Material Safety Data Sheet
Acetonitrile
Section 1. Chemical product and company identification
: Acetonitrile
Product Name
: AIRGAS INC., on behalf of its subsidiaries
Supplier
259 North Radnor-Chester Road
Suite 100
Radnor, PA 19087-5283
1-610-687-5253
: acetonitril (german, dutch); acetonitrile ; cyanomethane; cyanure de methyl (french);
Synonym
ethanenitrile; ethyl nitrile; methanecarbonitrile; methane, cyano-; methyl cyanide; nci-
c60822; usaf ek-488
: Other non specified industry: SOLVENT IN HYDROCARBON EXTRACTION PROCESSES,
Material uses
ESPECIALLY FOR BUTADIENE; SPECIALTY SOLVENT; INTERMEDIATE; CATALYST;
SEPARATION OF FATTY ACIDS FROM VEGETABLE OILS; MANUFACTURE OF
SYNTHETIC PHARMACEUTICALS.
: 001102
MSDS#
Date of : 5/31/2006.
Preparation/Revision
: 1-866-734-3438
In case of emergency
Section 2. Hazards identification
: Liquid. (COLORLESS LIQUID WITH A SWEET, ETHER-LIKE ODOR [NOTE:FORMS
Physical state
CYANIDE IN THE BODY])
: Danger!
Emergency overview
HIGHLY FLAMMABLE LIQUID AND VAPOR.
CAUSES DAMAGE TO THE FOLLOWING ORGANS: KIDNEYS, LIVER,
CARDIOVASCULAR SYSTEM, RESPIRATORY TRACT, SKIN, CENTRAL NERVOUS
SYSTEM, EYE, LENS OR CORNEA.
VAPOR MAY CAUSE FLASH FIRE.
Keep away from heat, sparks and flame. Keep container closed. Use only with
adequate ventilation.
: Dermal contact. Eye contact. Inhalation.
Routes of entry
Potential acute health effects
Irritating to eyes.
Eyes :
Irritating to skin.
Skin :
Harmful by inhalation.
Inhalation :
Harmful if swallowed.
:
Ingestion
CARCINOGENIC EFFECTS A4 (Not classifiable for human or animal.) by ACGIH.
:
Potential chronic health :
MUTAGENIC EFFECTS Not available.
:
effects
TERATOGENIC EFFECTS Not available.
:
: Repeated or prolonged exposure is not known to aggravate medical condition.
Medical conditions
aggravated by overexposure
See toxicological Information (section 11)
Section 3. Composition, Information on Ingredients
United States
Exposure limits
acetonitrile 75-05-8 100 ACGIH TLV (United States, 1/2005). Skin
Notes: Refers to Appendix A --
Carcinogens. 2002 Adoption.
TWA: 20 ppm 8 hour(s). Form: All forms
NIOSH REL (United States, 12/2001).
TWA: 34 mg/m 3 10 hour(s). Form: All forms
TWA: 20 ppm 10 hour(s). Form: All forms
Acetonitrile
OSHA PEL (United States, 8/1997).
TWA: 70 mg/m 3 8 hour(s). Form: All forms
TWA: 40 ppm 8 hour(s). Form: All forms
Section 4. First aid measures
: In case of contact, immediately flush eyes with plenty of water for at least 15 minutes.
Eye contact
Get medical attention if irritation occurs.
: In case of contact, immediately flush skin with plenty of water. Remove contaminated
Skin contact
clothing and shoes. Wash clothing before reuse. Thoroughly clean shoes before reuse.
Get medical attention.
: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is
Inhalation
difficult, give oxygen. Get medical attention if symptoms appear.
: Do NOT induce vomiting unless directed to do so by medical personnel. Never give
Ingestion
anything by mouth to an unconscious person. Get medical attention if symptoms
appear.
Section 5. Fire fighting measures
Flammable.
Flammability of the product :
524掳C (975.2掳F)
Auto-ignition temperature :
Closed cup: 5.85掳C (42.5掳F).
Flash point :
Lower: 4.4% Upper: 16%
Flammable limits :
These products are carbon oxides (CO, CO 2), nitrogen oxides (NO, NO 2...).
Products of combustion :
In case of fire, use water spray (fog), foam, dry chemicals, or CO 2.
Fire fighting media and :
instructions
Highly flammable liquid and vapor. Vapor may cause flash fire. Vapors may accumulate
in low or confined areas, travel considerable distance to source of ignition and flash
back. Runoff to sewer may create fire or explosion hazard.
: Fire fighters should wear appropriate protective equipment and self-contained breathing
Special protective
apparatus (SCBA) with a full facepiece operated in positive pressure mode.
equipment for fire-fighters
Section 6. Accidental release measures
: Immediately contact emergency personnel. Eliminate all ignition sources. Keep
Personal precautions
unnecessary personnel away. Use suitable protective equipment (Section 8). Do not
touch or walk through spilled material.
Environmental precautions : Avoid dispersal of spilled material and runoff and contact with soil, waterways, drains
and sewers.
: If emergency personnel are unavailable, contain spilled material. For small spills add
Methods for cleaning up
absorbent (soil may be used in the absence of other suitable materials) and use a non-
sparking or explosion proof means to transfer material to a sealed, appropriate container
for disposal. For large spills dike spilled material or otherwise contain material to ensure
runoff does not reach a waterway. Place spilled material in an appropriate container for
disposal.
Section 7. Handling and storage
: Keep container closed. Use only with adequate ventilation. Keep away from heat,
Handling
sparks and flame. To avoid fire or explosion, dissipate static electricity during transfer by
grounding and bonding containers and equipment before transferring material. Use
explosion-proof electrical (ventilating, lighting and material handling) equipment.
: Store in a segregated and approved area. Keep container in a cool, well-ventilated area.
Storage
Keep container tightly closed and sealed until ready for use. Avoid all possible sources
of ignition (spark or flame).
Acetonitrile
Section 8. Exposure Controls, Personal Protection
: Provide exhaust ventilation or other engineering controls to keep the airborne
Engineering controls
concentrations of vapors below their respective occupational exposure limits. Ensure
that eyewash stations and safety showers are proximal to the work-station location.
Personal protection
: Safety eyewear complying with an approved standard should be used when a risk
Eyes
assessment indicates this is necessary to avoid exposure to liquid splashes, mists or
dusts.
: Personal protective equipment for the body should be selected based on the task being
Skin
performed and the risks involved and should be approved by a specialist before handling
this product.
: Use a properly fitted, air-purifying or air-fed respirator complying with an approved
Respiratory
standard if a risk assessment indicates this is necessary.Respirator selection must be
based on known or anticipated exposure levels, the hazards of the product and the safe
working limits of the selected respirator.
: Chemical-resistant, impervious gloves or gauntlets complying with an approved standard
Hands
should be worn at all times when handling chemical products if a risk assessment
indicates this is necessary.
Personal protection in case : Splash goggles. Full suit. Vapor respirator. Boots. Gloves. A self-contained breathing
apparatus should be used to avoid inhalation of the product. Suggested protective
of a large spill
clothing might not be sufficient; consult a specialist BEFORE handling this product.
Product name Exposure limits
United States
acetonitrile ACGIH TLV (United States, 1/2005). Skin Notes: Refers to Appendix
A -- Carcinogens. 2002 Adoption.
TWA: 20 ppm 8 hour(s). Form: All forms
NIOSH REL (United States, 12/2001).
TWA: 34 mg/m 3 10 hour(s). Form: All forms
TWA: 20 ppm 10 hour(s). Form: All forms
OSHA PEL (United States, 8/1997).
TWA: 70 mg/m 3 8 hour(s). Form: All forms
TWA: 40 ppm 8 hour(s). Form: All forms
Section 9. Physical and chemical properties
: Liquid. (COLORLESS LIQUID WITH A SWEET, ETHER-LIKE ODOR [NOTE:FORMS
Physical state
CYANIDE IN THE BODY])
: SWEET; ETHEREAL
Odor
: 41.06 g/mole
Molecular weight
: C2-H3-N
Molecular formula
Boiling/condensation point : 81.67掳C (179掳F)
: -41.9掳C (-43.4掳F)
Melting/freezing point
: 274.8掳C (526.6掳F)
Critical temperature
: 0.787 (Water = 1)
Specific gravity
: 9.7 kPa (72.8 mm Hg) (at 20掳C)
Vapor pressure
: 1.42 (Air = 1)
Vapor density
: 2.33 compared to Butyl acetate.
Evaporation rate
Section 10. Stability and reactivity
: The product is stable.
Stability and reactivity
Incompatibility with various : Highly reactive with oxidizing agents.
substances
Hazardous polymerization : Will not occur.
Acetonitrile
Section 11. Toxicological information
Toxicity data
Ingredient name Test Result Route Species
acetonitrile LD50 2460 mg/kg Oral Rat
LD50 50 mg/kg Oral Rabbit
LD50 177 mg/kg Oral Guinea pig
LC50 21354 ppm (1 Inhalation Rat
hour(s))
: 500 ppm
IDLH
Chronic effects on humans : CARCINOGENIC EFFECTS A4 (Not classifiable for human or animal.) by ACGIH.
:
Causes damage to the following organs: kidneys, liver, cardiovascular system, upper
respiratory tract, skin, central nervous system (CNS), eye, lens or cornea.
: Hazardous in case of eye contact (irritant).
Other toxic effects on
humans
Specific effects
: No known significant effects or critical hazards.
Carcinogenic effects
: No known significant effects or critical hazards.
Mutagenic effects
: No known significant effects or critical hazards.
Reproduction toxicity
Section 12. Ecological information
Ingredient name Species Period Result
acetonitrile Daphnia magna (LC50) 96 hour(s) >100 mg/l
Pimephales promelas (LC50) 96 hour(s) >100 mg/l
Pimephales promelas (LC50) 96 hour(s) 1640 mg/l
: These products are carbon oxides (CO, CO 2) and water, nitrogen oxides (NO, NO 2...).
Products of degradation
: The products of degradation are less toxic than the product itself.
Toxicity of the products of
biodegradation
Section 13. Disposal considerations
: The generation of waste should be avoided or minimized wherever possible. Avoid
Waste disposal
dispersal of spilled material and runoff and contact with soil, waterways, drains and
sewers. Disposal of this product, solutions and any by-products should at all times
comply with the requirements of environmental protection and waste disposal legislation
and any regional local authority requirements.
Consult your local or regional authorities.
Section 14. Transport information
Regulatory UN number Proper shipping Class Packing group Label Additional
information name information
DOT Classification UN1648 ACETONITRILE. 3 II Marine
Marine pollutant pollutant
FLAMMABLE LIQUID
(acetonitrile) Marine
3
pollutant (P)
Reportable
quantity
5000 lbs.
(2268 kg)
Limited
quantity
Yes.
Packaging
instruction
Passenger
Acetonitrile
Aircraft
Quantity
limitation: 5 L
Cargo Aircraft
Quantity
limitation: 60 L
Special
provisions
IB2, T7, TP2
TDG Classification UN1648 ACETONITRILE 3 II Explosive
Limit and
Limited
3
Quantity
Index
1
Passenger
Carrying
Road or Rail
Index
5
UN1648 ACETONITRILE. 3 II
Mexico Marine
Marine pollutant
Classification pollutant
FLAMMABLE LIQUID
(acetonitrile) Marine
3
pollutant (P)
Reportable
quantity
5000 lbs.
(2268 kg)
Limited
quantity
Yes.
Packaging
instruction
Passenger
Aircraft
Quantity
limitation: 5 L
Cargo Aircraft
Quantity
limitation: 60 L
Special
provisions
IB2, T7, TP2
Acetonitrile
Section 15. Regulatory information
United States
: Flammable liquid
HCS Classification
Target organ effects
: TSCA 4(a) final test rules: acetonitrile
U.S. Federal regulations
TSCA 8(a) PAIR: acetonitrile
TSCA 8(b) inventory: acetonitrile
TSCA 12(b) one time export: acetonitrile
SARA 302/304/311/312 extremely hazardous substances: No products were found.
SARA 302/304 emergency planning and notification: No products were found.
SARA 302/304/311/312 hazardous chemicals: acetonitrile
SARA 311/312 MSDS distribution - chemical inventory - hazard identification:
acetonitrile: Fire hazard, Immediate (Acute) Health Hazard, Delayed (Chronic) Health
Hazard
Clean Water Act (CWA) 307: acetonitrile
Clean Water Act (CWA) 311: No products were found.
Clean air act (CAA) 112 accidental release prevention: No products were found.
Clean air act (CAA) 112 regulated flammable substances: No products were found.
Clean air act (CAA) 112 regulated toxic substances: No products were found.
SARA 313
Product name CAS number Concentration
: acetonitrile 75-05-8 100
Form R - Reporting
requirements
: acetonitrile 75-05-8 100
Supplier notification
SARA 313 notifications must not be detached from the MSDS and any copying and redistribution of the MSDS shall
include copying and redistribution of the notice attached to copies of the MSDS subsequently redistributed.
: Pennsylvania RTK: acetonitrile: (environmental hazard, generic environmental hazard)
State regulations
Massachusetts RTK: acetonitrile
New Jersey: acetonitrile
Canada
: Class B-2: Flammable liquid with a flash point lower than 37.8掳C (100掳F).
WHMIS (Canada)
Class D-1A: Material causing immediate and serious toxic effects (VERY TOXIC).
Class D-2B: Material causing other toxic effects (TOXIC).
CEPA DSL: acetonitrile
Section 16. Other information
: HIGHLY FLAMMABLE LIQUID AND VAPOR.
Label Requirements
CAUSES DAMAGE TO THE FOLLOWING ORGANS: KIDNEYS, LIVER,
CARDIOVASCULAR SYSTEM, RESPIRATORY TRACT, SKIN, CENTRAL NERVOUS
SYSTEM, EYE, LENS OR CORNEA.
VAPOR MAY CAUSE FLASH FIRE.
*2
Hazardous Material : Health
Information System (U.S.A.) 3
Fire hazard
0
Reactivity
C
Personal protection
National Fire Protection :
Flammability
3
Association (U.S.A.)
2 0
Health Instability
Special
Notice to reader
Acetonitrile
To the best of our knowledge, the information contained herein is accurate. However, neither the above named
supplier nor any of its subsidiaries assumes any liability whatsoever for the accuracy or completeness of the
information contained herein.
Final determination of suitability of any material is the sole responsibility of the user. All materials may present
unknown hazards and should be used with caution. Although certain hazards are described herein, we cannot
guarantee that these are the only hazards that exist.
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