NFPA RATING
FLAMMABILITY
4
2
3
HEALTH REACTIVITY
MATERIAL SAFETY DATA SHEET
Prepared to U.S. OSHA, CMA, ANSI and Canadian WHMIS Standards
OTHER
PART I What is the material and what do I need to know in an emergency?
1. PRODUCT IDENTIFICATION
PROPYLENE OXIDE
CHEMICAL NAME; CLASS:
SYNONYMS: 1,2-Epoxypropane, 1,2-Propylene Oxide, Epoxypropane,
Methyl Ethylene Oxide, Methyloxirane
Document Number: 001089
PRODUCT USE: For General Analytical/Synthetic Chemical Uses
SUPPLIER/MANUFACTURER'S NAME: AIRGAS INC.
ADDRESS: 259 North Radnor-Chester Road
Suite 100
Radnor, PA 19087-5283
BUSINESS PHONE: 1-610-687-5253
EMERGENCY PHONE: 1-800-949-7937
International: 1-423-479-0293
DATE OF PREPARATION: January 14, 2002
2. COMPOSITION and INFORMATION ON INGREDIENTS
CHEMICAL NAME CAS # mole % EXPOSURE LIMITS IN AIR
ACGIH OSHA NIOSH OTHER
TLV STEL PEL STEL IDLH
ppm ppm ppm ppm ppm ppm
Propylene Oxide 75-56-9 100 2 NE 100 NE 400 NIOSH REL:
(sensitizer) 20 Reduce to Lowest Feasible
(Vacated Concentration (LOQ = 8.4
1989 PEL) ppm)
Carcinogen: EPA-B2, IARC-2B,
MAK-2, NIOSH-Ca, NTP-R,
TLV-A3
NE = Not Established. LOQ = Limit of Quantitation See Section 16 for Definitions of Terms Used.
NOTE (1): ALL WHMIS required information is included in appropriate sections based on the ANSI Z400.1-1998 format. This product has been
classified in accordance with the hazard criteria of the CPR and the MSDS contains all the information required by the CPR.
3. HAZARD IDENTIFICATION
EMERGENCY OVERVIEW: Propylene Oxide is a flammable, colorless liquid that is shipped under its own vapor
pressure and which has an ethereal, or benzene-like odor. Propylene Oxide is a possible human carcinogen.
Inhalation over-exposures to Propylene Oxide irritate the respiratory system and can damage the lungs. Severe
inhalation over-exposure may be fatal. Propylene Oxide is corrosive to skin, eyes, and contaminated tissues.
Releases of Propylene Oxide present a serious fire hazard. The vapors of Propylene Oxide are heavier than air
and may spread long distances; distant ignition and flash-back are possible. Propylene Oxide can react with water
and a runaway reaction may occur. Propylene Oxide can undergo hazardous polymerization when in contact with
highly active catalysts, acids, and bases. Emergency responders must wear the proper personal protective
equipment (and have appropriate fire suppression equipment) suitable for the situation to which they are
responding.
PROPYLENE OXIDE (Document #001089) MSDS PAGE 1 OF 10
3. HAZARD IDENTIFICATION (Continued)
SYMPTOMS OF OVEREXPOSURE BY ROUTE OF
EXPOSURE: The most significant routes of occupational over- HAZARDOUS MATERIAL IDENTIFICATION SYSTEM
exposure are by inhalation and skin and eye contact.
Propylene Oxide is classified toxicologically as a primary
HEALTH
irritant, a mild antagonist of protoplasmic protein and a mild (BLUE) 3
depressant of central nervous system activity. The symptoms
of over-exposure to the Propylene Oxide, via route of
exposure, are as follows:
INHALATION: Inhalation of Propylene Oxide vapors irritate the
FLAMMABILITY (RED) 4
mucous membranes and upper respiratory tract. Inhalation of
Propylene Oxide vapors may cause headache, dizziness,
lightheadedness, incoordination, and unconsciousness.
Central nervous system effects consist of incoordination, ataxia
REACTIVITY
and general depression. Inhalation of very high concentrations
(YELLOW) 2
of the vapors, as may occur if Propylene Oxide is used or
released in a poorly ventilated area or confined space (or
during a release of large volumes of Propylene Oxide), may
PROTECTIVE EQUIPMENT X
cause lung damage and reduce resistance to pneumonia.
Repeated inhalation over-exposures may cause lung damage.
There is confirmed potential for worker sensitization as a
EYES HANDS BODY
RESPIRATORY
result of inhalation exposure, based on the weight of scientific
evidence. In susceptible individuals, repeated exposure may
result in allergic reaction. Severe inhalation over-exposure SEE SECTION 8 SEE SECTION 8
may be fatal.
CONTACT WITH SKIN or EYES: Depending on the duration
For Routine Industrial Use and Handling Applications
and concentration of over-exposure, contact of the liquid or
vapor of Propylene Oxide with the eyes may cause irritation, See Section 16 for Definition of Ratings
tearing, burns, and permanent injury. Corneal burns have
been reported. Depending on the duration and concentration of over-exposure, skin contact may cause redness,
severe irritation, and burns. Contact with skin, even with dilute solutions of Propylene Oxide may result in irritation
and necrosis of skin. There is confirmed potential for worker sensitization as a result of dermal contact and/or
inhalation exposure, based on the weight of scientific evidence. Repeated skin over-exposure may cause dermatitis
and allergic skin reaction in susceptible individuals.
SKIN ABSORPTION: Skin absorption is not known to be a significant route of entry for Propylene Oxide.
INGESTION: Ingestion is not anticipated to be a significant route of over-exposure for Propylene Oxide. If
Propylene Oxide is swallowed, it can cause nausea, vomiting, and diarrhea. Symptoms can include those described
in “Inhalation�. Ingested Propylene Oxide may be aspirated into the lungs and cause severe lung damage (edema)
and pneumonitis.
OTHER POTENTIAL HEALTH EFFECTS: Contact with rapidly expanding gases (which are released under high
pressure) may cause frostbite. Symptoms of frostbite include change in skin color to white or grayish-yellow. The
pain after such contact can quickly subside.
HEALTH EFFECTS OR RISKS FROM EXPOSURE: An Explanation in Lay Terms. Overexposure to Propylene
Oxide may cause the following health effects:
ACUTE: Inhalation and ingestion over-exposure to Propylene Oxide may cause headache, dizziness,
lightheadedness, incoordination, unconsciousness, lung damage, and reduced resistance to pneumonia. Severe
inhalation over-exposure may be fatal. Contamination of skin may cause severe irritation or burns. Contamination of
eyes may cause burns or permanent injury.
CHRONIC: Repeated skin over-exposure may cause allergic skin reaction. Repeated inhalation over-exposures
may cause lung damage. There is confirmed potential for worker sensitization as a result of dermal contact and/or
inhalation exposure, based on the weight of scientific evidence. Chronic over-exposure may cause liver damage.
Propylene Oxide is a confirmed animal carcinogen and probable human carcinogen and possible reproductive toxin.
See Section 11 (Toxicological Information) for additional information.
TARGET ORGANS: ACUTE: Respiratory system, skin, eyes. CHRONIC: Skin, respiratory system, liver (based on
animal test data), central nervous system, eyes.
PROPYLENE OXIDE (Document #001089) MSDS PAGE 2 OF 10
PART II What should I do if a hazardous situation occurs?
4. FIRST-AID MEASURES
RESCUERS SHOULD NOT ATTEMPT TO RETRIEVE VICTIMS OF EXPOSURE TO THIS PRODUCT WITHOUT
ADEQUATE PERSONAL PROTECTIVE EQUIPMENT. At a minimum, Self-Contained Breathing Apparatus and
Fire-Retardant Personal Protective equipment should be worn. Adequate fire protection must be provided
during rescue situations.
Victim(s) must be taken for medical attention. Rescuers should be taken for medical attention, if necessary. Take
copy of label and MSDS to physician or other health professional with victim(s). Remove victim(s) to fresh air, as
quickly as possible. In case of eye contact which leads to irritation, immediately flush eyes with copious amounts of
water for at least 15 minutes. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Only
trained personnel should administer supplemental oxygen.
In case of frostbite, place the frostbitten part in warm water. DO NOT USE HOT WATER. If warm water is not
available, or is impractical to use, wrap the affected parts gently in blankets. Alternatively, if the fingers or hands are
frostbitten, place the affected area in the armpit. Encourage victim to gently exercise the affected part while being
warmed. Seek immediate medical attention.
SKIN EXPOSURE: If this gas contaminates the skin, immediately begin decontamination with running water.
Minimum flushing is for 15 minutes. Remove exposed or contaminated clothing, taking care not to contaminate the
eyes. Victim must seek immediate medical attention.
EYE EXPOSURE: If this gas gets into the eyes, or if irritation of the eye develops after exposure to gas, open
victim's eyes while under gently running water. Use sufficient force to open eyelids. Have victim "roll" eyes.
Minimum flushing is for 15 minutes. Seek medical assistance immediately, preferably an ophthalmologist.
MEDICAL CONDITIONS AGGRAVATED BY EXPOSURE: Acute or chronic respiratory system, skin, or eye
conditions, as well as disorders involving the “Target Organs�, as listed in Section 3 (Hazard Information), may be
aggravated by overexposure to Propylene Oxide.
RECOMMENDATIONS TO PHYSICIANS: Administer oxygen if necessary, treat symptoms, and eliminate
exposure. Be observant for initial signs of pulmonary edema.
5. FIRE-FIGHTING MEASURES
FLASH POINT (closed cup): -35 to -37°C (-31 to �34.6°F)
AUTOIGNITION TEMPERATURE: 429°C - 465°C (804°F - 869°F);
NFPA RATING
570°C (1058°F) [in absence of air)
FLAMMABILITY
FLAMMABLE LIMITS (in air by volume, %):
Lower (LEL): 2.1 %
4
Upper (UEL): 37.0 %
FIRE EXTINGUISHING MATERIALS: Extremely flammable
2
3
material. Extinguish fires by shutting off the source of the leak. Do HEALTH REACTIVITY
NOT direct water onto the Propylene Oxide release. Use water
spray or a foam agent to cool fire-exposed containers, structures,
and equipment.
UNUSUAL FIRE AND EXPLOSION HAZARDS: Propylene Oxide OTHER
is corrosive and presents a serious contact hazard to firefighters.
Propylene Oxide is a Class IA flammable liquid; it will rapidly or
See Section 16 for
completely vaporize or readily disperse in air and burn. Propylene
Definition of Ratings
Oxide can react with water resulting in a runaway reaction. Water
should not be applied directly onto a fire that involves Propylene Oxide. Propylene Oxide can undergo hazardous
polymerization when in contact with highly active catalysts, acids, and bases. When involved in a fire, Propylene
Oxide may decompose and produce toxic gases (carbon monoxide and carbon dioxide). The vapors of Propylene
Oxide are heavier than air and may spread long distances; distant ignition and flash-back are possible.
DANGER! Fires impinging (direct flame) on the outside surface of cylinders or storage vessels can be very
dangerous. Direct flame exposure on the cylinder wall can cause an explosion. The resulting fire and explosion can
result in severe equipment damage and personnel injury or death over a large area around the vessel. For massive
fires in large areas, use unmanned hose holder or monitor nozzles; if this is not possible, withdraw from area and
allow fire to burn.
Explosion Sensitivity to Mechanical Impact: Not sensitive.
Explosion Sensitivity to Static Discharge: Static discharge may cause Propylene Oxide to ignite explosively.
PROPYLENE OXIDE (Document #001089) MSDS PAGE 3 OF 10
5. FIRE-FIGHTING MEASURES (Continued)
SPECIAL FIRE-FIGHTING PROCEDURES: In the event of fire, cool containers of Propylene Oxide with water to
prevent failure. Use a water spray or fog to reduce or direct vapors. Do NOT direct water onto the Propylene Oxide
release. Move containers from fire area if it can be done without risk to personnel. Stop leaks or discharges if
possible. For small releases, if it is not possible to stop the leak and it does not endanger personnel, let the fire burn
itself out. Incipient fire responders should wear eye protection. Structural firefighters must wear Self-Contained
Breathing Apparatus and full protective equipment. If Propylene Oxide is involved in a fire, fire runoff water should
be contained to prevent possible environmental damage.
6. ACCIDENTAL RELEASE MEASURES
SPILL AND LEAK RESPONSE: Uncontrolled releases should be responded to by trained personnel using pre-
planned procedures. Proper protective equipment should be used. Eliminate all sources of ignition prior to entering
the area. In case of a release, clear the affected area and protect people. Adequate fire protection must be
provided. Minimum Personal Protective Equipment should be Level B: fire-retardant protective clothing and a
chemically resistant suit, mechanically-resistant gloves and Self-Contained Breathing Apparatus. Use only
non-sparking tools and equipment. Locate and seal the source of the leaking gas. Protect personnel attempting the
shut-off with water-spray. Allow the gas to dissipate. Monitor the surrounding area for the level of Propylene Oxide,
and oxygen. If in liquid form, absorb or cover with dry earth, sand or other non-combustible material and transfer to
containers. Use clean non-sparking tools to collect absorbed material. Large spills: Dike far ahead of liquid spill for
later disposal. Water spray may reduce vapor; but may not prevent ignition in closed spaces.
Combustible vapor concentration must be below 10% of the LEL (LEL = 2.1% - see Section 5, Fire-Fighting
Measures) prior to entry of response personnel. The atmosphere must contain Propylene Oxide below levels listed
in Section 2 (Composition and Information on Ingredients) and have at least 19.5 percent oxygen before personnel
can be allowed in the area without Self-Contained Breathing Apparatus. Attempt to close the main source valve prior
to entering the area. If this does not stop the release (or if it is not possible to reach the valve), allow the gas to
release in-place or remove it to a safe area and allow the gas to be released there.
PART III How can I prevent hazardous situations from occurring?
7. HANDLING and STORAGE
WORK PRACTICES AND HYGIENE PRACTICES: As with all chemicals, avoid getting this gas IN YOU. Do not eat
or drink while handling chemicals. Be aware of any signs of overexposure [See Section 3 (Hazard Identification)],
because overexposure to fatal concentrations of this product could occur without any significant warning symptoms.
STORAGE AND HANDLING PRACTICES: Cylinders should be stored in dry, well-ventilated areas away from
sources of heat. Compressed gases can present significant safety hazards. Store containers away from heavily
trafficked areas and emergency exits. Post “No Smoking or Open Flames� signs in storage or use areas. Cylinders
should be separated from oxygen cylinders, or other oxidizers, by a minimum distance of 20 ft., or by a barrier of
non-combustible material at least 5 ft. high, having a fire-resistance rating of at least 0.5 hours. Isolate from other
incompatible chemicals (refer to Section 10, Stability and Reactivity). Storage areas must meet national electrical
codes for Class 1 Hazardous Areas. Post “No Smoking or Open Flames� signs in storage or use areas.
Consider installation of leak detection and alarm for storage and use areas. Have appropriate extinguishing
equipment in the storage area (i.e. sprinkler system, portable fire extinguishers).
SPECIAL PRECAUTIONS FOR HANDLING GAS CYLINDERS: Protect cylinders against physical damage. Store in
cool, dry, well-ventilated, fireproof area, away from flammable materials and corrosive atmospheres. Store away
from heat and ignition sources and out of direct sunlight. Do not store near elevators, corridors or loading docks. Do
not allow area where cylinders are stored to exceed 52°C (125°F). Avoid storing products by incompatible
chemicals. Do not store containers where they can come into contact with moisture. Cylinders should be stored
upright and be firmly secured to prevent falling or being knocked over. Cylinders can be stored in the open, but in
such cases, should be protected against extremes of weather and from the dampness of the ground to prevent
rusting. Never tamper with pressure relief devices in valves and cylinders. The following rules are applicable to
situations in which cylinders are being used:
Before Use: Move cylinders with a suitable hand-truck. Do not drag, slide or roll cylinders. Do not drop cylinders or
permit them to strike each other. Secure cylinders firmly. Leave the valve protection cap in-place until cylinder is
ready for use.
During Use: Use designated CGA fittings and other support equipment. Do not use adapters. Do not heat cylinder
by any means to increase the discharge rate of the product from the cylinder. Use check valve or trap in discharge
line to prevent hazardous backflow into the cylinder. Do not use oils or grease on gas-handling fittings or equipment.
After Use: Close main cylinder valve. Replace valve protection cap. Mark empty cylinders “EMPTY�.
PROPYLENE OXIDE (Document #001089) MSDS PAGE 4 OF 10
7. HANDLING and STORAGE (Continued)
SPECIAL PRECAUTIONS FOR HANDLING GAS CYLINDERS (continued):
NOTE: Use only DOT or ASME Code containers. Earth-ground and bond all lines and equipment associated with
this product. Close valve after each use and when empty. Cylinders must not be recharged except by or with the
consent of owner. For additional information refer to the Compressed Gas Association Pamphlet P-1, Safe Handling
of Compressed Gases in Containers. Additionally, refer to CGA Bulletin SB-2 “Oxygen Deficient Atmospheres�.
PROTECTIVE PRACTICES DURING MAINTENANCE OF CONTAMINATED EQUIPMENT: Follow practices
indicated in Section 6 (Accidental Release Measures). Make certain application equipment is locked and tagged-out
safely. Always use product in areas where adequate ventilation is provided.
8. EXPOSURE CONTROLS - PERSONAL PROTECTION
VENTILATION AND ENGINEERING CONTROLS: Use with adequate ventilation to ensure compliance with
exposure limits described in Section 2 (Composition and Information on Ingredients). Local exhaust ventilation is
preferred, because it prevents dispersion of this gas into the work place by eliminating it at its source. If appropriate,
install automatic monitoring equipment to detect the Propylene Oxide, and oxygen.
RESPIRATORY PROTECTION: Maintain Oxygen levels above 19.5% in the workplace. If respiratory protection is
needed, use only protection authorized in the U.S. Federal OSHA Standard (29 CFR 1910.134), applicable U.S.
State regulations, or the Canadian CSA Standard Z94.4-93 and applicable standards of Canadian Provinces.
Oxygen levels below 19.5% are considered IDLH by OSHA. In such atmospheres, use of a full-facepiece
pressure/demand SCBA or a full facepiece, supplied air respirator with auxiliary self-contained air supply is required
under OSHA’s Respiratory Protection Standard (1910.134-1998). The following are NIOSH respiratory protection
equipment recommendations for Propylene Oxide concentrations in air:
PROPYLENE OXIDE
CONCENTRATION RESPIRATORY PROTECTION
At Concentrations Above the NIOSH REL, or Where There is no REL, at any Detectable Concentration: Any Self-
Contained Breathing Apparatus (SCBA) that has a full facepiece and is operated in a
pressure-demand or other positive-pressure mode, or any Supplied-Air Respirator (SAR)
that has a full facepiece and is operated in a pressure-demand or other positive-pressure
mode in combination with an auxiliary SCBA operated in pressure-demand or other
positive-pressure mode.
Escape: Any Air-Purifying, Full-Facepiece Respirator (gas mask) with a chin-style, front- or back-mounted
canister providing protection Propylene Oxide, or any appropriate escape-type, SCBA.
EYE PROTECTION: Splash goggles, face-shields or safety glasses. If necessary, refer to U.S. OSHA 29 CFR
1910.133, or Canadian Standards.
HAND PROTECTION: Wear chemically-resistant gloves when handling Propylene Oxide. Wear mechanically-
resistant gloves when handling cylinders of this product. If necessary, refer to U.S. OSHA 29 CFR 1910.138 or
appropriate Standards of Canada.
BODY PROTECTION: Use body protection appropriate for task. Cotton clothing is recommended to prevent static
electric build up. Under certain circumstances of use and handling, the use of chemically resistant clothing may be
appropriate. If a hazard of injury to the feet exists due to falling objects, rolling objects, where objects may pierce the
soles of the feet or where employee’s feet may be exposed to electrical hazards, use foot protection, as described in
U.S. OSHA 29 CFR.
9. PHYSICAL and CHEMICAL PROPERTIES
VAPOR DENSITY (air = 1): 2.00 pH: Not applicable.
SPECIFIC GRAVITY (water = 1): 0.8304 MOLECULAR WEIGHT: 58.08
BOILING POINT(@ 1 atm.): 33.9°C (93°F) CRITICAL TEMPERATURE: 209.1°C (408°F)
EVAPORATION RATE (nBuAc = 1): Not available. EXPANSION RATIO: Not available.
ODOR THRESHOLD: 35 ppm (recognition) VAPOR PRESSURE @ 20°C: 59 kPa (445 mmHg)
MELTING/FREEZING POINT: -112°C (-170°F) SURFACE TENSION: 24.5 Newtons/metre (N/m)
CRITICAL PRESSURE: 4900 kPa (48.6 atm)
VISCOSITY-DYNAMIC @ 25°C: 0.28 mPa.s (0.28 centipoises)
SOLUBILITY IN WATER @ 20°C: Very soluble: 41 g/100 mL
SOLUBLE IN OTHER LIQUIDS: Soluble in ethanol, diethyl ether.
SATURATION VAPOR CONCENTRATION @ 20°C: 5.9 x 10 ppm (59%) [calculated]
COEFFICIENT WATER/OIL DISTRIBUTION: Log P(oct) = 0.03
APPEARANCE, ODOR AND COLOR: Propylene Oxide is a flammable, colorless liquid with an ethereal, or
benzene-like odor.
HOW TO DETECT THIS SUBSTANCE (warning properties): The odor of Propylene Oxide is not a reliable warning
of a release.
PROPYLENE OXIDE (Document #001089) MSDS PAGE 5 OF 10
10. STABILITY and REACTIVITY
STABILITY: Stable at standard temperatures and pressures.
DECOMPOSITION PRODUCTS: If ignited in air, or in the presence of water, Propylene Oxide will generate carbon
monoxide, carbon dioxide.
MATERIALS WITH WHICH SUBSTANCE IS INCOMPATIBLE: Propylene Oxide is incompatible with water, acids,
bases, oxidizing agents, metal chlorides, copper, and copper alloys.
HAZARDOUS POLYMERIZATION: Will occur on contact with highly active catalysts, acids, and bases.
CONDITIONS TO AVOID: Avoid exposing cylinders to extremely high temperatures, which could cause the
cylinders to rupture. Avoiding exposing this Propylene Oxide to incompatible chemicals.
PART IV Is there any other useful information about this material?
11. TOXICOLOGICAL INFORMATION
TOXICITY DATA: The following are toxicity data currently available for Propylene Oxide:
Open Irritation Test (Skin-Rabbit) 415 mg: TCLo (Inhalation-Rat) 1433 ppm/6 hours/12 TCLo (Inhalation-Mouse) 400 ppm/6 hours/2
Moderate days-intermittent: Lungs, Thorax, or years-intermittent: Tumorigenic:
Standard Draize Test (Skin-Rabbit) 50 mg/6 Respiration: dyspnea; Gastrointestinal: Carcinogenic by RTECS criteria; Sense
minutes: Severe hypermotility, diarrhea; Related to Chronic Organs and Special Senses (Olfaction):
Standard Draize Test (Eye-Rabbit) 20 mg: Data: death tumors
3
Severe TCLo (Inhalation-Rat) 25 mg/m /4 hours/26 TCLo (Inhalation-Guinea Pig) 457 ppm/7
Standard Draize Test (Eye-Rabbit) 20 mg/24 weeks-intermittent: Brain and Coverings: hours/22 weeks-intermittent: Sense Organs
hours: Moderate changes in surface EEG, other and Special Senses (Eye): effect, not
3
TCLo (Inhalation-Man)1400 gm/m /10 degenerative changes; Vascular: BP otherwise specified; Lungs, Thorax, or
minutes: Behavioral: somnolence (general lowering not characterized in autonomic Respiration: changes in lung weight;
depressed activity), headache; section Nutritional and Gross Metabolic: weight loss
Gastrointestinal: nausea or vomiting TCLo (Inhalation-Rat) 529 ppm/6 hours/4 or decreased weight gain
LC50 (Inhalation-Rat) 4000 ppm/4 hours: weeks-intermittent: Sense Organs and TCLo (Inhalation-Monkey) 100 ppm/7 hours:
Sense Organs and Special Senses Special Senses (Olfaction): effect, not male 2 year(s) pre-mating: Reproductive:
(Olfaction): effect, not otherwise specified, otherwise specified Paternal Effects: spermatogenesis (incl.
lacrimation; Lungs, Thorax, or Respiration: TCLo (Inhalation-Rat) 997 ppm/6 hours/2 genetic material, sperm morphology,
dyspnea weeks-intermittent: Cardiac: changes in motility, and count)
LC50 (Inhalation-Mouse) 1740 ppm/4 hours: heart weight; Lungs, Thorax, or Respiration: TDLo (Oral-Rat) 10,798 mg/kg/2 years-
Sense Organs and Special Senses structural or functional change in trachea or intermittent: Tumorigenic: Carcinogenic by
(Olfaction): effect, not otherwise specified; bronchi; Nutritional and Gross Metabolic: RTECS criteria; Gastrointestinal: tumors
Lungs, Thorax, or Respiration: dyspnea; weight loss or decreased weight gain TDLo (Subcutaneous-Rat) 1500 mg/kg/46
Gastrointestinal: changes in structure or TCLo (Inhalation-Rat) 100 ppm/7 hours/2 weeks-intermittent: Tumorigenic: equivocal
function of salivary glands years-intermittent: Tumorigenic: neoplastic tumorigenic agent by RTECS criteria,
LD50 (Oral-Rat) 380 mg/kg: Behavioral: by RTECS criteria; Endocrine: tumors facilitates action of known carcinogen
excitement, ataxia; Lungs, Thorax, or TCLo (Inhalation-Rat) 500 ppm/7 hours: TDLo (Intraperitoneal-Rat) 47 mg/kg: male 1
Respiration: respiratory stimulation female 7-16 day(s) after conception: day(s) pre-mating: Reproductive: Paternal
LD50 (Intraperitoneal-Rat) 150 mg/kg Reproductive: Effects on Embryo or Fetus: Effects: spermatogenesis (incl. genetic
LD50 (Intraperitoneal-Mouse) 175 mg/kg fetotoxicity (except death, e.g., stunted material, sperm morphology, motility, and
LD50 (Oral-Mouse) 440 mg/kg: Behavioral: fetus); Specific Developmental count)
excitement, ataxia; Lungs, Thorax, or Abnormalities: musculoskeletal system TDLo (Intraperitoneal-Rat) 1860 mg/kg: male
Respiration: respiratory stimulation TCLo (Inhalation-Rat) 500 ppm/7 hours: 6 week(s) pre-mating: Reproductive:
LD50 (Oral-Mammal-species unspecified) 440 female 7-16 day(s) after conception: Paternal Effects: spermatogenesis (incl.
mg/kg Reproductive: Specific Developmental genetic material, sperm morphology,
LD50 (Oral-Guinea Pig) 660 mg/kg: Abnormalities: craniofacial (including nose motility, and count), testes, epididymis,
Behavioral: somnolence (general and tongue) sperm duct
depressed activity); Liver: other changes; TCLo (Inhalation-Rat) 500 ppm/7 hours: TDLo (Subcutaneous-Mouse) 272 mg/kg/95
Kidney, Ureter, Bladder: other changes female 15 day(s) pre-mating female 1-16 weeks-intermittent: Tumorigenic:
LD50 (Skin-Rabbit) 1500 µL/kg day(s) after conception: Reproductive: Carcinogenic by RTECS criteria; Blood:
Fertility: pre-implantation mortality (e.g. lymphoma, including Hodgkin's disease;
LCLo (Inhalation-Dog) 2005 ppm/4 hours:
reduction in number of implants per female; Tumorigenic: tumors at site of application
Sense Organs and Special Senses
total number of implants per corpora lutea), TD (Subcutaneous-Mouse) 3640 mg/kg/91
(Olfaction): effect, not otherwise specified,
litter size (e.g. # fetuses per litter; measured weeks-intermittent: Tumorigenic: neoplastic
lacrimation; Gastrointestinal: nausea or
before birth), other measures of fertility by RTECS criteria; Blood: lymphoma,
vomiting
TCLo (Inhalation-Mouse) 487 ppm/6 hours/2 including Hodgkin's disease, tumors at site
LCLo (Inhalation-Guinea Pig) 4000 ppm/4
weeks-intermittent: Behavioral: somnolence of application
hours: Sense Organs and Special Senses
(general depressed activity); Lungs, Thorax, TD (Subcutaneous-Mouse) 868 mg/kg/95
(Eye): iritis; Behavioral: muscle weakness;
or Respiration: dyspnea weeks-intermittent: Tumorigenic:
Lungs, Thorax, or Respiration: dyspnea
TCLo (Inhalation-Mouse) 125 ppm/6 hours/13 Carcinogenic by RTECS criteria; Blood:
LCLo (Inhalation-Rat) 457 ppm/7 hours/28
weeks-intermittent: Related to Chronic lymphoma, including Hodgkin's disease,
weeks-intermittent: Sense Organs and
Data: death tumors at site of application
Special Senses (Eye): effect, not otherwise
TCLo (Inhalation-Mouse) 400 ppm/6 hours/2 TD (Subcutaneous-Mouse) 2912 mg/kg/95
specified; Lungs, Thorax, or Respiration:
years-intermittent: Tumorigenic: weeks-intermittent: Tumorigenic:
fibrosis, focal (pneumoconiosis); Related to
Carcinogenic by RTECS criteria; Sense Carcinogenic by RTECS criteria; Blood:
Chronic Data: death
Organs and Special Senses (Olfaction): lymphoma, including Hodgkin's disease,
TDLo (Oral-Rat) 1170 mg/kg/45 days-
tumors tumors at site of application
intermittent: Brain and Coverings: other
degenerative changes; Liver: other
changes; Blood: other changes
PROPYLENE OXIDE (Document #001089) MSDS PAGE 6 OF 10
11. TOXICOLOGICAL INFORMATION (Continued)
TOXICITY DATA (continued):
TD (Subcutaneous-Mouse) 6616 mg/kg/95 Specific Locus Test (Mouse-Lymphocyte) Heritable Translocation Test (Parenteral-
weeks-intermittent: Tumorigenic: 160 ppm/48 hours-continuous Drosophila melanogaster) 10 ppb
Carcinogenic by RTECS criteria; Blood: Mutation in Microorganisms (Bacteria- Gene Conversion and Mitotic Recombination
Salmonella typhimurium) 350 µg/plate
lymphoma, including Hodgkin's disease, (Yeast-Saccharomyces cerevisiae) 25
tumors at site of application mmol/L
Mutation in Microorganisms (Bacteria-
TD (Oral-Rat) 2714 mg/kg/2 years- Sister Chromatid Exchange (Yeast-
Salmonella typhimurium) 700 µg/plate
intermittent: Tumorigenic: equivocal Saccharomyces cerevisiae) 100 mmol/L
Mutation in Microorganisms (Bacteria-
tumorigenic agent by RTECS criteria; Sister Chromatid Exchange (Human-
Salmonella typhimurium) 1 pph
Gastrointestinal: tumors Lymphocyte) 25,000 ppm
Mutation in Microorganisms (Bacteria-
TC (Inhalation-Rat) 400 ppm/6 hours/2 years- Sister Chromatid Exchange (Intraperitoneal-
Escherichia coli) 700 µg/plate
intermittent: Tumorigenic: equivocal Mouse) 232 mg/kg
Mutation in Microorganisms (Bacteria-
tumorigenic agent by RTECS criteria; Sister Chromatid Exchange (Hamster-Ovary)
Klebsiella pneumoniae) 500 µmol/L
Sense Organs and Special Senses 5 mg/L
Mutation in Microorganisms (Microorganism-
(Olfaction): tumors Sister Chromatid Exchange (Hamster-Lung)
not otherwise specified) 25 mmol/L
2500 µmol/L
TC (Inhalation-Rat) 300 ppm/6 hours/2.3 Mutation in Microorganisms (Microorganism-
years-intermittent: Tumorigenic: neoplastic Cytogenetic Analysis (Human-Lymphocyte)
not otherwise specified): 5 mmol/plate
by RTECS criteria; Skin and Appendages: 1850 µg/L
Mutation in Microorganisms (Mold-
tumors Cytogenetic Analysis (Rat-Liver) 25 µg/L
Neurospora crassa) 500 mmol/L
DNA Damage (Bacteria-Escherichia coli) 1 Cytogenetic Analysis (Intraperitoneal-Mouse)
Mutation in Microorganisms (Yeast-
µmol/L 349 mg/kg
Saccharomyces cerevisiae) 50 mmol/L
DNA Damage (Microorganism-not otherwise Cytogenetic Analysis (Hamster-Ovary) 160
Mutation in Microorganisms (Yeast-
specified) 1 mmol/L mg/L
Schizosaccharomyces pombe) 183 mmol/L
DNA Damage (Salmon-Sperm) 5 minutes Dominant Lethal Test (Inhalation-Rat) 300
Sex Chromosome Loss and Nondisjunction
DNA Damage (Fish-not otherwise specified ppm/5 days-intermittent
(Inhalation-Drosophila melanogaster) 645
Testis) 5 gm Micronucleus Test (Intraperitoneal-Mouse)
ppm/24 hours-continuous
DNA Damage (Rat-Liver) 30 µmol/L 600 mg/kg/24 hours
Sex Chromosome Loss and Nondisjunction
DNA Damage (Intraperitoneal-Mouse) 200 Mutation in Mammalian Somatic Cells
(Oral-Drosophila melanogaster) 1 ppb
mg/kg (Mouse-Lymphocyte) 400 µg/L
Sex Chromosome Loss and Nondisjunction
DNA Damage (Mammal-species (Parenteral-Drosophila melanogaster) 10 DNA Adduct (Mammal-species unspecified-
unspecified-Lymphocyte) 75 mmol/L ppb Lymphocyte) 100 mmol/tube
Specific Locus Test (Inhalation-Drosophila
melanogaster) 1500 ppm
SUSPECTED CANCER AGENT: Propylene Oxide is listed as follows:
ACGIH TLV-A3 (Confirmed Animal Carcinogen); EPA-B2 (Probable Human Carcinogen: Sufficient Evidence from Animal Studies, Inadequate
Evidence or No Data from Epidemiologic Studies); IARC-2B (Probably Carcinogenic to Humans), MAK-2 (Substances That Are Considered to be
Carcinogenic for Man Because Sufficient Data From Long-Term Animal Studies or Limited Evidence From Animal Studies Substantiated by
Evidence From Epidemiological Studies Indicate that They Can Make a Significant Contribution to Cancer Risk.), NIOSH-Ca (Potential
Occupational Carcinogen, With No Further Categorization); NTP-R (Reasonably Anticipated to Be a Human Carcinogen)
IRRITANCY OF PRODUCT: Propylene Oxide can be irritating and corrosive to contaminated tissue and eyes.
SENSITIZATION OF PRODUCT: There are confirmed data of possible sensitization effects after dermal contact or
inhalation of Propylene Oxide.
REPRODUCTIVE TOXICITY INFORMATION: Listed below is information concerning the effects of Propylene Oxide
on the human reproductive system.
Mutagenicity: Human mutation data are available Propylene Oxide; these data were obtained during clinical
studies on specific human tissues exposed to high doses of this compound.
Embryotoxicity: Currently, there are no human embryotoxic data for Propylene Oxide.
Teratogenicity: Currently, there are no human teratogenic data for Propylene Oxide. Clinical studies on test
animals exposed to relatively high doses of Propylene Oxide indicate teratogenic effects.
Reproductive Toxicity: Currently, there are no human reproductive data for Propylene Oxide. Clinical studies on
test animals exposed to relatively high doses of Propylene Oxide indicate adverse reproductive effects.
A mutagen is a chemical which causes permanent changes to genetic material (DNA) such that the changes will
propagate through generation lines. An embryotoxin is a chemical which causes damage to a developing embryo
(i.e. within the first eight weeks of pregnancy in humans), but the damage does not propagate across generational
lines. A teratogen is a chemical which causes damage to a developing fetus, but the damage does not propagate
across generational lines. A reproductive toxin is any substance which interferes in any way with the reproductive
process.
ACGIH BIOLOGICAL EXPOSURE INDICES: Currently, there are no Biological Exposure Indices determined for
Propylene Oxide.
12. ECOLOGICAL INFORMATION
ENVIRONMENTAL STABILITY: Propylene Oxide readily hydrolyzes. Additional environmental data is available as
follows:
Terrestrial Fate: The aqueous hydrolysis of Propylene Oxide occurs at an environmentally important rate, therefore, hydrolysis in moist soil
conditions is likely to be important. The estimated Koc values of 3.6 and 30 indicate that propylene oxide is expected to be very mobile in
soil. The relatively high vapor pressure of Propylene Oxide, 439 mm Hg at 20°C, suggest that it should evaporate rapidly from dry soil
surfaces. Propylene Oxide is predicted to be moderately volatile from water; therefore, evaporation from wet soils may also be possible,
however, the rate of evaporation may be diminished by leaching. (continued on following page)
PROPYLENE OXIDE (Document #001089) MSDS PAGE 7 OF 10
12. ECOLOGICAL INFORMATION (Continued)
ENVIRONMENTAL STABILITY (continued):
Aquatic Fate: In freshwater, Propylene Oxide will hydrolyze with estimated half-lives of 11.6 days (pH's 7-9) and 6.6 days (pH 5) at 25°C. The
presence of chloride ion accelerates the degradation as the chemical degradation half-lives in seawater are estimated to be 4.1 days (pH's
7-9) and 1.5 days (pH 5) at 25°C. Reaction of Propylene Oxide with Cl ion in water yields approximately 90% 1-chloro-2-propanol and 10%
2-chloro-1-propanol as products under neutral pH conditions. Reaction with photochemically produced hydroxyl radicals in natural water has
no environmental significance as the estimated half-life at room temperature is 9.15 years. The estimated Koc values of 3.6 and 30 suggest
that partitioning of propylene oxide from the water column to sediments and particulate matter will not be important. Volatilization of
Propylene Oxide from the aquatic environment may be an important transport mechanism as the calculated half-life from a model river 1 m
deep flowing at 1 m/sec with a wind velocity of 3 m/sec is 10 hr at 20°C and the calculated half-life from a representative oligotrophic lake is
18 days at 20°C. Calculated log BCF's of -0.20 and -0.40 suggest that bioconcentration in aquatic organisms will not be environmentally
significant.
Atmospheric Fate: When released to the atmosphere, vapor phase Propylene Oxide will react with photochemically produced hydroxyl
radicals with a calculated half-life of 30 days. It is not expected to react significantly with ozone in the atmosphere. Physical removal of
Propylene Oxide from the ambient atmosphere is not expected to be generally important, although localized wash-out due to rainfall may
occur.
Biodegradation: Using the standard dilution method, a 5 day BODT of 8% was measured for Propylene Oxide using a filtered effluent seed
from a biological sanitary waste treatment plant while a 5 day BODT of 9% was measured using an adapted seed.
EFFECT OF MATERIAL ON PLANTS or ANIMALS: Exposure to animals may result in burns or may be fatal.
Additionally, frost produced in the presence of rapidly expanding gases may adversely affect plant life.
EFFECT OF CHEMICAL ON AQUATIC LIFE: Propylene Oxide may have an adverse effect on aquatic life if
released into an aquatic environment.
13. DISPOSAL CONSIDERATIONS
PREPARING WASTES FOR DISPOSAL: Product removed from cylinder must be disposed of in accordance with
appropriate U.S. Federal, State and local regulations or with regulations of Canada and its Provinces. Return
cylinders with residual product to Airgas, Inc. Do not dispose of locally.
14. TRANSPORTATION INFORMATION
THIS MATERIAL IS HAZARDOUS AS DEFINED BY 49 CFR 172.101 BY THE U.S. DEPARTMENT OF
TRANSPORTATION.
PROPER SHIPPING NAME: Propylene Oxide
HAZARD CLASS NUMBER and DESCRIPTION: 3 (Flammable)
UN IDENTIFICATION NUMBER: UN 1280
PACKING GROUP: I
DOT LABEL(S) REQUIRED: Class 3 (Flammable)
NORTH AMERICAN EMERGENCY RESPONSE GUIDEBOOK NUMBER (2000): 127P
MARINE POLLUTANT: Propylene Oxide is not classified by the DOT as a Marine Pollutant (as defined by 49 CFR
172.101, Appendix B).
TRANSPORT CANADA TRANSPORTATION OF DANGEROUS GOODS REGULATIONS: Propylene Oxide is
considered as dangerous goods, per regulations of Transport Canada. Use the above U.S. DOT shipping
information for the preparation of Canadian Shipments.
15. REGULATORY INFORMATION
ADDITIONAL U.S. REGULATIONS:
U.S. SARA REPORTING REQUIREMENTS: Propylene Oxide is subject to the reporting requirements of Sections
302, 304, and 313 of Title III of the Superfund Amendments and Reauthorization Act, as follows:
SARA 302 SARA 304 SARA 313
CHEMICAL NAME
(40 CFR 355, Appendix A) (40 CFR Table 302.4) (40 CFR 372.65)
Propylene Oxide Yes Yes Yes
U.S. SARA THRESHOLD PLANNING QUANTITY: Propylene Oxide = 10,000 lb (4540 kg); Extremely Hazardous
RQ (Section 304) = 100 lb (45.4 kg)
U.S. CERCLA REPORTABLE QUANTITY (RQ): Propylene Oxide = 100 lb (45.4 kg)
U.S. TSCA INVENTORY STATUS: Propylene Oxide is listed on the TSCA Inventory.
OTHER U.S. FEDERAL REGULATIONS: Propylene Oxide is subject to the reporting requirements of Section 112(r)
of the Clean Air Act. Threshold Quantity = 10,000 lbs (4540 kg). Propylene Oxide is listed as a Regulated
Substance (Toxic Substance) per 40 CFR, Part 68 of the Risk Management for Chemical Release Prevention.
Threshold Quantity = 10,000 lb (4540 kg). Depending on specific operations involving the use of Propylene Oxide,
the regulations of the Process Safety Management of Highly Hazardous Chemicals may be applicable (29 CFR
1910.119). Under this regulation, Propylene Oxide is not listed in Appendix A; however, any process that involves a
flammable liquid on site in one location in quantities of 10,000 lbs (4,553 kg) or greater is covered under this
regulation unless it is used as a fuel. Propylene Oxide is listed as a hazardous air pollutant (HAP) generally known
or suspected to cause serious health problems under the Clean Air Act.
PROPYLENE OXIDE (Document #001089) MSDS PAGE 8 OF 10
15. REGULATORY INFORMATION (Continued)
ADDITIONAL U.S. REGULATIONS (continued):
U.S. STATE REGULATORY INFORMATION: Propylene Oxide is covered under specific State regulations, as
denoted below:
Alaska - Designated Toxic and Hazardous Michigan - Critical Materials Register: No. Pennsylvania - Hazardous Substance List:
Propylene Oxide.
Substances: Propylene Oxide. Minnesota - List of Hazardous Substances:
Propylene Oxide. Rhode Island - Hazardous Substance List:
California - Permissible Exposure Limits
Propylene Oxide.
Missouri - Employer Information/Toxic
for Chemical Contaminants: Propylene
Texas - Hazardous Substance List:
Oxide. Substance List: Propylene Oxide.
Propylene Oxide.
Florida - Substance List: Propylene Oxide. New Jersey - Right to Know Hazardous
West Virginia - Hazardous Substance List:
Illinois - Toxic Substance List: Propylene Substance List: Propylene Oxide.
Propylene Oxide.
Oxide. North Dakota - List of Hazardous
Wisconsin - Toxic and Hazardous
Kansas - Section 302/313 List: Propylene Chemicals, Reportable Quantities:
Substances: Propylene Oxide.
Oxide. Propylene Oxide.
Massachusetts - Substance List: Propylene
Oxide.
CALIFORNIA SAFE DRINKING WATER AND TOXIC ENFORCEMENT ACT (PROPOSITION 65): Propylene
Oxide is on the California Proposition 65 lists. WARNING! This product contains a chemical known to the state of
California to cause cancer.
CGA LABELING (For Compressed Gas):
DANGER: HARMFUL, FLAMMABLE LIQUID OR GAS UNDER PRESSURE.
MAY BE FATAL IF INHALED.
CAN CAUSE EYE IRRITATION OR BURNS.
CAN CAUSE SENSITIZATION BY DERMAL CONTACT OR INHALATION.
CAN FORM EXPLOSIVE MIXTURES WITH AIR.
CAN POLYMERIZE UPON EXPOSURE TO WATER, INCOMPATIBLE MATERIALS.
ODOR: ETHEREAL OR BENZENE-LIKE.
Do not breath gas.
Store and use with adequate ventilation, and use in closed systems.
Keep away from heat, flames, and sparks.
Avoid contact with eyes.
Cylinder temperature should not exceed 52°C (125°F).
Close valve after each use and when empty.
Use in accordance with the Material Safety Data Sheet.
FIRST AID: IF INHALED, remove to fresh air. If not breathing, give artificial respiration. If breathing is
difficult, give oxygen. Call a physician, even if no symptoms are present. Keep under medical
observation. Symptoms may be delayed.
IN CASE OF CONTACT, immediately flush eyes or skin with water for at least 15 minutes
while removing contaminated clothing and shoes. Call a physician.
DO NOT REMOVE THIS PRODUCT LABEL.
ADDITIONAL CANADIAN REGULATIONS:
CANADIAN DSL INVENTORY: Propylene Oxide is listed on the DSL Inventory.
OTHER CANADIAN REGULATIONS: Not applicable.
CANADIAN ENVIRONMENTAL PROTECTION ACT (CEPA) PRIORITIES SUBSTANCES LISTS: Propylene Oxide is not
on the CEPA Priorities Substances Lists.
CANADIAN WHMIS CLASSIFICATION AND SYMBOLS:
Class B2: Flammable Liquid
Class C: Corrosive
Class D1A: Acute Lethality
Class D2B: Other Toxic Effects-Chronic Toxic Effects � Sensitization
Class F: Dangerously Reactive Material
PROPYLENE OXIDE (Document #001089) MSDS PAGE 9 OF 10
16. OTHER INFORMATION
PREPARED BY: CHEMICAL SAFETY ASSOCIATES, Inc.
PO Box 3519, La Mesa, CA 91944-3519
858/670-0609
The information contained herein is based on data considered accurate. However, no warranty is expressed or implied regarding the
accuracy of these data or the results to be obtained from the use thereof. AirGas, Inc. assumes no responsibility for injury to the vendee or
third persons proximately caused by the material if reasonable safety procedures are not adhered to as stipulated in the data sheet.
Additionally, AirGas, Inc. assumes no responsibility for injury to vendee or third persons proximately caused by abnormal use of the material
even if reasonable safety procedures are followed. Furthermore, vendee assumes the risk in his use of the material.
DEFINITIONS OF TERMS
A large number of abbreviations and acronyms appear on a MSDS. Some of these which are commonly used include the following:
CAS #: This is the Chemical Abstract Service Number which uniquely identifies each constituent.
EXPOSURE LIMITS IN AIR: NATIONAL FIRE PROTECTION ASSOCIATION (continued): 2
(materials that on intense or continued exposure under fire
ACGIH - American Conference of Governmental Industrial
conditions could cause temporary incapacitation or possible residual
Hygienists, a professional association which establishes exposure
injury); 3 (materials that can on short exposure could cause serious
limits. TLV - Threshold Limit Value - an airborne concentration of a
substance which represents conditions under which it is generally temporary or residual injury); 4 (materials that under very short
believed that nearly all workers may be repeatedly exposed without exposure could cause death or major residual injury). Flammability
adverse effect. The duration must be considered, including the 8- Hazard and Reactivity Hazard: Refer to definitions for “Hazardous
Materials Identification System�.
hour Time Weighted Average (TWA), the 15-minute Short Term
Exposure Limit, and the instantaneous Ceiling Level (C). Skin FLAMMABILITY LIMITS IN AIR:
absorption effects must also be considered. Much of the information related to fire and explosion is derived from
OSHA - U.S. Occupational Safety and Health Administration. the National Fire Protection Association (NFPA). Flash Point -
PEL - Permissible Exposure Limit - This exposure value means Minimum temperature at which a liquid gives off sufficient vapors to
exactly the same as a TLV, except that it is enforceable by OSHA. form an ignitable mixture with air. Autoignition Temperature: The
The OSHA Permissible Exposure Limits are based in the 1989 minimum temperature required to initiate combustion in air with no
PELs and the June, 1993 Air Contaminants Rule (Federal Register: other source of ignition. LEL - the lowest percent of vapor in air, by
58: 35338-35351 and 58: 40191). Both the current PELs and the volume, that will explode or ignite in the presence of an ignition
vacated PELs are indicated. The phrase, “Vacated 1989 PEL,� is source. UEL - the highest percent of vapor in air, by volume, that will
placed next to the PEL which was vacated by Court Order. explode or ignite in the presence of an ignition source.
IDLH - Immediately Dangerous to Life and Health - This level TOXICOLOGICAL INFORMATION:
represents a concentration from which one can escape within 30- Possible health hazards as derived from human data, animal
minutes without suffering escape-preventing or permanent injury. studies, or from the results of studies with similar compounds are
The DFG - MAK is the Republic of Germany’s Maximum Exposure presented. Definitions of some terms used in this section are: LD50 -
Level, similar to the U.S. PEL. NIOSH is the National Institute of Lethal Dose (solids & liquids) which kills 50% of the exposed
Occupational Safety and Health, which is the research arm of the animals; LC50 - Lethal Concentration (gases) which kills 50% of the
U.S. Occupational Safety and Health Administration (OSHA). exposed animals; ppm concentration expressed in parts of material
NIOSH issues exposure guidelines called Recommended Exposure 3
per million parts of air or water; mg/m concentration expressed in
Levels (RELs). When no exposure guidelines are established, an weight of substance per volume of air; mg/kg quantity of material,
entry of NE is made for reference. by weight, administered to a test subject, based on their body weight
in kg. Data from several sources are used to evaluate the cancer-
HAZARD RATINGS:
causing potential of the material. The sources are: IARC - the
HAZARDOUS MATERIALS IDENTIFICATION SYSTEM: Health
International Agency for Research on Cancer; NTP - the National
Hazard: 0 (minimal acute or chronic exposure hazard); 1 (slight
Toxicology Program, RTECS - the Registry of Toxic Effects of
acute or chronic exposure hazard); 2 (moderate acute or significant
Chemical Substances, OSHA and CAL/OSHA. IARC and NTP rate
chronic exposure hazard); 3 (severe acute exposure hazard;
chemicals on a scale of decreasing potential to cause human
onetime overexposure can result in permanent injury and may be
cancer with rankings from 1 to 4. Subrankings (2A, 2B, etc.) are
fatal); 4 (extreme acute exposure hazard; onetime overexposure
also used. Other measures of toxicity include TDLo, the lowest dose
can be fatal). Flammability Hazard: 0 (minimal hazard); 1 (materials
to cause a symptom and TCLo the lowest concentration to cause a
that require substantial pre-heating before burning); 2 (combustible
symptom; TDo, LDLo, and LDo, or TC, TCo, LCLo, and LCo, the
liquid or solids; liquids with a flash point of 38-93°C [100-200°F]); 3
lowest dose (or concentration) to cause lethal or toxic effects. BEI -
(Class IB and IC flammable liquids with flash points below 38°C
Biological Exposure Indices, represent the levels of determinants
[100°F]); 4 (Class IA flammable liquids with flash points below 23°C
which are most likely to be observed in specimens collected from a
[73°F] and boiling points below 38°C [100°F]. Reactivity Hazard: 0
healthy worker who has been exposed to chemicals to the same
(normally stable); 1 (material that can become unstable at elevated
extent as a worker with inhalation exposure to the TLV. Ecological
temperatures or which can react slightly with water); 2 (materials
Information: EC is the effect concentration in water.
that are unstable but do not detonate or which can react violently
REGULATORY INFORMATION:
with water); 3 (materials that can detonate when initiated or which
This section explains the impact of various laws and regulations on
can react explosively with water); 4 (materials that can detonate at
the material. EPA is the U.S. Environmental Protection Agency.
normal temperatures or pressures). PERSONAL PROTECTIVE
WHMIS is the Canadian Workplace Hazardous Materials
EQUIPMENT CODES: B: Gloves and goggles; C: Gloves,
Information System. DOT and TC are the U.S. Department of
goggles, rubber apron (appropriate body protection); D: Gloves,
Transportation and the Transport Canada, respectively. Superfund
goggles, faceshield; rubber apron (appropriate body protection);. X:
Amendments and Reauthorization Act (SARA); the Canadian
Special attention should be given to PPE Selection.
Domestic/Non-Domestic Substances List (DSL/NDSL); the U.S.
NATIONAL FIRE PROTECTION ASSOCIATION: Health Hazard: 0
Toxic Substance Control Act (TSCA); Marine Pollutant status
(material that on exposure under fire conditions would offer no
according to the DOT; the Comprehensive Environmental
hazard beyond that of ordinary combustible materials); 1 (materials
Response, Compensation, and Liability Act (CERCLA or
that on exposure under fire conditions could cause irritation or minor
Superfund); and various state regulations.
residual injury);
PROPYLENE OXIDE (Document #001089) MSDS PAGE 10 OF 10
|