1
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MaterialSafety Data $heet
Acetsritrile, for HPI-C
ACC# 95499
Section1 - Chemical Identification
Product
and Company
MSDS llamei,
AC268270010, AC26827OO4A,
ACg533032
Catafog Numbers: AC26827O000, AC268270025,
Ethanenitrile;Ethyl nitrile; Methylcyanide.
Synonyms: Cyanomethane;
Company ldentification :
AcrosOrganicsN.V.
One ReagentLane
FairLawn,NJ 07410
For inforrnation in North America, call: 800*ACROS-01
For emergencies in the US, call CHEIITREG: 800-424-9300
Section2 - Composition,
Informationon Ingredients
Hazard Symbols: XN F
Risk Phrases: 11 2Al2U22 36
Section3 - Hazards
Identification
EMERGENCY
OVERVIEW
Appearance:clear, colorlessliquid. Flash Point: 6 deg C" Warning! uay cause central nervous system
depression. May cause liver and kidney damage. May causereproductiveand fetal effects.Lachrymator
(substancewhich increasesthe flow of tears). Hygroscopic.Metabolizedto cyanide in the body, which may cause
headache, dizziness,weakness,unconsciousness, convulsions,coma and possibledeath. Flammable liquid and
vapor. Harmful if swallowedor absorbedthrough the skin. Causeseye irritation. May cause skin and respiratory
tract irritation" May be harmful if inhaled.
Target Organs: Blood,kidneys,central nervoussystem, liver, lungs.
Potential Health Effects
Eyel Causeseye irritation. Lachrymator (substancewhich increasesthe flow of tears). May produce superficial
reversibleinjury.
Skinl Causesmild skin irritation. Harmful if absorbedthrough the skin. May be metabolized ryanide which in
to
turn acts by inhibiting cytochrome oxidase impairing cellular respiration.
May causegastrointestinal irritation with nausea,vomiting and diarrhea.May causeeffectssimilar to
lestion:
frse for inhalation exposure. May cause tissue anoxia, characterizedby weakness,headache,dizziness,
confusion,cyanosis(bluishskin due to defrcientoxygenation the blood), weakand irregularheart beai,
of
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coma and death. May causecentral nervoussystem depression.
convulsions,
collapse,unconsciousness,
weakness,collapse,unconsciousness
dizziness,
may releasecyanlde,which may result in headache,
Metabolism
possible
and death.
Inhalation: Aspirationmay lead to pulmonaryedema. Vaporsmay causedizziness suffocation. Causesupper
or
cyanidewhich in turns act by inhibitingcytochromeoxidase
to
respiratorytract irritation. May be metabolized
impairingcellularrespiration.May causetissue anoxia,characterized weakness,headache, dizziness,
by
(bluish discCIloration skin due to deficientoxygenationof the blood), weak and irregular
confusion,cyanosis of
heart beat, collapse,uncongciousness, convulsions, coma and death.
Chronic: Prolonged repeatedskin contact may cause dermatitis.Chronicinhalationand ingestionmay cause
or
effectssimilar to those of acute inhalationand ingestion.May cause liver and kidney damage. May be
metabolized cyanidewhich in turn acts by inhibiting
to cytochrome oxidaseimpairing cellularrespiration.Animal
studies have reported that fetal effects/abnormalitiesmay occur when maternal toxicity is seen. Laboratory
experimentshave resultedin mutageniceffects.Exposure small amounts of cyanidecompoundsover long
to
periodsof time is reportedto cause lossof appetite,headache, weakness,nausea,dizziness, and symptomsof
irritationof the upper respiratorytract and eyes.
Section4 - FirstAid Measures
Eyes: Immediatelyflush eyes with plenty of water for at least 15 minutes,occasionally lifting the upper and
lower eyelids. Get medicafaid immediately. Do NOT allow victim to rub or keep eyes cfosed.
;Sinr Get medicalaid immediately. Immediatelyflush skin with plentyof soapand waterforat least 15 minutes
removingcontaminated clothingand shoes.Wash clothing before reuse.
l]l"
fhgestion: Do NOTinducevomiting. If victim is conscious and alert, give 2-4 cupfulsof milk or water. Never
give anything by mouth to an unconscious person.Get medicalaid immediately.
Inhalationl Get medicalaid immediately.Removefrom exposureto fresh air immediately.If not breathing,give
artificialrespiration.If breathingis difficult,give oxygen. Do NOTuse mouth-to-mouthreiuscitation.
Notes to Physician: Exposureshould be treated as a cyanide poisoning, Effects may be delayed. For
methemoglobinemia, administer oxygenaloneor with Methylene blue depending ihe methemoglobinemia
on
concentration the blood. May be partiallymetabolized cyanidein the body.
in to
Antidote: Always have a cyanideantidote kit on hand when working with cyanidecompounds. Get medical
adviceto use. Methyleneblue, alone or in combinationwith oxygenis indicatedas a treatment in nitrite
induced
methemoglobinemia.
Section5 - Fire FightingMeasures
General fnformation: Containers can buitd up pressureif exposedto heat and/or fire. As in any fire, wear a
self-contained breathingapparatusin pressure*demand, MSHA/NIOSH (approvedor equivalent),and full
protective gear. water runoff can cause environmental damage. Dike ano collect
water used to fight fire. vapors
may form an explosivemixture with air. During a fire, irritatiig and highly toxic gasesmay
be generatedby
thermal decompositionor combustion. use wafer spray to keef, Rre-exioied containers
cool. Water may be
ineffective.Materialis lighter than water qqd a fire may be spread ny the use of water.
Flammableliquid and
vapor. Approachfire from upwind to avoid hazardousvapors and toxic decompositionproducts.
vapors are
heavierthan air and may travel to a sourceof ignitionand flash back. Vaporscan spread
along the ground and
in low or confined areas.
llect
Medial For small fires, use dry chemical,carbondioxide, water spray or alcohol-resistant
linguishing foam,
Use water spray to cool fire-exposedcontainens.Water may be inefliective.oo ruor ise
straight streams of water.
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foam, or water spray. Cool containerswith
For large fires, use dry chemical,carbondioxide,alcohol-resistant
quantitiesof water until well after fire is out.
flooding
Flash Point: 6 deg C ( 42.80 deg F)
Autoignition Temperature! 524 deg C ( 975.20 deg F)
Expfosion Limits, Lower:4.4 val sh
Upper: 16.00 vol Vo
ilFPA Rating: (estimated)Health: 2; Flammability:3; Instability: 0
Section6 - Accidental Measures
Release
personalprotectiveequipmentas indicatedin Section8.
General Information: Use prCIper
Spills/Leaks: Avoid runoff into storm sewersand ditcheswhich lead to waterways.Cleanup spills immediately,
observingprecautions the ProtectiveEquipmentsection.Removeall sourcesof ignition.Absorbspill using an
in
materialsuch as earth, sand, or vermiculite.Do not use combustiblematerialssuch
absorbent,non-combustible
as saw dust. Provideventilation.A vapor suppressing foam may be used to reducevapors. Water spray may
reducevapor but may not prevent ignition in closedspaces.Approachspill from upwind.
Section - Handling
7 and Storage
trndling: Removecontaminatedclothingand wash before reuse. Use only in a well-ventilated area. Groundand
bond containerswhen transferringmaterial. Do not breathedust, vapor, mist, or gas. Do not get in eyes, on skin,
or on clothing.Empty containersretain product residue,(liquicland/or vapor), and can be dangerous,Keep
containertightly closed.Avoid contact with heat, sparksand flame. Do not ingest or inhale. Do not pressurize,
cut, weld, braze,solder, drill, grind, or exposeempty containers heat, sparks or open flames.
to
Storage: Keepaway frorn heat, sparks,and flame. Keepaway from sourcesof ignition.Store in a tightly closed
container. Keep from contact with oxidizing materials. Store in a cool, dry, well*ventilatedarea away from
patiblesubstances.Flammables-area.
incom Store protectedfrom moisture.
Section8 - Exposure
Controls,
Personal
Protection
Engineering Controls: Use explosion-proof ventilationequipment.Facilitiesstoring or utilizingthis material
should be equippedwith an eyewashfacility and a safety shower. Use adequategeneralor localexhaust
ventilation to keep airborne concentrationsbelow the permissibleexposure limits.
Limits
OSHA - Final PELs
Chernical Name ACGIH NIOSH
2Oppm TWA; skin - potential 2O ppm TWA; 34 mg/m3 TWA
Acetonitrile 4O ppm TWA; 7O mg/m3 TWA
'or cutaneousabsomtion ppm IDLH
5OO
OSHA Vacated PELs: Acetonitrile: 40 ppm TWA; 7O mglm3 TWA
Personal Protective Equi pment
^ies: Wear chemicalgoggles.
Wear appropriate protective gloves to prevent skin exposure.
Jn:
clothingr wear appropriate protective clothing to prevent skin exposure.
Respiratorsl A respiratory protection program that meets OSHA's29 CFR 1910.134 and ANSI ZBB.2
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StandardEN 149 must be followedwheneverworkplaceconditionswarrant a
requirements European
or
respirator'suse.
Section9 - Physical Properties
and Chemical
Physical State: Liquid
Appearance: clear, colorless
Odor: sweetishodor - etherealodor
pH: Not available.
Vapor Pressure: 73 mm Hg
Vapor Density: 1.42 (Air=1)
Evaporation Rate:5.79 (Butyl acetate=1)
Viscosityr 0.36 cP 20 deg C
BoilinE Pointr 82 deg C @ 760.00mmHg
FreeztngfMelting Point:-50 deg C
Decomposition Temperature!> 500 deg C
Solubility: Miscible.
Specifi c Gravity/ Density:, 78 I Og/cm3
lilolecular Formula :C2H3N
Molecular Weight:41. 04
Section 10 - Stability and Reactivity
Chemical Stability: Stable under normal temperaturesand pressures.
Conditions to Avoid: Incompatiblematerials,ignitionsources,excessheat, exposureto moist air or water,
oxidizers.
Incompatibilities with Other Materials: Oxidizingagents, reducingagents,acids, bases,alkati metals,
fluorine, nitric acid, perchlorates,
sulfuricacid, chlorosulfonic acid, oleum, dinitrogentetraoxide,sulfites, indium,
moisture,Attackssome forms of plastics,rubbers,and coatings.,nitrating agents, N-fluorocompounds(e.g.
perfluorourea acetonitrile),lanthanideperchlorates,
+ iron (III) perchlorate,Z-Cyano-2-propyl nitrate,
trichlorosilane, diphenylsulfoxide.
Hazardous Decomposition Products: Hydrogencyanide,nitrogenoxides,carbon monoxide,irritatingand toxic
fumes and gases,carbon dioxide.
Hazardous Polymerization: Will not occur.
Section 11 - Toxicological
Information
RTECS#:
CAS# 75-05-8: A17700000
LDSO/LCSO:
fff"i:#*'00,,, 1002693 ppm/LH;
eye: uA24H Moderate;
mouse:LC50 =
Inhalation,
rabbit: LC50 = 2828 ppm/4H;
Inhalation,
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Inhalation,rat: LC50 = 7551 PPm/8H;
Oral, mouse: LD50 : 269 mg/kg;
Oral, rabbit: LD50 = 50 mg/kg;
Oral, rat: LD50 : 246Omg/kg;
Skin, rabbit: LD50 = >2 gm/kg;
Carcinogenicity:
cAS# 75-05-8:
ACGIH; A4 - Not Classifiable a Human Carcinogen
as
Epidemiology: No informationavailable.
fetus: Inhalation,hamster: TCLo=8000ppm/lH (femaleB days after
Teratogenicity: Embryoor Fetus-stunted
- Oral, hamsterTCLo= 300 mglkg (female
conception).;SpecificDevelopmentalAbnormalities musculoskeletal:
B days after conception).
Reproductive Effectsl Fertility- post-implantationmortafity: Oral, hamster: TDLo=400mglkg and Inhalation,
harnsterTCLo:5000 ppm/1H (femaleB days after conception).
Neurotoxicityr No informationavailable.
cerevisiae= 47640 ppm and Drosophila
Saccharomyces
Mutagenicity: Sex Chromosome Loss/Non*disjunction:
melongaster= 131 ppm.; Sister ChromatidExchange:Hamster,ovary = 5 gmll.; Inhalation,rat: TDL0 = 400
ppml6H/24-I (producedliver tumorc)
onto the skin (rabbit) = 5gg mg (Mild).
Other Studies: Open irritationtest: Administration
SectiontZ - Ecological
Information
Minnow:1150 ppm;24Hr; TLm (hard water) Fathead
Ecotoxicity: Fish: Fathead Minnow:1000 mg/L;96 Hr;
TLm (soft water) BluegilflSunfish: 1850 mg/L; 96 Hr; TLm (soft water) FatheadMinnow: 1640 mg/L; 96 Hr;
LC50(flow-bioassay) FatheadMinnow: 1640 mg/L; 96 Hr; EC50(flow-bioassay) data available.
No
Environmental: Estimated Koc value = 16. Acetonitrile is expectedto weakly adsorb to most soils based on the
Koc value. Volitizationfrom soil surfacesand Ieachinginto ground water is expectedto be significant.Estimated
BCFvalue = 0.3. This value indicatesthat acetonitrilewill not significantlybioconcentrate aquaticorganismsor
in
adsorbto suspended solidsand sedimentsin water. Acetonitrileis unreactivetowards photochemically-generated
free radicalsand direct photolysisin the gaseousphase.
Physical: No informationavailable.
Other: Biodegradable.
Section 13 - DisposalConsiderations
Chemicalwaste generators must determine whether a discardedchemical is classifiedas a hazardouswaste. US
EPAguidelines the classification
for determinationare listed in 40 CFRParts251.3. Additionally,waste generators
must consultstate and local hazardouswaste regulations ensurecompleteand accurateclassification.
to
RCRA P-Series: None listed.
RCRAU-Series: CAS# 75-05*8: waste number U003 (Ignitablewaste, Toxic waste).
SectionL4 - TransportInformation
Canada
, US DOT rilo
IATA RIDIADR
TDG
No
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Section15 - Regulatory
Information
TSCA
CAS# 75-05-8 is listed on the TSCAinventory.
Health & Safety Reporting List
Date: fif4/82; Sunset Date: fA/4/92
CAS# 75-05-8: Effiective
Chernical Test Rules
None of the chemicalsin this productare under a ChemicalTest Rule.
Section 12b
None of the chemicalsare listed under TSCASection12b.
TSCA Significant ilew Use Rule
None of the chemicalsin this material have a SNURunder TSCA.
v
CERCLAHazardous Substances and corr鈧瑂ponding RQs
CAS# 75-05-8: 5000 lb final RQ; 227A kg final RQ
SARA Sectlon 3O2 Extremely Hazardous Substances
None of the chemicalsin this product have a TPQ,
SARA Codes
CAS# 75-05-8: acute,chronic, flarnmable.
Section 313
This materialcontainsAcetonitrile{CAS# 75-05-8, 99 696),whichis subject to the reportingrequirements of
Section313 of SARATitle III and 40 CFRPart 373.
Clean Air Act:
CAS# 75-05-8 is listed as a hazardous pollutant (HAP).This materialdoes not containany Class1 Ozone
air
depletors.This materialdoes not containany Class2 Ozonedepletors.
Clean Water Act:
Noneof the chemicalsin this productare listedas Hazardous Substances under the CWA.None of the chemicals
in this productare listedas PriorityPollutantsunder the CWA. None of the chemicalsin this productare listed as
Toxic Pollutantsunder the CWA.
OSHA:
None of the chemicalsin this productare considered highly hazardous OSHA.
by
STATE
CAS# 75-05-8 can be found on the following state right to know lists: California, New Jersey, Florida,
Pen nsylvania,Minnesota, Massachusetts.
CaliforniaNo SignificantRisk Level: None of the chemicalsin this productare listed.
ropean/International Regulations
opean Labeling in Accordance with EC Directives
Hazard Symbols:
XNF
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Risk Fhrases:
R 11 Highlyflammable.
RZAi2L/zz Harmful by inhalation,in contactwith
skin and if swallowed"
R 36 Irritating to eyes.
Satety Phrases:
S 16 Keepaway from sourcesof ignition - No
smoking.
S 36137Wear suitableprotectiveclothingand
gloves.
WGK {Water Dan gerr/ Protection )
CAS# 75-05-8: 2
Canada - DSL/NDSL
CAS# 75-05-8 is listed on Canada'sDSL List.
Canada - fflHifIS
This product has a WHMISclassificationof B.2,DlB, D2B.
Ganadian Ingredient Disclosure List
CAS# 75-05-8 is listed on the CanadianIngredient Disclosure
List.
Exposure Linrits
CAS# 75-05-8: OEL-ARAB Republic Egypt:TWA ppm (7O mgfm3);Skin
of 40
40 ppm (70 mg/m3);STEL60 ppm ;Skin OEL-AUSTRIA:TW
O_EL-AUSTRALIA:TWA
ppm (70 ms/m3) OEL-BELGIum:rwn ppm (bz rng/m3);STEL ppm (10
40 60
fo
'll+U/m3);Skin
OEL-DENMARK:TWA ppm (70 mg/m3);STEL60 ppm (10 mg/m3)
40
OEL-FINLAND:TWA ppm (70 mg/m3);STEL60 ppm (10 mg/m3) OEL-FRANCE
40
:TWA40 ppm (70 mg/m3) OEL-GERMANY:TWA ppm (70 mg/m3) OEL-HUNGARY
40
:TWA50 mg/m3;STEL100 mglm3;Skin JANSOEL-THE NETHERLANDS:TWA ppm
40
(70 mg/m3) OEL-THE PHILIPPINES:TWA ppm (70 mglm3) OEL-RUSSTA:STE
4O
L 10 mglm3 OEL-SWITZERLAND:TWA ppm (70 mg/m3);STH_ ppm ;Skin O
40 80
EL-TURKEY:TWA ppm (70 mg/m3) OEL-UNITED
40 KINGDOM:TWA ppm (70 mg/
40
M3);STEL60 ppm OELIN BULGARIA, COLOMBIA, JORDAN, KOREA checkACGIH
TLV OELIN NEWZEALAND, SINGAPORE, VIETNAMcheck ACGI TLV
Section16 - Additional
Information
IfSDS Creation Date: 4/23/1999
Revision #6 Date: 6/04/20A2
The information above is believed to be accura*e and rcpresents Hre best informatiur anrrendy availabfe fio us. Howeve4 we make no
war.ranty of
merchantability or any other warranty, express or implbd, with resre& to suck informat*>tt" ind we ass{/rne no liability resultil
fram iE use. lJsers
should make their own investigatiotls to determine the suitability d the information tvr their particular purpoes. In tw event
shall Fisher be liable for
any daims, Io*s, or dantages of any third party ar for la prcFi& or any spcial, indirect, iiaaentat, a n*guential ar exernplary damages,
howsoeverarising, evenrffsfterlrasbeen advi*dof thepossibjtrty of sttch darnaps.
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