NFPA RATING
FLAMMABILITY
3
MATERIAL SAFETY DATA SHEET 0
1
HEALTH REACTIVITY
to U.S. OSHA, CMA, ANSI and Canadian WHMIS Standards
Prepared
OTHER
PART I What is the material and what do I need to know in an emergency?
1. PRODUCT IDENTIFICATION
ACETONE - C3H6O
CHEMICAL NAME; CLASS:
Document Number: 001088
PRODUCT USE: General Chemical Use; Solvent
SUPPLIER: AIRGAS INC.
ADDRESS: 259 N. Radnor-Chester Road
Suite 100
Radnor, PA 19087-5283
BUSINESS PHONE: 1-610-687-5253
EMERGENCY PHONE: CHEMTREC: 1-800-424-9300
International: 703-527-3887 (Call Collect)
DATE OF PREPARATION: June 15, 1999
2. COMPOSITION and INFORMATION ON INGREDIENTS
CHEMICAL NAME CAS # mole % EXPOSURE LIMITS IN AIR
ACGIH-TLV OSHA-PEL
TWA STEL TWA STEL IDLH OTHER
ppm ppm ppm ppm ppm ppm
1000 1000 2500 NIOSH RELs:
Acetone 67-64-1 100% 500, A4 (Not 750, A4 (Not
(Vacated (Based TWA = 250
Classifiable Classifiable 750
1989 PEL) on 10%
as Human as Human (Vacated DFG MAKs:
LEL)
Carcinogen) Carcinogen) 1989 TWA = 500
PEL) PEAK = 2 MAK 5
min., momentary
value
CARCINOGEN:
EPA-D; MAK-B
NE = Not Established C = Ceiling Limit See Section 16 for Definitions of Terms Used
NOTE: All WHMIS required information is included. It is located in appropriate sections based on the ANSI Z400.1-1998 format.
ACETONE - C3H6O MSDS (Document # 001088) PAGE 1 OF 9
3. HAZARD IDENTIFICATION
EMERGENCY OVERVIEW: Acetone is a clear, colorless, mobile, flammable liquid with a fragrant fruity or mink-like odor.
Inhalation of Acetone鈥檚 vapors can irritate the upper respiratory system and cause central nervous system depression
(producing symptoms such as headaches, drowsiness, and confusion). Inhalation of high concentrations of the vapors
may be fatal if cardio-respiratory failure occurs. Direct skin or eye contact may be irritating. Vapors of Acetone may
spread long distances; distant ignition and flashback are possible. Acetone is not reactive. Emergency responders must
wear the proper personal protective equipment (and have appropriate fire-suppression equipment) suitable for the
situation to which they are responding.
SYMPTOMS OF OVEREXPOSURE BY ROUTE OF EXPOSURE: The
most significant routes of occupational overexposure are by inhalation, HAZARDOUS MATERIAL IDENTIFICATION
skin and eye contact. The symptoms of overexposure to Acetone are as SYSTEM
follows:
HEALTH
INHALATION: Inhalation of Acetone vapors will cause central nervous 1
(BLUE)
system depression. The symptoms of such exposure can include
headaches, nausea, dizziness, drowsiness, confusion, slurred speech,
nausea, vomiting and unconsciousness. Because Acetone is
metabolized slowly, effects can be delayed. Irritation of the nose, throat,
FLAMMABILITY 3
(RED)
and other tissues of the upper respiratory system may also occur.
Severe inhalation overexposures can result in anesthesia (loss of
feeling), cardiac effects including tachycardia and hypotension, as well
as serious respiratory depression, leading to cardiovascular and
REACTIVITY (YELLOW) 0
respiratory collapse, coma and death. Chronic inhalation exposure can
result in inflammation of airways, stomach and duodenum, as well as
dizziness and loss of strength. Chronic inhalation exposure can also
lead to liver damage.
PROTECTIVE EQUIPMENT C
CONTACT WITH SKIN or EYES: Contact of the liquid with the eyes
may cause redness and pain. Direct contact with the skin (especially EYES HANDS BODY
RESPIRATORY
after prolonged overexposure) can cause irritation. Prolonged or
repeated skin overexposures can cause dermatitis.
See See
SKIN ABSORPTION: Skin absorption is a potential route of
Section 8 Section 8
overexposure for Acetone, but is not considered a serious route of
exposure. For routine industrial applications
INGESTION: Ingestion of Acetone can cause irritation of the throat, See Section 16 for Definition of Ratings
esophagus, and stomach. Ingestion of large quantities will cause central
nervous system depression and effects described under 鈥淚nhalation鈥?.
INJECTION: Injection is not anticipated to be a significant route of overexposure for Acetone. If Acetone is 鈥渋njected鈥? (as
may occur through punctures by contaminated, sharp objects), local swelling and irritation can occur. Depending on the
degree of injection overexposure, symptoms described under 鈥淚nhalation鈥? may develop.
OTHER HEALTH EFFECTS: Exposure to Acetone may enhance liver toxicity of chlorinated solvents, such as 1,1-
dichloroethylene and 1,1,2-trichloroethane.
HEALTH EFFECTS OR RISKS FROM EXPOSURE: An Explanation in Lay Terms.
ACUTE: Inhalation of Acetone vapors can irritate the upper respiratory system and cause central nervous system
depression (producing symptoms such as headaches, drowsiness, and confusion). Serious acute Inhalation, or ingestion
of Acetone may cause severe depression of respiratory and cardiovascular systems. Inhalation of high concentrations of
the vapors or ingestion may be fatal. Symptoms can be delayed. Direct skin or eye contact may be irritating.
CHRONIC: Prolonged or repeated skin overexposures can cause dermatitis. Chronic inhalation of Acetone vapors can
cause liver damage, inflammation of respiratory system and muscle weakness. Refer to Section 11 (Toxicology
Information) for additional information.
TARGET ORGANS: Acute: Skin, eyes, central nervous system, cardiovascular system. Chronic: Skin, respiratory
system, liver.
ACETONE - C3H6O MSDS (Document # 001088) PAGE 2 OF 9
PART II What should I do if a hazardous situation occurs?
4. FIRST-AID MEASURES
SKIN EXPOSURE: If Acetone contaminates the skin, immediately begin decontamination with running water. Minimum
flushing is for 15 minutes. Remove exposed or contaminated clothing, taking care not to contaminate eyes. Victim must
seek medical attention if any adverse reaction occurs.
EYE EXPOSURE: If Acetone liquid or vapors enter the eyes, open victim's eyes while under gentle running water. Use
sufficient force to open eyelids. Have victim "roll" eyes. Minimum flushing is for 15 minutes. Victim must seek immediate
medical attention.
INHALATION: If vapors, mists, or sprays of Acetone are inhaled, remove victim to fresh air. If necessary, use artificial
respiration to support vital functions. Remove or cover gross contamination to avoid exposure to rescuers.
INGESTION: If Acetone is swallowed, CALL PHYSICIAN OR POISON CONTROL CENTER FOR MOST CURRENT
INFORMATION. DO NOT INDUCE VOMITING. Have victim rinse mouth with water, if conscious. Never induce vomiting
or give diluents (milk or water) to someone who is unconscious, having convulsions, or who cannot swallow. If vomiting
occurs naturally, have victim lean forward to reduce risk of aspiration.
Victims of chemical exposure must be taken for medical attention. Rescuers should be taken for medical attention, if
necessary. Take copy of label and MSDS to health professional with victim.
MEDICAL CONDITIONS AGGRAVATED BY EXPOSURE: Acute or chronic respiratory conditions, central nervous system
conditions, eye disorders, or skin problems may be aggravated by overexposure to Acetone.
RECOMMENDATIONS TO PHYSICIANS: Treat symptoms and eliminate exposure. If necessary, administer liver function
tests, and eye and vision exams. The following treatment is suggested for various alcohols, and is given as symptoms of
Acetone poisoning resembles that of ethyl alcohol:
鈥? Gastric lavage with 3-5% sodium bicarbonate, unless more than 2 hours have elapsed since ingestion occurred. Do
not use apomophine. Syrup of ipecac may be a safe way to empty stomach, if given promptly after ingestion.
鈥? Oxygen and artificial respiration as needed for hypoventilation.
鈥? Treat for circular collapse, dehydration and acidosis by intravenous infusions of isotonic sodium chloride or sodium
bicarbonate.
鈥? Intravenous glucose can be administered if hypoglycemia occurs.
鈥? Hemodialysis can be done in severe cases in which the alkali treatment may be delayed or is incomplete.
鈥? Keep patient warm. Avoid aspiration of vomitus.
5. FIRE-FIGHTING MEASURES
FLASH POINT: -18掳C (0掳F) [TCC]; -9掳C (15掳F) [TOC]
NFPA RATING
AUTOIGNITION TEMPERATURE: 465掳C (869掳F)
FLAMMABLE LIMITS (in air by volume, %): FLAMMABILITY
Lower (LEL): 2.6%
Upper (UEL): 12.8% 3
FIRE EXTINGUISHING MATERIALS:
0
1
Water Spray: YES Carbon Dioxide: YES HEALTH REACTIVITY
Foam: YES Dry Chemical: YES
Halon: YES Other: Any "B" Class.
UNUSUAL FIRE AND EXPLOSION HAZARDS: This is a Class IB
flammable liquid. When involved in a fire, this material will ignite and OTHER
See Section 16 for
produce toxic gases (including carbon monoxide and carbon dioxide). The
Definition of Ratings
vapors of Acetone may spread long distances. Distant ignition and flash-
back are possible.
Explosion Sensitivity to Mechanical Impact: Not sensitive.
Explosion Sensitivity to Static Discharge: Static discharge may cause Acetone to ignite.
SPECIAL FIRE-FIGHTING PROCEDURES: Structural firefighters must wear Self-Contained Breathing Apparatus and full
protective equipment. Water spray can be used to cool fire-exposed containers. Water fog or spray can also be used by
trained fire-fighters to disperse Acetone鈥檚 vapors and to protect personnel. If this liquid is involved in a fire, fire runoff water
should be contained to prevent possible environmental damage. If necessary, decontaminate fire-response equipment with
soap and water solution.
ACETONE - C3H6O MSDS (Document # 001088) PAGE 3 OF 9
6. ACCIDENTAL RELEASE MEASURES
SPILL AND LEAK RESPONSE: Uncontrolled releases should be responded to by trained personnel using pre-planned
procedures. Proper protective equipment should be used. In case of a spill, clear the affected area and protect people.
Eliminate all sources of ignition before clean-up begins. Use non-sparking tools. There is a colorimetric tube available for
Acetone. There is a colorimetric tube available for Acetone. If a colorimetric tube is used during spill response, the reading
must not be above background levels before non-emergency personnel are allowed into the release area. The atmosphere
must have levels of Acetone lower than those listed in Section 2, (Composition and Information on Ingredients) and at least
19.5 percent oxygen before personnel can be allowed into the area without Self-Contained Breathing Apparatus (SCBA).
For small spills, absorb spilled liquid with polypads or other suitable absorbent materials, wearing gloves, goggles and
apron. In the event of a non-incidental release, minimum Personal Protective Equipment should be Level B: triple-gloves
(rubber gloves and nitrile gloves, over latex gloves), chemically resistant suit and boots, hard-hat, and Self-
Contained Breathing Apparatus. Monitor area for combustible vapor levels. The level of vapors must be below 10% of
the LEL (LEL = 2.6%), before personnel are allowed into the spill area. Absorb spilled liquid with activated carbon,
polypads, or other suitable absorbent materials. Decontaminate the area thoroughly. Prevent material from entering sewer
or confined spaces. Place all spill residue in a double plastic bag and seal. Dispose of in accordance with applicable U.S.
Federal, State, or local procedures, or appropriate Canadian standards (see Section 13, Disposal Considerations).
PART III How can I prevent hazardous situations from occurring?
7. HANDLING and STORAGE
WORK AND HYGIENE PRACTICES: As with all chemicals, avoid getting this product ON YOU or IN YOU. Wash
thoroughly after handling this product. Do not eat, drink, smoke, or apply cosmetics while handling this product. Avoid
breathing vapors or mists generated by this product. Use in a well-ventilated location. Remove contaminated clothing
immediately.
STORAGE AND HANDLING PRACTICES: All employees who handle this material should be trained to handle it safely.
Keep away from heat, sparks, and other sources of ignition. Keep container tightly closed when not in use. Use non-
sparking tools. Bond and ground containers during transfers of material. If this product is transferred into another
container, only use portable containers and dispensing equipment (faucet, pump, drip can) approved for flammable liquids.
Store containers in a cool, dry location, away from direct sunlight, sources of intense heat, or where freezing is possible.
Material should be stored in secondary containers or in a diked area, as appropriate. Store containers away from
incompatible chemicals (see Section 10, Stability and Reactivity). Containers should be separated from oxidizing materials
by a minimum distance of 20 ft. or by a barrier of non-combustible material at least 5 ft. high having a fire-resistance rating
of at least 0.5 hours. Storage areas should be made of fire resistant materials. Post warning and 鈥淣O SMOKING鈥? signs in
storage and use areas, as appropriate. Have appropriate extinguishing equipment in the storage area (i.e., sprinkler
system, portable fire extinguishers). Inspect all incoming containers before storage to ensure containers are properly
labeled and not damaged. Refer to NFPA 30, Flammable and Combustible Liquids Code, for additional information on
storage.
Empty containers may contain residual liquid or vapors which are flammable; therefore, empty containers should be
handled with care. Never perform any welding, cutting, soldering, drilling, or other hot work on an empty container or
piping until all liquid, vapors, and residue have been cleared.
PROTECTIVE PRACTICES DURING MAINTENANCE OF CONTAMINATED EQUIPMENT: Follow practices indicated in
Section 6 (Accidental Release Measures). Make certain that application equipment is locked and tagged-out safely, if
necessary. Collect all rinsates and dispose of according to applicable U.S. Federal, State, or local procedures and
appropriate Canadian standards.
8. EXPOSURE CONTROLS - PERSONAL PROTECTION
VENTILATION AND ENGINEERING CONTROLS: Use with adequate ventilation. Use a mechanical fan or vent area to
outside. Where appropriate, use a non-sparking, grounded ventilation system separate from other exhaust ventilation
systems. Ensure eyewash/safety shower stations are available near areas where Acetone is used.
RESPIRATORY PROTECTION: Maintain airborne contaminant concentrations below exposure limits listed in Section 2
(Composition and Information on Ingredients), if applicable. If respiratory protection is needed, use only protection
authorized in the U.S. Federal OSHA Standard (29 CFR 1910.134), applicable U.S. State regulations, or the Canadian
CSA Standard Z94.4-93 and applicable standards of Canadian Provinces. Oxygen levels below 19.5% are considered
IDLH by OSHA. In such atmospheres, use of a full-facepiece pressure/demand SCBA or a full facepiece, supplied air
respirator with auxiliary self-contained air supply is required under OSHA鈥檚 Respiratory Protection Standard (1910.134-
1998).
ACETONE - C3H6O MSDS (Document # 001088) PAGE 4 OF 9
8. EXPOSURE CONTROLS - PERSONAL PROTECTION (Continued)
RESPIRATORY PROTECTION (continued): For additional information, the following NIOSH recommendations for
respiratory protection are provided for Acetone.
CONCENTRATION RESPIRATORY EQUIPMENT
Up to 2500 ppm: Chemical cartridge respirator with organic vapor cartridge, or powered air-purifying
respirator with organic vapor cartridge(s), or gas mask with organic vapor canister, or
Supplied Air Respirator (SAR), or full-facepiece Self-Contained Breathing Apparatus (SCBA).
Emergency or Planned Entry into Unknown Concentration or IDLH Conditions: Positive pressure, full facepiece SCBA or
positive pressure, full facepiece SAR with an auxiliary positive pressure SCBA.
Escape: Gas mask with organic vapor canister, or escape-type SCBA should be used.
The IDLH concentration for Acetone is 2500 ppm.
EYE PROTECTION: Splash goggles or safety glasses, with faceshield.
HAND PROTECTION: Wear butyl rubber, Teflon鈩?, Barricade鈩?, Chemrel鈩?, or similar gloves for routine industrial use.
Use triple gloves for spill response, as stated in Section 6 (Accidental Release Measures) of this MSDS.
BODY PROTECTION: Use body protection appropriate for task. Coveralls, chemically-resistant boots, and other body
protection may be appropriate, depending on the operation in which Acetone is used.
9. PHYSICAL and CHEMICAL PROPERTIES
RELATIVE VAPOR DENSITY (air = 1): 2.0 pH: Not applicable.
SPECIFIC GRAVITY (water = 1): 0.791 FREEZING/MELTING POINT: -95.4掳C (-139.7掳F)
SOLUBILITY IN WATER: Soluble. BOILING POINT: 56.2掳C (133.2掳F)
EVAPORATION RATE (n-BuAc = 1): Not established. ODOR THRESHOLD: 200-400 ppm
EXPANSION RATIO: Not applicable. SPECIFIC VOLUME: Not determined.
VAPOR PRESSURE @ 20掳C : 180 mm Hg MOLECULAR WEIGHT: 58.08
LOG COEFFICIENT WATER/OIL DISTRIBUTION: -0.24
APPEARANCE, ODOR AND COLOR: Acetone is a clear, colorless, mobile liquid with a fruity or mint-like odor.
HOW TO DETECT THIS SUBSTANCE (warning properties): The odor may be a distinctive characteristic of Acetone, if
accidentally released.
10. STABILITY and REACTIVITY
STABILITY: Stable at standard temperatures and pressures.
DECOMPOSITION PRODUCTS: When ignited in air, the products of thermal decomposition include carbon monoxide,
carbon dioxide, and formaldehyde.
MATERIALS WITH WHICH SUBSTANCE IS INCOMPATIBLE: Acetone reacts violently with strong oxidizing agents, and
chlorinated solvent/alkali mixtures. Acetone reacts vigorously with hexachloromelamine, sulfur dichloride and potassium
tert-butoxide.
HAZARDOUS POLYMERIZATION: Will not occur.
CONDITIONS TO AVOID: Contact with incompatible materials and exposure to heat, sparks and other sources of ignition.
PART III How can I prevent hazardous situations from occurring?
11. TOXICOLOGICAL INFORMATION
TOXICITY DATA: The following toxicology data are currently available for Acetone.
Standard Draize Test (Eye-Human) 500 ppm LD50 (Intravenous-Rat) 5500 mg/kg TCLo (Inhalation-Human) 500 ppm: Eye
Standard Draize Test (Eye effects-Rabbit, LD50 (Intraperitoneal-Mouse) 1297 mg/kg effects
adult) 3950 :Severe irritation effects LDLo (Intravenous-Mouse) 4 g/kg TCLo (Inhalation-Man) 12,000 ppm/4 hours:
Standard Draize Test (Eye effects-Rabbit, LDLo (Intraperitoneal-Rat) 500 mg/kg Central nervous system effects
adult) 20 mg/24 hours Moderate TDLo (Oral-Man) 2857 mg/kg TCLo (Inhalation-Man) 12,000 ppm/4 hours:
3
irritation effects TDLo (Inhalation-Man) 440 :g/m /6 minutes Gastrointestinal tract effects
3
Standard Draize Test (Skin-Rabbit, adult) TDLo (Inhalation-Man) 10 mg/m /6 hours TCLo (Inhalation: Mammal-species
3
unspecified) 31500 碌g/m /24 hours:
395 mg open Mild irritation effects TDLo (Oral-Rat) 273 gm/kg: male 13
Standard Draize Test (Skin-Rabbit, adult) week(s) pre-mating: Reproductive: female 1-13 day(s) after conception:
500 mg/24 hours Mild irritation effects Paternal Effects: spermatogenesis (incl. Reproductive: Fertility: post-implantation
LD50 (Oral-Rat) 5800 mg/kg genetic material, sperm morphology, mortality (e.g. dead and/or resorbed
LD50 (Oral-Mouse) 3000 mg/kg motility, and count) implants per total number of implants)
3
LD50 (Oral-Rabbit, adult) 5340 mg/kg LDLo (Oral-Dog, adult) 8 g/kg TCLo (Inhalation-Mammal) 31,500: g/m /24
3
LD50 (Skin-Rabbit, adult) 20 g/kg LC50 (Inhalation-Rat) 50,100 mg/m /8 hours hours (1-13 days preg): Reproductive
3
LD50 (Intravenous-Rat)5500 mg/kg LCLo (Inhalation-Mouse)110 g/m /1 hour effects
ACETONE - C3H6O MSDS (Document # 001088) PAGE 5 OF 9
11. TOXICOLOGICAL INFORMATION (Continued)
TOXICITY DATA (continued):
Cytogenetic Analysis (Saccharomyces Sex Chromosome Loss and Nondisjunction Sex chromosome loss and nondisjunction
cerevisiae) 200 mmol/tube (Saccharomyces cerevisiae) 47,600 (Saccharomyces cerevisiae) 47600 ppm
ppm Cytogenetic Analysis (Hamster-Fibroblast)
40 gm/L
SUSPECTED CANCER AGENT: Acetone is listed as follows:
EPA-D (Not Classifiable as to Human Carcinogenicity - inadequate human and animal evidence of carcinogenicity or no data available)
ACGIH TLV-A4 (Not Classifiable as a Human Carcinogen - agent which causes concern that it could be carcinogenic for humans, but which cannot
be assumed conclusively because of lack of data.
Acetone is not found on the following lists: FEDERAL OSHA Z LIST, NTP, IARC, or CAL/OSHA, and is therefore not
considered to be, nor suspected to be, a cancer-causing agent by these agencies.
IRRITANCY OF PRODUCT: The liquid or vapors of Acetone can be irritating to contaminated tissue.
SENSITIZATION OF PRODUCT: Acetone is not known to cause sensitization in humans after prolonged or repeated
exposures.
REPRODUCTIVE TOXICITY INFORMATION: Listed below is information concerning the effects of Acetone on the human
reproductive system.
Mutagenicity: Acetone is not reported to produce mutagenic effects in humans. Data are available for Acetone in
microorganisms.
Embryotoxicity: Acetone is not reported to produce embryotoxic effects in humans.
Teratogenicity: Acetone is not reported to cause teratogenic effects in humans.
Reproductive Toxicity: Acetone is not reported to cause reproductive effects in humans. Clinical studies on test
animals exposed to relatively high doses of this compound indicate reproductive effects.
A mutagen is a chemical which causes permanent changes to genetic material (DNA) such that the changes will propagate
through generation lines. An embryotoxin is a chemical which causes damage to a developing embryo (i.e. within the first
eight weeks of pregnancy in humans), but the damage does not propagate across generational lines. A teratogen is a
chemical which causes damage to a developing fetus, but the damage does not propagate across generational lines. A
reproductive toxin is any substance which interferes in any way with the reproductive process.
BIOLOGICAL EXPOSURE INDICES: The following Biological Exposure Indices (BEIs) are associated with Acetone:
CHEMICAL DETERMINANT SAMPLING TIME BEI
ACETONE
Acetone in urine End of shift 100 mg/L
12. ECOLOGICAL INFORMATION
ALL WORK PRACTICES MUST BE AIMED AT ELIMINATING ENVIRONMENTAL CONTAMINATION.
ENVIRONMENTAL STABILITY: Acetone will be degraded over time into other organic compounds. The following
environmental data are available for Acetone:
Estimated Log Kow = -0.24; Estimated Log Koc = 1; Water Solubility = Miscible.
Biodegradation: Although Acetone is quite readily degraded in the environment, the primary removal of Acetone is through evaporation. BOD =
122%; 5 days.
Bioconcentration: The potential for bioconcentration in fish is negligible. One experimental study of bioconcentration in adult haddock at 7-9掳C
(static test) resulted in a BCF of 0.69
Mobility/Soil Adsorption: Acetone is expected to be very mobile in soil, based on estimated Log Kow and Log Koc values. Acetone has shown no
adsorption to montorillonite, kaolinite clay or stream sediment.
Persistence: If released to soil, Acetone is expected to volatilize (from moist soil surfaces). Acetone will be highly mobile in soil, possible leaching
to groundwater. Acetone is expected to biodegrade from soils. If released to water, Acetone will not adsorb to suspended solids or sediments.
Acetone is expected to volatilize from water surfaces to the atmosphere. The estimated half-lives of Acetone in a model river and model lake
are 38 and 33 hours, respectively. If released to the atmosphere, Acetone will exist solely as a vapor in the atmosphere. Vapor-phase acetone
is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals. The half-life for this reaction in air is estimated to
be 71 days. The average rate of photodissociation of Acetone by natural sunlight in the lower troposphere has been measured as 1 x 10-7
sec-s. This corresponds to a half-life of about 80 days.
EFFECT OF MATERIAL ON PLANTS or ANIMALS: Acetone may be harmful or fatal to contaminated plant and animal-life
(especially if large quantities of Acetone are released). Refer to section 11 (Toxicological Information) for additional
information on effects on animals. The following data are available for bird life:
LC50 (Japanese quail) = 40,000 ppm, in diet, age 14 days, (no mortality to 40,000 ppm)
LC50 (Ring-necked pheasant) = 40,000 ppm, in diet, age 10 days, (no mortality to 40,000 ppm)
ACETONE - C3H6O MSDS (Document # 001088) PAGE 6 OF 9
12. ECOLOGICAL INFORMATION (Continued)
EFFECT OF CHEMICAL ON AQUATIC LIFE: Acetone can be harmful or fatal to contaminated aquatic plant and animal
life. The following aquatic toxicity data are available for Acetone:
TLm (Daphnia magna) 24 and 48 hours, = 10 mg/L (conditions of LC50 (Gammarus pulex) = 5,500 mg/L
bioassay not specified) LC50 (Pimephales promelas) 96 hours = 8,120 mg/L, (conditions of
TLm (brine shrimp) 24 and 48 hours = 2100 mg/L, (conditions of bioassay not specified)
bioassay not specified) LC50,F (fingerling trout) 24 hours = 6,100 mg/L
NOEC (Daphnia magna) reproduction = 3,200 mg/L LD100 (Asellus aquaticus) within 3 days = 3 mL (conditions of bioassay
NOEC (Daphnia magna) growth = 1,000 mg/L not specified)
LC50 (mosquito fish) 24-96 hours = 13,000 mg/L LD100 (Gamarus fossarum) 48 hours = 10 mL/L; (conditions of
LC50 (goldfish) 24 hours = 5,000 mg/L bioassay not specified)
LC50 (Lepomis macrochirus bluegill sunfish) 96 hours = 8,300 mg/L EC0 (Pseudomonas putida bacteria) 16 hours = 1,700 mg/L
LC50 (Poecilia reticulata guppy) 14 days = 7,032 mg/L EC0 (Microcystic aeruginosa algae) 8 days = 530 mg/L
LC50 (Mexican axolotl 3鈥?4 w after hatching) 48 hours = 20,000 mg/L EC0 (Scenedesmus quadricauda green algae) 7 days = 7,500 mg/L
LC50 (clawed toad 3鈥?4 w after hatching) 48 hours = 24,000 mg/L EC0 (Entosiphon sulcatum protozoa) 72 hours = 28 mg/L
LC50 (Daphnia magna) growth = 17,100 mg/L EC0 (Uronema parduczi Chatton-Lwoff protozoa) = 1,710 mg/L
EC50 (Daphnia magna) reproduction = 4,000 mg/L
LC50 (Salmo gairdeneri, rainbow trout) 86 hours = 5,540 mg/L @ 12掳C;
(95% confidence limit 4,740-6,330 mg/L), wt 1.0 g (static
bioassay)
13. DISPOSAL CONSIDERATIONS
PREPARING WASTES FOR DISPOSAL: Waste disposal must be in accordance with appropriate Federal, State, and local
regulations. Do not dispose of locally.
U.S. EPA WASTE NUMBER: D001 (Characteristic, Ignitability), applicable to wastes consisting only of this compound.
14. TRANSPORTATION INFORMATION
THIS MATERIAL IS HAZARDOUS AS DEFINED BY 49 CFR 172.101 BY THE U.S. DEPARTMENT OF
TRANSPORTATION.
PROPER SHIPPING NAME: Acetone
HAZARD CLASS NUMBER and DESCRIPTION: 3 (Flammable Liquid)
UN IDENTIFICATION NUMBER: UN 1090
PACKING GROUP: PG II
DOT LABEL(S) REQUIRED: Flammable Liquid
NORTH AMERICAN EMERGENCY RESPONSE GUIDEBOOK NUMBER (1996): 127
MARINE POLLUTANT: Acetone is not classified by the DOT as a Marine Pollutant (as defined by 49 CFR 172.101,
Appendix B).
TRANSPORT CANADA, TRANSPORTATION OF DANGEROUS GOODS REGULATIONS: THIS MATERIAL IS
CONSIDERED AS DANGEROUS GOODS. Use the following information for the preparation of Canadian Shipments.
15. REGULATORY INFORMATION
ADDITIONAL U.S. REGULATIONS:
U.S. SARA REPORTING REQUIREMENTS: Acetone is subject to the reporting requirements of Sections 302, 304 and
313 of Title III of the Superfund Amendments and Reauthorization Act, as follows:
CHEMICAL NAME SARA 302 SARA 304 SARA 313
(40 CFR 355, Appendix A) (40 CFR Table 302.4) (40 CFR 372.65)
Acetone NO YES NO
U.S. SARA THRESHOLD PLANNING QUANTITY: There are no specific Threshold Planning Quantities for Acetone. The
default Federal MSDS submission and inventory requirement filing threshold of 10,000 lb (4,540 kg) may apply, per 40 CFR
370.20.
U.S. CERCLA REPORTABLE QUANTITIES (RQ): 5000 lb. (2270 kg)
U.S. TSCA INVENTORY STATUS: Acetone is listed on the TSCA Inventory.
OTHER U.S. FEDERAL REGULATIONS: Depending on specific operations involving the use of Acetone, the regulations
of the Process Safety Management of Highly Hazardous Chemicals may be applicable (29 CFR 1910.119). Under this
regulation, Acetone is not listed in Appendix A; however, any process that involves a flammable liquid on-site, in one
location, in quantities of 10,000 lb (4,553 kg) or greater is covered under this regulation unless it is used as a fuel.
ACETONE - C3H6O MSDS (Document # 001088) PAGE 7 OF 9
15. REGULATORY INFORMATION (Continued)
U.S. STATE REGULATORY INFORMATION: Acetone is covered under specific State regulations, as denoted below:
Alaska - Designated Toxic and Hazardous Massachusetts - Substance List: Acetone. Pennsylvania - Hazardous Substance List:
Acetone.
Substances: Acetone. Michigan - Critical Materials Register: No.
Rhode Island - Hazardous Substance List:
California - Permissible Exposure Limits: Missouri - Employer Information/Toxic
Acetone.
Acetone. Substance List: Acetone.
Texas - Hazardous Substance List:
Florida - Substance List: Acetone. New Jersey - Right to Know Hazardous
Acetone.
Illinois - Toxic Substance List: Acetone. Substance List: Acetone.
West Virginia - Hazardous Substance List:
Kansas - Section 302/313 List: Acetone. North Dakota - List of Hazardous
Acetone.
Minnesota - List of Hazardous Substances: Chemicals, Reportable Quantities:
Wisconsin - Toxic and Hazardous
Acetone. Acetone.
Substances: Acetone.
CALIFORNIA SAFE DRINKING WATER AND TOXIC ENFORCEMENT ACT (PROPOSITION 65): Acetone is not on the
California Proposition 65 List.
LABELING: WARNING! FLAMMABLE LIQUID AND VAPOR. PROLONGED OR REPEATED SKIN CONTACT MAY
DRY SKIN AND CAUSE IRRITATION. HARMFUL OR FATAL IF SWALLOWED. CAN CAUSE CENTRAL NERVOUS
SYSTEM EFFECTS OR LIVER DAMAGE. CAN CAUSE DEATH IF TOO MUCH VAPOR IS BREATHED. Keep away
from heat, sparks and flame. Keep container closed. Use only with adequate ventilation. Avoid contact with skin and
clothing. Avoid exposure to vapor. Wash thoroughly after handling. FIRST-AID: In case of contact, immediately flush skin
with plenty of water. Remove contaminated clothing and shoes. Get medical attention if irritation develops or persists. If
inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. If swallowed, do
not induce vomiting. Get medical attention. IN CASE OF FIRE: Use water fog, foam, dry chemical, or CO2. IN CASE OF
SPILL: Absorb spill with inert materials (e.g. activated carbon, dry sand). Flush residual spill with water. Consult Material
Safety Data Sheet for additional information.
ADDITIONAL CANADIAN REGULATIONS:
OTHER CANADIAN REGULATIONS: Not applicable.
CANADIAN ENVIRONMENTAL PROTECTION ACT (CEPA) PRIORITIES SUBSTANCES LISTS: Acetone is not
on the CEPA Priorities Substances Lists.
CANADIAN DSL/NDSL INVENTORY STATUS: Acetone is listed on the Canadian DSL Inventory.
CANADIAN WHMIS SYMBOLS: Class B2: Flammable Liquid
Class D2B: Materials Causing Other Toxic Effects
16. OTHER INFORMATION
PREPARED BY: CHEMICAL SAFETY ASSOCIATES, Inc.
9163 Chesapeake Drive, San Diego, CA 92123-1002
619/565-0302
The information contained herein is based on data considered accurate. However, no warranty is expressed or implied regarding the
accuracy of these data or the results to be obtained from the use thereof. AIRGAS, Inc. assumes no responsibility for injury to the vendee or
third persons proximately caused by the material if reasonable safety procedures are not adhered to as stipulated in the data sheet.
Additionally, AIRGAS, Inc. assumes no responsibility for injury to vendee or third persons proximately caused by abnormal use of the material
even if reasonable safety procedures are followed. Furthermore, vendee assumes the risk in his use of the material.
ACETONE - C3H6O MSDS (Document # 001088) PAGE 8 OF 9
DEFINITIONS OF TERMS
A large number of abbreviations and acronyms appear on a MSDS. Some of these which are commonly used include the following:
CAS #: This is the Chemical Abstract Service Number which uniquely identifies each constituent. It is used for computer-related searching.
EXPOSURE LIMITS IN AIR: FLAMMABILITY LIMITS IN AIR:
Much of the information related to fire and explosion is derived from
ACGIH - American Conference of Governmental Industrial
Hygienists, a professional association which establishes exposure the National Fire Protection Association (NFPA). Flash Point -
limits. Minimum temperature at which a liquid gives off sufficient vapors to
form an ignitable mixture with air. Autoignition Temperature: The
TLV - Threshold Limit Value - an airborne concentration of a
minimum temperature required to initiate combustion in air with no
substance which represents conditions under which it is generally
other source of ignition. LEL - the lowest percent of vapor in air, by
believed that nearly all workers may be repeatedly exposed without
volume, that will explode or ignite in the presence of an ignition
adverse effect. The duration must be considered, including the 8-
source. UEL - the highest percent of vapor in air, by volume, that will
hour Time Weighted Average (TWA), the 15-minute Short Term
explode or ignite in the presence of an ignition source.
Exposure Limit, and the instantaneous Ceiling Level. Skin
absorption effects must also be considered.
TOXICOLOGICAL INFORMATION:
OSHA - U.S. Occupational Safety and Health Administration.
Possible health hazards as derived from human data, animal
PEL - Permissible Exposure Limit - This exposure value means
studies, or from the results of studies with similar compounds are
exactly the same as a TLV, except that it is enforceable by OSHA.
presented. Definitions of some terms used in this section are: LD50 -
The OSHA Permissible Exposure Limits are based in the 1989
Lethal Dose (solids & liquids) which kills 50% of the exposed
PELs and the June, 1993 Air Contaminants Rule (Federal Register:
animals; LC50 - Lethal Concentration (gases) which kills 50% of the
58: 35338-35351 and 58: 40191). Both the current PELs and the
exposed animals; ppm concentration expressed in parts of material
vacated PELs are indicated. The phrase, 鈥淰acated 1989 PEL,鈥? is 3
per million parts of air or water; mg/m concentration expressed in
placed next to the PEL which was vacated by Court Order.
weight of substance per volume of air; mg/kg quantity of material,
IDLH - Immediately Dangerous to Life and Health - This level
by weight, administered to a test subject, based on their body weight
represents a concentration from which one can escape within 30-
in kg. Data from several sources are used to evaluate the cancer-
minutes without suffering escape-preventing or permanent injury.
causing potential of the material. The sources are: IARC - the
The DFG - MAK is the Republic of Germany鈥檚 Maximum Exposure
International Agency for Research on Cancer; NTP - the National
Level, similar to the U.S. PEL. NIOSH is the National Institute of
Toxicology Program, RTECS - the Registry of Toxic Effects of
Occupational Safety and Health, which is the research arm of the
Chemical Substances, OSHA and CAL/OSHA. IARC and NTP rate
U.S. Occupational Safety and Health Administration (OSHA).
chemicals on a scale of decreasing potential to cause human
NIOSH issues exposure guidelines called Recommended Exposure
cancer with rankings from 1 to 4. Subrankings (2A, 2B, etc.) are
Levels (RELs). When no exposure guidelines are established, an
also used. Other measures of toxicity include TDLo, the lowest dose
entry of NE is made for reference.
to cause a symptom and TCLo the lowest concentration to cause a
HAZARD RATINGS: symptom; TDo, LDLo, and LDo, or TC, TCo, LCLo, and LCo, the
HAZARDOUS MATERIALS IDENTIFICATION SYSTEM: Health lowest dose (or concentration) to cause death. BEI - Biological
Exposure Indices, represent the levels of determinants which are
Hazard: 0 (minimal acute or chronic exposure hazard); 1 (slight
most likely to be observed in specimens collected from a healthy
acute or chronic exposure hazard); 2 (moderate acute or significant
worker who has been exposed to chemicals to the same extent as a
chronic exposure hazard); 3 (severe acute exposure hazard;
worker with inhalation exposure to the TLV.
onetime overexposure can result in permanent injury and may be
fatal); 4 (extreme acute exposure hazard; onetime overexposure
REGULATORY INFORMATION:
can be fatal). Flammability Hazard: 0 (minimal hazard); 1 (materials
This section explains the impact of various laws and regulations on
that require substantial pre-heating before burning); 2 (combustible
the material. EPA is the U.S. Environmental Protection Agency.
liquid or solids; liquids with a flash point of 38-93掳C [100-200掳F]); 3
WHMIS is the Canadian Workplace Hazardous Materials
(Class IB and IC flammable liquids with flash points below 38掳C
Information System. DOT and TC are the U.S. Department of
[100掳F]); 4 (Class IA flammable liquids with flash points below 23掳C Transportation and the Transport Canada, respectively. Superfund
[73掳F] and boiling points below 38掳C [100掳F]. Reactivity Hazard: 0 Amendments and Reauthorization Act (SARA); the Canadian
(normally stable); 1 (material that can become unstable at elevated Domestic Substances List (DSL); the U.S. Toxic Substance
temperatures or which can react slightly with water); 2 (materials Control Act (TSCA); Marine Pollutant status according to the DOT;
that are unstable but do not detonate or which can react violently California's Safe Drinking Water Act (Proposition 65); the
with water); 3 (materials that can detonate when initiated or which Comprehensive Environmental Response, Compensation, and
can react explosively with water); 4 (materials that can detonate at Liability Act (CERCLA or Superfund); and various state
normal temperatures or pressures). regulations. This section also includes information on the
NATIONAL FIRE PROTECTION ASSOCIATION: Health Hazard: 0 precautionary warnings which appear on the materials package
(material that on exposure under fire conditions would offer no label.
hazard beyond that of ordinary combustible materials); 1 (materials
that on exposure under fire conditions could cause irritation or minor
residual injury); 2 (materials that on intense or continued exposure
under fire conditions could cause temporary incapacitation or
possible residual injury); 3 (materials that can on short exposure
could cause serious temporary or residual injury); 4 (materials that
under very short exposure could cause death or major residual
injury). Flammability Hazard and Reactivity Hazard: Refer to
definitions for 鈥淗azardous Materials Identification System鈥?.
ACETONE - C3H6O MSDS (Document # 001088) PAGE 9 OF 9
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