-424-9300
Medical Emergency : 1-(800)441-3637
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COMPOSITION/INFORMATION ON INGREDIENTS
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Components
Material CAS Number %
Dimethylsulfoxide 67-68-5 100
Components (Remarks)
This material is a RESEARCH AND DEVELOPMENT chemical and has not
been tested to determine the physical, chemical, or toxicological
properties. Therefore, this chemical should be treated as a
hazardous material and this Material Safety Data Sheet is provided
to assist the laboratory personnel in handling the substance
safely.
E1001709 DuPont Page 2
Material Safety Data Sheet
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HAZARDS IDENTIFICATION
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Emergency Overview
Combustible. Readily absorbed through skin. Target
organ(s): Eyes. Skin.
Potential Health Effects
Unknown. This sample is for RESEARCH AND DEVELOPMENT purposes
only. As the chemical鈥檚 physical and toxicological properties
have not been fully tested, this material should be handled AS A
HAZARDOUS CHEMICAL and only by technically qualified persons using
good industrial hygiene practices to prevent ANY exposure.
Skin contact may initially include skin irritation with
discomfort or rash. Skin permeation can occur in
amounts capable of producing the effects of systemic
toxicity. Readily absorbed through the skin.
Eye contact may cause eye irritation with discomfort,
tearing, or blurring of vision.
Inhalation: may be harmful if inhaled. Materail may be
irritating to mucous membrane and upper respiratory tract.
Ingestion: may be harmful if swallowed.
Carcinogenicity Information
None of the components present in this material at concentrations
equal to or greater than 0.1% are listed by IARC, NTP, OSHA or ACGIH
as a carcinogen.
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FIRST AID MEASURES
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First Aid
INHALATION
If inhaled, remove to fresh air. If not breathing, give
artificial respiration. If breathing is difficult, give oxygen.
Call a physician.
SKIN CONTACT
In case of contact, immediately flush skin with plenty of water
for at least 15 minutes while removing contaminated clothing and
shoes. Call a physician. Wash contaminated clothing before reuse.
EYE CONTACT
E1001709 DuPont Page 3
Material Safety Data Sheet
(FIRST AID MEASURES - Continued)
In case of contact, immediately flush eyes with plenty of water
for at least 15 minutes. Call a physician.
INGESTION
Call a physician immediately.
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FIRE FIGHTING MEASURES
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Flammable Properties
Flash Point : 87 C (189 F)
Method : Closed Cup.
Autoignition : 301 C (574 F)
Explosion Limits : 3.5% Lower
: 42% Upper
The fire and explosion potential has not been investigated.
Therefore, handle the material as if it were a fire and explosion
hazard.
Extinguishing Media
Alcohol Resistant Foam, Dry Chemical, CO2.
For large fires, apply water from as far as possible. Use
very large quantities (flooding) of water applied as a mist
or spray; solid streams of water may be ineffective. Cool
all affected containers with flooding quantities of water.
Fire Fighting Instructions
Keep personnel removed and upwind of fire. Wear self-contained
breathing apparatus. Wear full protective equipment.
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ACCIDENTAL RELEASE MEASURES
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Safeguards (Personnel)
NOTE: Review FIRE FIGHTING MEASURES and HANDLING (PERSONNEL)
sections before proceeding with clean-up. Use appropriate
PERSONAL PROTECTIVE EQUIPMENT during clean-up.
Evacuate personnel, thoroughly ventilate area, use self-contained
breathing apparatus.
Initial Containment
Prevent material from entering sewers, waterways, or low areas.
E1001709 DuPont Page 4
Material Safety Data Sheet
(ACCIDENTAL RELEASE MEASURES - Continued)
Spill Clean Up
Cover with dry-lime, sand, or soda ash. Place in covered
containers using non-sparking tools and transport outdoors.
Ventilate area and wash spill site after material pickup is
complete.
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HANDLING AND STORAGE
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Handling (Personnel)
Do not breathe vapor or mist. Do not get in eyes, on skin or
clothing. Wash thoroughly after handling. Wash clothing after
use. Do not store or consume food, drink or tobacco in areas
where they may become contaminated with this material.
Avoid contact with DMSO solutions containing toxic materials
or materials with unknown toxicological properties. DMSO is
readily absorbed through the skin and may carry such
materials into the body. Avoid prolonged or repeated
exposure.
Storage
Store in a well ventilated place. Keep container tightly closed.
Do not store or consume food, drink or tobacco in areas where they
may become contaminated with this material. Store in a clean, dry
place. Keep away from heat, sparks and flames.
SPECIAL REQUIREMENTS
Store under inert gas. Hygroscopic
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EXPOSURE CONTROLS/PERSONAL PROTECTION
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Engineering Controls
Use only with adequate ventilation. Keep container tightly closed.
Personal Protective Equipment
EYE/FACE PROTECTION: Wear safety glasses with side shields. Wear
full face protection when handling in a non-enclosed system or
when the possibility exists for eye and face contact.
RESPIRATORS: If this material is not used in a chemical fume
hood, wear a NIOSH-approved air purifying respirator or positive
pressure air-supplied respirator where there is a potential for
inhalation exposure.
PROTECTIVE CLOTHING: Wear impervious clothing such as gloves,
whole bodysuit, apron, or boots, as appropriate. Consult the site
safety professional for additional guidance, as needed.
E1001709 DuPont Page 5
Material Safety Data Sheet
(EXPOSURE CONTROLS/PERSONAL PROTECTION - Continued)
Exposure Guidelines
Applicable Exposure Limits
Dimethylsulfoxide
PEL (OSHA) : None Established
TLV (ACGIH) : None Established
AEL * (DuPont) : 10 ppm, 8 Hr. TWA, Skin
WEEL (AIHA) : 250 ppm, 8 Hr. TWA
* AEL is DuPont鈥檚 Acceptable Exposure Limit. Where governmentally
imposed occupational exposure limits which are lower than the AEL
are in effect, such limits shall take precedence.
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PHYSICAL AND CHEMICAL PROPERTIES
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Physical Data
Form : Liquid.
Color : Colorless.
Boiling Point : 189 C (372 F)
Melting Point : 18.4 C (65.1 F)
Specific Gravity : 1.1 g/cm3
Vapor Density : 0.42 mm Hg 20 C (68 F)
Vapor Density : 2.7 g/L
Viscosity : 0.002 Pas 20 C
Solubility in H2O : Miscible
Other Solvents : Alcohols, Ethyl Ethers
Partition Coefficient Log Kow: -2.030
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STABILITY AND REACTIVITY
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Decomposition
Decomposition temperature: >190 C (>374 F)
Other Hazards
The hazardous reactivity of this material is unknown. DO
NOT mix with other materials unless specifically instructed
to do so under the guidance of a trained chemist. DO NOT
expose to heat, flame, or extreme temperatures.
E1001709 DuPont Page 6
Material Safety Data Sheet
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TOXICOLOGICAL INFORMATION
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Animal Data
Inhalation LC50: 40,250 ppm in rats
Skin absorption LD50: > 5000 mg/kg in rabbits
Oral LD50: 3300 mg/kg in rats
The compound is a mild skin irritant, a slight eye irritant,
but is not a skin sensitizer in animals.
Inhalation: Toxic effects described in animals from single
inhalation exposures include slight eye and nose irritation,
pulmonary edema, and alteration of serum clinical chemical
parameters. Repeated inhalation exposures to higher
concentrations demonstrated no adverse changes.
Skin: Toxicity described in animals from single dermal
exposure include an alteration of a serum enzyme, while
repeated exposures resulted in other changes in
clinical chemical parameters, dry scaly skin, and ocular
changes. Longer term studies also resulted in ocular
changes.
Ingestion: Single exposure by oral administration resulted
in increased serum blood sugar. Repeated and long term
oral administration caused liver changes and decreased body
and organ weights; ocular effects were observed in rodents
but no ocular effects were observed in studies on monkeys
and humans. Long term oral administration also caused some
kidney changes.
Tests in animals demonstrate no carcinogenic activity.
Tests in some animals indicate that the compound may
have developmental toxicity at very high doses.
In female mice administered up to 10,000 mg/kg/day of
DMSO while being paired with untreated male mice, only
about half became pregnant versus 100% pregnancy in controls
The difference in pregnancy rate might be explained by the
"garlic odor" associated with the DMSO-treated mice. The
authors speculate that the odor may interfere in the sexual
attractiveness of the DMSO-treated female mice. Limited
information available indicates it does not affect fertility
In a few cell cultures systems, the compound has produced
some chromosomal abnormalities. Currently available
animal data indicate that this compound does not cause
permanent genetic damage in reproductive cells of mammals
(does not cause heritable genetic damage).
E1001709 DuPont Page 7
Material Safety Data Sheet
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ECOLOGICAL INFORMATION
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Ecotoxicological Information
Aquatic Toxicity
96 hour LC50 - Fathead minnows: 34,000 mg/L
96 hour LC50 - Rainbow trout: 35,000 mg/L
EC50 - Daphnia pulex: 27,500 mg/L
96 hour EC50 - Algae: > 400,000 mg/L
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DISPOSAL CONSIDERATIONS
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Waste Disposal
Treatment, storage, transportation, and disposal must be in
accordance with applicable Federal, State/Provincial, and Local
regulations.
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TRANSPORTATION INFORMATION
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Shipping Information
DOT
Proper Shipping Name : Combustible Liquid, n.o.s.
Hazard Class : COMBUSTIBLE LIQUID
I.D. No. (UN/NA) : NA1993
Packing Group : III
IATA
Non-hazardous for Air Transport: Non-hazardous for Air
Transport
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OTHER INFORMATION
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NFPA, NPCA-HMIS
NFPA Rating
Health :0
Flammability :2
Reactivity :1
NPCA-HMIS Rating
Health :0
Flammability :2
Reactivity :1
E1001709 DuPont Page 8
Material Safety Data Sheet
(Continued)
Additional Information
This material is for RESEARCH AND DEVELOPMENT USE ONLY. It is
being supplied under the exemption for research and development
under the Toxic Substances Control Act (TSCA) and/or the Federal
Insecticide, Fungicide, and Rodenticide Act (FIFRA). Commercial
use of this material is a violation of Federal law.
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The data in this Material Safety Data Sheet relates only to the
specific material designated herein and does not relate to use in
combination with any other material or in any process.
Responsibility for MSDS : Product Safety Coordinator
Address : Experimental Station, Bldg. 400
Rt. 141 and Henry Clay Road
Wilmington, DE 19880
Telephone : 302-695-5300
This information is based upon technical information believed to be
reliable. It is subject to revision as additional knowledge and
experience is gained.
End of MSDS
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